Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
Open accessAbstract
Recent studies suggest that oxytocin (Oxt) is implicated in energy metabolism. We aimed to explore acute and sub-chronic effects of peripheral Oxt treatment via different routes on food intake and energy balance. Intraperitoneal (ip) injection of Oxt concentration-dependently decreased food intake in mice. Ip Oxt injection induced c-Fos expression in the hypothalamus and brain stem including arcuate nucleus (ARC), paraventricular nucleus (PVN) and nucleus tractus solitarius (NTS). Subcutaneous (sc) injection of Oxt suppressed food intake in normal and high fat diet-induced obese (DIO) mice. Daily sc injection of Oxt for 17 days in DIO mice reduced food intake for 6 days and body weight for the entire treatment period and additional 9 days after terminating Oxt. Oxt infusion by sc implanted osmotic minipumps for 13 days in DIO mice reduced food intake, body weight, and visceral fat mass and adipocyte size. Oxt infusion also decreased respiratory quotient specifically in light phase, ameliorated fatty liver and glucose intolerance, without affecting normal blood pressure in DIO mice. These results demonstrate that peripheral Oxt treatment reduces food intake and visceral fat mass, and ameliorates obesity, fatty liver and glucose intolerance. Peripheral Oxt treatment provides a new therapeutic avenue for treating obesity and hyperphagia.
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A study of chronic oxytocin infusion in mice reported a reduction in RQ.
“A study of chronic oxytocin infusion in mice similarly reported a reduction in RQ(34).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [34]
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- Authors
- Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., & Yada, T.
- Affiliations
- Jichi Medical University (JP)
- Corresponding author
- Yada, Toshihiko
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2011-12-17
- Volume
- 3
- Issue
- 12
- Pages
- 1169-1177
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC3273897
- OpenAlex
- W2125369584
- Cited by
- 220
- References
- 26
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 11 · 2023: 9 · 2022: 16 · 2021: 25 · 2020: 16 · 2019: 20 · 2018: 21 · 2017: 18 · 2016: 19 · 2015: 17 · 2014: 14 · 2013: 11 · 2012: 3
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (10036069, 23390044)
- Japan Society for the Promotion of Science (23390044, 23115715, 20790663, 18390065, 20390061, 22659044, 23126523)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- oxytocin, obesity, dietary intake, visceral fat, energy balance, high-fat diet-induced obesity, Fos expression, hypothalamus, arcuate nucleus, paraventricular nucleus, nucleus tractus solitarius, hepatic steatosis, impaired glucose tolerance, hyperphagia, subcutaneous infusion, osmotic minipump, respiratory quotient, adipocyte size
- MeSH terms
- Animals, Animal Feed, Diet, Dietary Fats, Dose-Response Relationship, Drug, Eating, Injections, Subcutaneous, Obesity, Oxytocics, Oxytocin, Time Factors, Glucose Intolerance, Intra-Abdominal Fat, Mice
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