The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Cited by
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
Shtutman, M., Zhurinsky, J., Simcha, I., Albanese, C., D’Amico, M., Pestell, R., & Ben-Ze’ev, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5522 · Cited by 2,230
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
Autosomal dominant polycystic kidney disease
Torres, V. E., Harris, P. C., & Pirson, Y. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60601-1 · Cited by 1,550
Caught up in a Wnt storm: Wnt signaling in cancer
Giles, R. H., van Es, J. H., & Clevers, H. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00005-2 · Cited by 1,482
GSK3 takes centre stage more than 20 years after its discovery
FRAME, S., & COHEN, P. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3590001 · Cited by 1,433
Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus
Peifer, M., & Polakis, P. (2000) · Science · doi:10.1126/science.287.5458.1606 · Cited by 1,253
Self-citationOsteocytes, mechanosensing and Wnt signaling
Bonewald, L. F., & Johnson, M. L. (2008) · Bone · doi:10.1016/j.bone.2007.12.224 · Cited by 1,076
The -Catenin Destruction Complex
Stamos, J. L., & Weis, W. I. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007898 · Cited by 1,062
APC, Signal transduction and genetic instability in colorectal cancer
Fodde, R., Smits, R., & Clevers, H. (2001) · Nature Reviews Cancer · doi:10.1038/35094067 · Cited by 937
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
Uversky, V. N., Oldfield, C. J., & Dunker, A. K. (2005) · Journal of Molecular Recognition · doi:10.1002/jmr.747 · Cited by 847
Wnt signaling in development and tissue homeostasis
Steinhart, Z., & Angers, S. (2018) · Development · doi:10.1242/dev.146589 · Cited by 821
Gurney, A., Axelrod, F., Bond, C. J., Cain, J., Chartier, C., Donigan, L., Fischer, M., Chaudhari, A., Ji, M., Kapoun, A. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120068109 · Cited by 614
Mutations and mechanisms of WNT pathway tumour suppressors in cancer
Bugter, J. M., Fenderico, N., & Maurice, M. M. (2021) · Nature Reviews Cancer · doi:10.1038/s41568-020-00307-z · Cited by 466
The APC gene in colorectal cancer
Fodde, R. (2002) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00040-0 · Cited by 461
Poltavets, V., Kochetkova, M., Pitson, S. M., & Samuel, M. S. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00431 · Cited by 377
Yamamoto, H., Kishida, S., Kishida, M., Ikeda, S., Takada, S., & Kikuchi, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10681 · Cited by 364
The APC tumour suppressor has a nuclear export function
Rosin-Arbesfeld, R., Townsley, F., & Bienz, M. (2000) · Nature · doi:10.1038/35023016 · Cited by 343
Control of β-Catenin Stability
Salic, A., Lee, E., Mayer, L., & Kirschner, M. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80446-3 · Cited by 335
Desbois-Mouthon, C., Cadoret, A., Blivet-Van Eggelpoël, M.-J., Bertrand, F., Cherqui, G., Perret, C., & Capeau, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204064 · Cited by 321
Wharton, K. A. (2003) · Developmental Biology · doi:10.1006/dbio.2002.0869 · Cited by 315
Structural basis for recruitment of glycogen synthase kinase 3β to the axin—APC scaffold complex
Dajani, R., Fraser, E., Roe, S. M., Yeo, M., Good, V. M., Thompson, V., Dale, T. C., & Pearl, L. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg068 · Cited by 315
GSK-3 and tau: a key duet in Alzheimer’s disease
Sayas, C. L., & Ávila, J. (2021) · Cells · doi:10.3390/cells10040721 · Cited by 314
Evidence that Fold-Change, and Not Absolute Level, of β-Catenin Dictates Wnt Signaling
Goentoro, L., & Kirschner, M. W. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.11.017 · Cited by 300
Glycogen Synthase Kinase 3β Phosphorylates Tau at Both Primed and Unprimed Sites
Cho, J.-H., & Johnson, G. V. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m206236200 · Cited by 266
Xing, Y., Clements, W. K., Kimelman, D., & Xu, W. (2003) · Genes & Development · doi:10.1101/gad.1142603 · Cited by 237
Lochhead, P. A., Coghlan, M., Rice, S. Q. J., & Sutherland, C. (2001) · Diabetes · doi:10.2337/diabetes.50.5.937 · Cited by 219
Roles and regulation of Wnt signaling and β-catenin in prostate cancer
Verras, M., & Sun, Z. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.06.004 · Cited by 180
Are Wnt/β-Catenin and PI3K/AKT/mTORC1 Distinct Pathways in Colorectal Cancer?
Prossomariti, A., Piazzi, G., Alquati, C., & Ricciardiello, L. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.04.007 · Cited by 155
Adamska, M., Larroux, C., Adamski, M., Green, K., Lovas, E., Koop, D., Richards, G. S., Zwafink, C., & Degnan, B. M. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00435.x · Cited by 139
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
Willert, K., Logan, C. Y., Arora, A., Fish, M., & Nusse, R. (1999) · Development · doi:10.1242/dev.126.18.4165 · Cited by 117
Arnold, H. K., & Sears, R. C. (2008) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9128-9 · Cited by 111
A Novel β-Catenin-binding Protein Inhibits β-Catenin-dependent Tcf Activation and Axis Formation
Sakamoto, I., Kishida, S., Fukui, A., Kishida, M., Yamamoto, H., Hino, S.-I., Michiue, T., Takada, S., Asashima, M., & Kikuchi, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004089200 · Cited by 106
Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon
Anderson, C. B., Neufeld, K. L., & White, R. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122235399 · Cited by 108
Lymphoid enhancer factor/T cell factor expression in colorectal cancer
Waterman, M. L. (2004) · Cancer and Metastasis Reviews · doi:10.1023/a:1025858928620 · Cited by 106
Intersection of Hippo/YAP and Wnt/β-catenin signaling pathways
Konsavage, W. M., & Yochum, G. S. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms084 · Cited by 94
Early Embryonic Death in Mice Lacking the β-Catenin-Binding Protein Duplin
Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A., & Nakayama, K. I. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8386-8394.2004 · Cited by 86
Atlasi, Y., Noori, R., Gaspar, C., Franken, P., Sacchetti, A., Rafati, H., Mahmoudi, T., Decraene, C., Calin, G. A., Merrill, B. J., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003424 · Cited by 84
The novel role of pyrvinium in cancer therapy
Momtazi‐borojeni, A. A., Abdollahi, E., Ghasemi, F., Caraglia, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26006 · Cited by 75
Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded
Noutsou, M., Duarte, A. M. S., Anvarian, Z., Didenko, T., Minde, D. P., Kuper, I., de Ridder, I., Oikonomou, C., Friedler, A., Boelens, R., et al. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2010.11.013 · Cited by 58
Stochastic machines as a colocalization mechanism for scaffold protein function
Xue, B., Romero, P. R., Noutsou, M., Maurice, M. M., Rüdiger, S. G. D., William, A. M., Mizianty, M. J., Kurgan, L., Uversky, V. N., & Dunker, A. K. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.04.006 · Cited by 47
Shen, C., Nayak, A., Neitzel, L. R., Adams, A. A., Silver-Isenstadt, M., Sawyer, L. M., Benchabane, H., Wang, H., Bunnag, N., Li, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25634-z · Cited by 43
PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development
Mao, Z., Liu, C., Lin, X., Sun, B., & Su, C. (2018) · Cancer Letters · doi:10.1016/j.canlet.2017.11.024 · Cited by 30
Telomeres, a busy platform for cell signaling.
Gardano, L., Pucci, F., Christian, L., Le Bihan, T., & Harrington, L. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00146 · Cited by 15
Costa, Â. M. S., Pereira-Castro, I., Ricardo, E., Spencer, F., Fisher, S., & Costa, L. T. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067694 · Cited by 13
Kim, J., Jeon, Y. J., Chang, I.-Y., Lee, J.-H., & You, H. J. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01381-1 · Cited by 4
Metadata
- Authors
- Hart, M. J., de los Santos, R., Albert, I. N., Rubinfeld, B., & Polakis, P.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 8
- Issue
- 10
- Pages
- 573-581
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2036864436
- Cited by
- 836
- References
- 1
- FWCI
- 22.62
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
