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Cited by 634

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls

Open access
Bruner, Ann B, Joffe, Alain, Duggan, Anne K, Casella, James F, Brandt, Jason·1996·The Lancet
DOI 10.1016/s0140-6736(96)02341-0
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Abstract

BACKGROUND: Up to 25% of adolescent girls in the USA are iron deficient. This double-blind, placebo-controlled clinical trial assessed the effects of iron supplementation on cognitive function in adolescent girls with non-anaemic iron deficiency. METHODS: 716 girls who enrolled at four Baltimore high schools were screened for non-anaemic iron deficiency (serum ferritin < or = 12 micrograms/L with normal haemoglobin). 98 (13.7%) girls had non-anaemic iron deficiency of whom 81 were enrolled in the trial. Participants were randomly assigned oral ferrous sulphate (650 mg twice daily) or placebo for 8 weeks. The effect of iron treatment was assessed by questionnaires and haematological and cognitive tests, which were done before treatment started and repeated after the intervention. We used four tests of attention and memory to measure cognitive functioning. Intention-to-treat and per-protocol analyses were done. FINDINGS: Of the 81 enrolled girls with non-anaemic iron deficiency, 78 (96%) completed the study (39 in each group). Five girls (three control, two treatment) developed anaemia during the intervention and were excluded from the analyses. Thus, 73 girls were included in the per-protocol analysis. Ethnic distribution, mean age, serum ferritin concentrations, haemoglobin concentrations, and cognitive test scores of the groups did not differ significantly at baseline. Postintervention haematological measures of iron status were significantly improved in the treatment group (serum ferritin 27.3 vs 12.1 micrograms/L, p < 0.001). Regression analysis showed that girls who received iron performed better on a test of verbal learning and memory than girls in the control group (p < 0.02). INTERPRETATION: In this urban population of non-anaemic iron-deficient adolescent girls, iron supplementation improved verbal learning and memory.

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Metadata

Authors
Bruner, A. B., Joffe, A., Duggan, A. K., Casella, J. F., & Brandt, J.
Venue
The Lancet
Publisher
Elsevier BV
Published
1996-10
Volume
348
Issue
9033
Pages
992-996
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(96)02341-0
OpenAlex
W2090470708
Cited by
634
References
2
FWCI
6.18
Type
journal article
Language
en
Open access
hybrid

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