Mechanisms of aging: an appraisal of the oxidative stress hypothesis1,2 1This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal. 2Guest Editor: Rajindar S. Sohal

Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease

Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638

Lipofuscin: mechanisms of age-related accumulation and influence on cell function12 1Guest Editor: Rajindar S. Sohal 2This article is part of a series of reviews on “Oxidative Stress and Aging.” The full list of papers may be found on the homepage of the journal.

Brunk, U. T., & Terman, A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00959-0 · Cited by 919

The Genetics of Aging

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Ubiquitous overexpression of CuZn superoxide dismutase does not extendlife span in mice

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Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

Halliwell, B., & Whiteman, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705776 · Cited by 2,238

Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants

Valavanidis, A., Vlahogianni, T., Dassenakis, M., & Scoullos, M. (2006) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2005.03.013 · Cited by 1,795

Oxidative DNA damage and disease: induction, repair and significance

Evans, M. D., Dizdaroglu, M., & Cooke, M. S. (2004) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.11.001 · Cited by 1,372

An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations

Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

Sykiotis, G. P., & Bohmann, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.002 · Cited by 660

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad, C. A., & Klann, E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3208 · Cited by 635

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554

Aging, adiposity, and calorie restriction

Fontana, L. (2007) · JAMA · doi:10.1001/jama.297.9.986 · Cited by 526

Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging

Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490

The redox stress hypothesis of aging

Sohal, R. S., & Orr, W. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.445 · Cited by 473

Oxidative stress and aberrant signaling in aging and cognitive decline

Dröge, W., & Schipper, H. M. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00294.x · Cited by 479

Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement

Schipper, H. M., Song, W., Zukor, H., Hascalovici, J. R., & Zeligman, D. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06160.x · Cited by 298

Calorie restriction and prevention of age‐associated chronic disease

Omodei, D., & Fontana, L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.015 · Cited by 293

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

Tenchov, R., Sasso, J. M., Wang, X., & Zhou, Q. A. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00531 · Cited by 276

Antioxidant and cytotoxic activities of Centella asiatica (L) Urb

Pittella, F., Dutra, R. C., Junior, D. D., Lopes, M. T. P., & Barbosa, N. R. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10093713 · Cited by 244

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae

Kruegel, U., Robison, B., Dange, T., Kahlert, G., Delaney, J. R., Kotireddy, S., Tsuchiya, M., Tsuchiyama, S., Murakami, C. J., Schleit, J., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002253 · Cited by 220

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

Ihara, Y., Morishima-Kawashima, M., & Nixon, R. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006361 · Cited by 190

The retardation of aging by caloric restriction: its significance in the transgenic era

Barger, J. L., Walford, R. L., & Weindruch, R. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.10.017 · Cited by 160

Age‐related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy

Speakman, J. R., Van Acker, A., & Harper, E. J. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00061.x · Cited by 156

Genetics of Aging in the Fruit Fly,Drosophila melanogaster

Helfand, S. L., & Rogina, B. (2003) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.040103.095211 · Cited by 152

Age-Associated Impairments in Mitochondrial ADP Sensitivity Contribute to Redox Stress in Senescent Human Skeletal Muscle

Holloway, G. P., Holwerda, A. M., Miotto, P. M., Dirks, M. L., Verdijk, L. B., & van Loon, L. J. C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.069 · Cited by 134

Alterations in xenobiotic metabolism in the long‐lived Little mice

Amador‐Noguez, D., Dean, A., Huang, W., Setchell, K., Moore, D., & Darlington, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00300.x · Cited by 134

Effect of Coenzyme Q10 Intake on Endogenous Coenzyme Q Content, Mitochondrial Electron Transport Chain, Antioxidative Defenses, and Life Span of Mice

Sohal, R. S., Kamzalov, S., Sumien, N., Ferguson, M., Rebrin, I., Heinrich, K. R., & Forster, M. J. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.037 · Cited by 131

NF‐κB as the mediator of metformin's effect on ageing and ageing‐related diseases

Kanigur Sultuybek, G., Soydas, T., & Yenmis, G. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13073 · Cited by 119

Thyroid Hormone Signaling and Homeostasis During Aging

Bowers, J., Terrien, J., Clerget-Froidevaux, M. S., Gothié, J. D., Rozing, M. P., Westendorp, R. G. J., van Heemst, D., & Demeneix, B. A. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1056 · Cited by 117

Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts

Stöckl, P., Hütter, E., Zwerschke, W., & Jansen-Dürr, P. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.04.009 · Cited by 99

Coenzyme Q10: From bench to clinic in aging diseases, a translational review

Gutierrez-Mariscal, F. M., Yubero-Serrano, E. M., Villalba, J. M., & Lopez-Miranda, J. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1442316 · Cited by 92

The oxidative damage theory of aging

Lin, M. T., & Flint Beal, M. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00007-0 · Cited by 89

Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila

Bayne, A.-C. V., Mockett, R. J., Orr, W. C., & Sohal, R. S. (2005) · Biochemical Journal · doi:10.1042/bj20041872 · Cited by 84

Effect of Antioxidant-Enriched Diets on Glutathione Redox Status in Tissue Homogenates and Mitochondria of the Senescence-Accelerated Mouse

Rebrin, I., Zicker, S., Wedekind, K. J., Paetau-Robinson, I., Packer, L., & Sohal, R. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.008 · Cited by 82

Aging related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury

Luceri, C., Bigagli, E., Femia, A. P., Caderni, G., Giovannelli, L., & Lodovici, M. (2018) · Toxicology Reports · doi:10.1016/j.toxrep.2017.12.017 · Cited by 79

Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures

Ali, S. S., Marcondes, M.-C. G., Bajova, H., Dugan, L. L., & Conti, B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.155432 · Cited by 71

Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer’s disease

Jackson, H. M., Soto, I., Graham, L. C., Carter, G. W., & Howell, G. R. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-831 · Cited by 66

The Neuroprotective Effect of Picroside II from Hu-Huang-Lian against Oxidative Stress

Li, T., Liu, J.-W., Zhang, X.-D., Guo, M.-C., & Ji, G. (2007) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x0700517x · Cited by 41

Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways

Navarro-Yepes, J., Anandhan, A., Bradley, E., Bohovych, I., Yarabe, B., de Jong, A., Ovaa, H., Zhou, Y., Khalimonchuk, O., Quintanilla-Vega, B., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9414-9 · Cited by 37

Early onset senescence occurs when fibroblasts lack the glutamate–cysteine ligase modifier subunit

Chen, Y., Johansson, E., Fan, Y., Shertzer, H. G., Vasiliou, V., Nebert, D. W., & Dalton, T. P. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.003 · Cited by 28

Free Radicals in Biochemistry and Medicine

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Brain aging phenomena in migrating sockeye salmon Oncorhynchus nerka nerka

Götz, M. E., Malz, C. R., Dirr, A., Blum, D., Gsell, W., Schmidt, S., Burger, R., Pohli, S., & Riederer, P. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-004-0257-1 · Cited by 11