Sleep and metabolism: Role of hypothalamic neuronal circuitry
Abstract
Sleep and metabolism are intertwined physiologically and behaviorally, but the neural systems underlying their coordination are still poorly understood. The hypothalamus is likely to play a major role in the regulation sleep, metabolism, and their interaction. And increasing evidence suggests that hypocretin cells in the lateral hypothalamus may provide particularly important contributions. Here we review: 1) direct interactions between biological arousal and metabolic systems in the hypothalamus, and 2) indirect interactions between these two systems mediated by stress or reward, emphasizing the role of hypocretins. An increased understanding of the mechanisms underlying these interactions may provide novel approaches for the treatment of patients with sleep disorders and obesity, as well as suggest new therapeutic strategies for symptoms of aging, stress, or addiction.
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The orexin system plays a central role in the interaction between feeding and arousal.
“Evidence has accumulated over the past 13 years to indicate that the orexin system plays a central role in this vital interaction between feeding and arousal.”
From Sleep and metabolic function (2012) · cites this paper as [136]
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Pathophysiology of migraine: a disorder of sensory processing
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Interactions between sleep, stress, and metabolism: From physiological to pathological conditions
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“Orexins (also called hypocretins), two distinct peptides (orexin A and B) synthesized by neurons in the lateral hypothalamus (LH), stimulate not only arousal but also feeding (see [136, 139] for review).”
Rapid eye movement sleep behavior disorder and subtypes of Parkinson's disease
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Impact of Obesity in Children with Narcolepsy
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Clinical relevance of sleep duration: results from a cross-sectional analysis using NHANES
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Mental Health Conditions According to Stress and Sleep Disorders
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Neuroscience-driven discovery and development of sleep therapeutics
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Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a
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History of narcolepsy at Stanford University
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A Novel Insight of Effects of a 3-Hz Binaural Beat on Sleep Stages During Sleep
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Sleep Disruption and Cancer: Chicken or the Egg?
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Is narcolepsy a classical autoimmune disease?
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Orexin and MCH neurons: regulators of sleep and metabolism
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Hypothalamic leptin‐neurotensin‐hypocretin neuronal networks in zebrafish
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Sleep and Orexins in Nonmammalian Vertebrates
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Olanzapine Causes a Leptin-Dependent Increase in Acetylcholine Release in Mouse Prefrontal Cortex
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- Authors
- Rolls, A., Borg, J. S., & de Lecea, L.
- Affiliations
- Stanford Medicine (US)
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 24
- Issue
- 5
- Pages
- 817-828
- ISSN
- 1521-690X (ISSN-L)
- OpenAlex
- W2154151380
- Cited by
- 39
- References
- 106
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 4
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- sleep, metabolism, hypothalamus, orexin, lateral hypothalamus, arousal, stress, reward, sleep disorders, obesity, aging, addiction
- MeSH terms
- Animals, Arousal, Feeding Behavior, Humans, Hypothalamus, Metabolism, Models, Biological, Nerve Net, Reward, Sleep, Stress, Physiological, Metabolic Networks and Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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