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Clonal hematopoiesis: Mutation-specific adaptation to environmental change
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Clonal hematopoiesis of indeterminate potential (CHIP) describes a widespread expansion of genetically variant hematopoietic cells that increases exponentially with age and is associated with increased risks of cancers, cardiovascular disease, and other maladies. Here, we discuss how environmental contexts associated with CHIP, such as old age, infections, chemotherapy, or cigarette smoking, alter tissue microenvironments to facilitate the selection and expansion of specific CHIP mutant clones. Further, we consider major remaining gaps in knowledge, including intrinsic effects, clone size thresholds, and factors affecting clonal competition, that will determine future application of this field in transplant and preventive medicine.
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“Over a lifetime of an organism, repeated infections, autoimmune dysregulation, systemic disease that promotes inflammatory signals such as CVD, or other physiological stresses including metabolic stress or sleep deprivation may lead to systemic inflammation that provides cumulative, chronic positive selective pressure upon CH clones [67].”
From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [67]
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Metadata
- Authors
- Florez, M. A., Tran, B. T., Wathan, T. K., DeGregori, J., Pietras, E. M., & King, K. Y.
- Affiliations
- Baylor College of Medicine (US)
- University of Colorado Anschutz (US)
- Corresponding author
- King, Katherine Y.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 29
- Issue
- 6
- Pages
- 882-904
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC9202417
- OpenAlex
- W4281715700
- Cited by
- 129
- References
- 259
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 38 · 2023: 20 · 2022: 7
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG066544, R01AG067584)
- National Heart, Lung, and Blood Institute (F31HL156500, R01HL134880, R01HL136333, R35HL155672)
- National Cancer Institute (P01CA265748)
- National Institute of Allergy and Infectious Diseases (R01AI141716)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK119394)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- clonal hematopoiesis of indeterminate potential, clonal evolution, somatic mutations, hematopoietic stem cells, tissue microenvironment, aging, infection, chemotherapy, cigarette smoking, clonal competition, cancer risk, cardiovascular disease, hematopoietic stem cell transplantation
- MeSH terms
- Clonal Hematopoiesis, Hematopoiesis, Hematopoietic Stem Cells, Mutation, Risk Factors
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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