Red fluorescent protein

Ultrasensitive fluorescent proteins for imaging neuronal activity

Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

Tian, L., Hires, S. A., Mao, T., Huber, D., Chiappe, M. E., Chalasani, S. H., Petreanu, L., Akerboom, J., McKinney, S. A., Schreiter, E. R., et al. (2009) · Nature Methods · doi:10.1038/nmeth.1398 · Cited by 1,967

Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise

Newman, J. R. S., Ghaemmaghami, S., Ihmels, J., Breslow, D. K., Noble, M., DeRisi, J. L., & Weissman, J. S. (2006) · Nature · doi:10.1038/nature04785 · Cited by 1,483

Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses

O'Connell, R. J., Thon, M. R., Hacquard, S., Amyotte, S. G., Kleemann, J., Torres, M. F., Damm, U., Buiate, E. A., Epstein, L., Alkan, N., et al. (2012) · Nature Genetics · doi:10.1038/ng.2372 · Cited by 1,047

Misfolded proteins partition between two distinct quality control compartments

Kaganovich, D., Kopito, R., & Frydman, J. (2008) · Nature · doi:10.1038/nature07195 · Cited by 932

Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections

Petreanu, L., Huber, D., Sobczyk, A., & Svoboda, K. (2007) · Nature Neuroscience · doi:10.1038/nn1891 · Cited by 930

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

Choi, C. K., Vicente-Manzanares, M., Zareno, J., Whitmore, L. A., Mogilner, A., & Horwitz, A. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1763 · Cited by 797

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

Dompierre, J. P., Godin, J. D., Charrin, B. C., Cordelières, F. P., King, S. J., Humbert, S., & Saudou, F. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0037-07.2007 · Cited by 792

Atg8 Controls Phagophore Expansion during Autophagosome Formation

Xie, Z., Nair, U., & Klionsky, D. J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1292 · Cited by 753

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

Kim, Y.-M., Brinkmann, M. M., Paquet, M.-E., & Ploegh, H. L. (2008) · Nature · doi:10.1038/nature06726 · Cited by 645

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

Murakoshi, H., Wang, H., & Yasuda, R. (2011) · Nature · doi:10.1038/nature09823 · Cited by 564

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

Hughes, A. L., & Gottschling, D. E. (2012) · Nature · doi:10.1038/nature11654 · Cited by 559

Multiple dynamic representations in the motor cortex during sensorimotor learning

Huber, D., Gutnisky, D. A., Peron, S., O’Connor, D. H., Wiegert, J. S., Tian, L., Oertner, T. G., Looger, L. L., & Svoboda, K. (2012) · Nature · doi:10.1038/nature11039 · Cited by 540

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

Hammond, G. R. V., Machner, M. P., & Balla, T. (2014) · Journal of Cell Biology · doi:10.1083/jcb.201312072 · Cited by 453

Mammalian end binding proteins control persistent microtubule growth

Komarova, Y., De Groot, C. O., Grigoriev, I., Gouveia, S. M., Munteanu, E. L., Schober, J. M., Honnappa, S., Buey, R. M., Hoogenraad, C. C., Dogterom, M., et al. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200807179 · Cited by 387

Control of mammalian translation by mRNA structure near caps

Babendure, J. R., Babendure, J. L., Ding, J.-H., & Tsien, R. Y. (2006) · RNA · doi:10.1261/rna.2309906 · Cited by 339

ER-Associated Mitochondrial Division Links the Distribution of Mitochondria and Mitochondrial DNA in Yeast

Murley, A., Lackner, L. L., Osman, C., West, M., Voeltz, G. K., Walter, P., & Nunnari, J. (2013) · eLife · doi:10.7554/elife.00422 · Cited by 326

The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

Chandra, A., Grecco, H. E., Pisupati, V., Perera, D., Cassidy, L., Skoulidis, F., Ismail, S. A., Hedberg, C., Hanzal-Bayer, M., Venkitaraman, A. R., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2394 · Cited by 325

Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation

Papapetrou, E. P., Tomishima, M. J., Chambers, S. M., Mica, Y., Reed, E., Menon, J., Tabar, V., Mo, Q., Studer, L., & Sadelain, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904825106 · Cited by 286

Sensory maps in the olfactory cortex defined by long-range viral tracing of single neurons

Ghosh, S., Larson, S. D., Hefzi, H., Marnoy, Z., Cutforth, T., Dokka, K., & Baldwin, K. K. (2011) · Nature · doi:10.1038/nature09945 · Cited by 276

Neural coding during active somatosensation revealed using illusory touch

O'Connor, D. H., Hires, S. A., Guo, Z. V., Li, N., Yu, J., Sun, Q.-Q., Huber, D., & Svoboda, K. (2013) · Nature Neuroscience · doi:10.1038/nn.3419 · Cited by 252

Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells

Dunn, S., Morrison, E. E., Liverpool, T. B., Molina-París, C., Cross, R. A., Alonso, M. C., & Peckham, M. (2008) · Journal of Cell Science · doi:10.1242/jcs.026492 · Cited by 242

Nervous systems of the sea anemone Nematostella vectensis are generated by ectoderm and endoderm and shaped by distinct mechanisms

Nakanishi, N., Renfer, E., Technau, U., & Rentzsch, F. (2012) · Development · doi:10.1242/dev.071902 · Cited by 188

Lineage specificity of primary cilia in the mouse embryo

Bangs, F. K., Schrode, N., Hadjantonakis, A.-K., & Anderson, K. V. (2015) · Nature Cell Biology · doi:10.1038/ncb3091 · Cited by 174

miR-132 Mediates the Integration of Newborn Neurons into the Adult Dentate Gyrus

Luikart, B. W., Bensen, A. L., Washburn, E. K., Perederiy, J. V., Su, K. G., Li, Y., Kernie, S. G., Parada, L. F., & Westbrook, G. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019077 · Cited by 160

Modulation of Phototropic Responsiveness in Arabidopsis through Ubiquitination of Phototropin 1 by the CUL3-Ring E3 Ubiquitin Ligase CRL3NPH3

Roberts, D., Pedmale, U. V., Morrow, J., Sachdev, S., Lechner, E., Tang, X., Zheng, N., Hannink, M., Genschik, P., & Liscum, E. (2011) · The Plant Cell · doi:10.1105/tpc.111.087999 · Cited by 150

Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response

Rand, U., Rinas, M., Schwerk, J., Nöhren, G., Linnes, M., Kröger, A., Flossdorf, M., Kály‐Kullai, K., Hauser, H., Höfer, T., et al. (2012) · Molecular Systems Biology · doi:10.1038/msb.2012.17 · Cited by 147

Transgenic analysis of a SoxB gene reveals neural progenitor cells in the cnidarian Nematostella vectensis

Richards, G. S., & Rentzsch, F. (2014) · Development · doi:10.1242/dev.112029 · Cited by 110

Origin and role of distal visceral endoderm, a group of cells that determines anterior–posterior polarity of the mouse embryo

Takaoka, K., Yamamoto, M., & Hamada, H. (2011) · Nature Cell Biology · doi:10.1038/ncb2251 · Cited by 127

MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis

Samora, C. P., Mogessie, B., Conway, L., Ross, J. L., Straube, A., & McAinsh, A. D. (2011) · Nature Cell Biology · doi:10.1038/ncb2297 · Cited by 124

Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair

Luijsterburg, M. S., von Bornstaedt, G., Gourdin, A. M., Politi, A. Z., Moné, M. J., Warmerdam, D. O., Goedhart, J., Vermeulen, W., van Driel, R., & Höfer, T. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200909175 · Cited by 121

Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC

Luijsterburg, M. S., Goedhart, J., Moser, J., Kool, H., Geverts, B., Houtsmuller, A. B., Mullenders, L. H. F., Vermeulen, W., & van Driel, R. (2007) · Journal of Cell Science · doi:10.1242/jcs.008367 · Cited by 105

PtdIns(3,4,5)P 3 is a regulator of myosin-X localization and filopodia formation

Plantard, L., Arjonen, A., Lock, J. G., Nurani, G., Ivaska, J., & Strömblad, S. (2010) · Journal of Cell Science · doi:10.1242/jcs.069609 · Cited by 84

Cullin 5 Regulates Cortical Layering by Modulating the Speed and Duration of Dab1-Dependent Neuronal Migration

Simó, S., Jossin, Y., & Cooper, J. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0035-10.2010 · Cited by 72

Extensions of MADM (mosaic analysis with double markers) in mice

Tasic, B., Miyamichi, K., Hippenmeyer, S., Dani, V. S., Zeng, H., Joo, W., Zong, H., Chen-Tsai, Y., & Luo, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033332 · Cited by 63

Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling

Allen, M. D., Neumann, S., & Gershengorn, M. C. (2011) · The FASEB Journal · doi:10.1096/fj.11-188961 · Cited by 65

Cellular Concentrations of DDB2 Regulate Dynamic Binding of DDB1 at UV-Induced DNA Damage

Alekseev, S., Luijsterburg, M. S., Pines, A., Geverts, B., Mari, P.-O., Giglia-Mari, G., Lans, H., Houtsmuller, A. B., Mullenders, L. H. F., Hoeijmakers, J. H. J., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01108-08 · Cited by 38

An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner

Hager, S., Frame, F. M., Collins, A. T., Burns, J. E., & Maitland, N. J. (2008) · Human Gene Therapy · doi:10.1089/hum.2007.165 · Cited by 30

Visualization of Cytolytic T Cell Differentiation and Granule Exocytosis with T Cells from Mice Expressing Active Fluorescent Granzyme B

Mouchacca, P., Schmitt-Verhulst, A.-M., & Boyer, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067239 · Cited by 29

Identification and In Vivo Characterization of NvFP-7R, a Developmentally Regulated Red Fluorescent Protein of Nematostella vectensis

Ikmi, A., & Gibson, M. C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011807 · Cited by 26

Fluorescent Protein Applications in Microscopy

Straight, A. F. (2007) · Methods in Cell Biology · doi:10.1016/s0091-679x(06)81006-x · Cited by 24