Cited by 225Plant tissue culture and regenerationPlant biochemistry and biosynthesisTransgenic Plants and Applications

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Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation

Chen, Da-Hua, Ye, He-Chun, Li, Guo-Feng·2000·Plant Science

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Abstract

An Agrobacterium tumefaciens-mediated transformation system was developed for Artemisia annua L. Using this system a cDNA encoding farnesyl diphosphate synthase (FDS placed under a CaMV 35S promoter) was transferred into A. annua via A. tumefaciens strain LB4404. Leaf or leaf discs were used as explants to be infected with A. tumefaciens and an optimal concentration of 20 mg/l kanamycin was applied to select kanamycin resistant shoots. Forty-five lines of resistance kanamycin shoots transformed with FDS were established. Analysis of PCR showed that at least 20 shoots transformed with the FDS gene were PCR positive. Southern blot analysis suggested the foreign FDS gene had been integrated into the A. annua genome, and Northern blot analysis revealed that the foreign FDS gene expressed at the transcriptional level in five shoot lines (F-1, F-4, F-61, F-62 and F-73 shoot lines). Analysis of artemisinin demonstrated that about 8 approximately 10 mg/g DW of artemisinin were then detected in transgenic plants regenerated from five shoot lines, this is about 2-3 times higher than that in the control.

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Authors: Chen, D.-H., Ye, H.-C., & Li, G.-F.
Venue: Plant Science
Publisher: Elsevier BV
Published: 2000-06
Volume: 155
Issue: 2
Pages: 179-185
ISSN: 0168-9452 (ISSN-L)
DOI: 10.1016/s0168-9452(00)00217-x
OpenAlex: W1988086615
Cited by: 225
References: 25
Citations by year: 2026: 2 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 10 · 2021: 2 · 2020: 8 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 15 · 2015: 10 · 2014: 12 · 2013: 17 · 2012: 10
FWCI: 1.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Plant Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant tissue culture and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Transgenic Plants and Applications
Keywords: farnesyl diphosphate synthase, Artemisia annua, transgenic plants, Agrobacterium-mediated transformation, artemisinin biosynthesis, CaMV 35S promoter, kanamycin selection, leaf disc explants, transgene integration, artemisinin yield

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Expression of a chimeric farnesyl diphosphate synthase gene in Artemisia annua L. transgenic plants via Agrobacterium tumefaciens-mediated transformation

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