Cited by 39Sleep and Wakefulness ResearchRegulation of Appetite and ObesityNeuroscience of respiration and sleep

Sleep and metabolism: Role of hypothalamic neuronal circuitry

Rolls, Asya, Borg, Jana Schaich, de Lecea, Luis·2010·Best Practice & Research Clinical Endocrinology & Metabolism

Abstract

Sleep and metabolism are intertwined physiologically and behaviorally, but the neural systems underlying their coordination are still poorly understood. The hypothalamus is likely to play a major role in the regulation sleep, metabolism, and their interaction. And increasing evidence suggests that hypocretin cells in the lateral hypothalamus may provide particularly important contributions. Here we review: 1) direct interactions between biological arousal and metabolic systems in the hypothalamus, and 2) indirect interactions between these two systems mediated by stress or reward, emphasizing the role of hypocretins. An increased understanding of the mechanisms underlying these interactions may provide novel approaches for the treatment of patients with sleep disorders and obesity, as well as suggest new therapeutic strategies for symptoms of aging, stress, or addiction.

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Crossref · 10.1016/j.beem.2010.08.002

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106 of 106 references verified0 citation errors · 0 not checkable

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  • The orexin system plays a central role in the interaction between feeding and arousal.

    “Evidence has accumulated over the past 13 years to indicate that the orexin system plays a central role in this vital interaction between feeding and arousal.”

    From Sleep and metabolic function (2012) · cites this paper as [136]

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Authors
Rolls, A., Borg, J. S., & de Lecea, L.
Affiliations
Stanford Medicine (US)
Venue
Best Practice & Research Clinical Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2010-10
Volume
24
Issue
5
Pages
817-828
ISSN
1521-690X (ISSN-L)
OpenAlex
W2154151380
Cited by
39
References
106
Citations by year
2026: 4 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 4
FWCI
0.19
Type
journal article
Language
en
Open access
closed
Locations
  • Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
sleep, metabolism, hypothalamus, orexin, lateral hypothalamus, arousal, stress, reward, sleep disorders, obesity, aging, addiction
MeSH terms
Animals, Arousal, Feeding Behavior, Humans, Hypothalamus, Metabolism, Models, Biological, Nerve Net, Reward, Sleep, Stress, Physiological, Metabolic Networks and Pathways

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