Exercise improves physical and psychological quality of life in people with depression: A meta-analysis including the evaluation of control group response
Open accessAbstract
Exercise has established efficacy as an antidepressant in people with depression. However, few meta-analyses have assessed the effects of exercise across different domains of Quality of Life (QoL) in people with depression. Furthermore, there has been no previous meta-analysis of control group response in relation to QoL in exercise trials for depression. Randomized Clinical Trials(RCTs) were initially identified from a Cochrane review, and those including QoL assessments were included in the analysis. Search of major electronic databases were conducted to identify RCTs that compared the exercise effects on QoL versus control condition in people with depression. A random effects meta-analysis was employed to evaluate the Standardized Mean Difference (SMD). Six RCTs were included. Exercise significantly improved physical and psychological domains and overall QoL. Effects on social relationship and environment domains were not significant. No significant control group response was found for any domain or overall QoL. Exercise can be considered as a therapeutic strategy to improve physical and psychological domains and overall QoL of people with depression, with no effect evident across the social and environmental domains. The lack of improvement among control groups reinforces the role of exercise as a treatment for depression with benefits to QoL.
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Aerobic exercise improves quality of life in patients with depression.
“Aerobic exercise also improves quality of life [98]”
From The effects of exercise on sleep in unipolar depression: a systematic review and network meta-analysis (2021) · cites this paper as [98]
In mental health conditions, physical activity has wider benefits including improved quality of life, less psychological distress and improved physical health.
“In such mental health conditions, PA has been shown to have wider benefits to peoples’ wellbeing, including an improved quality of life, less psychological distress and, importantly, improved physical health [28, 29, 38–43].”
From Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety (2018) · cites this paper as [41]
Physical activity in the general population has established efficacy in preventing and managing cardiovascular disease and improving wellbeing.
“PA in the general population has established efficacy in preventing and managing cardiovascular disease and improving wellbeing.”
From Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety (2018) · cites this paper as [41]
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- Authors
- Schuch, F. B., Vancampfort, D., Rosenbaum, S., Richards, J., Ward, P. B., & Stubbs, B.
- Affiliations
- Universidade Federal do Rio Grande do Sul (BR)
- KU Leuven (BE)
- UNSW Sydney (AU)
- The University of Sydney (AU)
- National Health Service (GB)
- Corresponding author
- Schuch, Felipe B.
- ORCID
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 241
- Pages
- 47-54
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2345153356
- Cited by
- 165
- References
- 51
- Citations by year
- 2026: 13 · 2025: 12 · 2024: 11 · 2023: 20 · 2022: 11 · 2021: 16 · 2020: 14 · 2019: 21 · 2018: 27 · 2017: 13 · 2016: 6
- FWCI
- 2.63
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
- Lirias (KU Leuven) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (CNPq)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- physical activity, depression, quality of life, physical quality of life, psychological quality of life, antidepressant effects, interpersonal relationships, environmental quality of life
- MeSH terms
- Depressive Disorder, Exercise Therapy, Humans
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