Sexually dimorphic role of BNST vasopressin cells in sickness and social behavior in male and female mice
Open accessAbstract
Circumstantial evidence supports the hypothesis that the sexually dimorphic vasopressin (AVP) innervation of the brain tempers sickness behavior in males. Here we test this hypothesis directly, by comparing sickness behavior in animals with or without ablations of BNST AVP cells, a major source of sexually dimorphic AVP in the brain. We treated male and female AVP-iCre+ and AVP-iCre- mice that had been injected with viral Cre-dependent caspase-3 executioner construct into the BNST with lipopolysaccharide (LPS) or sterile saline, followed by behavioral analysis. In all groups, LPS treatment reliably reduced motor behavior, increased anxiety-related behavior, and reduced sucrose preference and consumption. Male mice, whose BNST AVP cells had been ablated (AVP-iCre+), displayed only minor reductions in LPS-induced sickness behavior, whereas their female counterparts displayed, if anything, an increase in sickness behaviors. All saline-treated mice with BNST AVP cell ablations consumed more sucrose than did control mice, and males, but not females, with BNST AVP cell ablations showed reduced preference for novel conspecifics compared to control mice. These data confirm that BNST AVP cells control social behavior in a sexually dimorphic way, but do not play a critical role in altering sickness behavior.
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Bed nucleus of the stria terminalis vasopressin cell ablation impairs social recognition in males, likely through its projection to the lateral septum, and restoration of BNST-LS vasopressin signaling in Magel2-KO mice ameliorated social discrimination deficits.
“For example, BNST AVP cell ablation impairs social recognition in males, likely through its projection to the LS (94, 108, 109), and restoration of BNST-LS AVP signaling in Magel2-KO mice ameliorated social discrimination deficits (110).”
From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [108]
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- Authors
- Whylings, J., Rigney, N., Peters, N. V., de Vries, G. J., & Petrulis, A.
- Affiliations
- Georgia State University (US)
- Corresponding author
- Whylings, Jack
- Venue
- Brain Behavior and Immunity
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 83
- Pages
- 68-77
- ISSN
- 0889-1591 (ISSN-L)
- PMC
- PMC6906230
- OpenAlex
- W2974846915
- Cited by
- 37
- References
- 55
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 10 · 2022: 5 · 2021: 7 · 2020: 7
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Brain Behavior and Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- vasopressin, bed nucleus of the stria terminalis, sickness behavior, lipopolysaccharide, anxiety-like behavior, sucrose preference, social behavior, neuronal ablation
- MeSH terms
- Animals, Arginine Vasopressin, Brain, Eating, Female, Male, Sex Characteristics, Social Behavior, Sucrose, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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