GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain

Structure and subunit composition of GABAA receptors

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Selective Allocation of GABAA Receptors Containing the α1 Subunit to Neurochemically Distinct Subpopulations of Rat Hippocampal Interneurons

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Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

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International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

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Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

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A new benzodiazepine pharmacology

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Ovarian cycle–linked changes in GABAA receptors mediating tonic inhibition alter seizure susceptibility and anxiety

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Regulation and function of adult neurogenesis: from genes to cognition.

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GABA-based therapeutic approaches: GABAA receptor subtype functions

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Extrasynaptic GABA A Receptors: Form, Pharmacology, and Function

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Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans

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Which GABA A Receptor Subunits Are Necessary for Tonic Inhibition in the Hippocampus?

Glykys, J., Mann, E. O., & Mody, I. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4751-07.2008 · Cited by 370

Ion Channels in Genetic Epilepsy: From Genes and Mechanisms to Disease-Targeted Therapies

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Sedation and Anesthesia Mediated by Distinct GABA A Receptor Isoforms

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Brain-Derived Neurotrophic Factor Modulates Fast Synaptic Inhibition by Regulating GABAAReceptor Phosphorylation, Activity, and Cell-Surface Stability

Jovanovic, J. N., Thomas, P., Kittler, J. T., Smart, T. G., & Moss, S. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3606-03.2004 · Cited by 273

Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABAAReceptors

Sarkar, J., Wakefield, S., MacKenzie, G., Moss, S. J., & Maguire, J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2560-11.2011 · Cited by 254

GABAA receptor changes in δ subunit‐deficient mice: Altered expression of α4 and γ2 subunits in the forebrain

Peng, Z., Hauer, B., Mihalek, R. M., Homanics, G. E., Sieghart, W., Olsen, R. W., & Houser, C. R. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10210 · Cited by 247

Evidence for a Significant Role of α3-Containing GABAAReceptors in Mediating the Anxiolytic Effects of Benzodiazepines

Dias, R., Sheppard, W. F. A., Fradley, R. L., Garrett, E. M., Stanley, J. L., Tye, S. J., Goodacre, S., Lincoln, R. J., Cook, S. M., Conley, R., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1166-05.2005 · Cited by 247

Segregating two inhibitory circuits in human motor cortex at the level of GABAA receptor subtypes: A TMS study

Di Lazzaro, V., Pilato, F., Dileone, M., Profice, P., Ranieri, F., Ricci, V., Bria, P., Tonali, P. A., & Ziemann, U. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.07.005 · Cited by 240

The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type

Lee, V., & Maguire, J. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00003 · Cited by 228

Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain

Hörtnagl, H., Tasan, R. O., Wieselthaler, A., Kirchmair, E., Sieghart, W., & Sperk, G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.01.008 · Cited by 229

Regulation of GABAA Receptor Subunit Expression by Pharmacological Agents

Uusi-Oukari, M., & Korpi, E. R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002063 · Cited by 213

Neurosteroid regulation of central nervous system development

Mellon, S. H. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.04.011 · Cited by 209

A schizophrenia-related sensorimotor deficit links α3-containing GABA A receptors to a dopamine hyperfunction

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Regulating anxiety with extrasynaptic inhibition

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Memory Deficits Induced by Inflammation Are Regulated by α5-Subunit-Containing GABAA Receptors

Wang, D.-S., Zurek, A. A., Lecker, I., Yu, J., Abramian, A. M., Avramescu, S., Davies, P. A., Moss, S. J., Lu, W.-Y., & Orser, B. A. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.08.022 · Cited by 182

Modulation of native and recombinant GABAA receptors by endogenous and synthetic neuroactive steroids

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Searching for perfect sleep: the continuing evolution of GABA A receptor modulators as hypnotics

Nutt, D. J., & Stahl, S. M. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109106927 · Cited by 163

Binge alcohol drinking is associated with GABA A α2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala

Liu, J., Yang, A. R., Kelly, T., Puche, A., Esoga, C., June, H. L., Elnabawi, A., Merchenthaler, I., Sieghart, W., June, H. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019020108 · Cited by 152

Synaptic targets: chronic alcohol actions

Roberto, M., & Varodayan, F. P. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.013 · Cited by 149

Dysfunctional hippocampal activity affects emotion and cognition in mood disorders

Femenía, T., Gómez-Galán, M., Lindskog, M., & Magara, S. (2012) · Brain Research · doi:10.1016/j.brainres.2012.03.053 · Cited by 143

Immunoreactivity for the GABAA Receptor 1 Subunit, Somatostatin and Connexin36 Distinguishes Axoaxonic, Basket, and Bistratified Interneurons of the Rat Hippocampus

Baude, A., Bleasdale, C., Dalezios, Y., Somogyi, P., & Klausberger, T. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl117 · Cited by 137

Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression

Maguire, J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00083 · Cited by 113

Allopregnanolone-based treatments for postpartum depression: Why/how do they work?

Walton, N., & Maguire, J. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100198 · Cited by 103

Opposite effects of oxytocin and vasopressin on the emotional expression of the fear response

VIVIANI, D., & STOOP, R. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00418-4 · Cited by 96

Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in mice

Smith, K. S., Engin, E., Meloni, E. G., & Rudolph, U. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.03.001 · Cited by 94

The role of ovarian hormone-derived neurosteroids on the regulation of GABAA receptors in affective disorders

MacKenzie, G., & Maguire, J. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3423-z · Cited by 84

Revisiting enigmatic cortical calretinin-expressing interneurons

Cauli, B., Zhou, X., Tricoire, L., Toussay, X., & Staiger, J. F. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00052 · Cited by 86

Neurosteroid withdrawal regulates GABA-A receptor α4-subunit expression and seizure susceptibility by activation of progesterone receptor-independent early growth response factor-3 pathway

Gangisetty, O., & Reddy, D. S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.037 · Cited by 84

Cocaine effects on mouse incentive-learning and human addiction are linked to α2 subunit-containing GABA A receptors

Dixon, C. I., Morris, H. V., Breen, G., Desrivieres, S., Jugurnauth, S., Steiner, R. C., Vallada, H., Guindalini, C., Laranjeira, R., Messas, G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910117107 · Cited by 77

The ventral hippocampus and the lateral septum work in tandem to regulate rats' open-arm exploration in the elevated plus-maze

Trent, N. L., & Menard, J. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.04.035 · Cited by 76

α4-Containing GABA A Receptors in the Nucleus Accumbens Mediate Moderate Intake of Alcohol

Rewal, M., Jurd, R., Gill, T. M., He, D.-Y., Ron, D., & Janak, P. H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3199-08.2009 · Cited by 71

Tonic Inhibition of Accumbal Spiny Neurons by Extrasynaptic α4βδ GABA A Receptors Modulates the Actions of Psychostimulants

Maguire, E. P., Macpherson, T., Swinny, J. D., Dixon, C. I., Herd, M. B., Belelli, D., Stephens, D. N., King, S. L., & Lambert, J. J. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3232-13.2014 · Cited by 69

The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits alpha1, beta2, and delta along their extrasynaptic cell membrane

Milenkovic, I., Vasiljevic, M., Maurer, D., Höger, H., Klausberger, T., & Sieghart, W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.019 · Cited by 62

Focus on: neurotransmitter systems.

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Subtype-Selective GABAA Receptor Modulation Yields a Novel Pharmacological Profile: The Design and Development of TPA023

Atack, J. R. (2009) · Advances in Pharmacology · doi:10.1016/s1054-3589(08)57004-9 · Cited by 52

Differential roles of GABAA receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward

Reynolds, L. M., Engin, E., Tantillo, G., Lau, H. M., Muschamp, J. W., Carlezon, W. A., & Rudolph, U. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.115 · Cited by 49

The α1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala

Wiltgen, B. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.037.2009 · Cited by 47

Reduced tonic inhibition in the dentate gyrus contributes to chronic stress-induced impairments in learning and memory

Lee, V., MacKenzie, G., Hooper, A., & Maguire, J. (2016) · Hippocampus · doi:10.1002/hipo.22604 · Cited by 47

Amygdala-Specific Reduction of α1-GABA A Receptors Disrupts the Anticonvulsant, Locomotor, and Sedative, But Not Anxiolytic, Effects of Benzodiazepines in Mice

Heldt, S. A., & Ressler, K. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0693-10.2010 · Cited by 42

Neural Basis of Benzodiazepine Reward: Requirement for α2 Containing GABAA Receptors in the Nucleus Accumbens

Engin, E., Bakhurin, K. I., Smith, K. S., Hines, R. M., Reynolds, L. M., Tang, W., Sprengel, R., Moss, S. J., & Rudolph, U. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.41 · Cited by 40

Emerging strategies in the management of essential tremor

Hedera, P. (2017) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285616679123 · Cited by 36

Plasticity and function of extrasynaptic GABAA receptors during pregnancy and after delivery

Mostallino, M. C., Sanna, E., Concas, A., Biggio, G., & Follesa, P. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.013 · Cited by 32

Distinct neurodevelopmental and epileptic phenotypes associated with gain- and loss-of-function GABRB2 variants

Mohammadi, N. A., Ahring, P. K., Yu Liao, V. W., Chua, H. C., Ortiz de la Rosa, S., Johannesen, K. M., Michaeli-Yossef, Y., Vincent-Devulder, A., Meridda, C., Bruel, A.-L., et al. (2024) · eBioMedicine · doi:10.1016/j.ebiom.2024.105236 · Cited by 27

Benzodiazepines counteract rostral anterior cingulate cortex activation induced by cholecystokinin-tetrapeptide in humans

Leicht, G., Mulert, C., Eser, D., Sämann, P. G., Ertl, M., Laenger, A., Karch, S., Pogarell, O., Meindl, T., Czisch, M., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.004 · Cited by 21

Role of protein kinase A in GABAAreceptor dysfunction in CA1 pyramidal cells following chronic benzodiazepine treatment

Lilly, S. M., Zeng, X. J., & Tietz, E. I. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01746.x · Cited by 21

Formation of GABAA receptor complexes containing α1 and α5 subunits is paralleling a multiple T-maze learning task in mice

Ghafari, M., Falsafi, S. K., Szodorai, E., Kim, E.-J., Li, L., Höger, H., Berger, J., Fuchs, K., Sieghart, W., & Lubec, G. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1233-x · Cited by 19

Surface expression of GABAA receptors in the rat nucleus accumbens is increased in early but not late withdrawal from extended-access cocaine self-administration

Purgianto, A., Loweth, J. A., Miao, J. J., Milovanovic, M., & Wolf, M. E. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.014 · Cited by 11

Recruitment of Plasma Membrane GABA-A Receptors by Submembranous Gephyrin/Collybistin Clusters

George, S., Chiou, T.-T., Kanamalla, K., & De Blas, A. L. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01050-1 · Cited by 8