Cited by 273Neuroscience and Neuropharmacology ResearchCellular transport and secretionReceptor Mechanisms and Signaling

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Postsynaptic Positioning of Endocytic Zones and AMPA Receptor Cycling by Physical Coupling of Dynamin-3 to Homer

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Lu, Jiuyi, Helton, Thomas D., Blanpied, Thomas A., Rácz, Bence, Newpher, Thomas M., Weinberg, Richard J., Ehlers, Michael D.·2007·Neuron

DOI 10.1016/j.neuron.2007.06.041PMC PMC2597538

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Abstract

Endocytosis of AMPA receptors and other postsynaptic cargo occurs at endocytic zones (EZs), stably positioned sites of clathrin adjacent to the postsynaptic density (PSD). The tight localization of postsynaptic endocytosis is thought to control spine composition and regulate synaptic transmission. However, the mechanisms that situate the EZ near the PSD and the role of spine endocytosis in synaptic transmission are unknown. Here, we report that a physical link between dynamin-3 and the postsynaptic adaptor Homer positions the EZ near the PSD. Disruption of dynamin-3 or its interaction with Homer uncouples the PSD from the EZ, resulting in synapses lacking postsynaptic clathrin. Loss of the EZ leads to a loss of synaptic AMPA receptors and reduced excitatory synaptic transmission that corresponds with impaired synaptic recycling. Thus, a physical link between the PSD and the EZ ensures localized endocytosis and recycling by recapturing and maintaining a proximate pool of cycling AMPA receptors.

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Authors: Lu, J., Helton, T. D., Blanpied, T. A., Rácz, B., Newpher, T. M., Weinberg, R. J., & Ehlers, M. D.
Affiliations: Duke Medical Center (US)
University of North Carolina at Chapel Hill (US)
Howard Hughes Medical Institute (US)
Corresponding author: Ehlers, Michael D.
ORCID: Helton, Thomas D.
Blanpied, Thomas A.
Rácz, Bence
Newpher, Thomas M.
Weinberg, Richard J.
Ehlers, Michael D.
Venue: Neuron
Publisher: Elsevier BV
Published: 2007-09
Volume: 55
Issue: 6
Pages: 874-889
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2007.06.041
PMC: PMC2597538
OpenAlex: W1997282555
Cited by: 273
References: 51
Citations by year: 2026: 8 · 2025: 5 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 13 · 2019: 10 · 2018: 19 · 2017: 11 · 2016: 8 · 2015: 16 · 2014: 15 · 2013: 21 · 2012: 18
FWCI: 8.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2146 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: DNM3, Homer, postsynaptic density, clathrin, synaptic transmission, dendritic spine morphology, excitatory synapses, receptor recycling, protein-protein interaction
MeSH terms: Homer Scaffolding Proteins, Animals, Carrier Proteins, Clathrin, DNA, Electrophysiology, Humans, Immunohistochemistry, Microscopy, Electron, Synaptic Transmission, Neurons, Receptors, AMPA, Patch-Clamp Techniques, Microscopy, Confocal, GTP Phosphohydrolases, Transport Vesicles, Dynamin III, RNA Interference, Lipid Metabolism

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Postsynaptic Positioning of Endocytic Zones and AMPA Receptor Cycling by Physical Coupling of Dynamin-3 to Homer

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