Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
Griciuc, Ana, Serrano-Pozo, Alberto, Parrado, Antonio R., Lesinski, Andrea N., Asselin, Caroline N., Mullin, Kristina, Hooli, Basavaraj, Choi, Se Hoon +2 more·2013·Neuron
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Items 101–150 of 150
- CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer’s disease susceptibilityRaj, T., Ryan, K. J., Replogle, J. M., Chibnik, L. B., Rosenkrantz, L., Tang, A., Rothamel, K., Stranger, B. E., Bennett, D. A., Evans, D. A. et al. · 2014 · Human Molecular Genetics
- Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's DiseaseBhatti, Gurjit Kaur, Reddy, Arubala P., Reddy, P. Hemachandra, Bhatti, Jasvinder Singh · 2020 · Frontiers in Aging Neuroscience
- Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory responsePimenova, Anna A., Herbinet, Manon, Gupta, Ishaan, Machlovi, Saima I., Bowles, Kathryn R., Marcora, Edoardo, Goate, Alison M. · 2021 · Neurobiology of Disease
- Potassium Channel Kv1.3 Is Highly Expressed by Microglia in Human Alzheimer's DiseaseRangaraju, Srikant, Gearing, Marla, Jin, Lee-Way, Levey, Allan · 2015 · Journal of Alzheimer's Disease
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- Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future DirectionsElmaleh, David R., Farlow, Martin R., Conti, Peter S., Tompkins, Ronald G., Kundakovic, Ljiljana, Tanzi, Rudolph E. · 2019 · Journal of Alzheimer’s Disease
- ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processingSatoh, Kanayo, Abe-Dohmae, Sumiko, Yokoyama, Shinji, St George-Hyslop, Peter, Fraser, Paul E. · 2015 · Journal of Biological Chemistry
- Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathologyHaure-Mirande, Jean-Vianney, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Klein, William L., Glabe, Charles, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Wang, Minghui et al. · 2017 · Acta Neuropathologica
- Microglia in Aging and Alzheimer’s Disease: A Comparative Species ReviewEdler, Melissa K., Mhatre-Winters, Isha, Richardson, Jason R. · 2021 · Cells
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- Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid StimulationCaldeira, Cláudia, Cunha, Carolina, Vaz, Ana R., Falcão, Ana S., Barateiro, Andreia, Seixas, Elsa, Fernandes, Adelaide, Brites, Dora · 2017 · Frontiers in Aging Neuroscience
- Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathologyEl Hajj, Hassan, Savage, Julie C., Bisht, Kanchan, Parent, Martin, Vallières, Luc, Rivest, Serge, Tremblay, Marie-Ève · 2019 · Journal of Neuroinflammation
- Genetic variability in response to amyloid beta deposition influences Alzheimer’s disease riskSalih, Dervis A, Bayram, Sevinc, Guelfi, Sebastian, Reynolds, Regina H, Shoai, Maryam, Ryten, Mina, Brenton, Jonathan W, Zhang, David, Matarin, Mar, Botia, Juan A et al. · 2019 · Brain Communications
- A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer’s DiseaseSun, Miao, Ma, Kai, Wen, Jie, Wang, Guangxian, Zhang, Changliang, Li, Qi, Bao, Xiaofeng, Wang, Hui · 2020 · Journal of Alzheimer’s Disease
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- VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD miceEl Gaamouch, Farida, Audrain, Mickael, Lin, Wei-Jye, Beckmann, Noam, Jiang, Cheng, Hariharan, Siddharth, Heeger, Peter S., Schadt, Eric E., Gandy, Sam, Ehrlich, Michelle E. et al. · 2020 · Molecular Neurodegeneration
- Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearanceShibuya, Yohei, Chang, Catherine C.Y., Huang, Li-Hao, Bryleva, Elena Y., Chang, Ta-Yuan · 2014 · The Journal of Neuroscience
- The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?Doty, Kevin R., Guillot-Sestier, Marie-Victoire, Town, Terrence · 2015 · Brain Research
- Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent AdvancesDeng, Qianting, Wu, Chongyun, Parker, Emily, Liu, Timon Cheng-Yi, Duan, Rui, Yang, Luodan · 2023 · Aging and disease
- ABCA7 expression is associated with Alzheimer's disease polymorphism and disease statusVasquez, Jared B., Fardo, David W., Estus, Steven · 2013 · Neuroscience Letters
- Key role of MIF-related neuroinflammation in neurodegeneration and cognitive impairment in Alzheimer’s diseaseNasiri, Elham, Sankowski, Roman, Dietrich, Henriette, Oikonomidi, Aikaterini, Huerta, Patricio T., Popp, Julius, Al-Abed, Yousef, Bacher, Michael · 2020 · Molecular Medicine
- Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial PhagocytosisZhang, Can, Griciuc, Ana, Hudry, Eloise, Wan, Yu, Quinti, Luisa, Ward, Joseph, Forte, Angela M., Shen, Xunuo, Ran, ChongZhao, Elmaleh, David R. et al. · 2018 · Scientific Reports
- Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adultsYang, Hyun‐Sik, Zhang, Can, Carlyle, Becky C., Zhen, Sherri Y., Trombetta, Bianca A., Schultz, Aaron P., Pruzin, Jeremy J., Fitzpatrick, Colleen D., Yau, Wai‐Ying W., Kirn, Dylan R. et al. · 2022 · Alzheimer's & Dementia
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- The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative DiseaseBonham, Luke W., Sirkis, Daniel W., Yokoyama, Jennifer S. · 2019 · Frontiers in Immunology
- Tracking neuroinflammatory biomarkers in Alzheimer’s disease: a strategy for individualized therapeutic approaches?Lista, Simone, Imbimbo, Bruno P., Grasso, Margherita, Fidilio, Annamaria, Emanuele, Enzo, Minoretti, Piercarlo, López-Ortiz, Susana, Martín-Hernández, Juan, Gabelle, Audrey, Caruso, Giuseppe et al. · 2024 · Journal of Neuroinflammation
- The neuroinflammatory role of microglia in Alzheimer's disease and their associated therapeutic targetsAmeliMojarad, Melika, AmeliMojarad, Mandana · 2024 · CNS Neuroscience & Therapeutics
- Microbiota‐microglia connections in age‐related cognition declineZhou, Rui, Qian, Shufang, Cho, William C. S., Zhou, Jinyun, Jin, Chentao, Zhong, Yan, Wang, Jing, Zhang, Xiaohui, Xu, Zhoujiao, Tian, Mei et al. · 2022 · Aging Cell
- The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathologyLau, Shun-Fat, Wu, Wei, Wong, Hiu Yi, Ouyang, Li, Qiao, Yi, Xu, Jiahui, Lau, Jessica Hiu-Yan, Wong, Carlton, Jiang, Yuanbing, Holtzman, David M. et al. · 2023 · Nature Aging
- Galectin-3 is elevated in CSF and is associated with Aβ deposits and tau aggregates in brain tissue in Alzheimer’s diseaseBoza-Serrano, Antonio, Vrillon, Agathe, Minta, Karolina, Paulus, Agnes, Camprubí-Ferrer, Lluís, Garcia, Megg, Andreasson, Ulf, Antonell, Anna, Wennström, Malin, Gouras, Gunnar et al. · 2022 · Acta Neuropathologica
- Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and InfectionBrown, Madeleine R., Radford, Sheena E., Hewitt, Eric W. · 2020 · Frontiers in Molecular Neuroscience
- Activated Cyclin-Dependent Kinase 5 Promotes Microglial Phagocytosis of Fibrillar β-Amyloid by Up-regulating Lipoprotein Lipase ExpressionMa, Yuanhui, Bao, Jintao, Zhao, Xuyang, Shen, Hongyan, Lv, Junniao, Ma, Shuaipeng, Zhang, Xuefei, Li, Zeyang, Wang, Shuxin, Wang, Qingsong et al. · 2013 · Molecular & Cellular Proteomics
- Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectinsLinnartz-Gerlach, B., Mathews, M., Neumann, H. · 2014 · Neuroscience
- LILRB2-mediated TREM2 signaling inhibition suppresses microglia functionsZhao, Peng, Xu, Yuanzhong, Jiang, Lu-Lin, Fan, Xuejun, Ku, Zhiqiang, Li, Leike, Liu, Xiaoye, Deng, Mi, Arase, Hisashi, Zhu, Jay-Jiguang et al. · 2022 · Molecular Neurodegeneration
- γ-Secretase and its modulators: Twenty years and beyondXia, Weiming · 2019 · Neuroscience Letters
- Inflammatory response of microglia to prions is controlled by sialylation of PrPScSrivastava, Saurabh, Katorcha, Elizaveta, Makarava, Natallia, Barrett, James P., Loane, David J., Baskakov, Ilia V. · 2018 · Scientific Reports
- Therapeutic Role of Inflammasome Inhibitors in Neurodegenerative DisordersLahooti, Behnaz, Chhibber, Tanya, Bagchi, Sounak, Varahachalam, Sree Pooja, Jayant, Rahul D. · 2021 · Brain, Behavior, and Immunity
- Altered Neuroinflammation and behavior after traumatic brain injury in a mouse model of Alzheimer’s diseaseKokiko-Cochran, Olga, Ransohoff, Lena, Veenstra, Mike, Lee, Sungho, Saber, Maha, Sikora, Matt, Teknipp, Ryan, Xu, Guixiang, Bemiller, Shane, Wilson, Gina et al. · 2016 · Journal of Neurotrauma
- Microglia in Alzheimer's Disease: a Key Player in the Transition Between Homeostasis and PathogenesisMcFarland, Karen N., Chakrabarty, Paramita · 2022 · Neurotherapeutics
- Genetic risk factors for Alzheimer disease: emerging roles of microglia in disease pathomechanismsTakatori, Sho, Wang, Wenbo, Iguchi, Akihiro, Tomita, Taisuke · 2019 · Advances in Experimental Medicine and Biology
- Early and sustained altered expression of aging-related genes in young 3xTg-AD miceGatta, V, D'Aurora, M, Granzotto, A, Stuppia, L, Sensi, S L · 2014 · Cell Death & Disease
- Regulation of microglial survival and proliferation in health and diseasesUlland, Tyler K., Wang, Yaming, Colonna, Marco · 2015 · Seminars in Immunology
- Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila modelsSekiya, Michiko, Wang, Minghui, Fujisaki, Naoki, Sakakibara, Yasufumi, Quan, Xiuming, Ehrlich, Michelle E., De Jager, Philip L., Bennett, David A., Schadt, Eric E., Gandy, Sam et al. · 2018 · Genome Medicine
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- Senescence in aging and disorders of the central nervous systemSwenson, Barbara L., Meyer, Charlton F., Bussian, Tyler J., Baker, Darren J. · 2019 · Translational Medicine of Aging
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- Molecular mechanisms of Alzheimer’s disease: From therapeutic targets to promising drugsAlan, Elif, Kerry, Zeliha, Sevin, Gulnur · 2023 · Fundamental & Clinical Pharmacology
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