Cited by 606Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and PathologyRedox biology and oxidative stress

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Taking a good look at free radicals in the aging process

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Hekimi, Siegfried, Lapointe, Jérôme, Wen, Yang·2011·Trends in Cell Biology

DOI 10.1016/j.tcb.2011.06.008PMC PMC4074523

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Abstract

The mitochondrial free radical theory of aging (MFRTA) proposes that aging is caused by damage to macromolecules by mitochondrial reactive oxygen species (ROS). This is based on the observed association of the rate of aging and the aged phenotype with the generation of ROS and oxidative damage. However, recent findings, in particular in Caenorhabditis elegans but also in rodents, suggest that ROS generation is not the primary or initial cause of aging. Here, we propose that ROS are tightly associated with aging because they play a role in mediating a stress response to age-dependent damage. This could generate the observed correlation between aging and ROS without implying that ROS damage is the earliest trigger or main cause of aging.

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Authors: Hekimi, S., Lapointe, J., & Wen, Y.
Affiliations: McGill University (CA)
Corresponding author: Hekimi, Siegfried
ORCID: Hekimi, Siegfried
Lapointe, Jérôme
Venue: Trends in Cell Biology
Publisher: Elsevier BV
Published: 2011-10
Volume: 21
Issue: 10
Pages: 569-576
ISSN: 0962-8924 (ISSN-L)
DOI: 10.1016/j.tcb.2011.06.008
PMC: PMC4074523
OpenAlex: W2085525271
Cited by: 606
References: 90
Citations by year: 2026: 17 · 2025: 19 · 2024: 30 · 2023: 31 · 2022: 45 · 2021: 43 · 2020: 46 · 2019: 43 · 2018: 49 · 2017: 43 · 2016: 51 · 2015: 38 · 2014: 48 · 2013: 57 · 2012: 39
FWCI: 5.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Canadian Institutes of Health Research (97869_1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: reactive oxygen species, aging, oxidative damage, macromolecular damage, stress response, Caenorhabditis elegans, rodents
MeSH terms: Aging, Animals, DNA Damage, Free Radicals, Humans, Mitochondria, Models, Molecular, Mutation, Rodentia, Superoxide Dismutase, Signal Transduction, Caenorhabditis elegans, Reactive Oxygen Species, Oxidative Stress

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Taking a good look at free radicals in the aging process

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