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Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats
Abstract
Disruption of bacterial colonization during the early postnatal period is increasingly being linked to adverse health outcomes. Indeed, there is a growing appreciation that the gut microbiota plays a role in neurodevelopment. However, there is a paucity of information on the consequences of early-life manipulations of the gut microbiota on behavior. To this end we administered an antibiotic (vancomycin) from postnatal days 4-13 to male rat pups and assessed behavioral and physiological measures across all aspects of the brain-gut axis. In addition, we sought to confirm and expand the effects of early-life antibiotic treatment using a different antibiotic strategy (a cocktail of pimaricin, bacitracin, neomycin; orally) during the same time period in both female and male rat pups. Vancomycin significantly altered the microbiota, which was restored to control levels by 8 weeks of age. Notably, vancomycin-treated animals displayed visceral hypersensitivity in adulthood without any significant effect on anxiety responses as assessed in the elevated plus maze or open field tests. Moreover, cognitive performance in the Morris water maze was not affected by early-life dysbiosis. Immune and stress-related physiological responses were equally unaffected. The early-life antibiotic-induced visceral hypersensitivity was also observed in male rats given the antibiotic cocktail. Both treatments did not alter visceral pain perception in female rats. Changes in visceral pain perception in males were paralleled by distinct decreases in the transient receptor potential cation channel subfamily V member 1, the α-2A adrenergic receptor and cholecystokinin B receptor. In conclusion, a temporary disruption of the gut microbiota in early-life results in very specific and long-lasting changes in visceral sensitivity in male rats, a hallmark of stress-related functional disorders of the brain-gut axis such as irritable bowel disorder.
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“Fourthly, preclinical studies with antibiotic administration, either in early life (O'Mahony et al., 2014) or adulthood (Verdu et al., 2008), have shown long-lasting effects on brain, spinal cord, and the ENS.”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as O'Mahony et al., 2014
In the citing paper
“While chronic antibiotic treatment impaired spatial memory in the Morris Water Maze in adult rats (Hoban et al., 2016a;Wang et al., 2015) acute treatments did not affect this type of memory when administered in early life in rats (O'Mahony et al., 2014), nor when administered during adulthood in mice and tested in the Barnes maze (Frohlich et al., 2016).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as O'Mahony et al., 2014
In the citing paper
“Disruption of the gut microbiota in early-life also has been associated with longterm changes in visceral sensitivity, emphasizing the importance of the gut microbiome in neurodevelopment of pain pathways68.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [68]
Citations
Cites
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Morris water maze: procedures for assessing spatial and related forms of learning and memory
Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Self-citationBravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
Self-citationHsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460
Factors influencing the composition of the intestinal microbiota in early infancy
Penders, J., Thijs, C., Vink, C., Stelma, F. F., Snijders, B., Kummeling, I., van den Brandt, P. A., & Stobberingh, E. E. (2006) · PEDIATRICS · doi:10.1542/peds.2005-2824 · Cited by 2,232
Clarke, G., Grenham, S., Scully, P., Fitzgerald, P., Moloney, R. D., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.77 · Cited by 1,893
Self-citationThe Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead
Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789
Bercik, P., Denou, E., Collins, J., Jackson, W., Lu, J., Jury, J., Deng, Y., Blennerhassett, P., Macri, J., McCoy, K. D., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.04.052 · Cited by 1,748
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 5×
“This has led to the concept of the brain–gut–microbiota axis (Rhee et al., 2009; Collins et al., 2012; Cryan and Dinan, 2012).”
BackgroundInfluentialBarbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
The role of gut microbiota in immune homeostasis and autoimmunity
Wu, H.-J., & Wu, E. (2012) · Gut Microbes · doi:10.4161/gmic.19320 · Cited by 1,426
Principles and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · cited 1×
“This has led to the concept of the brain–gut–microbiota axis (Rhee et al., 2009; Collins et al., 2012; Cryan and Dinan, 2012).”
BackgroundMicrobiota and neurodevelopmental windows: implications for brain disorders
Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089
Self-citationO'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069
Self-citationEffects of the probiotic Bifidobacterium infantis in the maternal separation model of depression
Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999
Self-citationThe microbiome-gut-brain axis: from bowel to behavior
Cryan, J. F., & O’Mahony, S. M. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01664.x · Cited by 990
Self-citationBrain-gut-microbe communication in health and disease
Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952
Self-citationBacteria activate sensory neurons that modulate pain and inflammation
Chiu, I. M., Heesters, B. A., Ghasemlou, N., Von Hehn, C. A., Zhao, F., Tran, J., Wainger, B., Strominger, A., Muralidharan, S., Horswill, A. R., et al. (2013) · Nature · doi:10.1038/nature12479 · Cited by 949
Bacterial infection causes stress-induced memory dysfunction in mice
Gareau, M. G., Wine, E., Rodrigues, D. M., Cho, J. H., Whary, M. T., Philpott, D. J., MacQueen, G., & Sherman, P. M. (2011) · Gut · doi:10.1136/gut.2009.202515 · Cited by 909 · cited 2×
“Germ-free mice also show memory deficits (Gareau et al., 2011) and social deficits of relevance to autism (Desbonnet et al.”
BackgroundClaesson, M. J., O’Sullivan, Ó., Wang, Q., Nikkilä, J., Marchesi, J. R., Smidt, H., de Vos, W. M., Ross, R. P., & O’Toole, P. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006669 · Cited by 900
Self-citationMicrobiota is essential for social development in the mouse
Desbonnet, L., Clarke, G., Shanahan, F., Dinan, T. G., & Cryan, J. F. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.65 · Cited by 866
Self-citationLactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors
Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793
Al–Chaer, E. D., Kawasaki, M., & Pasricha, P. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.19576 · Cited by 727
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637
Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612
Development of intestinal microbiota in infants and its impact on health
Matamoros, S., Guen, C. G., Vacon, F. L., Potel, G., & de la Cochetière, M.-F. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2012.12.001 · Cited by 563
Fouhy, F., Guinane, C. M., Hussey, S., Wall, R., Ryan, C. A., Dempsey, E. M., Murphy, B. P., Ross, R. P., Fitzgerald, G. F., Stanton, C., et al. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00789-12 · Cited by 518
The brain-gut axis in abdominal pain syndromes.
Mayer, E. A., & Tillisch, K. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-012309-103958 · Cited by 511
Brain gut microbiome interactions and functional bowel disorders
Mayer, E. A., Savidge, T., & Shulman, R. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.037 · Cited by 496
Shaw, S. Y., Blanchard, J., & Bernstein, C. N. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.398 · Cited by 484
Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice
Verdú, E. F., Bercik, P., Verma-Gandhu, M., Huang, X.-X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F., & Collins, S. M. (2006) · Gut · doi:10.1136/gut.2005.066100 · Cited by 448
The microbiome: stress, health and disease
Moloney, R. D., Desbonnet, L., Clarke, G., Dinan, T. G., & Cryan, J. F. (2014) · Mammalian Genome · doi:10.1007/s00335-013-9488-5 · Cited by 430
Self-citationV. Stress and irritable bowel syndrome
Mayer, E. A., Naliboff, B. D., Chang, L., & Coutinho, S. V. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.4.g519 · Cited by 413 · cited 1×
“IBS is now recognized as a disorder of the brain–gut microbiome axis, characterized by visceral hypersensitivity, enhanced stress and anxiety (Mayer et al., 2001, 2014; Longstreth et al., 2006; Mayer and Tillisch, 2011; Fashner and Gitu, 2013).”
BackgroundCamilleri, M., Lasch, K. L., & Zhou, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00155.2012 · Cited by 412
Development of the human gastrointestinal microbiota and insights from high-throughput sequencing
Dominguez-Bello, M. G., Blaser, M. J., Ley, R. E., & Knight, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.011 · Cited by 405
Gut bacteria in health and disease.
Quigley, E. M. M. (2013) · Europe PMC (PubMed Central) · Cited by 394
Self-citationSuzuki, T., Yoshida, S., & Hara, H. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508888733 · Cited by 370
A role for the gut microbiota in IBS
Collins, S. M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.40 · Cited by 351
Kunze, W. A., Mao, Y., Wang, B., Huizinga, J. D., Ma, X., Forsythe, P., & Bienenstock, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00686.x · Cited by 328
Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus
Moreno‐Indias, I., Cardona, F., Tinahones, F. J., & Queipo‐Ortuño, M. I. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00190 · Cited by 325
Commensal microbiota is fundamental for the development of inflammatory pain
Amaral, F. A., Sachs, D., Costa, V. V., Fagundes, C. T., Cisalpino, D., Cunha, T. M., Ferreira, S. H., Cunha, F. Q., Silva, T. A., Nicoli, J. R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711891105 · Cited by 289
Sex hormones in the modulation of irritable bowel syndrome
Mulak, A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2433 · Cited by 287
Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma
Russell, S., Gold, M. J., Willing, B. P., Thorson, L., McNagny, K. M., & Finlay, B. B. (2013) · Gut Microbes · doi:10.4161/gmic.23567 · Cited by 285
Beneficial modulation of the gut microbiota
Walsh, C. J., Guinane, C. M., O'Toole, P. W., & Cotter, P. D. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.035 · Cited by 274
Self-citationXu, D., Gao, J., Gillilland, M., Wu, X., Song, I., Kao, J. Y., & Owyang, C. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.10.026 · Cited by 271
Communication between gastrointestinal bacteria and the nervous system
Bravo, J. A., Julio-Pieper, M., Forsythe, P., Kunze, W., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2012) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2012.09.010 · Cited by 261
Self-citationYap, I. K. S., Li, J. V., Saric, J., Martin, F., Davies, H., Wang, Y., Wilson, I. D., Nicholson, J. K., Utzinger, J., Marchesi, J. R., et al. (2008) · Journal of Proteome Research · doi:10.1021/pr700864x · Cited by 235
Self-citationDoes Antibiotic Exposure During Infancy Lead to Development of Asthma?
Marra, F., Lynd, L. D., Coombes, M., Richardson, K., Legal, M., FitzGerald, J. M., & Marra, C. A. (2006) · CHEST Journal · doi:10.1378/chest.129.3.610 · Cited by 225
Clarke, G. A., Cryan, J. F., Dinan, T. G., & Quigley, E. M. M. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04965.x · Cited by 221
Self-citationWinston, J. H., Shenoy, M. M., Medley, D., Naniwadekar, A. S., & Pasricha, P. J. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.11.014 · Cited by 219
The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat
McKernan, D. P., Fitzgerald, P., Dinan, T. G., & Cryan, J. F. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01520.x · Cited by 205
Self-citationRapidly expanding knowledge on the role of the gut microbiome in health and disease
Cénit, M. C., Matzaraki, V., Tigchelaar, E. F., & Zhernakova, A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.023 · Cited by 197
Sullivan, A. F., Dashwood, M. R., & Dickenson, A. H. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90430-4 · Cited by 192
Immunomodulation by commensal and probiotic bacteria
Forsythe, P., & Bienenstock, J. (2010) · Immunological Investigations · doi:10.3109/08820131003667978 · Cited by 189
Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour
Clarke, G., O'Mahony, S., Dinan, T., & Cryan, J. (2014) · Acta Paediatrica · doi:10.1111/apa.12674 · Cited by 179
Self-citationBourdu, S., Dapoigny, M., Chapuy, E., Artigue, F., Vasson, M.-P., Dechelotte, P., Bommelaer, G., Eschalier, A., & Ardid, D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.082 · Cited by 176
Antibiotics increase functional abdominal symptoms
Maxwell, P., Rink, E., Kumar, D., & Mendall, M. A. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05428.x · Cited by 176
DuPont, H. L. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12728 · Cited by 171
Butyrate-Induced Transcriptional Changes in Human Colonic Mucosa
Vanhoutvin, S. A. L. W., Troost, F. J., Hamer, H. M., Lindsey, P. J., Koek, G. H., Jonkers, D. M. A. E., Kodde, A., Venema, K., & Brummer, R. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006759 · Cited by 170
Eutamene, H., Lamine, F., Chabo, C., Theodorou, V., Rochat, F., Bergonzelli, G. E., Corthésy-Theulaz, I., Fioramonti, J., & Bueno, L. (2007) · The Journal of Nutrition · doi:10.1093/jn/137.8.1901 · Cited by 169
Altered peripheral toll-like receptor responses in the irritable bowel syndrome
McKernan, D. P., Gaszner, G., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04624.x · Cited by 162
Self-citationMiranda, A., Nordstrom, E. M., Mannem, A., Smith, C. R., Banerjee, B., & Sengupta, J. N. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.034 · Cited by 151
Brain response to cecal infection with Campylobacter jejuni: analysis with Fos immunohistochemistry
Gaykema, R. P. A., Goehler, L. E., & Lyte, M. (2003) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2003.08.002 · Cited by 147
Barreau, F., Salvador‐Cartier, C., Houdeau, E., Bueno, L., & Fioramonti, J. (2008) · Gut · doi:10.1136/gut.2007.126680 · Cited by 133
Probiotics, prebiotics, and the host microbiome: the science of translation
Petschow, B., Doré, J., Hibberd, P., Dinan, T., Reid, G., Blaser, M., Cani, P. D., Degnan, F. H., Foster, J., Gibson, G., et al. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12303 · Cited by 124
Self-citationAguilera, M., Vergara, P., & Martínez, V. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12154 · Cited by 119
van den Wijngaard, R. M., Klooker, T. K., Welting, O., Stanisor, O. I., Wouters, M. M., van der Coelen, D., Bulmer, D. C., Peeters, P. J., Aerssens, J., Hoogt, R. D., et al. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01339.x · Cited by 117
Wang, B., Mao, Y., Diorio, C. J., Wang, L., Huizinga, J. D., Bienenstock, J., & Kunze, W. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01384.x · Cited by 106
Kukkar, A., Singh, N., & Jaggi, A. (2014) · Journal of the Formosan Medical Association = Taiwan yi zhi · doi:10.1016/j.jfma.2013.05.013 · Cited by 105
The visceromotor response to colorectal distention fluctuates with the estrous cycle in rats
Ji, Y., Tang, B., & Traub, R. J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.04.070 · Cited by 99
Ma, X., Mao, Y., Wang, B., Huizinga, J. D., Bienenstock, J., & Kunze, W. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90511.2008 · Cited by 93
Estrous variations in behavioral responses to vaginal and uterine distention in the rat
Bradshaw, H. B., Temple, J. L., Wood, E., & Berkley, K. J. (1999) · Pain · doi:10.1016/s0304-3959(99)00049-4 · Cited by 90
Effects of Rifaximin Treatment and Retreatment in Nonconstipated IBS Subjects
Pimentel, M., Morales, W., Chua, K., Barlow, G., Weitsman, S., Kim, G., Amichai, M. M., Pokkunuri, V., Rook, E., Mathur, R., et al. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1728-5 · Cited by 86
Ruigómez, A., Rodríguez, L. A. G., & Panés, J. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.02.008 · Cited by 84
Toll-Like Receptor 4 Regulates Chronic Stress-Induced Visceral Pain in Mice
Tramullas, M., Finger, B. C., Moloney, R. D., Golubeva, A. V., Moloney, G., Dinan, T. G., & Cryan, J. F. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.004 · Cited by 81
Self-citationChaloner, A., & Meerveld, B. G. (2013) · Journal of Pain · doi:10.1016/j.jpain.2012.11.008 · Cited by 79
Effects of Bifidobacterium infantis 35624 on Post-Inflammatory Visceral Hypersensitivity in the Rat
Johnson, A. C., Greenwood-Van Meerveld, B., & McRorie, J. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1730-y · Cited by 76
Scarpellini, E., Giorgio, V., Gabrielli, M., Filoni, S., Vitale, G., Tortora, A., Ojetti, V., Gigante, G. E., Fundaro, C., & Gasbarrini, A. (2013) · PubMed · Cited by 72
The Fecal Microflora of 1–3-Month-Old Infants during Treatment with Eight Oral Antibiotics
Bennet, R., Eriksson, M. K., & Nord, C. E. (2002) · Infection · doi:10.1007/s15010-002-2140-z · Cited by 71
Diamond, B., Huerta, P. T., Tracey, K., & Volpe, B. T. (2011) · BioEssays · doi:10.1002/bies.201100042 · Cited by 69
Tarrerias, L. A., Millecamps, M., Alloui, A., Beaughard, C., Kemeny, L. J., Bourdu, S., Bommelaer, G., Eschalier, A., Dapoigny, M. C., & Ardid, D. (2002) · Pain · doi:10.1016/s0304-3959(02)00234-8 · Cited by 66
Ait‐belgnaoui, A., Eutamene, H., Houdeau, E., Bueno, L., Fioramonti, J., & Theodorou, V. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01280.x · Cited by 61 · cited 1×
“Moreover, it has been suggested that Lactobacillus farciminis exerts antinociceptive effects by altering central sensitization (Ait-Belgnaoui et al., 2009).”
BackgroundBissière, S., McAllister, K. H., Olpe, H.-R., & Cryan, J. F. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.022 · Cited by 61
Self-citationIntestinal microbiota during early life – impact on health and disease
Nylund, L., Satokari, R. M., Salminen, S., & de Vos, W. M. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114000627 · Cited by 60
It's a gut feeling: How the gut microbiota affects the state of mind
Farmer, A. D., Randall, H. A., & Aziz, Q. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.270389 · Cited by 58
Role of Microbiome in Regulating the HPA Axis and Its Relevance to Allergy
Sudo, N. (2012) · Chemical Immunology and Allergy · doi:10.1159/000336510 · Cited by 54
Rodent Models of Colorectal Distension
O’Mahony, S. M., Tramullas, M., Fitzgerald, P., & Cryan, J. F. (2012) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0940s61 · Cited by 54
Self-citationEarly Life Adversity as a Risk Factor for Visceral Pain in Later Life: Importance of Sex Differences
Chaloner, A., & Meerveld, B. G. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00013 · Cited by 51
Friedrich, A. E., & Gebhart, G. F. (2003) · Pain · doi:10.1016/s0304-3959(02)00469-4 · Cited by 46
The Human Microbiome and Probiotics: Implications for Pediatrics
Versalovic, J. A. (2013) · Annals of Nutrition and Metabolism · doi:10.1159/000354899 · Cited by 44
Matricon, J., Gelot, A., Etiennel, M., Lazdunskil, M., Mullerl, E., & Ardid, D. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.08.005 · Cited by 39
Review of Continuous-Infusion Vancomycin
DiMondi, V. P., & Rafferty, K. D. (2013) · Annals of Pharmacotherapy · doi:10.1345/aph.1r420 · Cited by 39
Estrous cycle influences on sexual diergism of HPA axis responses to cholinergic stimulation in rats
Rhodes, M. E., Balestreire, E. M., Czambel, R. K., & Rubín, R. T. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00868-7 · Cited by 38
Hyland, N. P., Julio‐Pieper, M., O’Mahony, S. M., Bulmer, D. C., Lee, K., Quigley, E. M. M., Dinan, T. G., & Cryan, J. F. (2009) · Gut · doi:10.1136/gut.2008.167882 · Cited by 34
Self-citationMillion, M., Zhao, J.-F., Luckey, A. E., Czimmer, J., Maynard, G. D., Kehne, J. H., Hoffman, D. C., & Taché, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073749 · Cited by 29
The effects of gabapentin in two animal models of co-morbid anxiety and visceral hypersensitivity
O’Mahony, S. M., Coelho, A.-M., Fitzgerald, P., Lee, K., Winchester, W. J., Dinan, T. G., & Cryan, J. F. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.05.055 · Cited by 25
Self-citationReview: Effect of probiotics on gastrointestinal function: evidence from animal models
Verdu, E. F., Berčík, P., & Collins, S. M. (2009) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x09337645 · Cited by 21
Tache, Y., Adelson, D. W., & Yang, H. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990578 · Cited by 20
Marra, F., Lynd, L., Coombes, M., Richardson, K., Legal, M., FitzGerald, J. M., & Marra, C. A. (2009) · UEA Digital Repository (University of East Anglia) · Cited by 14
Common gastrointestinal symptoms: irritable bowel syndrome.
Fashner, J., & Gitu, A. C. (2013) · PubMed · Cited by 6
Bailey (1999) · doi:10.1002/(sici)1098-2302(199909)35:2
Research works printed but not linked: 1
- Bercik, 2012, Transfer of IBS phenotype to GERM-free mice through microbiota transplantation, Neurogastroenterol Motil, 24, 33
Cited by
Sorted by citations
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Self-citationThe Bidirectional Relationship of Depression and Inflammation: Double Trouble
Beurel, E., Toups, M., & Nemeroff, C. B. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.002 · Cited by 2,136
“Similarly, antibiotic treatments alter multiple behaviors of mice, suggesting that bacteria influence neurobehavioral outcomes (Desbonnet et al., 2015; Hao et al., 2013; Hoban et al., 2016; Majidi et al., 2016; O’Mahony et al., 2014; Wang et al., 2017).”
BackgroundMilani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950
The central nervous system and the gut microbiome
Sharon, G., Sampson, T. R., Geschwind, D. H., & Mazmanian, S. K. (2016) · Cell · doi:10.1016/j.cell.2016.10.027 · Cited by 1,513
“However, during adulthood, these rats showed visceral hypersensitivity, indicating that gut microbes can impact nociception (Amaral et al., 2008; O’Mahony et al., 2014).”
BackgroundGut/brain axis and the microbiota
Mayer, E. A., Tillisch, K., & Gupta, A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76304 · Cited by 1,503
“Support for such long-lasting consequences for adult phenotypes of early life perturbations of the gut microbiota comes from two recent studies of the effects of early life antibiotic administration on adult visceral pain sensitivity (84) and metabolism (85).”
Metadata
- Authors
- O’Mahony, S. M., Felice, V. D., Nally, K., Savignac, H. M., Claesson, M. J., Scully, P., Woznicki, J., Hyland, N. P., Shanahan, F., Quigley, E. M., Marchesi, J. R., O’Toole, P. W., Dinan, T. G., & Cryan, J. F.
- Affiliations
- University College Cork (IE)
- ORCID
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 277
- Pages
- 885-901
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2055122111
- Cited by
- 272
- References
- 106
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 24 · 2023: 15 · 2022: 18 · 2021: 42 · 2020: 24 · 2019: 26 · 2018: 23 · 2017: 25 · 2016: 34 · 2015: 16 · 2014: 5
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Science Foundation Ireland (02/CE/B124, 07/CE/B1368)
- GlaxoSmithKline
- European Community’s Seventh Framework Programme (FP7/2007-2013)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- gut microbiota, early-life antibiotic exposure, vancomycin, visceral hypersensitivity, visceral pain, gut-brain axis, brain development, anxiety-like behavior, cognitive performance, sex differences, TRPV1, alpha2A-adrenergic receptor, cholecystokinin B receptor, irritable bowel syndrome
- MeSH terms
- Animals, Animals, Newborn, Anti-Bacterial Agents, Anxiety, Bacitracin, Behavior, Animal, Cognition, Female, Hyperalgesia, Male, Neomycin, Natamycin, Vancomycin, Rats, Sprague-Dawley, Gastrointestinal Tract, Visceral Pain, Microbiota
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