Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 628

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

The neurobiology, investigation, and treatment of chronic insomnia

Riemann, Dieter, Nissen, Christoph, Palagini, Laura, Otte, Andreas, Perlis, Michael L, Spiegelhalder, Kai·2015·The Lancet Neurology

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s1474-4422(15)00021-6

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 30 references

Research works printed but not linked: 77

  1. Laugsand, 2011, Insomnia and the risk of acute myocardial infarction: a population study, Circulation, 124, 2073, 10.1161/CIRCULATIONAHA.111.025858 · DOI · Paper page
  2. Palagini, 2013, Sleep loss and hypertension: a systematic review, Curr Pharm Des, 19, 2409, 10.2174/1381612811319130009 · DOI · Paper page
  3. Fernandez-Mendoza, 2012, Insomnia with objective short sleep duration and incident hypertension: the Penn State Cohort, Hypertension, 60, 929, 10.1161/HYPERTENSIONAHA.112.193268 · DOI · Paper page
  4. Mayer, 2011, Insomnia in neurological diseases—occurrence and management, Sleep Med Rev, 15, 369, 10.1016/j.smrv.2011.01.005 · DOI
  5. Sexton, 2014, Poor sleep quality is associated with increased cortical atrophy in community-dwelling adults, Neurology, 83, 967, 10.1212/WNL.0000000000000774 · DOI
  6. Bjørngaard, 2011, Sleeping problems and suicide in 75,000 Norwegian adults: A 20 year follow-up of the HUNT I Study, Sleep, 34, 1155, 10.5665/SLEEP.1228 · DOI
  7. Kucharczyk, 2012, The occupational impact of sleep quality and insomnia symptoms, Sleep Med Rev, 16, 547, 10.1016/j.smrv.2012.01.005 · DOI
  8. Léger, 2010, Societal costs of insomnia, Sleep Med Rev, 14, 379, 10.1016/j.smrv.2010.01.003 · DOI · Paper page
  9. Vgontzas, 2013, Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder, Sleep Med Rev, 17, 241, 10.1016/j.smrv.2012.09.005 · DOI · Paper page
  10. Borbély, 1982, A two-process model of sleep regulation, Hum Neurobiol, 1, 195
  11. Perlis, 2014, The incidence and temporal patterning of insomnia: a second study, J Sleep Res, 23, 499, 10.1111/jsr.12150 · DOI
  12. Vallieres, 2005, Variability and predictability in sleep patterns of chronic insomniacs, J Sleep Res, 14, 447, 10.1111/j.1365-2869.2005.00480.x · DOI
  13. Fisher, 2013, The circadian control of sleep, Handb Exp Pharmacol, 217, 157, 10.1007/978-3-642-25950-0_7 · DOI
  14. Liu, 2007, Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep promoting effect, J Neurophysiol, 97, 837, 10.1152/jn.00873.2006 · DOI
  15. Porkka–Heiskanen, 1997, Adenosine: a mediator of the sleep-inducing effects of prolonged wakefulness, Science, 276, 1265, 10.1126/science.276.5316.1265 · DOI · Paper page
  16. Provini, 2005, Insomnia in neurological diseases, Semin Neurol, 25, 81, 10.1055/s-2005-867074 · doi:10.1055/s-2005-867074
  17. Quellet, 2004, Insomnia following traumatic brain injury: a review, Neurorehabil Neural Repair, 18, 187, 10.1177/1545968304271405 · DOI
  18. Koenigs, 2010, Left dorsomedial frontal brain damage is associated with insomnia, J Neurosci, 30, 16041, 10.1523/JNEUROSCI.3745-10.2010 · DOI
  19. Saper, 2010, Sleep state switching, Neuron, 68, 1023, 10.1016/j.neuron.2010.11.032 · DOI · Paper page
  20. Spiegelhalder, 2012, Increased EEG sigma and beta power during NREM sleep in primary insomnia, Biol Psychol, 91, 329, 10.1016/j.biopsycho.2012.08.009 · DOI
  21. Riemann, 2012, REM sleep instability – a new pathway for insomnia?, Pharmacopsychiatry, 45, 167
  22. Revel, 2009, Rodent models of insomnia: a review of experimental procedures that induce sleep disturbances, Neurosci Biobehav Rev, 33, 874, 10.1016/j.neubiorev.2009.03.002 · DOI
  23. Cano, 2008, Neural circuitry of stress-induced insomnia in rats, J Neurosci, 28, 10167, 10.1523/JNEUROSCI.1809-08.2008 · DOI
  24. Beaulieu-Bonneau, 2007, Family history of insomnia in a population-based sample, Sleep, 30, 1739, 10.1093/sleep/30.12.1739 · DOI
  25. Wing, 2012, Familial aggregation and heritability of insomnia in a community-based study, Sleep Med, 13, 985, 10.1016/j.sleep.2012.04.013 · DOI
  26. Watson, 2006, Genetic and environmental influences on insomnia, daytime sleepiness, and obesity in twins, Sleep, 29, 645, 10.1093/sleep/29.5.645 · DOI
  27. Barclay, 2010, Diurnal preference and sleep quality: same genes? A study of young adult twins, Chronobiol Int, 27, 278, 10.3109/07420521003663801 · DOI
  28. Hublin, 2011, Heritability and mortality risk of insomnia-related symptoms: a genetic epidemiologic study in a population-based twin cohort, Sleep, 34, 957, 10.5665/SLEEP.1136 · DOI
  29. Drake, 2011, Sleep reactivity and insomnia: genetic and environmental influences, Sleep, 34, 1179, 10.5665/SLEEP.1234 · DOI · Paper page
  30. Buhr, 2002, Functional characterization of the new human GABA(A) receptor mutation beta3(R192H), Hum Genet, 111, 154, 10.1007/s00439-002-0766-7 · DOI
  31. Deuschle, 2010, Association between a serotonin transporter length polymorphism and primary insomnia, Sleep, 33, 343, 10.1093/sleep/33.3.343 · DOI
  32. Ban, 2011, Genetic and metabolic characterization of insomnia, PLoS One, 6, e18455, 10.1371/journal.pone.0018455 · DOI
  33. Byrne, 2013, A genome-wide association study of sleep habits and insomnia, Am J Med Genet B Neuropsychiatr Genet, 162B, 439, 10.1002/ajmg.b.32168 · DOI
  34. Palagini, 2014, The genetics of insomnia—evidence for epigenetic mechanisms, Sleep Med Rev, 18, 225, 10.1016/j.smrv.2013.05.002 · DOI
  35. Barclay, 2013, Quantitative genetic research on sleep: a review of normal sleep, sleep disturbances and associated emotional, behavioural, and health-related difficulties, Sleep Med Rev, 17, 29, 10.1016/j.smrv.2012.01.008 · DOI · Paper page
  36. Zhang, 2014, A community-based study on the association between insomnia and hypothalamic-pituitary-adrenal axis: sex and pubertal influences, J Clin Endocrinol Metab, 99, 2277, 10.1210/jc.2013-3728 · DOI
  37. Xia, 2013, Alterations in hypothalamus-pituitary-adrenal/thyroid axes and gonadotropin-releasing hormone in the patients with primary insomnia: a clinical research, PLoS One, 8, e71065, 10.1371/journal.pone.0071065 · DOI · Paper page
  38. Seelig, 2013, Neuroendocrine regulation and metabolism of glucose and lipids in primary chronic insomnia: a prospective case-control study, PLoS One, 8, e61780, 10.1371/journal.pone.0061780 · DOI
  39. Farina, 2014, Heart rate and heart rate variability modification in chronic insomnia patients, Behav Sleep Med, 12, 290, 10.1080/15402002.2013.801346 · DOI
  40. Maes, 2014, Sleep misperception, EEG characteristics and autonomous nervous system activity in primary insomnia: a retrospective study on polysomnographic data, Int J Psychophysiol, 91, 163, 10.1016/j.ijpsycho.2013.10.012 · DOI
  41. Spiegelhalder, 2011, Heart rate and heart rate variability in subjectively reported insomnia, J Sleep Res, 20, 137, 10.1111/j.1365-2869.2010.00863.x · DOI
  42. De Zambotti, 2011, Sleep onset and cardiovascular activity in primary insomnia, J Sleep Res, 20, 318, 10.1111/j.1365-2869.2010.00871.x · DOI
  43. Yang, 2011, Reduced physiologic complexity is associated with poor sleep in patients with major depression and primary insomnia, J Affect Disord, 131, 179, 10.1016/j.jad.2010.11.030 · DOI
  44. Wu, 2013, EEG power during waking and NREM sleep in primary insomnia, J Clin Sleep Med, 9, 1031, 10.5664/jcsm.3076 · DOI
  45. St-Jean, 2013, REM and NREM power spectral analysis on two consecutive nights in psychophysiological and paradoxical insomnia sufferers, Int J Psychophysiol, 89, 181, 10.1016/j.ijpsycho.2013.06.004 · DOI
  46. Corsi-Cabrera, 2012, Enhanced frontoparietal synchronized activation during the wake-sleep transition in patients with primary insomnia, Sleep, 35, 501, 10.5665/sleep.1734 · DOI
  47. Otte, 2002, Nuclear Medicine asleep in sleep research?, Eur J Nucl Med, 29, 1417, 10.1007/s00259-002-0951-x · DOI
  48. Altena, 2010, Reduced orbitofrontal and parietal gray matter in chronic insomnia: a voxel-based morphometric study, Biol Psychiatry, 67, 182, 10.1016/j.biopsych.2009.08.003 · DOI · Paper page
  49. Stoffers, 2012, Orbitofrontal gray matter relates to early morning awakening: a neural correlate of insomnia complaints?, Front Neurol, 3, 105, 10.3389/fneur.2012.00105 · DOI
  50. Winkelman, 2013, Increased rostral anterior cingulate cortex volume in chronic primary insomnia, Sleep, 36, 991, 10.5665/sleep.2794 · DOI
  51. Joo, 2013, Brain gray matter deficits in patients with chronic primary insomnia, Sleep, 36, 999, 10.5665/sleep.2796 · DOI · Paper page
  52. Spiegelhalder, 2013, Insomnia does not appear to be associated with substantial structural brain changes, Sleep, 36, 731, 10.5665/sleep.2638 · DOI
  53. Riemann, 2007, Chronic insomnia and MRI-measured hippocampal volumes: a pilot study, Sleep, 30, 955, 10.1093/sleep/30.8.955 · DOI · Paper page
  54. Neylan, 2010, Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield, Biol Psychiatry, 68, 494, 10.1016/j.biopsych.2010.04.035 · DOI
  55. Joo, 2014, Hippocampal substructural vulnerability to sleep disturbance and cognitive impairment in patients with chronic primary insomnia: MRI morphometry, Sleep, 37, 1189, 10.5665/sleep.3836 · DOI
  56. Winkelman, 2010, Lack of hippocampal volume differences in primary insomnia and good sleeper controls: an MRI volumetric study at 3 Tesla, Sleep Med, 11, 576, 10.1016/j.sleep.2010.03.009 · DOI
  57. Bumb, 2014, Pineal gland volume in primary insomnia and healthy controls: a magnetic resonance imaging study, J Sleep Res, 23, 274, 10.1111/jsr.12125 · DOI
  58. Plante, 2012, Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder?, Neuropsychopharmacology, 37, 1548, 10.1038/npp.2012.4 · DOI
  59. Winkelman, 2008, Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS), Sleep, 31, 1499, 10.1093/sleep/31.11.1499 · DOI · Paper page
  60. Morgan, 2012, Cortical GABA levels in primary insomnia, Sleep, 35, 807, 10.5665/sleep.1880 · DOI
  61. Harper, 2013, Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 Tesla, Sleep, 36, 493, 10.5665/sleep.2530 · DOI
  62. Altena, 2008, Prefrontal hypoactivation and recovery in insomnia, Sleep, 31, 1271
  63. Drummond, 2013, Neural correlates of working memory performance in primary insomnia, Sleep, 36, 1307, 10.5665/sleep.2952 · DOI
  64. Stoffers, 2014, The caudate: a key node in the neuronal network imbalance of insomnia?, Brain, 137, 610, 10.1093/brain/awt329 · DOI
  65. Spiegelhalder, 2014, Reduced anterior internal capsule white matter integrity in primary insomnia, Hum Brain Mapp, 35, 3431, 10.1002/hbm.22412 · DOI
  66. Baglioni, 2014, Insomnia disorder is associated with increased amygdala reactivity to insomnia-related stimuli, Sleep, 37, 1907, 10.5665/sleep.4240 · DOI
  67. Harvey, 2002, A cognitive model of insomnia, Behav Res Ther, 40, 869, 10.1016/S0005-7967(01)00061-4 · DOI · Paper page
  68. Sämann, 2011, Development of the brain‘s default mode network from wakefulness to slow wave sleep, Cereb Cortex, 21, 2082, 10.1093/cercor/bhq295 · DOI · Paper page
  69. Morin, 2009, Cognitive behavioral therapy, singly and combined with medication, for persistent insomnia, JAMA, 301, 2005, 10.1001/jama.2009.682 · DOI · Paper page
  70. Krystal, 2010, Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia, Sleep Med, 33, 669
  71. Troxel, 2012, Clinical management of insomnia with brief behavioral treatment (BBTI), Behav Sleep Med, 10, 266, 10.1080/15402002.2011.607200 · DOI
  72. Kripke, 2009, Do hypnotics cause death and cancer? The burden of proof, Sleep Med, 10, 275, 10.1016/j.sleep.2009.01.002 · DOI · Paper page
  73. Michelson, 2014, Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial, Lancet Neurol, 13, 461, 10.1016/S1474-4422(14)70053-5 · DOI · Paper page
  74. Riemann, 2014, Orexin receptor antagonists: a new treatment for insomnia?, Lancet Neurol, 13, 441, 10.1016/S1474-4422(13)70311-9 · DOI
  75. Broese, 2012, α-adrenergic receptor function, arousal and sleep: mechanisms and therapeutic implications, Pharmacopsychiatry, 45, 209, 10.1055/s-0031-1299728 · DOI
  76. Nofzinger, 2011, Frontal cerebral thermal transfer as a treatment for insomnia: a dose-ranging study, Sleep, 34, A0534
  77. Schabus, 2014, Enhancing sleep quality and memory in insomnia using instrumental sensorimotor rhythm conditioning, Biol Psychol, 95, 126, 10.1016/j.biopsycho.2013.02.020 · DOI

Cited by

Metadata

Authors
Riemann, D., Nissen, C., Palagini, L., Otte, A., Perlis, M. L., & Spiegelhalder, K.
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2015-05
Volume
14
Issue
5
Pages
547-558
ISSN
1474-4422 (ISSN-L)
OpenAlex
W2016332473
Cited by
628
References
30
FWCI
58.43
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.