Cited by 200Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanismsNeurogenesis and neuroplasticity mechanisms

Bidirectional plasticity in fast-spiking GABA circuits by visual experience

Yazaki-Sugiyama, Yoko, Kang, Siu, Câteau, Hideyuki, Fukai, Tomoki, Hensch, Takao K.·2009·Nature

Abstract

Experience-dependent plasticity in the brain requires balanced excitation-inhibition. How individual circuit elements contribute to plasticity outcome in complex neocortical networks remains unknown. Here we report an intracellular analysis of ocular dominance plasticity-the loss of acuity and cortical responsiveness for an eye deprived of vision in early life. Unlike the typical progressive loss of pyramidal-cell bias, direct recording from fast-spiking cells in vivo reveals a counterintuitive initial shift towards the occluded eye followed by a late preference for the open eye, consistent with a spike-timing-dependent plasticity rule for these inhibitory neurons. Intracellular pharmacology confirms a dynamic switch of GABA (gamma-aminobutyric acid) impact to pyramidal cells following deprivation in juvenile mice only. Together these results suggest that the bidirectional recruitment of an initially binocular GABA circuit may contribute to experience-dependent plasticity in the developing visual cortex.

Integrity signals

Registry

Crossref · 10.1038/nature08485

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yazaki-Sugiyama, Y., Kang, S., Câteau, H., Fukai, T., & Hensch, T. K.
Affiliations
  • RIKEN Center for Brain Science (JP)
  • Japan Science and Technology Agency (JP)
Corresponding author
Hensch, Takao K.
Venue
Nature
Published
2009-11
Volume
462
Issue
7270
Pages
218-221
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W2017144698
Cited by
200
References
37
Citations by year
2026: 2 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 8 · 2021: 9 · 2020: 5 · 2019: 7 · 2018: 14 · 2017: 15 · 2016: 11 · 2015: 13 · 2014: 17 · 2013: 28 · 2012: 20
FWCI
7.62
Type
journal article
Language
en
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
experience-dependent plasticity, ocular dominance, monocular deprivation, fast-spiking interneurons, GABAergic circuits, excitation-inhibition balance, spike-timing-dependent plasticity, visual cortex development, binocular vision, pyramidal neurons, bidirectional plasticity
MeSH terms
Action Potentials, Aging, Animals, gamma-Aminobutyric Acid, Interneurons, Mice, Inbred C57BL, Models, Neurological, Neuronal Plasticity, Neurons, Photic Stimulation, Visual Cortex, Visual Pathways, Visual Perception, Pyramidal Cells, Receptors, GABA, Dominance, Ocular, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review