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Cited by 38Microtubule and mitosis dynamicsNeurogenesis and neuroplasticity mechanismsGenetic and Kidney Cyst Diseases

Cellular cartography: Towards an atlas of the neuronal microtubule cytoskeleton

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Iwanski, Malina K., Kapitein, Lukas C.·2023·Frontiers in Cell and Developmental Biology
DOI 10.3389/fcell.2023.1052245PMC PMC10073685
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Abstract

Microtubules, one of the major components of the cytoskeleton, play a crucial role during many aspects of neuronal development and function, such as neuronal polarization and axon outgrowth. Consequently, the microtubule cytoskeleton has been implicated in many neurodevelopmental and neurodegenerative disorders. The polar nature of microtubules is quintessential for their function, allowing them to serve as tracks for long-distance, directed intracellular transport by kinesin and dynein motors. Most of these motors move exclusively towards either the plus- or minus-end of a microtubule and some have been shown to have a preference for either dynamic or stable microtubules, those bearing a particular post-translational modification or those decorated by a specific microtubule-associated protein. Thus, it becomes important to consider the interplay of these features and their combinatorial effects on transport, as well as how different types of microtubules are organized in the cell. Here, we discuss microtubule subsets in terms of tubulin isotypes, tubulin post-translational modifications, microtubule-associated proteins, microtubule stability or dynamicity, and microtubule orientation. We highlight techniques used to study these features of the microtubule cytoskeleton and, using the information from these studies, try to define the composition, role, and organization of some of these subsets in neurons.

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  • The finding that stable cellular microtubules display expanded lattices directly supports the emerging model that microtubule lattice geometry functions as an additional cellular mechanism to guide protein binding specificity, on top of the previously established elements of the tubulin code.

    “Our finding that stable cellular microtubules display expanded lattices now directly supports the emerging model that the microtubule lattice geometry functions as an additional cellular mechanism to guide protein binding specificity, on top of the previously established elements of the tubulin code”

    From StableMARK-decorated microtubules in cells have expanded lattices (2025) · cites this paper as Iwanski and Kapitein, 2023

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Cited by

Sorted by citations

Authors
Iwanski, M. K., & Kapitein, L. C.
Affiliations
Utrecht University (NL)
Corresponding author
Kapitein, Lukas C.
ORCID
Venue
Frontiers in Cell and Developmental Biology
Publisher
Frontiers Media SA
Published
2023-03-22
Volume
11
Pages
1052245-1052245
ISSN
2296-634X (ISSN-L)
DOI
10.3389/fcell.2023.1052245
PMC
PMC10073685
OpenAlex
W4353087297
Cited by
38
References
15
Citations by year
2026: 12 · 2025: 16 · 2024: 6 · 2023: 4
FWCI
1.19
Type
journal article
Language
en
Update notices
corrigendum (2023-06-15)
Open access
Licence
Locations
  • Frontiers in Cell and Developmental Biology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
neuronal microtubules, microtubule cytoskeleton, tubulin isoforms, tubulin post-translational modifications, microtubule-associated proteins, microtubule stability, microtubule orientation, kinesin, dynein, intracellular transport, neuronal polarity, axon growth, neurodevelopmental disorders, neurodegenerative diseases

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