New insights into osteoclastogenic signaling mechanisms

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Mochizuki, S.-I., Tomoyasu, A., Yano, K., Goto, M., Murakami, A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3597 · Cited by 4,228

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701

Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.

Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., & Martin, T. J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0367 · Cited by 2,336

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290

The amazing osteocyte

Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287

Bone Quality — The Material and Structural Basis of Bone Strength and Fragility

Seeman, E., & Delmas, P. D. (2006) · New England Journal of Medicine · doi:10.1056/nejmra053077 · Cited by 2,080

Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems

Takayanagi, H. (2007) · Nature Reviews Immunology · doi:10.1038/nri2062 · Cited by 1,878

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.

Kong, Y.-Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., et al. (1999) · Nature · doi:10.1038/46303 · Cited by 1,856

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

Nakashima, T., Hayashi, M., Fukunaga, T., Kurata, K., Oh-hora, M., Feng, J. Q., Bonewald, L. F., Kodama, T., Wutz, A., Wagner, E. F., et al. (2011) · Nature Medicine · doi:10.1038/nm.2452 · Cited by 1,778

RANK is essential for osteoclast and lymph node development.

Dougall, W. C., Glaccum, M., Charrier, K., Rohrbach, K., Brasel, K., De Smedt, T., Daro, E., Smith, J., Tometsko, M. E., Maliszewski, C. R., et al. (1999) · Genes & Development · doi:10.1101/gad.13.18.2412 · Cited by 1,478

NFAT Signaling

Crabtree, G. R., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00699-2 · Cited by 1,323

Matrix-embedded cells control osteoclast formation

Xiong, J., Onal, M., Jilka, R. L., Weinstein, R. S., Manolagas, S. C., & O'Brien, C. A. (2011) · Nature Medicine · doi:10.1038/nm.2448 · Cited by 1,304

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

Lomaga, M. A., Yeh, W.-C., Sarosi, I., Duncan, G. S., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., et al. (1999) · Genes & Development · doi:10.1101/gad.13.8.1015 · Cited by 1,267

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis, and regulation of bone mass and calcium metabolism.

Li, J., Sarosi, I., Yan, X.-Q., Morony, S., Capparelli, C., Tan, H.-L., McCabe, S., Elliott, R., Scully, S., Van, G., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1566 · Cited by 1,119

TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells

Wong, B. R., Rho, J., Arron, J., Robinson, E., Orlinick, J., Chao, M., Kalachikov, S., Cayani, E., Bartlett, F. S., Frankel, W. N., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25190 · Cited by 1,042

Requirement for NF-κB in osteoclast and B-cell development

Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., & Siebenlist, U. (1997) · Genes & Development · doi:10.1101/gad.11.24.3482 · Cited by 996

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

Iotsova, V., Caamaño, J., Loy, J., Yang, Y., Lewin, A., & Bravo, R. (1997) · Nature Medicine · doi:10.1038/nm1197-1285 · Cited by 990

Role of osteoblasts in hormonal control of bone resorption—A hypothesis

Rodan, G. A., & Martin, T. J. (1981) · Calcified Tissue International · doi:10.1007/bf02409454 · Cited by 982

OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J. M., Martin, T. J., & Suda, T. (1988) · Endocrinology · doi:10.1210/endo-123-5-2600 · Cited by 933

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis

Asagiri, M., Sato, K., Usami, T., Ochi, S., Nishina, H., Yoshida, H., Morita, I., Wagner, E. F., Mak, T. W., Serfling, E., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051150 · Cited by 849

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., et al. (2004) · Nature · doi:10.1038/nature02444 · Cited by 828

RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution

Theill, L. E., Boyle, W. J., & Penninger, J. M. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064753 · Cited by 819

TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis.

Pettit, A. R., Ji, H., von Stechow, D., Müller, R., Goldring, S. R., Choi, Y., Benoist, C., & Gravallese, E. M. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63016-7 · Cited by 807

Buried alive: How osteoblasts become osteocytes

Franz‐Odendaal, T. A., Hall, B. K., & Witten, P. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20603 · Cited by 795

Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis.

Tsuda, E., Goto, M., Mochizuki, S.-I., Yano, K., Kobayashi, F., Morinaga, T., & Higashio, K. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6603 · Cited by 787

Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin.

Mizuno, A., Amizuka, N., Irie, K., Murakami, A., Fujise, N., Kanno, T., Sato, Y., Nakagawa, N., Yasuda, H., Mochizuki, S.-I., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8697 · Cited by 775

The osteoclast differentiation factor osteoprotegerin ligand is essential for mammary gland development.

Fata, J. E., Kong, Y.-Y., Li, J., Sasaki, T., Irie-Sasaki, J., Moorehead, R. A., Elliott, R., Scully, S., Voura, E. B., Lacey, D. L., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00103-3 · Cited by 756

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

Naito, A., Azuma, S., Tanaka, S., Miyazaki, T., Takaki, S., Takatsu, K., Nakao, K., Nakamura, K., Katsuki, M., Yamamoto, T., et al. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00265.x · Cited by 635

RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis

Gonzalez-Suarez, E., Jacob, A. P., Jones, J., Miller, R., Roudier-Meyer, M. P., Erwert, R., Pinkas, J., Branstetter, D., & Dougall, W. C. (2010) · Nature · doi:10.1038/nature09495 · Cited by 596

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

Schramek, D., Leibbrandt, A., Sigl, V., Kenner, L., Pospisilik, J. A., Lee, H. J., Hanada, R., Joshi, P. A., Aliprantis, A., Glimcher, L., et al. (2010) · Nature · doi:10.1038/nature09387 · Cited by 592

Osteocyte Wnt/β-Catenin Signaling Is Required for Normal Bone Homeostasis

Kramer, I., Halleux, C., Keller, H., Pegurri, M., Gooi, J. H., Weber, P. B., Feng, J. Q., Bonewald, L. F., & Kneissel, M. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01428-09 · Cited by 567

Osteoimmunology: Interactions of the Bone and Immune System

Lorenzo, J., Horowitz, M., & Choi, Y. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0038 · Cited by 563

Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis.

Min, H., Morony, S., Sarosi, I., Dunstan, C. R., Capparelli, C., Scully, S., Van, G., Kaufman, S., Kostenuik, P. J., Lacey, D. L., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.463 · Cited by 550

Fos/AP‐1 proteins in bone and the immune system

Wagner, E. F., & Eferl, R. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00332.x · Cited by 537

Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis.

Gravallese, E. M., Harada, Y., Wang, J. T., Gorn, A. H., Thornhill, T. S., & Goldring, S. R. (1998) · Europe PMC (PubMed Central) · Cited by 516

Protein Expression and Functional Difference of Membrane-Bound and Soluble Receptor Activator of NF-κB Ligand: Modulation of the Expression by Osteotropic Factors and Cytokines

Nakashima, T., Kobayashi, Y., Yamasaki, S., Kawakami, A., Eguchi, K., Sasaki, H., & Sakai, H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3379 · Cited by 509

The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

Akiyama, T., Shimo, Y., Yanai, H., Qin, J., Ohshima, D., Maruyama, Y., Asaumi, Y., Kitazawa, J., Takayanagi, H., Penninger, J. M., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.015 · Cited by 503

RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

Rossi, S. W., Kim, M.-Y., Leibbrandt, A., Parnell, S. M., Jenkinson, W. E., Glanville, S. H., McConnell, F. M., Scott, H. S., Penninger, J. M., Jenkinson, E. J., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062497 · Cited by 487

Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis

Hughes, A. E., Ralston, S. H., Marken, J., Bell, C., MacPherson, H., Wallace, R. G. H., van Hul, W., Whyte, M. P., Nakatsuka, K., Hovy, L., et al. (2000) · Nature Genetics · doi:10.1038/71667 · Cited by 481

Osteoprotegerin Deficiency and Juvenile Paget's Disease

Whyte, M. P., Obrecht, S. E., Finnegan, P. M., Jones, J. L., Podgornik, M. N., McAlister, W. H., & Mumm, S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013096 · Cited by 445

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

Hikosaka, Y., Nitta, T., Ohigashi, I., Yano, K., Ishimaru, N., Hayashi, Y., Matsumoto, M., Matsuo, K., Penninger, J. M., Takayanagi, H., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.06.018 · Cited by 433

Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells

Loser, K., Mehling, A., Loeser, S., Apelt, J., Kuhn, A., Grabbe, S., Schwarz, T., Penninger, J. M., & Beissert, S. (2006) · Nature Medicine · doi:10.1038/nm1518 · Cited by 402

Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

O'Brien, C. A., Plotkin, L. I., Galli, C., Goellner, J. J., Gortazar, A. R., Allen, M. R., Robling, A. G., Bouxsein, M., Schipani, E., Turner, C. H., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002942 · Cited by 390

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL

Sobacchi, C., Frattini, A., Guerrini, M. M., Abinun, M., Pangrazio, A., Susani, L., Bredius, R., Mancini, G., Cant, A., Bishop, N., et al. (2007) · Nature Genetics · doi:10.1038/ng2076 · Cited by 389

NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

Aliprantis, A. O., Ueki, Y., Sulyanto, R., Park, A., Sigrist, K. S., Sharma, S. M., Ostrowski, M. C., Olsen, B. R., & Glimcher, L. H. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35711 · Cited by 350

Regulation of osteoclast differentiation and function by the CaMK-CREB pathway

Sato, K., Suematsu, A., Nakashima, T., Takemoto-Kimura, S., Aoki, K., Morishita, Y., Asahara, H., Ohya, K., Yamaguchi, A., Takai, T., et al. (2006) · Nature Medicine · doi:10.1038/nm1515 · Cited by 346

Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals

Shinohara, M., Koga, T., Okamoto, K., Sakaguchi, S., Arai, K., Yasuda, H., Takai, T., Kodama, T., Morio, T., Geha, R. S., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.037 · Cited by 321

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

Guerrini, M. M., Sobacchi, C., Cassani, B., Abinun, M., Kilic, S. S., Pangrazio, A., Moratto, D., Mazzolari, E., Clayton-Smith, J., Orchard, P., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.06.015 · Cited by 309

Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

Kim, N., Odgren, P. R., Kim, D.-K., Marks, S. C., & Choi, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200294797 · Cited by 299

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

Zhao, B., Takami, M., Yamada, A., Wang, X., Koga, T., Hu, X., Tamura, T., Ozato, K., Choi, Y., Ivashkiv, L. B., et al. (2009) · Nature Medicine · doi:10.1038/nm.2007 · Cited by 292

Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint

Bromley, M., & Woolley, D. E. (1984) · Arthritis & Rheumatism · doi:10.1002/art.1780270902 · Cited by 277

Identification of differentially expressed genes between osteoblasts and osteocytes

Paic, F., Igwe, J. C., Nori, R., Kronenberg, M. S., Franceschetti, T., Harrington, P., Kuo, L., Shin, D.-G., Rowe, D. W., Harris, S. E., et al. (2009) · Bone · doi:10.1016/j.bone.2009.06.010 · Cited by 263

MafB negatively regulates RANKL-mediated osteoclast differentiation

Kim, K., Kim, J. H., Lee, J., Jin, H. M., Kook, H., Kim, K. K., Lee, S. Y., & Kim, N. (2007) · Blood · doi:10.1182/blood-2006-09-048249 · Cited by 238

Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-κB ligand.

Hikita, A., Yana, I., Wakeyama, H., Nakamura, M., Kadono, Y., Oshima, Y., Nakamura, K., Seiki, M., & Tanaka, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606656200 · Cited by 236

Dissociation between bone resorption and bone formation in osteopenic transgenic mice

Corral, D. A., Amling, M., Priemel, M., Loyer, E., Fuchs, S., Ducy, P., Baron, R., & Karsenty, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13835 · Cited by 229

A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype

Cundy, T. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.18.2119 · Cited by 228

RANK Signaling Is Not Required for TNFα-Mediated Increase in CD11bhi Osteoclast Precursors but Is Essential for Mature Osteoclast Formation in TNFα-Mediated Inflammatory Arthritis

Li, P., Schwarz, E. M., O'Keefe, R. J., Ma, L., Boyce, B. F., & Xing, L. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301233 · Cited by 220

Osteoimmunology: Crosstalk Between the Immune and Bone Systems

Nakashima, T., & Takayanagi, H. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9316-6 · Cited by 216

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

Barrow, A. D., Raynal, N., Andersen, T. L., Slatter, D. A., Bihan, D., Pugh, N., Cella, M., Kim, T., Rho, J., Negishi-Koga, T., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45913 · Cited by 207

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis

Miyauchi, Y., Ninomiya, K., Miyamoto, H., Sakamoto, A., Iwasaki, R., Hoshi, H., Miyamoto, K., Hao, W., Yoshida, S., Morioka, H., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20091957 · Cited by 199

A New Mechanism of Bone Destruction in Rheumatoid Arthritis: Synovial Fibroblasts Induce Osteoclastogenesis

Takayanagi, H., Oda, H., Yamamoto, S., Kawaguchi, H., Tanaka, S., Nishikawa, T., & Koshihara, Y. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7404 · Cited by 187

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis

Wada, T., Nakashima, T., Oliveira-dos-Santos, A. J., Gasser, J., Hara, H., Schett, G., & Penninger, J. M. (2005) · Nature Medicine · doi:10.1038/nm1203 · Cited by 182

Expansile Skeletal Hyperphosphatasia Is Caused by a 15-Base Pair Tandem Duplication in TNFRSF11A Encoding RANK and Is Allelic to Familial Expansile Osteolysis

Whyte, M. P., & Hughes, A. E. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.26 · Cited by 180

Blimp1-mediated repression of negative regulators is required for osteoclast differentiation

Nishikawa, K., Nakashima, T., Hayashi, M., Fukunaga, T., Kato, S., Kodama, T., Takahashi, S., Calame, K., & Takayanagi, H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912779107 · Cited by 170

Osteoclast formation from mononuclear phagocytes: role of bone-forming cells.

Burger, E. H., van der Meer, J. W., & Nijweide, P. J. (1984) · The Journal of cell biology · doi:10.1083/jcb.99.6.1901 · Cited by 162

Transgenic mice overexpressing soluble osteoclast differentiation factor (sODF) exhibit severe osteoporosis

Mizuno, A., Kanno, T., HOSHI, M., Shibata, O., Yano, K., Fujise, N., Kinosaki, M., Yamaguchi, K., Tsuda, E., Murakami, A., et al. (2002) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740200049 · Cited by 148

DAP12 Couples c-Fms Activation to the Osteoclast Cytoskeleton by Recruitment of Syk

Zou, W., Reeve, J., Liu, Y., Teitelbaum, S. L., & Ross, F. P. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.023 · Cited by 135

Idiopathic Hyperphosphatasia and TNFRSF11B Mutations: Relationships Between Phenotype and Genotype

Chong, B., Hegde, M., Fawkner, M., Simonet, W. S., Cassinelli, H., Çöker, M., Kanis, J. А., Seidel, J., Tau, C., Tüysüz, B., et al. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.12.2095 · Cited by 126

An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor κB ligand

Miyamoto, T. K., Arai, F., Ohneda, O., Takagi, K., Anderson, D. M., & Suda, T. (2000) · Blood · doi:10.1182/blood.v96.13.4335 · Cited by 110

FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner

Bai, S., Kitaura, H., Zhao, H., Chen, J., Müller, J. M., Schüle, R., Darnay, B., Novack, D. V., Ross, F. P., & Teitelbaum, S. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24921 · Cited by 92

Isolated primary osteocytes express functional gap junctions in vitro

Gu, G., Nars, M., Hentunen, T. A., Metsikkö, K., & Väänänen, H. K. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-0066-3 · Cited by 91

Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin

Kanzaki, S., Ito, M., Takada, Y., Ogawa, K., & Matsuo, K. (2006) · Bone · doi:10.1016/j.bone.2006.01.155 · Cited by 69

Familial expansile osteolysis in a large Spanish kindred resulting from an insertion mutation in the TNFRSF11A gene

Palenzuela, L., Vives-Bauzá, C., Fernández‐Cadenas, I., Meseguer, A., Font, N., Sarret, E., Schwartz, S., & Andreu, A. L. (2002) · Journal of Medical Genetics · doi:10.1136/jmg.39.10.e67 · Cited by 53

Bone resorption by isolated osteoclasts in living versus devitalized bone: Differences in mode and extent and the effects of human recombinant tissue inhibitor of metalloproteinases

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Commitment to the Osteoblast Lineage Is Not Required for RANKL Gene Expression

Galli, C., Fu, Q., Wang, W., Olsen, B. R., Manolagas, S. C., Jilka, R. L., & O’Brien, C. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m806628200 · Cited by 51

Effects of osteocytes on osteoinduction in the autogenous rib graft in the rat mandible

KAMIJOU, T., Nakajima, T., & Ozawa, H. (1994) · Bone · doi:10.1016/8756-3282(94)90311-5 · Cited by 42

A nonsynonymous TNFRSF11A variation increases NFκB activity and the severity of Paget's disease

Gianfrancesco, F., Rendina, D., Stefano, M. D., Mingione, A., Esposito, T., Merlotti, D., Gallone, S., Magliocca, S., Goode, A., Formicola, D., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.542 · Cited by 33

Rheumatoid arthritis associated with osteopetrosis

Kadono, Y., Tanaka, S., Nishino, J., Nishimura, K., Nakamura, I., Miyazaki, T., Takayanagi, H., & Nakamura, K. (2009) · Modern Rheumatology · doi:10.1007/s10165-009-0208-7 · Cited by 22

The effects of interferon-beta treatment of synovial inflammation and expression of metalloproteinases in patients with rheumatoid arthritis

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RANKL biology: bone metabolism, the immune system, and beyond

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