The effects of physical activity and exercise on brain‐derived neurotrophic factor in healthy humans: A review
Abstract
The purpose of this study was to summarize the effects of physical activity and exercise on peripheral brain‐derived neurotrophic factor ( BDNF ) in healthy humans. Experimental and observational studies were identified from P ub M ed, W eb of K nowledge, S copus, and SPORT D iscus. A total of 32 articles met the inclusion criteria. Evidence from experimental studies suggested that peripheral BDNF concentrations were elevated by acute and chronic aerobic exercise. The majority of the studies suggested that strength training had no influence on peripheral BDNF . The results from most observational studies suggested an inverse relationship between the peripheral BDNF level and habitual physical activity or cardiorespiratory fitness. More research is needed to confirm the findings from the observational studies.
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Exercise can act as an inductor of neuronal plasticity, neurogenesis, and neuronal survival.
“Thus, exercise can act as an inductor of neuronal plasticity, neurogenesis and neuronal survival [208, 209].”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [208]
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- Authors
- Huang, T., Larsen, K. T., Ried‐Larsen, M., Møller, N. C., & Andersen, L. B.
- Affiliations
- University of Southern Denmark (DK)
- Corresponding author
- Huang, T.
- Venue
- Scandinavian Journal of Medicine & Science in Sports
- Publisher
- Wiley
- Published
- 2013-04-22
- Volume
- 24
- Issue
- 1
- Pages
- 1-10
- ISSN
- 0905-7188 (ISSN-L)
- 1600-0838
- OpenAlex
- W1575064912
- Cited by
- 485
- References
- 62
- Citations by year
- 2026: 26 · 2025: 47 · 2024: 34 · 2023: 34 · 2022: 36 · 2021: 37 · 2020: 49 · 2019: 43 · 2018: 48 · 2017: 43 · 2016: 42 · 2015: 31 · 2014: 14 · 2013: 1
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Medicine and Science in Sports (publishedVersion)
- PubMed (publishedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- brain-derived neurotrophic factor, physical activity, aerobic exercise, resistance training, cardiorespiratory fitness, healthy humans
- MeSH terms
- Cognition, Humans, Motor Activity, Physical Fitness, Exercise, Brain-Derived Neurotrophic Factor, Resistance Training
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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