PER2 controls lipid metabolism by direct regulation of PPARγ

Coordination of circadian timing in mammals

Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379 · see citing works

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,533 · see citing works

Adipocyte differentiation from the inside out

Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607 · see citing works

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · cited 6× · see citing works

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works

Fat and Beyond: The Diverse Biology of PPARγ

Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085 · see citing works

PPARs and the complex journey to obesity

Evans, R. M., Barish, G. D., & Wang, Y.-X. (2004) · Nature Medicine · doi:10.1038/nm1025 · Cited by 1,621 · see citing works

The Many Faces of PPARγ

Lehrke, M., & Lazar, M. A. (2005) · Cell · doi:10.1016/j.cell.2005.11.026 · Cited by 1,452 · see citing works

Interacting molecular loops in the mammalian circadian clock

Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367 · see citing works

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318 · see citing works

Time zones: a comparative genetics of circadian clocks

Young, M. W., & Kay, S. A. (2001) · Nature Reviews Genetics · doi:10.1038/35088576 · Cited by 1,143 · see citing works

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works

Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock

Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., & Weaver, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00302-6 · Cited by 900 · see citing works

Circadian Regulator CLOCK Is a Histone Acetyltransferase

Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 890 · see citing works

Three period Homologs in Mammals: Differential Light Responses in the Suprachiasmatic Circadian Clock and Oscillating Transcripts Outside of Brain

Zylka, M. J., Shearman, L. P., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80492-4 · Cited by 865 · see citing works

Circadian Cycling of the Mouse Liver Transcriptome, as Revealed by cDNA Microarray, Is Driven by the Suprachiasmatic Nucleus

Akhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works

A Web of Circadian Pacemakers

Schibler, U., & Sassone‐Corsi, P. (2002) · Cell · doi:10.1016/s0092-8674(02)01225-4 · Cited by 752 · see citing works

The mPer2 gene encodes a functional component of the mammalian circadian clock

Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., & Bradley, A. (1999) · Nature · doi:10.1038/22118 · Cited by 718 · see citing works

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works

Metabolism and cancer: the circadian clock connection

Sahar, S., & Sassone-Corsi, P. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2747 · Cited by 551 · see citing works

Molecular Genetics of Circadian Rhythms in Mammals

King, D. P., & Takahashi, J. S. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.713 · Cited by 551 · see citing works

Circadian Mutant Overtime Reveals F-box Protein FBXL3 Regulation of Cryptochrome and Period Gene Expression

Siepka, S. M., Yoo, S. H., Park, J., Song, W., Kumar, V., Hu, Y., Lee, C., & Takahashi, J. S. (2007) · Cell · doi:10.1016/j.cell.2007.04.030 · Cited by 536 · see citing works

Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance

Ricquier, D., & Bouillaud, F. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00003.x · Cited by 385 · see citing works

Distinct Transcriptional Profiles of Adipogenesisin Vivo and in Vitro

Soukas, A. A., Socci, N. D., Saatkamp, B. D., Novelli, S. E., & Friedman, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104421200 · Cited by 368 · see citing works

Nuclear receptor corepressor RIP140 regulates fat accumulation

Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401013101 · Cited by 366 · see citing works

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors

Schmutz, I., Ripperger, J. A., Baeriswyl-Aebischer, S., & Albrecht, U. (2010) · Genes & Development · doi:10.1101/gad.564110 · Cited by 361 · see citing works

Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms

Field, M. D., Maywood, E. S., O'Brien, J. A., Weaver, D. R., Reppert, S. M., & Hastings, M. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80906-x · Cited by 343 · see citing works

Comprehensive Messenger Ribonucleic Acid Profiling Reveals That Peroxisome Proliferator-Activated Receptor γ Activation Has Coordinate Effects on Gene Expression in Multiple Insulin-Sensitive Tissues

Way, J. M., Harrington, W. W., Brown, K. K., Gottschalk, W. K., Sundseth, S. S., Mansfield, T. A., Ramachandran, R. K., Willson, T. M., & Kliewer, S. A. (2001) · Endocrinology · doi:10.1210/endo.142.3.8037 · Cited by 338 · see citing works

Interplay of Circadian Clocks and Metabolic Rhythms

Wijnen, H., & Young, M. W. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090603 · Cited by 335 · see citing works

Circadian Programs of Transcriptional Activation, Signaling, and Protein Turnover Revealed by Microarray Analysis of Mammalian Cells

Duffield, G. E., Best, J. D., Meurers, B. H., Bittner, A., Loros, J., & Dunlap, J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00765-0 · Cited by 329 · see citing works

Retinoic Acid Blocks Adipogenesis by Inhibiting C/EBPβ-Mediated Transcription

Schwarz, E. J., Reginato, M. J., Shao, D., Krakow, S. L., & Lazar, M. A. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.3.1552 · Cited by 302 · see citing works

Untitled work

Zheng (1999) · doi:10.1038/22659 · Cited by 293 · see citing works

Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase

Kadenbach, B., Hüttemann, M., Arnold, S., Lee, I., & Bender, E. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00305-1 · Cited by 268 · see citing works

The role of mPer2 clock gene in glucocorticoid and feeding rhythms

Yang, S., Liu, A., Weidenhammer, A., Cooksey, R. C., McClain, D., Kim, M. K., Aguilera, G., Abel, E. D., & Chung, J. H. (2009) · Endocrinology · doi:10.1210/en.2008-0705 · Cited by 263 · see citing works

Daily rhythms of food-anticipatory behavioral activity do not require the known circadian clock

Storch, K.-F., & Weitz, C. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902063106 · Cited by 222 · see citing works

Lack of Food Anticipation in Per2 Mutant Mice

Feillet, C. A., Ripperger, J. A., Magnone, M. C., Dulloo, A. G., Albrecht, U., & Challet, É. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.053 · Cited by 208 · see citing works

Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity

Rangwala, S. M., Rhoades, B., Shapiro, J. S., Rich, A. S., Kim, J. K., Shulman, G. I., Kaestner, K. H., & Lazar, M. A. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00274-0 · Cited by 204 · see citing works

A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.

Fukui, Y., Masui, S., Osada, S., Umesono, K., & Motojima, K. (2000) · Diabetes · doi:10.2337/diabetes.49.5.759 · Cited by 168 · see citing works

Direct Association between Mouse PERIOD and CKIε Is Critical for a Functioning Circadian Clock

Lee, C., Weaver, D. R., & Reppert, S. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.584-594.2004 · Cited by 159 · see citing works

ELOVL3 Is an Important Component for Early Onset of Lipid Recruitment in Brown Adipose Tissue

Westerberg, R., Månsson, J.-E., Golozoubova, V., Shabalina, I. G., Backlund, E. C., Tvrdík, P., Retterstøl, K., Capecchi, M. R., & Jacobsson, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511588200 · Cited by 149 · see citing works

Metabolism control by the circadian clock and vice versa

Eckel‐Mahan, K. L., & Sassone‐Corsi, P. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1595 · Cited by 146 · see citing works

Dysregulation of the Peroxisome Proliferator-Activated Receptor Target Genes by XPD Mutations

Compe, E., Drané, P., Laurent, C., Diderich, K. E. M., Braun, C., Hoeijmakers, J. H. J., & Egly, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6065-6076.2005 · Cited by 139 · see citing works

Structural and functional features of transcription factors controlling the circadian clock

Hirayama, J., & Sassone‐Corsi, P. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.07.003 · Cited by 101 · see citing works

Nuclear Receptors, Metabolism, and the Circadian ClockPreprint

Yang, X., Lamia, K. A., & Evans, R. M. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.058 · Cited by 87 · see citing works

Peroxisomal β-Oxidation Enzymes

Hashimoto, T. (1999) · Neurochemical Research · doi:10.1023/a:1022540030918 · Cited by 79 · see citing works

Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo

Rossmeisl, M., Barbatelli, G., Flachs, P., Brauner, P., Zingaretti, M. C., Marelli, M., Janovská, P., Horáková, M., Syrový, I., Cinti, S., et al. (2002) · European Journal of Biochemistry · doi:10.1046/j.0014-2956.2002.02627.x · Cited by 75 · see citing works

Increased fatty acid oxidation in transgenic mice overexpressing UCP3 in skeletal muscle

Wang, S., Subramaniam, A., Cawthorne, M. A., & Clapham, J. C. (2003) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2003.00273.x · Cited by 74 · see citing works

Mitochondrial uncoupling and lipid metabolism in adipocytes

Kopecký, J., Rossmeisl, M., Flachs, P., Bardová, K., & Brauner, P. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290791 · Cited by 59 · see citing works

A null mutation in H-FABP only partially inhibits skeletal muscle fatty acid metabolism

Binas, B., Han, X.-X., Erol, E., Luiken, J. J. F. P., Glatz, J. F. C., Dyck, D. J., Motazavi, R., Adihetty, P. J., Hood, D. A., & Bonen, A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00060.2003 · Cited by 47 · see citing works

Peroxisomal β-Oxidation Enzymes

Hashimoto, T. (2000) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:32:1-3:63 · Cited by 31 · see citing works

Proteolytic cleavage of ALF into α‐ and β‐subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells

Catena, R., Argentini, M., Martianov, I., Parello, C., Brancorsini, S., Parvinen, M., Sassone‐Corsi, P., & Davidson, I. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.04.083 · Cited by 20 · see citing works

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works

Adipogenesis and metabolic health

Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395 · see citing works

Timing to perfection: the biology of central and peripheral circadian clocks

Albrecht, U. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.006 · Cited by 915 · see citing works

Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock

Asher, G., & Sassone-Corsi, P. (2015) · Cell · doi:10.1016/j.cell.2015.03.015 · Cited by 844 · see citing works

Circadian clocks and insulin resistance

Stenvers, D. J., Scheer, F. A. J. L., Schrauwen, P., la Fleur, S. E., & Kalsbeek, A. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0122-1 · Cited by 733 · see citing works

Crosstalk between metabolism and circadian clocks

Reinke, H., & Asher, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0096-9 · Cited by 598 · see citing works

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

Papagiannakopoulos, T., Bauer, M. R., Davidson, S. M., Heimann, M., Subbaraj, L., Bhutkar, A., Bartlebaugh, J., Vander Heiden, M. G., & Jacks, T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.001 · Cited by 557 · see citing works

Genomics of circadian rhythms in health and disease

Rijo‐Ferreira, F., & Takahashi, J. S. (2019) · Genome Medicine · doi:10.1186/s13073-019-0704-0 · Cited by 537 · see citing works

Metabolism and the Circadian Clock Converge

Eckel‐Mahan, K. L., & Sassone‐Corsi, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00016.2012 · Cited by 530 · see citing works

The Effects of Light at Night on Circadian Clocks and Metabolism

Fonken, L. K., & Nelson, R. J. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1051 · Cited by 468 · see citing works

Circadian Disruption Leads to Insulin Resistance and Obesity

Shi, S.-Q., Ansari, T. S., McGuinness, O. P., Wasserman, D. H., & Johnson, C. H. (2013) · Current Biology · doi:10.1016/j.cub.2013.01.048 · Cited by 452 · see citing works

Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides

Adamovich, Y., Rousso-Noori, L., Zwighaft, Z., Neufeld-Cohen, A., Golik, M., Kraut-Cohen, J., Wang, M., Han, X., & Asher, G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.016 · Cited by 410 · see citing works

Adipogenesis at a glance

Lowe, C. E., O’Rahilly, S., & Rochford, J. J. (2011) · Journal of Cell Science · doi:10.1242/jcs.079699 · Cited by 342 · see citing works

Time-restricted eating for the prevention and management of metabolic diseases

Manoogian, E. N. C., Chow, L. S., Taub, P. R., Laferrère, B., & Panda, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab027 · Cited by 344 · see citing works

Circadian control of glucose metabolism

Kalsbeek, A., la Fleur, S., & Fliers, E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.03.002 · Cited by 338 · see citing works

Circadian Clock Control of Liver Metabolic Functions

Reinke, H., & Asher, G. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.11.043 · Cited by 321 · see citing works

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

Eckle, T., Hartmann, K., Bonney, S., Reithel, S., Mittelbronn, M., Walker, L. A., Lowes, B. D., Han, J., Borchers, C. H., Buttrick, P. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2728 · Cited by 314 · see citing works

Health Consequences of Circadian Disruption in Humans and Animal Models

Evans, J. A., & Davidson, A. J. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00010-5 · Cited by 291 · see citing works

Clocks, metabolism, and the epigenome

Feng, D., & Lazar, M. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.026 · Cited by 271 · see citing works

Daily eating patterns and their impact on health and disease

Zarrinpar, A., Chaix, A., & Panda, S. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.11.007 · Cited by 263 · see citing works

Feeding Rhythms and the Circadian Regulation of Metabolism

Pickel, L., & Sung, H. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00039 · Cited by 259 · see citing works

DNA methylation markers in obesity, metabolic syndrome, and weight loss

Samblas, M., Milagro, F. I., & Martínez, J. A. (2019) · Epigenetics · doi:10.1080/15592294.2019.1595297 · Cited by 238 · see citing works

Circadian regulation of lipid mobilization in white adipose tissues

Shostak, A., Meyer-Kovac, J., & Oster, H. (2013) · Diabetes · doi:10.2337/db12-1449 · Cited by 243 · see citing works

The circadian clock and liver function in health and disease

Mukherji, A., Bailey, S. M., Staels, B., & Baumert, T. F. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.020 · Cited by 246 · see citing works

Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals

Kumar Jha, P., Challet, E., & Kalsbeek, A. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.024 · Cited by 235 · see citing works

Mammalian circadian clock and metabolism – the epigenetic link

Bellet, M. M., & Sassone‐Corsi, P. (2010) · Journal of Cell Science · doi:10.1242/jcs.051649 · Cited by 237 · see citing works

Regulation of metabolism: the circadian clock dictates the time

Sahar, S., & Sassone-Corsi, P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.10.005 · Cited by 222 · see citing works

Functional Regulation of PPARs through Post-Translational Modifications

Brunmeir, R., & Xu, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061738 · Cited by 221 · see citing works

Impact of nutrients on circadian rhythmicity

Oosterman, J. E., Kalsbeek, A., la Fleur, S. E., & Belsham, D. D. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00322.2014 · Cited by 221 · see citing works

Nutrients, Clock Genes, and Chrononutrition

Oike, H., Oishi, K., & Kobori, M. (2014) · Current Nutrition Reports · doi:10.1007/s13668-014-0082-6 · Cited by 198 · see citing works

When Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis

Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 198 · see citing works

Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

Weger, B. D., Gobet, C., David, F. P. A., Atger, F., Martín, E., Phillips, N. E., Charpagne, A., Weger, M., Naef, F., & Gachon, F. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015803118 · Cited by 187 · see citing works

Circadian regulation of lipid metabolism

Gooley, J. (2016) · Proceedings of the Nutrition Society · doi:10.1017/s0029665116000288 · Cited by 162 · see citing works

High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in <i>Cry</i> -deficient mice

Barclay, J. L., Shostak, A., Leliavski, A., Tsang, A. H., Jöhren, O., Müller-Fielitz, H., Landgraf, D., Naujokat, N., van der Horst, G. T. J., & Oster, H. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2012 · Cited by 173 · see citing works

Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease

Chao, H., Chao, S.-W., Lin, H., Ku, H., & Cheng, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020298 · Cited by 183 · see citing works

Circadian metabolism in the light of evolution

Gerhart-Hines, Z., & Lazar, M. A. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1007 · Cited by 178 · see citing works

RORγt protein modifications and IL-17-mediated inflammation

Kumar, R., Theiss, A. L., & Venuprasad, K. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.09.005 · Cited by 174 · see citing works

The clock gene, brain and muscle Arnt‐like 1, regulates adipogenesis via Wnt signaling pathway

Guo, B., Chatterjee, S., Li, L., Kim, J. M., Lee, J., Yechoor, V. K., Minze, L. J., Hsueh, W. A., & Ma, K. (2012) · The FASEB Journal · doi:10.1096/fj.12-205781 · Cited by 168 · see citing works

Misalignment with the external light environment drives metabolic and cardiac dysfunction

West, A. C., Smith, L. C., Ray, D. W., Loudon, A. S. I., Brown, T. M., & Bechtold, D. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00462-2 · Cited by 168 · see citing works

Clock Genes and Clock-Controlled Genes in the Regulation of Metabolic Rhythms

Mazzoccoli, G., Pazienza, V., & Vinciguerra, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.658127 · Cited by 171 · see citing works

Interconnections between circadian clocks and metabolism

Guan, D., & Lazar, M. A. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148278 · Cited by 166 · see citing works

Shift Work or Food Intake during the Rest Phase Promotes Metabolic Disruption and Desynchrony of Liver Genes in Male Rats

Salgado‐Delgado, R., Saderi, N., Basualdo, M. D. C., Guerrero‐Vargas, N. N., Escobar, C., & Buijs, R. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060052 · Cited by 159 · see citing works

Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy

Hwang‐Verslues, W. W., Chang, P.-H., Jeng, Y., Kuo, W., Chiang, P.-H., Chang, Y., Hsieh, T.-H., Su, F., Lin, L.-C., Abbondante, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222684110 · Cited by 158 · see citing works

Circadian gene variants in cancer

Kettner, N. M., Katchy, C. A., & Fu, L. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.914808 · Cited by 147 · see citing works

Gut microbiota directs PPARγ‐driven reprogramming of the liver circadian clock by nutritional challenge

Murakami, M., Tognini, P., Liu, Y., Eckel‐Mahan, K. L., Baldi, P., & Sassone‐Corsi, P. (2016) · EMBO Reports · doi:10.15252/embr.201642463 · Cited by 155 · see citing works

The Circadian Clock in White and Brown Adipose Tissue: Mechanistic, Endocrine, and Clinical Aspects

Froy, O., & Garaulet, M. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00193 · Cited by 148 · see citing works

Off the Clock: From Circadian Disruption to Metabolic Disease

Maury, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071597 · Cited by 142 · see citing works

The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

Wu, R., Dang, F., Li, P., Wang, P., Xu, Q., Liu, Z., Li, Y., Wu, Y., Chen, Y., & Liu, Y. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.11.006 · Cited by 136 · see citing works

Diurnal Regulation of Lipid Metabolism and Applications of Circadian Lipidomics

Gooley, J. J., & Chua, E. C.-P. (2014) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2014.04.001 · Cited by 136 · see citing works

Transcriptional control of energy metabolism by nuclear receptors

Scholtes, C., & Giguère, V. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00486-7 · Cited by 134 · see citing works

Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health

Ribas‐Latre, A., & Eckel‐Mahan, K. L. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.12.006 · Cited by 133 · see citing works

Inter‐relationships of the chronobiotic, melatonin, with leptin and adiponectin: implications for obesity

Szewczyk‐Golec, K., Woźniak, A., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12257 · Cited by 153 · see citing works

Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock

Ye, R., Selby, C. P., Öztürk, N., Annayev, Y., & Sancar, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254680 · Cited by 129 · see citing works

Interactive Features of Proteins Composing Eukaryotic Circadian Clocks

Crane, B. R., & Young, M. W. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035644 · Cited by 125 · see citing works

Cycles in spatial and temporal chromosomal organization driven by the circadian clock

Aguilar‐Arnal, L., Hakim, O., Patel, V. R., Baldi, P., Hager, G. L., & Sassone‐Corsi, P. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2667 · Cited by 125 · see citing works

Role of the circadian clock gene Per2 in adaptation to cold temperature

Chappuis, S., Ripperger, J. A., Schnell, A., Rando, G., Jud, C., Wahli, W., & Albrecht, U. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.05.002 · Cited by 125 · see citing works

Metabolic rivalry: circadian homeostasis and tumorigenesis

Kinouchi, K., & Sassone‐Corsi, P. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0291-9 · Cited by 125 · see citing works

Loss of Bmal1 leads to uncoupling and impaired glucose-stimulated insulin secretion in β-cells

Lee, J., Kim, M.-S., Li, R., Liu, V. Y., Fu, L., Moore, D. D., Ma, K., & Yechoor, V. K. (2011) · Islets · doi:10.4161/isl.3.6.18157 · Cited by 124 · see citing works

High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation

Wang, A., Wan, X., Zhuang, P., Wei, J., Yang, A., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221097120 · Cited by 125 · see citing works

The Circadian Clock Maintains Cardiac Function by Regulating Mitochondrial Metabolism in Mice

Kohsaka, A., Das, P., Hashimoto, I., Nakao, T., Deguchi, Y., Gouraud, S. S., Waki, H., Muragaki, Y., & Maeda, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112811 · Cited by 120 · see citing works

The role of the circadian clock in rheumatoid arthritis

Gibbs, J. E., & Ray, D. W. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4146 · Cited by 119 · see citing works

Interactions between metabolism and circadian clocks: reciprocal disturbances

Delezie, J., & Challet, É. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06246.x · Cited by 118 · see citing works

Circadian Metabolism: From Mechanisms to Metabolomics and Medicine

Brown, S. A. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.015 · Cited by 118 · see citing works

Circadian rhythm and disease: Relationship, new insights, and future perspectives

Neves, A. R., Albuquerque, T., Quintela, T., & Costa, D. R. B. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30815 · Cited by 120 · see citing works

Dual inhibition of REV-ERBβ and autophagy as a novel pharmacological approach to induce cytotoxicity in cancer cells

Mei, C. D., Ercolani, L., Parodi, C., Veronesi, M., Vecchio, C. L., Bottegoni, G., Torrente, E., Scarpelli, R., Marotta, R., Ruffili, R., et al. (2014) · Oncogene · doi:10.1038/onc.2014.203 · Cited by 115 · see citing works

Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism

Gnocchi, D., Pedrelli, M., Hurt-Camejo, E., & Parini, P. (2015) · Biology · doi:10.3390/biology4010104 · Cited by 115 · see citing works

Hypothalamic clocks and rhythms in feeding behaviour

Bechtold, D. A., & Loudon, A. S. I. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.007 · Cited by 114 · see citing works

Bile acid metabolism and circadian rhythms

Yang, Y., & Zhang, J. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00152.2020 · Cited by 114 · see citing works

Attenuating myocardial ischemia by targeting A2B adenosine receptors

Eltzschig, H. K., Bonney, S. K., & Eckle, T. D. L. G. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.02.005 · Cited by 113 · see citing works

CRY1/2 Selectively Repress PPARδ and Limit Exercise Capacity

Jordan, S. D., Kriebs, A., Vaughan, M. E., Duglan, D., Fan, W., Henriksson, E., Huber, A., Papp, S. J., Nguyen, M., Afetian, M. E., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.002 · Cited by 112 · see citing works

Nuclear receptors rock around the clock

Zhao, X., Cho, H., Yu, R. T., Atkins, A. R., Downes, M., & Evans, R. M. (2014) · EMBO Reports · doi:10.1002/embr.201338271 · Cited by 108 · see citing works

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro

Loizides‐Mangold, U., Perrin, L., Vandereycken, B., Betts, J. A., Walhin, J., Templeman, I., Chanon, S., Weger, B. D., Durand, C., Robert, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705821114 · Cited by 104 · see citing works

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity

Kriebs, A., Jordan, S. D., Soto, E., Henriksson, E., Sandate, C. R., Vaughan, M. E., Chan, A. B., Duglan, D., Papp, S. J., Huber, A., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704955114 · Cited by 105 · see citing works

Melatonin Orchestrates Lipid Homeostasis through the Hepatointestinal Circadian Clock and Microbiota during Constant Light Exposure

Hong, F., Pan, S., Xu, P., Xue, T., Wang, J., Guo, Y., Li, J., Qiao, X., Li, L., & Zhai, Y. (2020) · Cells · doi:10.3390/cells9020489 · Cited by 105 · see citing works

Bindarit

Mora, E. M., Guglielmotti, A., Biondi, G., & Sassone‐Corsi, P. (2012) · Cell Cycle · doi:10.4161/cc.11.1.18559 · Cited by 102 · see citing works

Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease

Shi, D., Chen, J., Wang, J., Yao, J., Huang, Y., Zhang, G., & Bao, Z. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00423 · Cited by 101 · see citing works

Peripheral Circadian Oscillators

Cuninkova, L., & Brown, S. A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.005 · Cited by 101 · see citing works

EGCG ameliorates diet-induced metabolic syndrome associating with the circadian clock

Mi, Y., Qi, G., Fan, R., Ji, X.-H., Liu, Z., & Liu, X. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.04.009 · Cited by 99 · see citing works

Coupled network of the circadian clocks: a driving force of rhythmic physiology

Finger, A., Dibner, C., & Kramer, A. (2020) · FEBS Letters · doi:10.1002/1873-3468.13898 · Cited by 99 · see citing works

Circadian Regulation of the Hepatic Endobiotic and Xenobitoic Detoxification Pathways: The Time Matters

Zmrzljak, U. P., & Rozman, D. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200538r · Cited by 97 · see citing works

Stem cells and the circadian clock

Weger, M., Diotel, N., Dorsemans, A.-C., Dickmeis, T., & Weger, B. D. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.09.012 · Cited by 97 · see citing works

Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology

Bolshette, N. B., Ibrahim, H., Reinke, H., & Asher, G. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00792-1 · Cited by 99 · see citing works

Circadian Clocks, Food Intake, and Metabolism

Challet, É. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396971-2.00005-1 · Cited by 97 · see citing works

Nuclear receptor signal transduction in C. elegans

Antebi, A. (2015) · WormBook · doi:10.1895/wormbook.1.64.2 · Cited by 92 · see citing works

Long-term environmental exposure to microcystins increases the risk of nonalcoholic fatty liver disease in humans: A combined fisher-based investigation and murine model study

Zhao, Y., Yan, Y., Xie, L., Wang, L., He, Y., Wan, X., & Xue, Q. (2020) · Environment International · doi:10.1016/j.envint.2020.105648 · Cited by 95 · see citing works

The daily rhythm of mice

Ripperger, J. A., Jud, C., & Albrecht, U. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.027 · Cited by 93 · see citing works

Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

Man, A. W. C., Li, H., & Xia, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020676 · Cited by 91 · see citing works

Transcriptional Control of Antioxidant Defense by the Circadian Clock

Patel, S. A., Velingkaar, N., & Kondratov, R. V. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5671 · Cited by 91 · see citing works

The Circadian Clock Regulates Adipogenesis by a Per3 Crosstalk Pathway to Klf15

Aggarwal, A., Costa, M. J. D. C., Rivero‐Gutiérrez, B., Ji, L., Morgan, S. L., & Feldman, B. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.004 · Cited by 89 · see citing works

Circadian regulation of mitochondrial uncoupling and lifespan

Ulgherait, M., Chen, A., McAllister, S. F., Kim, H. X., Delventhal, R., Wayne, C. R., Garcia, C., Recinos, Y., Oliva, M. K., Canman, J. C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15617-x · Cited by 89 · see citing works

Regulation of Fatty Acid Metabolism by Cell Autonomous Circadian Clocks: Time to Fatten up on Information?

Bray, M. S., & Young, M. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.214643 · Cited by 82 · see citing works

Circadian Rhythm Gene Period 3 Is an Inhibitor of the Adipocyte Cell Fate

Costa, M. J. D. C., So, A. Y., Kaasik, K., Krueger, K. C., Pillsbury, M. L., Fu, Y., Ptáček, L. J., Yamamoto, K. R., & Feldman, B. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.164558 · Cited by 83 · see citing works

Coupling the Circadian Clock to Homeostasis: The Role of Period in Timing Physiology

Kim, P., Oster, H., Lehnert, H., Schmid, S. M., Salamat, N., Barclay, J. L., Maronde, E., Inder, W. J., & Rawashdeh, O. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00049 · Cited by 83 · see citing works

Circadian clock and the onset of cardiovascular events

Takeda, N., & Maemura, K. (2016) · Hypertension Research · doi:10.1038/hr.2016.9 · Cited by 80 · see citing works

A role for circadian clock in metabolic disease

Shimizu, I., Yoshida, Y., & Minamino, T. (2016) · Hypertension Research · doi:10.1038/hr.2016.12 · Cited by 79 · see citing works

Potential Roles of Dec and Bmal1 Genes in Interconnecting Circadian Clock and Energy Metabolism

Sato, F., Kohsaka, A., BHAWAL, U. K., & Muragaki, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030781 · Cited by 78 · see citing works

The PPAR–microbiota–metabolic organ trilogy to fine‐tune physiology

Oh, H. Y. P., Visvalingam, V., & Wahli, W. (2019) · The FASEB Journal · doi:10.1096/fj.201802681rr · Cited by 78 · see citing works

The emerging roles of lipids in circadian control

Adamovich, Y., Aviram, R., & Asher, G. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.11.013 · Cited by 78 · see citing works

PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and GL expression

Zani, F., Breasson, L., Becattini, B., Vukolic, A., Montani, J.-P., Albrecht, U., Provenzani, A., Ripperger, J. A., & Solinas, G. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.06.006 · Cited by 75 · see citing works

Circadian Clocks and Metabolism: Implications for Microbiome and Aging

Paschos, G. K., & FitzGerald, G. A. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.07.010 · Cited by 77 · see citing works

Circadian regulator PER2 plays a critical role in regulating fat metabolism and the development of fatty liver disease

Pope, B. A., Menio, J., Deng, J. M., & Wheeler, M. D. (2010) · The FASEB Journal · doi:10.1096/fasebj.24.1_supplement.926.4

DEC1 regulates the rhythmic expression of PPARγ target genes involved in lipid metabolism in white adipose tissue

Noshiro, M., Kawamoto, T., Nakashima, A., Ozaki, N., Saeki, M., Honda, K. K., Fujimoto, K., & Kato, Y. (2020) · Genes to Cells · doi:10.1111/gtc.12752 · Cited by 20 · see citing works

Bioinformatics Analysis on Regulatory Mechanism of Peroxisome Proliferator-activated Receptor-γ Gene on Lipid Metabolism

Hu, G., Wang, S., & Li, H. (2011) · Journal of Northeast Agricultural University (English edition) · doi:10.1016/s1006-8104(13)60082-3

Circadian Gene PER2 Silencing Downregulates PPARG and SREBF1 and Suppresses Lipid Synthesis in Bovine Mammary Epithelial Cells

Jing, Y., Chen, Y., Wang, S., Ouyang, J., Hu, L., Yang, Q., Wang, M., Zhang, B., & Loor, J. J. (2021) · Biology · doi:10.3390/biology10121226 · Cited by 13 · see citing works

Analysis of influence of peroxisome proliferator-activated receptor-γ gene on lipid metabolism by using bioinformatics tools

Li, H. (2009) · Dongbei Nongye Daxue xuebao