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Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells
Open accessAbstract
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To investigate neurogenic potential and cellular diversity, we profiled single-nucleus transcriptomes in five hippocampal-entorhinal subregions in humans, macaques, and pigs. Integrated cross-species analysis revealed robust transcriptomic and histologic signatures of neurogenesis in the adult mouse, pig, and macaque but not humans. Doublecortin (DCX), a widely accepted marker of newly generated granule cells, was detected in diverse human neurons, but it did not define immature neuron populations. To explore species differences in cellular diversity and implications for disease, we characterized subregion-specific, transcriptomically defined cell types and transitional changes from the three-layered archicortex to the six-layered neocortex. Notably, METTL7B defined subregion-specific excitatory neurons and astrocytes in primates, associated with endoplasmic reticulum and lipid droplet proteins, including Alzheimer's disease-related proteins. This resource reveals cell-type- and species-specific properties shaping hippocampal-entorhinal neurogenesis and function.
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“EC-specific subtypes that clustered separately from neocortical subtypes for the same layers were often marked by expression of RELN, TOX3 and GPC5, and contained subtypes from both the lateral (L2 RELN+GPC5+) and medial (L2 TOX3+POSTN+) EC41–43”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [41]
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“Five of the miR-132 targets (BMI1, FOXO1, SPRY1, DPYSL3, CITED2) displaying the highest betweenness centrality, a proxy of network connectivity, have all shown to be involved in cell cycle, and more specifically, in neurogenesis [68–72] (Fig. 5D) (Supplementary Table 7).”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [70]
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“Although some brain regions relevant to AD have been studied individually at scale or jointly in samples from a few individuals8–16, a comprehensive molecular characterization of region-specific differences in AD is currently lacking”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [13]
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“Five of the miR-132 targets (BMI1, FOXO1, SPRY1, DPYSL3, CITED2) displaying the highest betweenness centrality, a proxy of network connectivity, have all shown to be involved in cell cycle, and more specifically, in neurogenesis [68–72] (Fig. 5D) (Supplementary Table 7).”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [70]
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“Our data indicate that while there are common ‘core’ miR-132 targets across conditions, possibly involved in ‘housekeeping’ cellular functions, like cell cycle [68–72], there are also context-dependent targets, specific to healthy control or sAD iMGs.”
From microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients (2026) · cites this paper as [70]
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“Some groups have reported absent or minimal hippocampal neurogenesis in the mature brain using double immunofluorescence targeting markers expressed by neuronal cells at different maturational stages95, 96 and single nucleus transcriptomics97.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [97]
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“The explanatory power of neurogenesis in depression and antidepressant drug effects is complicated by the fact that neurogenesis is only observed in the dentate gyrus, putting a severe limit on the possible depression symptom domains it can impact, and by recent findings that neurogenesis may be very limited or absent in humans [102].”
From Plasticity of synapses and reward circuit function in the genesis and treatment of depression (2023) · cites this paper as [102]
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“We also conducted integration of our ATAC data and scATAC-seq data from human brain samples42 (Fig. 5b), and our RNA data with adult human brain snRNA-seq data43, to show the dominant cell identities and states.”
From Spatial epigenome–transcriptome co-profiling of mammalian tissues (2023) · cites this paper as [43]
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Citations
Cites
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Fast, sensitive and accurate integration of single-cell data with Harmony
Korsunsky, I., Millard, N., Fan, J., Slowikowski, K., Zhang, F., Wei, K., Baglaenko, Y., Brenner, M., Loh, P.-R., & Raychaudhuri, S. (2019) · Nature Methods · doi:10.1038/s41592-019-0619-0 · Cited by 10,488
Scenic: single-cell regulatory network inference and clustering.
Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Dimensionality reduction for visualizing single-cell data using UMAP
Becht, E., McInnes, L., Healy, J., Dutertre, C.-A., Kwok, I. W. H., Ng, L. G., Ginhoux, F., & Newell, E. W. (2019) · Nature Biotechnology · doi:10.1038/nbt.4314 · Cited by 5,358
A statistical model for identifying proteins by tandem mass spectrometry.
Nesvizhskii, A., Keller, A., Kolker, E., & Aebersold, R. (2003) · Analytical Chemistry · doi:10.1021/ac0341261 · Cited by 4,902
La Manno, G., Soldatov, R., Zeisel, A., Braun, E., Hochgerner, H., Petukhov, V., Lidschreiber, K., Kastriti, M. E., Lönnerberg, P., Furlan, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0414-6 · Cited by 4,118
BioGRID: a general repository for interaction datasets
Stark, C. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj109 · Cited by 3,960
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Zeisel, A., Muñoz-Manchado, A. B., Codeluppi, S., Lönnerberg, P., La Manno, G., Juréus, A., Marques, S., Munguba, H., He, L., Betsholtz, C., et al. (2015) · Science · doi:10.1126/science.aaa1934 · Cited by 3,124
Generalizing RNA velocity to transient cell states through dynamical modeling
Bergen, V., Lange, M., Peidli, S., Wolf, F. A., & Theis, F. J. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0591-3 · Cited by 2,951
Scrublet: computational identification of cell doublets in single-cell transcriptomic data
Wolock, S. L., Lopez, R., & Klein, A. M. (2018) · doi:10.1101/357368 · Cited by 2,758 · cited 1×
“Doublet scores were calculated using Scrublet package (Wolock et al., 2019).”
Scrublet: computational identification of cell doublets in single-cell transcriptomic data
Wolock, S. L., Lopez, R., & Klein, A. M. (2019) · Cell Systems · doi:10.1016/j.cels.2018.11.005 · Cited by 2,758
Single-cell transcriptomic analysis of Alzheimer’s disease
Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1195-2 · Cited by 2,568
Roux, K. J., Kim, D. I., Raida, M., & Burke, B. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201112098 · Cited by 2,416
Spatio-temporal transcriptome of the human brain
Kang, H. J., Kawasawa, Y. I., Cheng, F., Zhu, Y., Xu, X., Li, M., Sousa, A. M. M., Pletikos, M., Meyer, K. A., Sedmak, G., et al. (2011) · Nature · doi:10.1038/nature10523 · Cited by 2,084
Self-citationNeuronal Diversity and Temporal Dynamics: The Unity of Hippocampal Circuit Operations
Klausberger, T., & Somogyi, P. (2008) · Science · doi:10.1126/science.1149381 · Cited by 2,050
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,992
A molecular atlas of cell types and zonation in the brain vasculature
Vanlandewijck, M., He, L., Mäe, M. A., Andrae, J., Ando, K., Del Gaudio, F., Nahar, K., Lebouvier, T., Laviña, B., Gouveia, L., et al. (2018) · Nature · doi:10.1038/nature25739 · Cited by 1,892
Memory, navigation and theta rhythm in the hippocampal-entorhinal system
Buzsáki, G., & Moser, E. I. (2013) · Nature Neuroscience · doi:10.1038/nn.3304 · Cited by 1,847
Dynamics of hippocampal neurogenesis in adult humans
Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.002 · Cited by 1,841
Conserved cell types with divergent features in human versus mouse cortex
Hodge, R. D., Bakken, T. E., Miller, J. A., Smith, K. A., Barkan, E. R., Graybuck, L. T., Close, J. L., Long, B., Johansen, N., Penn, O., et al. (2019) · Nature · doi:10.1038/s41586-019-1506-7 · Cited by 1,775 · cited 22×
“InN clusters were first classified to major groups based on the expression of three canonical function markers (PVALB, SST, VIP) as well as LAMP5, a marker mostly representing a group of neurogliaform InN and recently being adopted as a major InN marker (Tasic et al., 2018; Hodge et al., 2019).”
InfluentialShared and distinct transcriptomic cell types across neocortical areas
Tasic, B., Yao, Z., Graybuck, L. T., Smith, K. A., Nguyen, T. N., Bertagnolli, D., Goldy, J., Garren, E., Economo, M. N., Viswanathan, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0654-5 · Cited by 1,746
Moreno-Jiménez, E. P., Flor-García, M., Terreros-Roncal, J., Rábano, A., Cafini, F., Pallas-Bazarra, N., Ávila, J., & Llorens-Martín, M. (2019) · Nature Medicine · doi:10.1038/s41591-019-0375-9 · Cited by 1,577 · cited 3×
“, progenitors [nestin]; neuroblasts and immature granule cells [DCX]) (Boldrini et al., 2018; Moreno-Jiménez et al., 2019; Tobin et al., 2019), single-cell RNA-seq studies are more comprehensive because they leverage combinatorial gene expression profiles to identify cell populations more robustly (Hochgerner et al.”
Uniquely Hominid Features of Adult Human Astrocytes
Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J., Auguste, K. I., et al. (2018) · Nature · doi:10.1038/nature25975 · Cited by 1,422
Use of within-array replicate spots for assessing differential expression in microarray experiments
Smyth, G. K., Michaud, J., & Scott, H. S. (2005) · Computer applications in the biosciences · doi:10.1093/bioinformatics/bti270 · Cited by 1,406
Gould, E., Tanapat, P., McEwen, B. S., Flügge, G., & Fuchs, E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3168 · Cited by 1,395
Tabb, D. L., McDonald, W. H., & Yates, J. R. (2002) · Journal of Proteome Research · doi:10.1021/pr015504q · Cited by 1,369
Human Hippocampal Neurogenesis Persists throughout Aging
Boldrini, M., Fulmore, C. A., Tartt, A. N., Simeon, L. R., Pavlova, I., Poposka, V., Rosoklija, G. B., Stankov, A., Arango, V., Dwork, A. J., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.03.015 · Cited by 1,345
(2006) · doi:10.1093/acprof:oso/9780195100273.001.0001 · Cited by 1,186
Massively parallel single-nucleus RNA-seq with DroNc-seq
Habib, N., Avraham-Davidi, I., Basu, A., Burks, T., Shekhar, K., Hofree, M., Choudhury, S. R., Aguet, F., Gelfand, E., Ardlie, K., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4407 · Cited by 1,069
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation
Yao, Z., van Velthoven, C. T. J., Nguyen, T. N., Goldy, J., Sedeno-Cortes, A. E., Baftizadeh, F., Bertagnolli, D., Casper, T., Chiang, M., Crichton, K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.021 · Cited by 1,065 · cited 1×
“Nevertheless, there was one DG granule cell subtype that transcriptomically resembled one upper-layer ExN subtype in the EC (Figure 5A), which might recapitulate the similarities found between the HIP and neocortex in the mouse (Yao et al., 2021).”
Electroporation and RNA interference in the rodent retina in vivo and in vitro
Matsuda, T., & Cepko, C. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235688100 · Cited by 1,032
Grubman, A., Chew, G., Ouyang, J. F., Sun, G., Choo, X. Y., McLean, C., Simmons, R. K., Buckberry, S., Vargas-Landin, D. B., Poppe, D., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0539-4 · Cited by 956
Single-cell genomics identifies cell type–specific molecular changes in autism
Velmeshev, D., Schirmer, L., Jung, D., Haeussler, M., Perez, Y., Mayer, S., Bhaduri, A., Goyal, N., Rowitch, D. H., & Kriegstein, A. R. (2019) · Science · doi:10.1126/science.aav8130 · Cited by 927
Selective vulnerability of the hippocampus in brain ischemia
Schmidt‐Kastner, R., & Freund, T. F. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90001-5 · Cited by 887
Gene expression across mammalian organ development
Cardoso-Moreira, M., Halbert, J., Valloton, D., Velten, B., Chen, C., Shao, Y., Liechti, A., Ascenção, K., Rummel, C., Ovchinnikova, S., et al. (2019) · Nature · doi:10.1038/s41586-019-1338-5 · Cited by 838
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
Bonaguidi, M. A., Wheeler, M. A., Shapiro, J. S., Stadel, R. P., Sun, G. J., Ming, G.-L., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.024 · Cited by 831
Integrative functional genomic analysis of human brain development and neuropsychiatric risks
Li, M., Santpere, G., Imamura Kawasawa, Y., Evgrafov, O. V., Gulden, F. O., Pochareddy, S., Sunkin, S. M., Li, Z., Shin, Y., Zhu, Y., et al. (2018) · Science · doi:10.1126/science.aat7615 · Cited by 810
Self-citationSAINT: probabilistic scoring of affinity purification–mass spectrometry data
Choi, H., Larsen, B., Lin, Z.-Y., Breitkreutz, A., Mellacheruvu, D., Fermin, D., Qin, Z. S., Tyers, M., Gingras, A.-C., & Nesvizhskii, A. I. (2011) · Nature Methods · doi:10.1038/nmeth.1541 · Cited by 800
Continuation of neurogenesis in the hippocampus of the adult macaque monkey
Kornack, D. R., & RAKIC, P. T. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5768 · Cited by 792
Self-citationHuman Adult Neurogenesis: Evidence and Remaining Questions
Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.04.004 · Cited by 790
SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software
Teo, G., Liu, G., Zhang, J., Nesvizhskii, A. I., Gingras, A., & Choi, H. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.10.023 · Cited by 693
Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years
Knoth, R., Singec, I., Ditter, M., Pantazis, G., Capetian, P., Meyer, R. P., Horvat, V., Volk, B., & Kempermann, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008809 · Cited by 650
Cenquizca, L. A., & Swanson, L. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.002 · Cited by 640
Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients
Tobin, M. K., Musaraca, K., Disouky, A., Shetti, A., Bheri, A., Honer, W. G., Kim, N., Dawe, R. J., Bennett, D. A., Arfanakis, K., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.003 · Cited by 603
Probing nuclear pore complex architecture with proximity-dependent biotinylation
Kim, D. I., KC, B., Zhu, W., Motamedchaboki, K., Doye, V., & Roux, K. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406459111 · Cited by 560
BioID: A Screen for Protein‐Protein Interactions
Roux, K. J., Kim, D. I., & Burke, B. E. (2013) · Current Protocols in Protein Science · doi:10.1002/0471140864.ps1923s74 · Cited by 505
Molecular characterization of selectively vulnerable neurons in Alzheimer’s disease
Leng, K., Li, E., Eser, R., Piergies, A., Sit, R., Tan, M., Neff, N., Li, S. H., Rodriguez, R. D., Suemoto, C. K., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00764-7 · Cited by 485
Hochgerner, H., Zeisel, A., Lönnerberg, P., & Linnarsson, S. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0056-2 · Cited by 482
Hipposeq: a comprehensive RNA-seq database of gene expression in hippocampal principal neurons
Cembrowski, M. S., Wang, L., Sugino, K., Shields, B. C., & Spruston, N. (2016) · eLife · doi:10.7554/elife.14997 · Cited by 438
Axon Regeneration in Young Adult Mice Lacking Nogo-A/B
Kim, J., Li, S., GrandPré, T., Qiu, D., & Strittmatter, S. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00147-8 · Cited by 416
Self-citationSpatiotemporal transcriptomic divergence across human and macaque brain development
Zhu, Y., Sousa, A. M. M., Gao, T., Skarica, M., Li, M., Santpere, G., Esteller-Cucala, P., Juan, D., Ferrández-Peral, L., Gulden, F. O., et al. (2018) · Science · doi:10.1126/science.aat8077 · Cited by 414
Self-citationA quantitative analysis software tool for mass spectrometry–based proteomics
Park, S. K., Venable, J. D., Xu, T., & Yates, J. R. (2008) · Nature Methods · doi:10.1038/nmeth.1195 · Cited by 395
The Temporal Lobe and Limbic System
GLOOR, P. (1997) · Medical Entomology and Zoology · Cited by 391
Witter, M. P., Doan, T. P., Jacobsen, B., Nilssen, E. S., & Ohara, S. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00046 · Cited by 389
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling
Breunig, J. J., Sarkisian, M. R., Arellano, J. I., Morozov, Y. M., Ayoub, A. E., Sojitra, S., Wang, B., Flavell, R. A., Rakic, P., & Town, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804558105 · Cited by 344
Self-citationSpatial Gene-Expression Gradients Underlie Prominent Heterogeneity of CA1 Pyramidal Neurons
Cembrowski, M. S., Bachman, J. L., Wang, L., Sugino, K., Shields, B. C., & Spruston, N. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.013 · Cited by 328
Lanjakornsiripan, D., Pior, B., Kawaguchi, D., Furutachi, S., Tahara, T., Katsuyama, Y., Suzuki, Y., Fukazawa, Y., & Gotoh, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-03940-3 · Cited by 324
Subcortical origins of human and monkey neocortical interneurons
Ma, T., Wang, C., Wang, L., Zhou, X., Tian, M., Zhang, Q., Zhang, Y., Li, J., Liu, Z., Cai, Y., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3536 · Cited by 322
Human adult neurogenesis across the ages: An immunohistochemical study
Dennis, C. V., Suh, L. S., Rodriguez, M. L., Kril, J. J., & Sutherland, G. T. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12337 · Cited by 286
Evidences for Adult Hippocampal Neurogenesis in Humans
Moreno-Jiménez, E. P., Terreros-Roncal, J., Flor-García, M., Rábano, A., & Llorens-Martín, M. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.0675-20.2020 · Cited by 272
A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis
Berg, D. A., Su, Y., Jimenez-Cyrus, D., Patel, A., Huang, N., Morizet, D., Lee, S., Shah, R., Ringeling, F. R., Jain, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.010 · Cited by 267
Molecular and cellular reorganization of neural circuits in the human lineage
Sousa, A. M. M., Zhu, Y., Raghanti, M. A., Kitchen, R. R., Onorati, M., Tebbenkamp, A. T. N., Stutz, B., Meyer, K. A., Li, M., Kawasawa, Y. I., et al. (2017) · Science · doi:10.1126/science.aan3456 · Cited by 253
Self-citationDecoding the development of the human hippocampus
Zhong, S., Ding, W., Sun, L., Lu, Y., Dong, H., Fan, X., Liu, Z., Chen, R., Zhang, S., Ma, Q., et al. (2020) · Nature · doi:10.1038/s41586-019-1917-5 · Cited by 242
Self-citationAyhan, F., Kulkarni, A., Berto, S., Sivaprakasam, K., Douglas, C., Lega, B. C., & Konopka, G. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.003 · Cited by 207
Seki, T. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10387 · Cited by 204
Dissociable Structural and Functional Hippocampal Outputs via Distinct Subiculum Cell Classes
Cembrowski, M. S., Phillips, M. G., DiLisio, S. F., Shields, B. C., Winnubst, J., Chandrashekar, J. V., Bas, E., & Spruston, N. (2018) · Cell · doi:10.1016/j.cell.2018.03.031 · Cited by 195
Adult Hippocampal Neurogenesis: A Coming-of-Age Story
Kuhn, H. G., Toda, T., & Gage, F. H. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2144-18.2018 · Cited by 195
Turró, S., Ingelmo‐Torres, M., Estanyol, J. M., Tebar, F., Fernandez-Rojo, M. A., Albor, C. V., Gaus, K., Grewal, T., Enrich, C., & Pol, A. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00465.x · Cited by 193
Adult neurogenesis in the mammalian dentate gyrus
Abbott, L. C., & Nigussie, F. (2019) · Anatomia Histologia Embryologia · doi:10.1111/ahe.12496 · Cited by 183
Kohler, S. J., Williams, N. I., Stanton, G. B., Cameron, J. L., & Greenough, W. T. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017099108 · Cited by 183
Patzke, N., Spocter, M. A., Karlsson, K. Æ., Bertelsen, M. F., Haagensen, M., Chawana, R., Streicher, S., Kaswera, C., Gilissen, E., Alagaili, A. N., et al. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0660-1 · Cited by 175
Cipriani, S., Ferrer, I., Aronica, E., Kovacs, G. G., Verney, C., Nardelli, J., Khung, S., Delezoide, A.-L., Milenkovic, I., Rasika, S., et al. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy096 · Cited by 169 · cited 2×
“Conversely, other studies have failed to identify neural progenitors or DCX-expressing neuroblasts after childhood in human DG samples (Dennis et al., 2016; Cipriani et al., 2018; Sorrells et al., 2018; Seki et al., 2019).”
Mikkonen, M., Soininen, H. S., Kälviäinen, R. K., Tapiola, T., Ylinen, A., Vapalahti, M. P., Paljärvi, L., & Pitkänen, A. (1998) · Annals of Neurology · doi:10.1002/ana.410440611 · Cited by 169
Braak, H., & Tredici, K. D. (2014) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-12679-1_1 · Cited by 164
Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets
Hodges, B. D. M., & Wu, C. C. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r003582 · Cited by 159
Neuroanatomy and pathology of sporadic Alzheimer's disease.
Braak, H., & Trecidi, K. D. (2014) · Advances in Anatomy, Embryology and Cell Biology · doi:10.1007/978-3-319-12679-1 · Cited by 158
Hippocampal pyramidal cells: the reemergence of cortical lamination
Slomianka, L., Amrein, I., Knuesel, I., Sørensen, J. C. H., & Wolfer, D. P. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0322-0 · Cited by 153
Immature excitatory neurons develop during adolescence in the human amygdala
Sorrells, S. F., Paredes, M. F., Velmeshev, D., Herranz‐Pérez, V., Sandoval, K., Mayer, S., Chang, E. F., Insausti, R., Kriegstein, A. R., Rubenstein, J. L. R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10765-1 · Cited by 147
Laminar organization of the pyramidal cell layer of the subiculum in the rat
Ishizuka, N. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1195 · Cited by 144
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's‐like pathology
Paspalas, C. D., Carlyle, B. C., Leslie, S., Preuss, T. M., Crimins, J. L., Huttner, A. J., van Dyck, C. H., Rosene, D. L., Nairn, A. C., & Arnsten, A. F. T. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.11.005 · Cited by 140
Self-citationSorrells, S. F., Paredes, M. F., Zhang, Z., Kang, G., Pastor-Alonso, O., Biagiotti, S. W., Page, C. E., Sandoval, K., Knox, A., Connolly, A. J., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0676-20.2020 · Cited by 140
Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease
Edler, M. K., Sherwood, C. C., Meindl, R. S., Hopkins, W. D., Ely, J. J., ERWIN, J. M., Mufson, E. J., Hof, P. R., & Raghanti, M. A. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.07.006 · Cited by 138
Kostylev, M. A., Kaufman, A. C., Nygaard, H. B., Patel, P., Haas, L. T., Gunther, E. C., Vortmeyer, A., & Strittmatter, S. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.643577 · Cited by 133
Self-citationRoles of Primary Cilia in the Developing Brain
Park, S. M., Jang, H. J., & Lee, J. H. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00218 · Cited by 129
Jabès, A., Lavenex, P. B., Amaral, D. G., & Lavenex, P. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.07061.x · Cited by 127
Gómez‐Climent, M. Á., Castillo-Gómez, E., Varea, E., Guirado, R., Blasco‐Ibáñez, J. M., Crespo, C., Martinez-Guijarro, F. J., & Nácher, J. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm255 · Cited by 122
Reiner, A. J. (2008) · Brain Behavior and Evolution · doi:10.1159/000114379 · Cited by 121
Cellular physiology of the turtle visual cortex: synaptic properties and intrinsic circuitry
Kriegstein, A. R., & Connors, B. W. (1986) · Journal of Neuroscience · doi:10.1523/jneurosci.06-01-00178.1986 · Cited by 119
Unraveling human adult hippocampal neurogenesis
Flor-García, M., Terreros-Roncal, J., Moreno-Jiménez, E. P., Ávila, J., Rábano, A., & Llorens-Martín, M. (2020) · Nature Protocols · doi:10.1038/s41596-019-0267-y · Cited by 113
Does Adult Neurogenesis Persist in the Human Hippocampus?
Paredes, M. F., Sorrells, S. F., Cebrián‐Silla, A., Sandoval, K., Qi, D., Kelley, K. W., James, D., Mayer, S., Chang, J. W., Auguste, K. I., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.11.006 · Cited by 113
Functional Neuroanatomy of the Medial Temporal Lobe Memory System
SUZUKI, W., & AMARAL, D. (2004) · Cortex · doi:10.1016/s0010-9452(08)70958-4 · Cited by 111
The Temporal Lobe and Limbic System.
MacLean, P. D. (1998) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199811000-00015 · Cited by 108
Kostylev, M. A., Tuttle, M. D., Lee, S., Klein, L. E., Takahashi, H., Cox, T. O., Gunther, E. C., Zilm, K. W., & Strittmatter, S. M. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.10.009 · Cited by 103
Self-citationPerez, S. E., Raghanti, M. A., Hof, P. R., Kramer, L., Ikonomovic, M. D., Lacor, P. N., Erwin, J. M., Sherwood, C. C., & Mufson, E. J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23428 · Cited by 95 · cited 1×
“Importantly, our results suggest that these functional interactions in a subset of ExNs and astrocytes seem to be phylogenetically specific to OldWorldmonkeys and apes (parvorder Catarrhini), species that show more marked signs of pathology related to aging, such as AD, than other species (Perez et al., 2013; Finch an…”
Ontologizing gene-expression microarray data: characterizing clusters with Gene Ontology
Robinson, P. N., Wollstein, A., Böhme, U., & Beattie, B. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth040 · Cited by 90
Zhang, X.-M. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.017.2009 · Cited by 88
Epp, J. R., Beasley, C. L., & Galea, L. A. M. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.132 · Cited by 84
Hoogland, P. V. J. M., & Vermeulen‐Vanderzee, E. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902850302 · Cited by 84
Ohara, S., Onodera, M., Simonsen, Ø. W., Yoshino, R., Hioki, H., Iijima, T., Tsutsui, K., & Witter, M. P. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.014 · Cited by 79
Maître, T. W. L., Dhanabalan, G., Bogdanović, N., Alkass, K., & Druid, H. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.251 · Cited by 73
Commentary: is Alzheimer's disease uniquely human?
Finch, C. E., & Austad, S. N. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.10.025 · Cited by 72
Frazer, S., Prados, J., Niquille, M., Cadilhac, C., Markopoulos, F., Gomez, L., Tomasello, U., Telley, L., Holtmaat, A., Jabaudon, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms14219 · Cited by 72 · cited 2×
“Apart from these InN clusters, we also identified aMEIS2-expressing InN cluster corresponding to the white-matter residing InN type described before (Frazer et al., 2017; Tasic et al., 2018) and a neuron cluster co-clustered with InN showing strong signals of RELN, NDNF, highly indicative of Cajal Retzius cells.”
Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells
Walker, T. L., Overall, R. W., Vogler, S., Sykes, A. M., Ruhwald, S., Lasse, D., Ichwan, M., Fabel, K., & Kempermann, G. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.03.002 · Cited by 72
Nielsen, J. V., Blom, J. B., Noraberg, J., & Jensen, N. A. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp261 · Cited by 68
Ramsden, H. L., Sürmeli, G., McDonagh, S., & Nolan, M. F. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004032 · Cited by 63
Tang, Q., Ebbesen, C. L., Sanguinetti-Scheck, J. I., Preston‐Ferrer, P., Gundlfinger, A., Winterer, J., Beed, P. S., Ray, S., Naumann, R. K., Schmitz, D., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0696-15.2015 · Cited by 63
Neocortical Lamination: Insights from Neuron Types and Evolutionary Precursors
Shepherd, G. M., & Rowe, T. B. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00100 · Cited by 62
Ngwenya, L. B., Peters, A., & Rosene, D. L. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21045 · Cited by 59
Conserved rules in embryonic development of cortical interneurons
Laclef, C., & Métin, C. (2018) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.09.017 · Cited by 57
Angata, K., Suzuki, M., & Fukuda, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204632200 · Cited by 57
Luzzati, F. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00162 · Cited by 55
Systems approach to explore components and interactions in the presynapse
Abul‐Husn, N. S., Bushlin, I., Morón, J. A., Jenkins, S. L., Dolios, G., Wang, R., Iyengar, R., Ma'ayan, A., & Devi, L. A. (2009) · PROTEOMICS · doi:10.1002/pmic.200800767 · Cited by 53
Seki, T., Hori, T., Miyata, H., Maehara, M., & Namba, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-54684-z · Cited by 53
Adult Human Hippocampal Neurogenesis: Controversy and Evidence
Lee, H. A., & Thuret, S. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.002 · Cited by 52
Brill, L. M., Motamedchaboki, K., Wu, S., & Wolf, D. A. (2009) · Methods · doi:10.1016/j.ymeth.2009.02.023 · Cited by 44
Rhee, S., Kirschen, G. W., Gu, Y., & Ge, S. (2016) · Scientific Reports · doi:10.1038/srep34370 · Cited by 39
Radial Glial Cells: New Views on Old Questions
Arellano, J. I., Morozov, Y. M., Micali, N., & RAKIC, P. T. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03296-z · Cited by 39
Self-citationSekine, Y., Lindborg, J. A., & Strittmatter, S. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009896 · Cited by 36
Self-citationCipriani, S., Nardelli, J., Verney, C., Delezoide, A., Guimiot, F., Gressèns, P., & Adle‐Biassette, H. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv079 · Cited by 27
Thomas, A., Klein, M. S., Stevens, A. P., Reinders, Y., Hellerbrand, C., Dettmer, K., Gronwald, W., Oefner, P. J., & Reinders, J. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2012.12.027 · Cited by 27
Evidence of adult neurogenesis in non-human primates and human
Yuan, T.-F., Li, J., Ding, F., & Arias-Carrion, O. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1980-z · Cited by 26
Guidi, S., Bianchi, P., Alstrup, A. K. O., Henningsen, K., Smith, D. F., & Bartesaghi, R. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.03.028 · Cited by 18
Cornu Ammonis Regions–Antecedents of Cortical Layers?
Mercer, A., & Thomson, A. M. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00083 · Cited by 17
Freund, T. F. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36018-7 · Cited by 7
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Research works printed but not linked: 1
- Xu, 2006, ProLuCID, a fast and sensitive tandem mass spectra-based protein identification program, Mol. Cell. Proteomics, 5, S174
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Spatial epigenome–transcriptome co-profiling of mammalian tissues
Zhang, D., Deng, Y., Kukanja, P., Agirre, E., Bartosovic, M., Dong, M., Ma, C., Ma, S., Su, G., Bao, S., et al. (2023) · Nature · doi:10.1038/s41586-023-05795-1 · Cited by 483
Self-citationTartt, A. N., Mariani, M. B., Hen, R., Mann, J. J., & Boldrini, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01520-y · Cited by 408
Ageing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407
Single-cell multiregion dissection of Alzheimer’s disease
Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07606-7 · Cited by 343
Molecular landscapes of human hippocampal immature neurons across lifespan
Zhou, Y. F., Su, Y., Li, S., Kennedy, B. C., Zhang, D. Y., Bond, A. M., Sun, Y. Y., Jacob, F., Lu, L., Hu, P., et al. (2022) · Nature · doi:10.1038/s41586-022-04912-w · Cited by 314
Metadata
- Authors
- Franjic, D., Skarica, M., Ma, S., Arellano, J. I., Tebbenkamp, A. T. N., Choi, J., Xu, C., Li, Q., Morozov, Y. M., Andrijevic, D., Vrselja, Z., Spajic, A., Santpere, G., Li, M., Zhang, S., Liu, Y., Spurrier, J., Zhang, L., Gudelj, I., Rapan, L., Takahashi, H., Huttner, A., Fan, R., Strittmatter, S. M., Sousa, A. M. M., Rakic, P., & Sestan, N.
- Affiliations
- Yale University (US)
- Universitat Pompeu Fabra (ES)
- Yale Cancer Center (US)
- ORCID
- Franjic, Daniel
- Ma, Shaojie
- Arellano, Jon I.
- Tebbenkamp, Andrew T.N.
- Choi, Jinmyung
- Xu, Chuan
- Li, Qian
- Morozov, Yury M.
- Andrijevic, David
- Spajic, Ana
- Santpere, Gabriel
- Li, Mingfeng
- Liu, Yang
- Spurrier, Joshua
- Zhang, Le
- Gudelj, Ivan
- Rapan, Lucija
- Takahashi, Hideyuki
- Huttner, Anita
- Fan, Rong
- Strittmatter, Stephen M.
- Rakic, Pasko
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 110
- Issue
- 3
- Pages
- 452-469.e14
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC8813897
- OpenAlex
- W3212895337
- Cited by
- 308
- References
- 130
- Citations by year
- 2026: 48 · 2025: 68 · 2024: 58 · 2023: 74 · 2022: 58
- FWCI
- 17.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by-nc-nd)
- Funders
- “la Caixa” Foundation (100010434)
- Instituto de Salud Carlos III (MS20/00064)
- European Social Fund
- Agencia Estatal de Investigación (PID2019-104700GA-I00)
- Fundacion La Caixa
- National Institutes of Health (MH103339, MH106934, MH109904, MH110926)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult neurogenesis, single-nucleus transcriptomics, cross-species comparison, doublecortin, METTL7B, excitatory neurons, astrocytes, lipid droplets, endoplasmic reticulum, granule cells
- MeSH terms
- Doublecortin Protein, Animals, Hippocampus, Humans, Macaca, Swine, Mice, Neurogenesis, Transcriptome
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