Vasopressin regulates daily rhythms and circadian clock circuits in a manner influenced by sex
Open accessAbstract
Arginine vasopressin (AVP) is a neurohormone that alters cellular physiology through both endocrine and synaptic signaling. Circadian rhythms in AVP release and other biological processes are driven by the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. Loss of vasopressin signaling alters circadian behavior, but the basis of these effects remains unclear. Here we investigate the role of AVP signaling in circadian timekeeping by analyzing behavior and SCN function in a novel AVP-deficient mouse model. Consistent with previous work, loss of AVP signaling increases water consumption and accelerates recovery to simulated jetlag. We expand on these results to show that loss of AVP increases period, imprecision and plasticity of behavioral rhythms under constant darkness. Interestingly, the effect of AVP deficiency on circadian period was influenced by sex, with loss of AVP lengthening period in females but not males. Examining SCN function directly with ex vivo bioluminescence imaging of clock protein expression, we demonstrate that loss of AVP signaling modulates the period, precision, and phase relationships of SCN neurons in both sexes. This pattern of results suggests that there are likely sex differences in downstream targets of the SCN. Collectively, this work indicates that AVP signaling modulates circadian circuits in a manner influenced by sex, which provides new insight into sexual dimorphisms in the regulation of daily rhythms.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Vasopressin is also produced in the suprachiasmatic nucleus, which regulates circadian rhythms, and in the accessory nuclei/nucleus circularis region, a likely source of vasopressin regulating aggression and competitive communication.
“AVP is also produced in other hypothalamic nuclei such as the suprachiasmatic nucleus, well known for regulating circadian rhythms (42), and the accessory nuclei/nucleus circularis region, a likely source of AVP regulating aggression and competitive communication (43).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329 · see citing works
A circadian gene expression atlas in mammals: Implications for biology and medicine
Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304 · see citing works
Sex bias in neuroscience and biomedical research
Beery, A. K., & Zucker, I. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.07.002 · Cited by 1,763 · see citing works
Welsh, D. K., Logothetis, D., Meister, M., & Reppert, S. (1995) · Neuron · doi:10.1016/0896-6273(95)90214-7 · Cited by 1,535 · see citing works
Molecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449 · see citing works
Generation of circadian rhythms in the suprachiasmatic nucleus
Hastings, M. H., Maywood, E. S., & Brancaccio, M. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0026-z · Cited by 1,065 · see citing works
Synchronization of Cellular Clocks in the Suprachiasmatic Nucleus
Yamaguchi, S., Isejima, H., Matsuo, T., Okura, R., Yagita, K., Kobayashi, M., & Okamura, H. (2003) · Science · doi:10.1126/science.1089287 · Cited by 934 · see citing works
Female mice liberated for inclusion in neuroscience and biomedical research
Prendergast, B. J., Onishi, K. G., & Zucker, I. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.001 · Cited by 788 · see citing works
Abrahamson, E. E., & Moore, R. Y. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02890-6 · Cited by 788 · see citing works
Molecular components of the mammalian circadian clock
Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738 · see citing works
Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation
Harris, J. A., Hirokawa, K. E., Sorensen, S. A., Gu, H., Mills, M., Ng, L. L., Bohn, P., Mortrud, M., Ouellette, B., Kidney, J., et al. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00076 · Cited by 485 · see citing works
Dendritic Release of Vasopressin and Oxytocin
Ludwig (1998) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1998.00279.x · Cited by 342 · see citing works
Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag
Yamaguchi, Y., Suzuki, T., Mizoro, Y., Kori, H., Okada, K., Chen, Y., Fustin, J., Yamazaki, F., Mizuguchi, N., Zhang, J., et al. (2013) · Science · doi:10.1126/science.1238599 · Cited by 334 · see citing works
Maywood, E. S., Chesham, J. E., O’Brien, J., & Hastings, M. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101767108 · Cited by 284 · see citing works
Temporal Precision in the Mammalian Circadian System: A Reliable Clock from Less Reliable Neurons
Herzog, E. D., Aton, S. J., Numano, R., Sakaki, Y., & Tei, H. (2004) · Journal of Biological Rhythms · doi:10.1177/0748730403260776 · Cited by 281 · see citing works
Mieda, M., Ono, D., Hasegawa, E., Okamoto, H., Honma, K., Honma, S., & Sakurai, T. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.005 · Cited by 254 · see citing works
Intrinsic, nondeterministic circadian rhythm generation in identified mammalian neurons
Webb, A. B., Angelo, N., Huettner, J. E., & Herzog, E. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902768106 · Cited by 236 · see citing works
Dynamic Interactions Mediated by Nonredundant Signaling Mechanisms Couple Circadian Clock Neurons
Evans, J. A., Leise, T., Castañón‐Cervantes, O., & Davidson, A. J. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.022 · Cited by 199 · see citing works
Self-citationSchwartz, W., & Reppert, S. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-10-02771.1985 · Cited by 195 · see citing works
Vasopressin and the Output of the Hypothalamic Biological Clock
Kalsbeek, A., Fliers, E., Hofman, M. A., Swaab, D. F., & Buijs, R. M. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.01956.x · Cited by 192 · see citing works
Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system
Davidson, A. J., Castanon‐Cervantes, O., Leise, T. L., Molyneux, P. C., & Harrington, M. E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06534.x · Cited by 171 · see citing works
Vida, B., Deli, L., Hrabovszky, E., Kalamatianos, T., Caraty, A., Coen, C. W., Liposits, Z., & Kalló, I. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02045.x · Cited by 156 · see citing works
Gonadal- and Sex-Chromosome-Dependent Sex Differences in the Circadian System
Kuljis, D. A., Loh, D. H., Truong, D. A., Vosko, A. M., Ong, M. L., McClusky, R., Arnold, A. P., & Colwell, C. S. (2013) · Endocrinology · doi:10.1210/en.2012-1921 · Cited by 151 · see citing works
Low-Zeddies, S. S., & Takahashi, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00294-x · Cited by 147 · see citing works
Li, J., Burton, K. J., Zhang, C., Hu, S.-B., & Zhou, Q. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90463.2008 · Cited by 135 · see citing works
Iwahana, E., Karatsoreos, I., Shibata, S., & Silver, R. (2008) · Hormones and Behavior · doi:10.1016/j.yhbeh.2007.11.014 · Cited by 127 · see citing works
Rood, B. D., Stott, R. T., You, S., Smith, C. J. W., Woodbury, M. E., & De Vries, G. J. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23288 · Cited by 120 · see citing works
Daily and seasonal adaptation of the circadian clock requires plasticity of the SCN neuronal network
Meijer, J. H., Michel, S., VanderLeest, H. T., & Rohling, J. H. T. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07522.x · Cited by 119 · see citing works
Intrinsic Regulation of Spatiotemporal Organization within the Suprachiasmatic Nucleus
Evans, J. A., Leise, T., Castañón‐Cervantes, O., & Davidson, A. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015869 · Cited by 111 · see citing works
Self-citationCircadian rhythms in vasopressin deficient rats
Groblewski, T. A., Núñez, A. A., & Gold, R. M. (1981) · Brain Research Bulletin · doi:10.1016/s0361-9230(81)80036-6 · Cited by 105 · see citing works
Androgens modulate structure and function of the suprachiasmatic nucleus brain clock
Karatsoreos, I. N., Butler, M. P., LeSauter, J., & Silver, R. (2011) · Endocrinology · doi:10.1210/en.2010-1398 · Cited by 97 · see citing works
Sex Differences in Behavioral Circadian Rhythms in Laboratory Rodents
Krizo, J. A., & Mintz, E. M. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00234 · Cited by 82 · see citing works
Bult, A., Hiestand, L., van der Zee, E. A., et al. (1993) · Brain Research Bulletin · doi:10.1016/0361-9230(93)90164-7 · Cited by 78 · see citing works
Collective timekeeping among cells of the master circadian clock
Evans, J. A. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0054 · Cited by 77 · see citing works
Self-citationMieda, M., Okamoto, H., & Sakurai, T. (2016) · Current Biology · doi:10.1016/j.cub.2016.07.022 · Cited by 75 · see citing works
Ono, D., Honma, S., & Honma, K. (2016) · Science Advances · doi:10.1126/sciadv.1600960 · Cited by 73 · see citing works
Edwards, M. D., Brancaccio, M., Chesham, J. E., Maywood, E. S., & Hastings, M. H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1519044113 · Cited by 68 · see citing works
Smyllie, N. J., Chesham, J. E., Hamnett, R., Maywood, E. S., & Hastings, M. H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511351113 · Cited by 67 · see citing works
Rigney, N., Whylings, J., Mieda, M., de Vries, G. J., & Petrulis, A. (2019) · eNeuro · doi:10.1523/eneuro.0415-18.2019 · Cited by 63 · see citing works
Krajnak, K., Kashon, M. L., Rosewell, K. L., & Wise, P. M. (1998) · Endocrinology · doi:10.1210/endo.139.10.6259 · Cited by 62 · see citing works
ESR1 and ESR2 Differentially Regulate Daily and Circadian Activity Rhythms in Female Mice
Royston, S. E., Yasui, N., Kondilis, A., Lord, S., Katzenellenbogen, J. A., & Mahoney, M. M. (2014) · Endocrinology · doi:10.1210/en.2014-1101 · Cited by 55 · see citing works
Ingram, C. D., Snowball, R. K., & Mihai, R. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00274-6 · Cited by 52 · see citing works
In synch but not in step: Circadian clock circuits regulating plasticity in daily rhythms
Evans, J. A., & Gorman, M. R. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.072 · Cited by 49 · see citing works
Self-citationRigney, N., Beaumont, R., & Petrulis, A. (2020) · Hormones and Behavior · doi:10.1016/j.yhbeh.2020.104715 · Cited by 47 · see citing works
Rigney, N., Whylings, J., de Vries, G. J., & Petrulis, A. (2021) · Neuroendocrinology · doi:10.1159/000509421 · Cited by 42 · see citing works
Mahoney, M. M., Ramanathan, C., Hagenauer, M. H., Thompson, R. C., Smale, L., & Lee, T. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06936.x · Cited by 41 · see citing works
Sexual Dimorphism in Circadian Physiology Is Altered in LXRα Deficient Mice
Feillet, C. A., Guérin, S., Lonchampt, M., Dacquet, C., Gustafsson, J.-Α., Delaunay, F., & Teboul, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150665 · Cited by 39 · see citing works
Amin, S. R., Gruszczynski, C., Guiard, B. P., Callebert, J., Launay, J., Louis, F., Betancur, C., Vialou, V., & Gautron, S. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14684 · Cited by 38 · see citing works
Whylings, J., Rigney, N., Peters, N. V., de Vries, G. J., & Petrulis, A. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.09.015 · Cited by 37 · see citing works
Brockman, R., Bunick, D., & Mahoney, M. M. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.07.011 · Cited by 34 · see citing works
Photic Phase-Response Curve in 2 Strains of Mice with Impaired Responsiveness to Estrogens
Blattner, M. S., & Mahoney, M. M. (2013) · Journal of Biological Rhythms · doi:10.1177/0748730413497190 · Cited by 33 · see citing works
Different Roles for VIP Neurons in the Neonatal and Adult Suprachiasmatic Nucleus
Mazuski, C. N., Chen, S. P., & Herzog, E. D. (2020) · Journal of Biological Rhythms · doi:10.1177/0748730420932073 · Cited by 33 · see citing works
Cheng, A. H., Fung, S. W., & Cheng, H. M. (2019) · Journal of Biological Rhythms · doi:10.1177/0748730419871184 · Cited by 29 · see citing works
Asymmetric vasopressin signaling spatially organizes the master circadian clock
Bedont, J. L., Rohr, K. E., Bathini, A., Hattar, S. S., Blackshaw, S., Sehgal, A., & Evans, J. A. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24478 · Cited by 28 · see citing works
Self-citationBlattner, M. S., & Mahoney, M. M. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00831.x · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities
Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191 · see citing works
Arakawa, H., & Higuchi, Y. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104597 · Cited by 8 · see citing works
- Authors
- Rohr, K. E., Telega, A., Savaglio, A., & Evans, J. A.
- Affiliations
- Marquette University (US)
- Corresponding author
- Evans, Jennifer A.
- ORCID
- Evans, Jennifer A.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 127
- Pages
- 104888
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC7855892
- OpenAlex
- W3102134631
- Cited by
- 35
- References
- 55
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 4
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- e-Publications@Marquette (Marquette University) (submittedVersion)
- Funders
- Whitehall Foundation
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- vasopressin, circadian clock, suprachiasmatic nucleus, sex differences, circadian period, water consumption, circadian phase, daily rhythms
- MeSH terms
- Animals, Arginine Vasopressin, Circadian Rhythm, Female, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Sex Characteristics, Suprachiasmatic Nucleus, Signal Transduction, Mice, CLOCK Proteins, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
