Low sympathetic tone and obese phenotype in oxytocin-deficient mice
Open accessAbstract
Oxytocin (Oxt) is secreted both peripherally and centrally and is involved in several functions including parturition, milk let-down reflex, social behavior, and food intake. Recently, it has been shown that mice deficient in Oxt receptor develop late-onset obesity. In this study, we characterized a murin model deficient in Oxt peptide (Oxt(-/-)) to evaluate food intake and body weight, glucose tolerance and insulin tolerance, leptin and adrenaline levels. We found that Oxt(-/-) mice develop late-onset obesity and hyperleptinemia without any alterations in food intake in addition to having a decreased insulin sensitivity and glucose intolerance. The lack of Oxt in our murin model also results in lower adrenalin levels which led us to hypothesize that the metabolic changes observed are associated with a decreased sympathetic nervous tone. It has been shown that Oxt neurons in the paraventricular nucleus (PVN) are a component of a leptin-sensitive signaling circuit between the hypothalamus and caudal brain stem for the regulation of food intake and energy homeostasis. Nevertheless, the lack of Oxt in these mice does not have a direct impact on feeding behavior whose regulation is probably dependent on the complex interplay of several factors. The lack of hyperphagia evident in the Oxt(-/-) mice may, in part, be attributed to the developmental compensation of other satiety factors such as cholecystokinin or bombesin-related peptides which merits further investigation. These findings identify Oxt as an important central regulator of energy homeostasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oxytocin and oxytocin receptor knockout mice develop late-onset obesity in the absence of hyperphagia.
“These mice develop late-onset obesity in the absence of hyperphagia (65, 66).”
From Oxytocin during Development: Possible Organizational Effects on Behavior (2015) · cites this paper as [66]
Preclinical research indicates that oxytocin may be involved in glucose homeostasis.
“Preclinical research indicates that oxytocin may be involved in glucose homeostasis.”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [38]
Oxytocin knockout mice develop insulin resistance and glucose intolerance.
“Oxytocin knockout mice develop insulin resistance and glucose intolerance(38).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [38]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077 · see citing works
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01049-8 · Cited by 1,735 · see citing works
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734 · see citing works
Qian, S., Chen, H., Weingarth, D. T., Trumbauer, M. E., Novi, D. E., Guan, X.-M., Yu, H., Shen, Z., Feng, Y., Frazier, E. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5027-5035.2002 · Cited by 430 · see citing works
Blevins, J. E., Schwartz, M. W., & Baskin, D. G. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00604.2003 · Cited by 332 · see citing works
The magnocellular oxytocin system, the fount of maternity: Adaptations in pregnancy
Russell, J. A., Leng, G., & Douglas, A. J. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00104-8 · Cited by 295 · see citing works
Oxytocin receptor-deficient mice developed late-onset obesity
Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3283021ca9 · Cited by 294 · see citing works
Centrally released oxytocin mediates mating-induced anxiolysis in male rats
Waldherr, M., & Neumann, I. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705860104 · Cited by 261 · see citing works
Oxytocin inhibits food and fluid intake in rats
Arletti, R., Benelli, A., & Bertolini, A. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90234-u · Cited by 246 · see citing works
Oxytocin Deficiency Mediates Hyperphagic Obesity of Sim1 Haploinsufficient Mice
Kublaoui, B. M., Gemelli, T., Tolson, K. P., Wang, Y., & Zinn, A. R. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0067 · Cited by 239 · see citing works
Crawley, J. N., Chen, T., Puri, A., Washburn, R., Sullivan, T. L., Hill, J. M., Young, N. B., Nadler, J. J., Moy, S. S., Young, L. J., et al. (2007) · Neuropeptides · doi:10.1016/j.npep.2007.02.002 · Cited by 232 · see citing works
OLSON, B. R., DRUTAROSKY, M. D., STRICKER, E. M., & VERBALIS, J. G. (1991) · Endocrinology · doi:10.1210/endo-129-2-785 · Cited by 180 · see citing works
The acute effects of intranasal oxytocin administration on endocrine and sexual function in males
Burri, A., Heinrichs, M., Schedlowski, M., & Kruger, T. H. C. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.01.014 · Cited by 168 · see citing works
Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin
Blevins, J. E., Eakin, T. J., Murphy, J. A., Schwartz, M. W., & Baskin, D. G. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.036 · Cited by 164 · see citing works
Douglas, A. J., Johnstone, L. E., & Leng, G. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.012 · Cited by 108 · see citing works
Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance
Mauvais‐Jarvis, F., Kulkarni, R., & Kahn, C. R. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01563.x · Cited by 82 · see citing works
Oxytocin gene deletion mice overconsume palatable sucrose solution but not palatable lipid emulsions
Miedlar, J. A., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00228.2007 · Cited by 82 · see citing works
Impaired Glucose Homeostasis in Mice Lacking the α1b-Adrenergic Receptor Subtype
Burcelin, R., Uldry, M., Foretz, M., Perrin, C., Dacosta, A., Nenniger-Tosato, M., Seydoux, J., Cotecchia, S., & Thorens, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307788200 · Cited by 59 · see citing works
Lokrantz, C.-M., Uvnäs‐Moberg, K., & Kaplan, J. M. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00021-8 · Cited by 57 · see citing works
Dehydration anorexia is attenuated in oxytocin-deficient mice
Rinaman, L., Vollmer, R. R., Karam, J. R., Phillips, D., Li, X., & Amico, J. A. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00860.2004 · Cited by 48 · see citing works
Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice
Amico, J. A., Vollmer, R. R., Karam, J. R., Lee, P. R., Li, X., Koenig, J. I., & McCarthy, M. M. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.04.006 · Cited by 46 · see citing works
Cholecystokinin and D-fenfluramine inhibit food intake in oxytocin-deficient mice
Mantella, R. C., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00383.2002 · Cited by 44 · see citing works
Facilitative role of endogenous oxytocin in noradrenaline release in the rat supraoptic nucleus
Onaka, T., Ikeda, K., Yamashita, T., & Honda, K. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03037.x · Cited by 43 · see citing works
Selvage, D. J., & Johnston, C. A. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01235.x · Cited by 29 · see citing works
Lipschitz, D. L., Crowley, W. R., & Bealer, S. L. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00572.2003 · Cited by 29 · see citing works
Flagged first, then by citations
1 of the 26 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Kronenberg H, Melmed S, Polonsky KS, Larsen PR. Williams Textbook of Endocrinology. Saunders Elseviers: Amsterdam, the Netherlands, 2007.
Cited by
Sorted by citations
Miller, G. E., Chen, E., & Parker, K. J. (2011) · Psychological Bulletin · doi:10.1037/a0024768 · Cited by 1,785 · see citing works
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748 · see citing works
The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
Napso, T., Yong, H. E. J., Lopez-Tello, J., & Sferruzzi-Perri, A. N. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01091 · Cited by 470 · see citing works
Elabd, C., Cousin, W., Upadhyayula, P., Chen, R. Y., Chooljian, M. S., Li, J., Kung, S., Jiang, K. P., & Conboy, I. M. (2014) · Nature Communications · doi:10.1038/ncomms5082 · Cited by 411 · see citing works
Vasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
Koshimizu, T., Nakamura, K., Egashira, N., Hiroyama, M., Nonoguchi, H., & Tanoue, A. (2012) · Physiological Reviews · doi:10.1152/physrev.00035.2011 · Cited by 413 · see citing works
Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin
Poutahidis, T., Kearney, S. M., Levkovich, T., Qi, P., Varian, B. J., Lakritz, J. R., Ibrahim, Y. M., Chatzigiagkos, A., Alm, E. J., & Erdman, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078898 · Cited by 310 · see citing works
“Shift-and-Persist” Strategies: Why Low Socioeconomic Status Isn’t Always Bad for Health
Chen, E., & Miller, G. E. (2012) · Perspectives on Psychological Science · doi:10.1177/1745691612436694 · Cited by 359 · see citing works
Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats
Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., Bussier, A.-L., Petrosino, S., Piscitelli, F., Legros, J.-J., Geenen, V., Foti, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025565 · Cited by 254 · see citing works
Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass
Maejima, Y., Iwasaki, Y., Yamahara, Y., Kodaira, M., Sedbazar, U., & Yada, T. (2011) · Aging · doi:10.18632/aging.100408 · Cited by 220 · see citing works
An Allostatic Theory of Oxytocin
Quintana, D. S., & Guastella, A. J. (2020) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2020.03.008 · Cited by 212 · see citing works
Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2011 · Cited by 213 · see citing works
Oxytocin reduces caloric intake in men
Lawson, E. A., Marengi, D. A., DeSanti, R. L., Holmes, T. M., Schoenfeld, D. A., & Tolley, C. J. (2015) · Obesity · doi:10.1002/oby.21069 · Cited by 208 · see citing works
Lorenzo-Almorós, A., Hang, T., Peiró, C., Soriano-Guillén, L., Egido, J., Tuñón, J., & Lorenzo, Ó. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0935-9 · Cited by 202 · see citing works
The effects of oxytocin on eating behaviour and metabolism in humans
Lawson, E. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.115 · Cited by 196 · see citing works
Miller, G. E., Lachman, M. E., Chen, E., Gruenewald, T. L., Karlamangla, A. S., & Seeman, T. E. (2011) · Psychological Science · doi:10.1177/0956797611419170 · Cited by 196 · see citing works
Blevins, J. E., Graham, J. L., Morton, G. J., Bales, K. L., Schwartz, M. W., Baskin, D. G., & Havel, P. J. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00441.2014 · Cited by 187 · see citing works
An obligate role of oxytocin neurons in diet induced energy expenditure
Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045167 · Cited by 181 · see citing works
Zhang, G., & Cai, D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2011 · Cited by 171 · see citing works
Microbial Reprogramming Inhibits Western Diet-Associated Obesity
Poutahidis, T., Kleinewietfeld, M., Smillie, C., Levkovich, T., Perrotta, A., Bhela, S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Kearney, S. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068596 · Cited by 164 · see citing works
Hormone Interactions Regulating Energy Balance During Pregnancy
Ladyman, S. R., Augustine, R. A., & Grattan, D. R. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02017.x · Cited by 161 · see citing works
Control of Food Intake and Energy Expenditure by Nos1 Neurons of the Paraventricular Hypothalamus
Sutton, A. K., Pei, H., Burnett, K. H., Myers, M. G., Rhodes, C. J., & Olson, D. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0226-14.2014 · Cited by 153 · see citing works
Sarcopenic obesity: molecular clues to a better understanding of its pathogenesis?
Kob, R., Bollheimer, L. C., Bertsch, T., Fellner, C., Djukic, M., Sieber, C. C., & Fischer, B. E. (2015) · Biogerontology · doi:10.1007/s10522-014-9539-7 · Cited by 151 · see citing works
Decreased Circulating Levels of Oxytocin in Obesity and Newly Diagnosed Type 2 Diabetic Patients
Qian, W., Zhu, T., Tang, B., Yu, S., Hu, H., Sun, W., Pan, R., Wang, J., Wang, D., Yang, L., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-2206 · Cited by 149 · see citing works
Hypothalamic control of energy metabolism via the autonomic nervous system
Kalsbeek, A., Bruinstroop, E., Yi, C., Klieverik, L. P., la Fleur, S. E., & Fliers, E. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05800.x · Cited by 148 · see citing works
Li, C., Navarrete, J. S., Liang-Guallpa, J., Lü, C., Funderburk, S. C., Chang, R. B., Liberles, S. D., Olson, D. P., & Krashes, M. J. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.016 · Cited by 145 · see citing works
McCormack, S. E., Blevins, J. E., & Lawson, E. A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz012 · Cited by 140 · see citing works
Blevins, J. E., & Baskin, D. G. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.05.023 · Cited by 132 · see citing works
Roles of Oxytocin Neurones in the Control of Stress, Energy Metabolism, and Social Behaviour
Onaka, T., Takayanagi, Y., & Yoshida, M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02300.x · Cited by 123 · see citing works
Lawson, E. A., Donoho, D. A., Blum, J. I., Meenaghan, E. M., Misra, M., Herzog, D. B., Sluss, P. M., Miller, K. K., & Klibanski, A. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06617 · Cited by 124 · see citing works
Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders
Grinevich, V., Desarménien, M. G., Chini, B., Tauber, M., & Muscatelli, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00164 · Cited by 121 · see citing works
Gaetani, S., Fu, J., Cassano, T., Dipasquale, P., Romano, A., Righetti, L., Cianci, S., Laconca, L., Giannini, E., Scaccianoce, S., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0036-10.2010 · Cited by 124 · see citing works
Appetite Regulation: Hormones, Peptides, and Neurotransmitters and Their Role in Obesity
Miller, G. D. (2017) · American Journal of Lifestyle Medicine · doi:10.1177/1559827617716376 · Cited by 126 · see citing works
The long-term psychiatric and medical prognosis of perinatal mental illness
Meltzer-Brody, S. E., & Stuebe, A. M. (2013) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2013.08.009 · Cited by 121 · see citing works
The Role of PVH Circuits in Leptin Action and Energy Balance
Sutton, A. K., Myers, M. G., & Olson, D. P. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105347 · Cited by 121 · see citing works
Oxytocin in metabolic homeostasis: implications for obesity and diabetes management
Ding, C., Leow, M., & Magkos, F. (2018) · Obesity Reviews · doi:10.1111/obr.12757 · Cited by 101 · see citing works
Postolache, T. T., del Bosque‐Plata, L., Jabbour, S. A., Vergare, M. J., Wu, R., & Gragnoli, C. (2019) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32712 · Cited by 107 · see citing works
Nonsocial Functions of Hypothalamic Oxytocin
Yang, H.-P., Wang, L., Han, L., & Wang, S. C. (2013) · ISRN Neuroscience · doi:10.1155/2013/179272 · Cited by 111 · see citing works
Role of oxytocin signaling in the regulation of body weight
Blevins, J. E., & Ho, J. M. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-013-9260-x · Cited by 108 · see citing works
Oxytocin Treatment Prevents the Cardiomyopathy Observed in Obese Diabetic Male db/db Mice
Plante, É., Ménaouar, A., Danalache, B. A., Yip, D., Broderick, T. L., Chiasson, J., Jankowski, M., & Gutkowska, J. (2015) · Endocrinology · doi:10.1210/en.2014-1718 · Cited by 107 · see citing works
Blevins, J. E., Thompson, B. W., Anekonda, V. T., Ho, J. M., Graham, J. L., Roberts, Z. S., Hwang, B. H., Ogimoto, K., Wolden‐Hanson, T., Nelson, J. T., et al. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00220.2015 · Cited by 107 · see citing works
Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00118.2014 · Cited by 102 · see citing works
From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders
Romano, A., Tempesta, B., Bonaventura, M. V. M. D., & Gaetani, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00497 · Cited by 102 · see citing works
Ablation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure
Xi, D., Gandhi, N. M., Lai, M., & Kublaoui, B. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036453 · Cited by 100 · see citing works
The role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis
Lawson, E. A., Olszewski, P. K., Weller, A., & Blevins, J. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12805 · Cited by 97 · see citing works
Kasahara, Y., Sato, K., Takayanagi, Y., Mizukami, H., Ozawa, K., Hidema, S., So, K.-H., Kawada, T., Inoue, N., Ikeda, I., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2206 · Cited by 96 · see citing works
The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 94 · see citing works
Oxytocin as feeding inhibitor: Maintaining homeostasis in consummatory behavior
Olszewski, P. K., Klockars, A., Schiöth, H. B., & Levine, A. S. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.05.026 · Cited by 92 · see citing works
Leng, G., & Sabatier, N. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.02.007 · Cited by 89 · see citing works
Expanding the definition of hypothalamic obesity
Hochberg, I., & Hochberg, Z. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00727.x · Cited by 88 · see citing works
Perelló, M., & Raingo, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059625 · Cited by 84 · see citing works
Role of oxytocin in energy metabolism
Chaves, V. E., Tilelli, C. Q., Brito, N. A., & Brito, M. N. (2013) · Peptides · doi:10.1016/j.peptides.2013.04.010 · Cited by 90 · see citing works
Satiety: a gut–brain–relationship
Barakat, G. M., Ramadan, W., Assi, G., & Khoury, N. B. E. (2024) · The Journal of Physiological Sciences · doi:10.1186/s12576-024-00904-9 · Cited by 82 · see citing works
Maejima, Y., Rita, R. S., Santoso, P., Aoyama, M., Hiraoka, Y., Nishimori, K., Gantulga, D., Shimomura, K., & Yada, T. (2015) · Neuroendocrinology · doi:10.1159/000371636 · Cited by 81 · see citing works
Oxytocin during Development: Possible Organizational Effects on Behavior
Miller, T. V., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00076 · Cited by 79 · see citing works
Ho, J. M., Anekonda, V. T., Thompson, B. W., Zhu, M., Curry, R. W., Hwang, B. H., Morton, G. J., Schwartz, M. W., Baskin, D. G., Appleyard, S. M., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1148 · Cited by 74 · see citing works
Roberts, Z. S., Wolden‐Hanson, T., Matsen, M. E., Ryu, V., Vaughan, C. H., Graham, J. L., Havel, P. J., Chukri, D. W., Schwartz, M. W., Morton, G. J., et al. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00169.2017 · Cited by 68 · see citing works
Appetite- and Weight-Regulating Neuroendocrine Circuitry in Hypothalamic Obesity
Gan, H., Cerbone, M., & Dattani, M. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad033 · Cited by 71 · see citing works
Coming Full Circle: Contributions of Central and Peripheral Oxytocin Actions to Energy Balance
Ho, J. M., & Blevins, J. E. (2012) · Endocrinology · doi:10.1210/en.2012-1751 · Cited by 67 · see citing works
Erdman, S. E., & Poutahidis, T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.07.004 · Cited by 67 · see citing works
Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds
Neelkantan, N., Mikhaylova, A., Stewart, A., Arnold, R., Gjeloshi, V., Kondaveeti, D., Poudel, M. K., & Kalueff, A. V. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400090q · Cited by 65 · see citing works
Altirriba, J., Poher, A.-L., & Rohner‐Jeanrenaud, F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00119 · Cited by 63 · see citing works
Oxytocin enhances cognitive control of food craving in women
Striepens, N., Schröter, F., Stoffel‐Wagner, B., Maier, W., Hurlemann, R., & Scheele, D. (2016) · Human Brain Mapping · doi:10.1002/hbm.23308 · Cited by 63 · see citing works
PVN pathways controlling energy homeostasis
Hill, J. W. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105581 · Cited by 62 · see citing works
Ong, Z. Y., Alhadeff, A. L., & Grill, H. J. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00534.2014 · Cited by 62 · see citing works
Brain to bone: What is the contribution of the brain to skeletal homeostasis?
Idelevich, A., & Baron, R. (2018) · Bone · doi:10.1016/j.bone.2018.05.018 · Cited by 60 · see citing works
Supraoptic oxytocin and vasopressin neurons function as glucose and metabolic sensors
Song, Z., Levin, B. E., Stevens, W., & Sladek, C. D. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00520.2013 · Cited by 58 · see citing works
Current findings on the role of oxytocin in the regulation of food intake
Spetter, M. S., & Hallschmid, M. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.03.007 · Cited by 58 · see citing works
Impact of sex, fat distribution and initial body weight on oxytocin’s body weight regulation
Maejima, Y., Aoyama, M., Sakamoto, K., Jojima, T., Aso, Y., Takasu, K., Takenosihita, S., & Shimomura, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-09318-7 · Cited by 59 · see citing works
Hypooxytocinaemia in obese Zucker rats relates to oxytocin degradation in liver and adipose tissue
Balážová, L., Kršková, K., Segarra, A. B., Špolcová, A., Suski, M., Olszanecki, R., & Zórad, Š. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0417 · Cited by 57 · see citing works
Breuil, V., Amri, E., Panaïa‐Ferrari, P., Testa, J., Elabd, C., Albert-Sabonnadière, C., Roux, C. H., Ailhaud, G. P., Dani, C., Carle, G. F., et al. (2011) · Joint Bone Spine · doi:10.1016/j.jbspin.2011.02.002 · Cited by 56 · see citing works
Serum Irisin and Oxytocin Levels as Predictors of Metabolic Parameters in Obese Children
Binay, Ç., Paketçi, C., Güzel, S., & Samancı, N. (2017) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.3963 · Cited by 55 · see citing works
Oxytocin and Eating Disorders: A Narrative Review on Emerging Findings and Perspectives
Giel, K. E., Zipfel, S., & Hallschmid, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666171128143158 · Cited by 53 · see citing works
The Regulation of Oxytocin Receptor Gene Expression during Adipogenesis
Yi, K., So, K. H., Hata, Y., Suzuki, Y., Kato, D., Watanabe, K., Aso, H., Kasahara, Y., Nishimori, K., Chen, C., et al. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12268 · Cited by 51 · see citing works
Ganella, D. E., Ma, S., & Gundlach, A. L. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00128 · Cited by 51 · see citing works
Camerino, C., Zayzafoon, M., Rymaszewski, M., Heiny, J. A., Rios, M., & Hauschka, P. V. (2012) · Endocrinology · doi:10.1210/en.2012-1378 · Cited by 48 · see citing works
Elabd, S., & Sabry, I. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00121 · Cited by 46 · see citing works
Ablation of Oxytocin Neurons Causes a Deficit in Cold Stress Response
Dong, X., Long, C., Lai, M., Casella, A., O’Lear, L., Kublaoui, B. M., & Roizen, J. D. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00136 · Cited by 46 · see citing works
Oxytocin: Potential to mitigate cardiovascular risk
Reiss, A. B., Glass, D. S., Lam, E., Glass, A. D., Leon, J. D., & Kasselman, L. J. (2019) · Peptides · doi:10.1016/j.peptides.2019.05.001 · Cited by 44 · see citing works
Birth signalling hormones and the developmental consequences of caesarean delivery
Kenkel, W. M. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12912 · Cited by 45 · see citing works
Yuan, J., Zhang, R., Wu, R., Gu, Y., & Lu, Y. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110903 · Cited by 45 · see citing works
Sex Differences and Estrous Influences on Oxytocin Control of Food Intake
Liu, C. M., Davis, E. A., Suarez, A. N., Wood, R. I., Noble, E. E., & Kanoski, S. E. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.10.020 · Cited by 44 · see citing works
Loid, P., Mustila, T., Mäkitie, R. E., Viljakainen, H. T., Kämpe, A. J., Tossavainen, P. H., Lipsanen‐Nyman, M., Pekkinen, M., & Mäkitie, O. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00081 · Cited by 43 · see citing works
Peptides in the regulation of glucagon secretion
Andersen, D. B., & Holst, J. J. (2021) · Peptides · doi:10.1016/j.peptides.2021.170683 · Cited by 46 · see citing works
Bush, N. R., Allison, A. L., Miller, A. L., Deardorff, J., Adler, N. E., & Boyce, W. T. (2016) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2016.2332 · Cited by 42 · see citing works
Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells
Watanabe, S., Wei, F., Matsunaga, T., Matsunaga, N., Kaitsuka, T., & Tomizawa, K. (2016) · Scientific Reports · doi:10.1038/srep25185 · Cited by 40 · see citing works
Quintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.004 · Cited by 39 · see citing works
Harshaw, C., Leffel, J. K., & Alberts, J. R. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.12.007 · Cited by 39 · see citing works
Oxytocin signaling in the posterior hypothalamus prevents hyperphagic obesity in mice
Inada, K., Tsujimoto, K., Yoshida, M., Nishimori, K., & Miyamichi, K. (2022) · eLife · doi:10.7554/elife.75718 · Cited by 39 · see citing works
Sensory Circumventricular Organs, Neuroendocrine Control, and Metabolic Regulation
Jeong, J. K., Dow, S. A., & Young, C. N. (2021) · Metabolites · doi:10.3390/metabo11080494 · Cited by 38 · see citing works
Freeman, S. M., Ngo, J., Singh, B., Masnaghetti, M., Bales, K. L., & Blevins, J. E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.07.037 · Cited by 37 · see citing works
Neuropeptides in Obesity and Metabolic Disease
van der Klaauw, A. A. (2017) · Clinical Chemistry · doi:10.1373/clinchem.2017.281568 · Cited by 37 · see citing works
Crosstalk between Schizophrenia and Metabolic Syndrome: The Role of Oxytocinergic Dysfunction
Goh, K. K., Chen, C. Y.-A., Wu, T., Chen, C.-H., & Lu, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137092 · Cited by 37 · see citing works
An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow
Fukushima, A., Kataoka, N., & Nakamura, K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111380 · Cited by 40 · see citing works
Intranasal Neuropeptide Administration To Target the Human Brain in Health and Disease
Spetter, M. S., & Hallschmid, M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00047 · Cited by 35 · see citing works
Oxytocin and Vasopressin Systems in Obesity and Metabolic Health: Mechanisms and Perspectives
Ding, C., & Magkos, F. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00355-z · Cited by 36 · see citing works
Camerino, C., Conte, E., Cannone, M., Caloiero, R., Fonzino, A., & Tricarico, D. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00456 · Cited by 36 · see citing works
Oxytocin administration suppresses hypothalamic activation in response to visual food cues
van der Klaauw, A. A., Ziauddeen, H., Keogh, J. M., Henning, E., Dachi, S. V., Fletcher, P. C., & Farooqi, I. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-04600-0 · Cited by 34 · see citing works
High serum oxytocin is associated with metabolic syndrome in older men – The MINOS study
Szulc, P., Amri, E., Varennes, A., Panaïa‐Ferrari, P., Fontas, É., Goudable, J., Chapurlat, R. D., & Breuil, V. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.09.022 · Cited by 33 · see citing works
Loss of Acute Satiety Response to Cholecystokinin in Pregnant Rats
Ladyman, S. R., Sapsford, T. J., & Grattan, D. R. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02191.x · Cited by 33 · see citing works
Yuan, G., Qian, W., Pan, R., Jia, J., Jiang, D., Yang, Q., Wang, S., Liu, Y., Yu, S., Hu, H., et al. (2016) · Endocrine Journal · doi:10.1507/endocrj.ej16-0078 · Cited by 33 · see citing works
- Authors
- Camerino, C.
- Affiliations
- University of Bari Aldo Moro (IT)
- Corresponding author
- Camerino, Claudia
- ORCID
- Camerino, Claudia
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2009-05
- Volume
- 17
- Issue
- 5
- Pages
- 980-984
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- OpenAlex
- W2013694191
- Cited by
- 235
- References
- 26
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 24 · 2023: 11 · 2022: 9 · 2021: 17 · 2020: 10 · 2019: 15 · 2018: 19 · 2017: 18 · 2016: 17 · 2015: 16 · 2014: 18 · 2013: 12 · 2012: 13
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- oxytocin, late-onset obesity, hyperleptinemia, insulin resistance, impaired glucose tolerance, epinephrine, paraventricular nucleus, energy homeostasis, dietary intake, leptin, cholecystokinin, bombesin, satiety peptides
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Body Weight, Brain Stem, Energy Intake, Crosses, Genetic, Hypothalamus, Insulin, Mice, Inbred C57BL, Obesity, Oxytocin, Stomach, Sympathetic Nervous System, Signal Transduction, Glucose Intolerance, Mice, Knockout, Leptin, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
