Cited by 500Probiotics and Fermented FoodsGut microbiota and healthGastrointestinal motility and disorders

The DOI matches its Crossref record; 231 of the 232 references it cites were found in a registry or an index.

Can probiotics modulate human disease by impacting intestinal barrier function?

Open access

Bron, Peter A., Kleerebezem, Michiel, Brummer, Robert-Jan, Cani, Patrice D., Mercenier, Annick, MacDonald, Thomas T., Garcia-Ródenas, Clara L., Wells, Jerry M.·2017·British Journal Of Nutrition

DOI 10.1017/s0007114516004037PMC PMC5297585

Open this paper in CoChat — free account Open PDF

Abstract

Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease. The notion that specific probiotic bacterial strains can affect barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are used to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorises the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1017/s0007114516004037

Cites

231 of 231 references verified0 citation errors · 0 not checkable

Statistics

Fig. 1 Direct and indirect mechanisms by which commensals or probiotics can antagonise pathogens. Graphical display of exemplary direct (a) and indirect (b) mechanisms of barrier function modulation by bacterial (probiotic) interaction. (a) Direct mechanisms of barrier function modulation by interaction of commensals and probiotics. Bacteria can compete with enteric pathogens by competition for carbohydrates depending on the diet( 227 ). A probiotic strain of Lactobacillus salivarius UCC118 produces a bacteriocin in vivo that can significantly protect mice against infection with the invasive foodborne pathogen Listeria monocytogenes ( 36 ). In diverse Bacteroides species, a type VI secretion system (T6SS) mediates cell-contact-dependent mechanisms of inter-bacterial antagonism via the export antibacterial proteins( 228 ). Probiotics have been shown to inhibit the colonisation of pathogens through competition for common receptors of adhesion( 48 ). (b) Indirect mechanisms of pathogen antagonism. Recognition of microbe-associated molecular patterns by host pattern recognition receptors such as TLR and NLR activate immune defences and protect against infection. TLR signalling induces expression of defensins in enterocytes and antimicrobial factors in Paneth cells via the myeloid differentiation primary response 88 (MYD88) activation of NF-κB leading to the production of antimicrobial peptides. Similarly, nucleotide-binding oligomerisation domain 2 (NOD2) recognition of bacterial peptidoglycan induces cryptdin expression by Paneth cells. Sensing of an unknown signal from commensal microbes stimulates type 3 innate lymphoid cells (ILC) to secrete IL-22, which signals through the receptor (IL-22R) on intestinal epithelial cells to increase expression of the fucosyltransferase (FUT), mucin expression and antimicrobials, including regenerating family member 3 (Reg3) proteins. Segmented filamentous bacteria (SFB) closely associate with the ileum epithelium and stimulate maturation of the B- and T-cell compartments leading to enhanced IgA production by B cells and serum amyloid A (SAA)-dependent T helper 17 (Th17) cell differentiation. Th17 cells produce inflammatory cytokines and IL-22, which stimulate innate immune defence mechanisms to fight off infections.CC BY-NC-ND · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Lactobacillus bulgaricus Prevents Intestinal Epithelial Cell Injury Caused by Enterobacter sakazakii -Induced Nitric Oxide both In Vitro and in the Newborn Rat Model of Necrotizing Enterocolitis
Hunter, C. J., Williams, M., Petrosyan, M., Guner, Y. S., Mittal, R., Mock, D. C., Upperman, J. S., Ford, H. R., & Prasadarao, N. V. (2008) · Infection and Immunity · doi:10.1128/iai.01192-08 · Cited by 60 · cited 1×
“Probiotics were also shown to enhance enterocyte proliferation and migration((148)), to reduce apoptosis and promote epithelial cytoprotective responses((160,162,163)), to improve the expression of the enterocyte injury markers intestinal-type and liver-type fatty-acidbinding proteins (I-FABP and L-FABP)((164)), to re…”
Background
Retracted
The “Golden Age” of Probiotics: A Systematic Review and Meta-Analysis of Randomized and Observational Studies in Preterm Infants
Dermyshi, E., Wang, Y., Yan, C., Hong, W., Qiu, G., Gong, X., & Zhang, T. (2017) · Neonatology · doi:10.1159/000454668 · Cited by 24,586
Untitled work
Hill (2014) · doi:10.1038/nrgastro.2014.66 · Cited by 9,592 · cited 1×
“The latter are defined as ‘live micro-organisms that, when administered in adequate amounts, confer a health benefit on the host’((5,6)).”
Background
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Self-citation
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · cited 1×
“anti-inflammatory properties, Reg3γ, and increased the mucus layer thickness((120,121)).”
Background
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752

Show all 232 references

Research works printed but not linked: 1

10.1172/JCI20514 · DOI · Paper page

Sorted by citations

Items 301–400 of 500

Impact of probiotics in alleviating type 2 diabetes risk in clinical trials: A meta-analysis study
Singh, J., ., P., Kumar, P., Singh, J., & Dhanda, S. (2023) · Human Gene · doi:10.1016/j.humgen.2023.201149 · Cited by 7
Age and aging process alter the gut microbes
Zhanbo, Q., Jing, Z., Han, S., Wu, Y., Chu, J., Yu, X., Zhao, F., Liu, J., Wu, X., Wu, W., et al. (2024) · Aging · doi:10.18632/aging.205728 · Cited by 7
Microbes as a tool to defend against antibiotic resistance in food animal production
BHUNIA, A. K. (2019) · Indian Journal of Animal Health · doi:10.36062/ijah.58.2spl.2019.01-18 · Cited by 7
“…production of antimicrobial compounds (acids, bacteriocins), competitive exclusion and colonization resistance, immunomodulation and improved epithelial barrier function to prevent pathogen invasion (Pagnini et al. , 2010; Amalaradjou and Bhunia, 2012; Bron et al. , 2017; Ryan and Bhunia, 2017).”
[A machine learning model based on initial gut microbiome data for predicting changes of Bifidobacterium after prebiotics consumption].
Luo, Y.-M., Liu, F.-T., Chen, M.-X., Tang, W., Yang, Y., Tan, X.-L., & Zhou, H. (2018) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-4254.2018.03.03 · Cited by 7
The Immunomodulatory Role of Microbiota in Rheumatic Heart Disease: What Do We Know and What Can We Learn from Other Rheumatic Diseases?
Kohil, A., Abdalla, W., Ibrahim, W. N., Al-Harbi, K. M., Al-Haidose, A., Al‐Asmakh, M., & Abdallah, A. M. (2023) · Medicina · doi:10.3390/medicina59091629 · Cited by 7
“, short-chain fatty acids, SCFAs) to regulate the immune system and improve health [92,93].”
Background
Protective Effect of Lactobacillus fermentum on Lead-induced Hematological and Body Weight Alterations in Rats
Ghazanfarpour, E., Fatemi, M., & Ghandehari, F. (2019) · Iranian Journal of Toxicology · doi:10.32598/ijt.13.3.596.1 · Cited by 7
Development of a freeze-dried symbiotic obtained from rice bran
Ferronatto, A. N., Rossi, R. C., Pinto, L. M. N., & Garavaglia, J. (2021) · Biotechnology Reports · doi:10.1016/j.btre.2021.e00636 · Cited by 7
Efficacy of a Novel Therapeutic, Based on Natural Ingredients and Probiotics, in a Murine Model of Multiple Food Intolerance and Maldigestion
Ardizzone, A., Lanza, M., Casili, G., Campolo, M., Paterniti, I., Cuzzocrea, S., & Esposito, E. (2022) · Nutrients · doi:10.3390/nu14112251 · Cited by 7
“These positive outcomes are attributable to the modulation of intestinal bacteria activities and to protective barrier properties exerted on the intestinal mucosa [59,60]; which led to a restoration of the intestinal epithelial barrier.”
Background
Microbes in food to treat and prevent disease
Reid, G. (2018) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2018.1429217 · Cited by 7
Probiotics: mechanism of action and gastrointestinal health: gut guardians: unlocking the power of probiotics
Rana, A., & Smriti (2026) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70275 · Cited by 7
“31,49 Probiotics possess an anti-in ﬂ ammatory and pro-in ﬂ ammatory effect as a result of binding to the receptors present on the surface of epithelial cells of the intestine and inducing an antibody-mediated or cellular immune response.”
Effects of Combined Live Bifidobacterium, Lactobacillus, Enterococcus, and Bacillus Cereus Tablets on the Structure and Function of the Intestinal Flora in Rabbits Undergoing Hepatic Artery Infusion Chemotherapy
Yan, X.-D., Bai, L., Lv, J., Qi, P., Song, X., & Zhang, L. (2024) · Biology · doi:10.3390/biology13050327 · Cited by 6
“Probiotics can increase the proportion of beneficial bacteria, regulate the balance of intestinal flora, reduce the levels of inflammatory factors, and restore the intestinal barrier [13,14].”
Background
Tight junction proteins and intestinal health in preterm infants
Garg, P. M., Denton, M. X., Ravisankar, S. S., Herco, M., Shenberger, J. S., & Chen, Y. (2025) · Journal of Neonatal-Perinatal Medicine · doi:10.1177/19345798251349394 · Cited by 6
“31 In an in vitro study, pretreatment with pro-biotics before barrier disruption with LPS or EGTA resulted in increased transepithelial resistance (TER), implying improved tight junction function.”
Colorectal Cancer Mitigation Through Probiotics: Current Evidence and Future Directions
Chaturvedi, P., Pathak, R., Dayal, R., Parihar, H., Kaliyaperumal, K. A., & Tirumalai, P. S. (2025) · Current Microbiology · doi:10.1007/s00284-025-04297-9 · Cited by 7
“In Gram-negative bacteria, adhesins often appear as fimbriae or pili, like FimH and Type IV pili, which are crucial for mucosal colonization [37].”
Protective effect on intestinal barrier and cell viability of probiotic Lacticaseibacillus strain after simulated gastrointestinal digestion with dairy and vegetal products
Moreno, A., Meca, G., Esteban-Torres, M., & Escrivá, L. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107583 · Cited by 6
The gut microbiome as a rainforest: probiotic colonization resistance, functional effects, and next-generation strategies
Lewandowski, R. (2026) · FEMS Microbiology Letters · doi:10.1093/femsle/fnag035 · Cited by 6
Gut microbiota and autoimmune diseases: Insights from Mendelian randomization
Mu, F., Rusip, G., & Florenly, F. (2024) · FASEB BioAdvances · doi:10.1096/fba.2024-00037 · Cited by 6
“34,35 The dynamic relationship between the gut microbiota and the human immune system is fundamental for maintaining immunologic balance and preventing AID.”
Background
Impact of dairy food products on type 2 diabetes: Gut-pancreas axis for lower glucose level
Ağagündüz, D., Yılmaz, B., Cemali, Ö., Šimat, V., Akkuş, G., Kulawik, P., & Özoğul, F. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104741 · Cited by 7
The antiviral effects and underlying mechanisms of probiotics on viral infections
Javanshir, N., Ebrahimi, V., Mazhary, Z., Jahromi, B. S., Zuo, T., & Fard, N. A. (2025) · Microbial Pathogenesis · doi:10.1016/j.micpath.2025.107377 · Cited by 8
Effects of Oral and Vaginal Administration of Probiotic Bacteria on the Vaginal Microbiota and Cytokines Production in the Case of Experimental Staphylococcosis in Mice
Lazarenko, L. M., Babenko, L. P., Mokrozub, V. V., Demchenko, O. M., Bila, V. V., Spivak, M. Y., & DIAPROF, L. (2017) · Mikrobiolohichnyi Zhurnal · doi:10.15407/microbiolj79.06.105 · Cited by 6
“Traditionally, probiotics, based of commensal microbiota, in particular lactic acid bacteria (LAB) and bifidobacteria, are widely used for the treatment and prevention of intestinal or vaginal microbiota imbalance in many infectious and non-infectious human diseases [1, 2, 3, 4].”
Background
Probiotic Bacillus spp. enhance TLR3 ‐mediated TNF signalling in macrophages
Winther, K. D., Boll, E. J., Sandvang, D., & Williams, A. R. (2023) · Immunology · doi:10.1111/imm.13721 · Cited by 7
“The proposed beneficial effects of probiotics include improvement of intestinal barrier function [2, 3], interaction with resident microbiota by producing antimicrobial products [4, 5] or cross-feeding other resident microorganisms [ 3], and interaction with immune cells [6].”
Background
Probiotic research in neonates with congenital gastrointestinal surgical conditions – Now is the time
Rao, S. C., & Patole, S. (2018) · Microbial Biotechnology · doi:10.1111/1751-7915.13358 · Cited by 5
“Probiotics inhibit gut colonization with pathogenic bacteria (Sassone-Corsi and Raffatellu, 2015), enhance gut barrier function (Bron et al., 2017), facilitate colonization with healthy commensals (Garrido et al.”
Background
Interplay between Mediterranean Diet and Gut Microbiota in the Interface of Autoimmunity: An OverviewPreprint
Tsigalou, C., Tsolou, A., Konstantinidis, T. G., Zafiriou, E., Efthimios, D., Tsirogianni, A., & Bogdanos, D. P. (2020) · Preprints.org · doi:10.20944/preprints202001.0228.v1 · Cited by 5
Causation between the gut microbiota and inguinal hernia: a two-sample double-sided Mendelian randomization study
Wu, C., Zhu, Y., & Xi, H. (2024) · Scientific Reports · doi:10.1038/s41598-024-71253-1 · Cited by 5
“Certain probiotic strains have been documented to induce mucin-3 expression in intestinal epithelial cells 47 , promoting mucus production 48 and thereby contributing to the preservation of intestinal barrier integrity.”
Background
Bottom‐Up Design of Prebiotics and Probiotics: An Intestinal Microbiota‐Centered Approach to Chronic and Functional Constipation Management
He, P., Chen, S., Lyu, C., An, R., & Wang, D. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70140 · Cited by 6
Interplay between viral infections and gut microbiota dysbiosis: Mechanisms and therapeutic potential
Velikova, T. V., Ali, H., Batselova, H., Chervenkov, L., Miteva, D., Peruhova, M., Gulinac, M., Tomov, L., Mitova-Mineva, Y., & Velev, V. R. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i3.112437 · Cited by 6
Triple probiotics attenuate colitis via inhibiting macrophage glycolysis dependent pro-inflammatory response
Cai, H., Li, T., Feng, W., Wu, X., Zhao, Y., & Wang, T. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151128 · Cited by 5
Interaction Between Natural Products and Gut Microbiota
Ağagündüz, D., Cemali, Ö., & Çelik, E. (2022) · Current Pharmacology Reports · doi:10.1007/s40495-022-00309-5 · Cited by 6
Invitro inhibitory effect of Lactic acid bacteria isolated from Kunun zaki against multi-drug resistant diarrhogenic bacteria in HIV patients in Jos, Nigeria
Ngene, A. C., Musa, S., Egbere, O. J., Odu, C. E., Danladi, M. M. A., Onyimba, I. A., Dashen, M. M., Ochiheche, E., Nguhemen, H., & Ogaji, A. O. (2023) · Microbes and Infectious Diseases /Microbes and Infectious Diseases · doi:10.21608/mid.2023.175533.1418 · Cited by 6
Role of functional foods and nutraceuticals for depression, post-traumatic stress disorder, and suicidal behaviors
Kumar, P., Rai, S., & Joshi, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18951-7.00006-2 · Cited by 8
Probiotics as an Adjunct Approach to the Prevention and Treatment of Colon Cancer: A Review
Kumar, A., Goyal, N., Pramanik, J., Bawa, Y., Singh, S. K., & Prajapati, B. G. (2024) · Current Nutrition & Food Science · doi:10.2174/0115734013270901231124063616 · Cited by 5
The epithelium takes the stage in asthma and inflammatory bowel diseases
López-Posadas, R., Bagley, D., Pardo-Pastor, C., & Zapater, E. O. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1258859 · Cited by 5
“Thus, bacteria such as Bacillus subtilis (Li et al., 2020b; Ahl et al., 2016), or Lactobacillus spp (Bron et al., 2017) or the Lactobacillus reuteri alter mucin production.”
Background
Institutional review of the implementation and use of a Clostridium difficile infection bundle and probiotics in adult trauma patients
Bommiasamy, A. K., Connelly, C., Moren, A., Dodgion, C. M., Bestall, K., Cline, A., Martindale, R. G., Schreiber, M. A., & Kiraly, L. N. (2018) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2018.01.005 · Cited by 5
Effects of Bifidobacterium animalis ssp. lactis 420 on gastrointestinal inflammation induced by a nonsteroidal anti‐inflammatory drug: A randomized, placebo‐controlled, double‐blind clinical trial
Mäkelä, S. M., Forssten, S. D., Kailajärvi, M., Langén, V. L., Scheinin, M., Tiihonen, K., & Ouwehand, A. C. (2021) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14880 · Cited by 5
“Diarrhoea 5 (4) 2 (2) 5 (3) 5 (5) 4 (1) 5 (3) 10 (9) 6 (3)”
Influential
Effect of Probiotic Therapy on Hemodynamic Response Associated with Systemic Inflammatory Reaction and Antibiotic-Induced Dysbiosis in Chronic Experiments in Rats
Borshchev, Y. Y., Процак, Е. С., Burovenko, I. Y., Semenova, N. Y., Zubkov, I. G., & Galagudza, M. M. (2022) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-022-05455-w · Cited by 5
“The therapeutic potential of probiotics in the pathologies of higher nervous activity [4,5], cardiovascular [13] and digestive systems [7] is now actively studied.”
Background
Harnessing Probiotics: Emerging Strategies for Health and Disease Management
Parmar, B., Arya, R., & Patel, G. (2025) · Indian Journal of Microbiology · doi:10.1007/s12088-025-01478-9 · Cited by 5
Pinto Bean Supplementation Modulates Gut Microbiota and Improves Markers of Gut Integrity in a Mouse Model of Estrogen Deficiency
Olawale, F., Alake, S. E., Chandrashekar, R., Islam, P., Sutton, B., Chaffin, N., Ugo, C. H., Jin, J. B., Lightfoot, S. A., Debédat, J., et al. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.07.008 · Cited by 5
“Accumulating evidence has, however, shown that the use of prebiotics can indeed help improve gut barrier, which helps to prevent leakage of harmful substances such as pathogens and toxins, thereby improving health outcomes [51].”
Millet-based probiotic beverages: a comprehensive review of nutritional potential and applications in extended and challenging environments
Janani, B., & Adeyeye, S. A. O. (2025) · Nutrition & Food Science · doi:10.1108/nfs-04-2025-0131 · Cited by 4
The Effects of the Crohn's Disease Exclusion Diet (CDED) Alone Versus CDED Plus Partial Enteral Nutrition (PEN) on Gut Microbiome Composition in Pediatric CD Patients
Rohani, P., Ansari, A., Shaygantabar, M., Hekmatdoost, A., & Sohouli, M. H. (2025) · MicrobiologyOpen · doi:10.1002/mbo3.70099 · Cited by 4
Evaluating the Quality of Selected Commercial Probiotic Products, Both Dietary Supplements and Foods for Special Medical Purposes
Zawistowska-Rojek, A., Rybak, J., Smoleń, P., Kociszewska, A., Rudnicki-Velasquez, P. B., Węgrzyńska, K., Zaręba, T., Tyski, S. S., & Baraniak, A. (2026) · Foods · doi:10.3390/foods15020373 · Cited by 5
Probiotics and prebiotics, including fibers and medicinal foods
Jana, T., Acker, B. W., & Cash, B. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813037-7.00042-x · Cited by 4
Sucralfate enemas reduce the oxidative tissue damage and preserves the contents of E-cadherin and ?-catenin in colonic mucosa without fecal stream
Sato, D. T., Campos, F. G., Kotze, P. G., Mendonça, R. L. D. S., Kanno, D. T., Pereira, J. A., & Martinez, C. A. R. (2021) · Acta Cirúrgica Brasileira · doi:10.1590/acb361007 · Cited by 4
Faecal markers of intestinal inflammation in slum infants following yogurt intervention: A pilot randomized controlled trial in Bangladesh
Jannat, K., Kader, M. A., Parvez, S. M., Thomson, R. J., Rahman, M. M., Kabir, M., Agho, K., Haque, R., & Merom, D. (2023) · Frontiers in Microbiomes · doi:10.3389/frmbi.2023.1029839 · Cited by 4
“Probiotics can in ﬂ uence gut barrier functions in various ways; these include controlling mucus production, preventing bacterial adhesion, enrichment of tight junctions, increasing cell survival, and inducing defense mechanisms (O ’ Flaherty et al., 2010; Bron et al., 2017).”
Effect of Morchella esculenta polysaccharides on the rectal microbiota of mice challenged with lipopolysaccharides
Zhang, Y., Qiu, R., Zhang, Z., Almutairi, M. H., Nawaz, S., & Dong, S. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1446924 · Cited by 4
The Efficacy of Probiotics Supplementation on the Quality of Life of Patients with Gastrointestinal Disease: A Systematic Review of Clinical Studies
Moludi, J., Saber, A., Arab‐Zozani, M., Moradi, S., Azamian, Y., Hajiahmadi, S., Pasdar, Y., & Moradi, F. (2024) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2024.29.3.237 · Cited by 5
“…includes the following: improving mucus secretion, producing antimicrobial peptides, maintaining the function of the gastric-intestinal-epithelial barrier, and ensuring proper interaction between intestinal microbiota and mucosal immune cells (Bron et al., 2017; López-Moreno et al., 2020).”
Background
Research Progress of Intestinal Flora and Health
杨, 丽. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.115319 · Cited by 4
Antidiabetogenic mechanisms of probiotic action in food matrices: A review
Castro, V. M. R., & Luchese, R. H. (2022) · PharmaNutrition · doi:10.1016/j.phanu.2022.100302 · Cited by 4
Atypical Viral Infections in Gastroenterology
Crnčević, N., Rifatbegović, Z., Hukić, M., Deumić, S., Pramenković, E., Selimagić, A., Gavrankapetanović, I., & Avdić, M. (2022) · Diseases · doi:10.3390/diseases10040087 · Cited by 4
“Although it can be challenging to apply the findings of in vitro and animal studies to human populations, numerous studies indicate that probiotics can enhance mucosal barrier function [22].”
Background
Probiotics in the treatment of gastrointestinal diseases
Przerwa, F., Kukowka, A., Kotrych, K., & Uzar, I. (2021) · Herba Polonica · doi:10.2478/hepo-2021-0012 · Cited by 4
“This weakens the growth of colonies of potentially dangerous bacteria, limiting the development of their pathogenic potential [15].”
Background
The role of probiotics in maintaining immune homeostasis
Thipe, V. C., Mentor, S., de Lima, C. S. A., de Freitas, L. F., Fonseca, A. C. M., Nogueira, K. M., Rodrigues, A. S., Batista, J. G. S., Ferreira, A. H., & Lugão, A. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00024-6 · Cited by 4
Influence of the Microbiota Through the Gut-Brain Axis in Neurological Diseases
Guarnotta, V., Mandarino, F. V., Fasulo, E., Maida, M. F., Laterza, L., Sferrazza, S., Raimondo, D., & Sinagra, E. (2024) · Integrated science · doi:10.1007/978-3-031-73061-0_20 · Cited by 3
Lactiplantibacillus plantarum HCS03-001 and Lacticaseibacillus paracasei HCS17-040 Synergize to Combat Helicobacter pylori Colonization and Gastric Inflammation
Liu, Y., Lin, Z., Yang, M., Chen, X., He, Y., Zheng, P., Li, M., & Lü, M. (2025) · Infectious Microbes & Diseases · doi:10.1097/im9.0000000000000187 · Cited by 3
Microbial modulators of the mind: probiotic interventions in hippocampal neurogenesis and cognitive flexibility
Zhao, J., Liu, H., & Badehnoosh, B. (2025) · Antonie van Leeuwenhoek · doi:10.1007/s10482-025-02162-0 · Cited by 4
“…gut microbial homeostasis, boosting the diversity of the intestinal microbiota, and enhancing the structural and functional integrity of the gut barrier, a critical selective filter between the gut lumen and the internal host environment (Liang et al. 2018; Gou et al. 2022; Bron et al. 2017).”
Effect of multistrain probiotics on symptom severity in irritable bowel syndrome: a systematic review and meta-analysis of irritable bowel syndrome–symptom severity score outcomes
Anwar, D. F. F., Salma, Z. N., Oktaviani, S. D., Adiyatma, F. N., Tauhid, F. M., Mustofa, A., Saputra, P. B. T., Karimah, R., & Alkaff, F. F. (2025) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000003074 · Cited by 3
“Furthermore, improved intestinal barrier function achieved through probiotic action prevents the entry of luminal antigens, reducing immune activation and restoring mucosal integrity, ultimately contributing to lower pain frequency and severity [51].”
Fermented food microbiome: influence on oral and gut microbiota, and human health
Kim, D., Joe, H.-I., Bae, J., Wu, G. D., Compher, C. W., & Koo, H. (2026) · Nature Reviews Microbiology · doi:10.1038/s41579-026-01333-8 · Cited by 4
“…microorganisms are generally not considered long-term gut residents; instead, their ability to tolerate stress might support their transient passage through the gastrointestinal tract and the opportunity to establish localized interactions with resident communities and mucosal surfaces 23,89 .”
The natural symbiotic bacterium Enterococcus faecalis LX10 drives Bombyx mori refractoriness to Nosema bombycis infection via the secretion of enterococcin
Zhang, X., Yang, L., Cai, T., Liao, H., Cai, P., Zhao, X., Gu, N., Yue, Z., Gu, Y., Zhang, F., et al. (2025) · BMC Microbiology · doi:10.1186/s12866-025-03980-y · Cited by 3
Xylose-Oligosaccharide Alleviating Type 2 Diabetes in Mice via Reducing Blood Glucose, Oxidative Stress, Inflammation and Regulating Intestinal Microbiota
Li, X., Xia, X., Cai, Z., Pang, X., Sun, J. Y., & Lu, Y. (2025) · Foods · doi:10.3390/foods14122093 · Cited by 3
In Vitro Analysis of an Alkalihalobacillus clausii Spore-Based Probiotic Formulation Clarifies the Mechanisms Underlying Its Beneficial Properties
Mazzantini, D., Calvigioni, M., Celandroni, F., Saba, A., & Ghelardi, E. (2025) · Biomolecules · doi:10.3390/biom15091294 · Cited by 4
The Role of Probiotics in the Prevention of Necrotizing Enterocolitis
Trivić, I., Mlakar, A. S., & Hojsak, I. (2019) · Current Pediatric Reviews · doi:10.2174/1573396315666181224123223 · Cited by 3
Efficacy and Safety of Probiotic Bacillus coagulans-SNZ 1969 in Gastrointestinal Discomfort: A Randomized, Placebo-Controlled Study
Soman, R. J., Singh, K., & Swamy, M. V. (2022) · International Journal of Health Sciences and Research · doi:10.52403/ijhsr.20220336 · Cited by 3
Dysbiosis in Multiple Sclerosis: Can Immunoglobulin Y Supplements Help?
Paraschiv, A.-C., Văcăraș, V., Nistor, C., Văcăraș, C., Nistor, D.-T., Vesa, Ș. C., Iluţ, S., & Muresanu, D. F. (2024) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-5241 · Cited by 3
Catalase-mimetic gold nanoparticles inhibit the antagonistic action ofLactobacillus gasseritoward foodborne enteric pathogens in associative cultures
Zhu, S., Zeng, M., Guo, W. Y., Feng, G., & Wu, H. (2019) · Journal of Environmental Science and Health Part C · doi:10.1080/10590501.2019.1591698 · Cited by 3
Probiotics in Experimental Ulcerative Colitis: Mast Cell Density and Neuronal Hypertrophy
Hizay, A., Çelik, N. K., Acar, N., Göçer, E. M. Ç., Şekerci, R., Öz, N., Golal, E., & Elpek, G. Ö. (2022) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2022.21550 · Cited by 3
Probiotics Action Against Biofilms
Memar, M. Y., Saadat, Y. R., Hejazian, S. M., Ardalan, M., Ahmadian, E., & Vahed, S. Z. (2022) · Springer series on biofilms · doi:10.1007/978-3-031-10992-8_5 · Cited by 3
Clinical significance of perioperative probiotic intervention on recovery following intestinal surgery
Wu, Y., Zhang, X., Wang, G., & Jiao, Y. (2025) · World Journal of Gastrointestinal Surgery · doi:10.4240/wjgs.v17.i2.97503 · Cited by 5
“Additionally, probiotics compete with pathogens for survival resources, utilize common receptors for epithelial adhesion to inhibit infection, and increase the output of antimicrobial proteins[43].”
Antibiotic-Associated Diarrhea and Update on Probiotics Recommendations
Henry, D. E., & Rao, V. V. (2021) · Springer eBooks · doi:10.1007/978-981-33-6236-9_6 · Cited by 2
Lactic acid bacteria (LAB) strains modulate inflammatory genes in RTgutGC cells, and triploid Chinook salmon (Oncorhynchus tshawytscha) challenged with V. anguillarum
Soto‐Dávila, M., Langlois, L., Rodríguez‐Ramos, T., Hawey, C., McKenzie, E., Dixon, A. G., Reid, G., & Dixon, B. (2025) · Comparative Immunology Reports · doi:10.1016/j.cirep.2025.200244 · Cited by 2
“Probiotic-mediated improvement of gut barrier function has been positively associated with health benefits in several vertebrate species [69].”
Assessment of the role of probiotics in prevention of ventilator-associated pneumonia in neonates
Khodair, H. A., Elmahdy, H. S., Zidan, L. K., Elashry, S. M., & Elmashad, A. (2025) · European Journal of Pediatrics · doi:10.1007/s00431-025-06380-6 · Cited by 2
Bacterial fructan-metabolizing enzymes: modular architecture and biotechnological potential
Siziya, I. N., Seo, M., Park, C.-S., & Jung, D.-H. (2026) · 3 Biotech · doi:10.1007/s13205-026-04695-1 · Cited by 3
“Harmo-nizing global standards and developing clear guidelines for enzyme-enriched functional foods would support broader market access (Hill et al. 2014; Angelin and Kavitha 2020; Berstad et al. 2016; Bron et al. 2017).”
Membrane Vesicles from Lactobacillus acidophilus Promote Superior Cytokine Modulation and Antimicrobial Signaling Compared with Their Whole Cells in RAW 264.7 Macrophages
Sosa, C. D. L., Díaz, F. R. G., Álvarez, H. R., Ruíz, A. V., Higuera-Piedrahita, R. I., de la Crúz-Crúz, H. A., Cuéllar-Ordaz, J. A., Rico, G. R., Negrete‐Abascal, E., Reyes‐López, M., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062764 · Cited by 2
“The interaction between probiotic bacteria and the innate immune system has garnered considerable interest due to its potential to modulate inflammatory and antimicrobial responses in mucosal epithelial tissues [1,2].”
From testosterone to 11-oxygenated androgens: Integrating endocrine biology, nutrition, and systemic health across the lifespan
Xu, H., Zhang, H., Yang, R., Xie, X., Cao, Z., Zhao, Y. (., Lin, H., Lu, D., Bischoff, F. Z., Zhang, X., et al. (2026) · The Innovation Nutrition · doi:10.59717/j.xinn-nutri.2026.100004 · Cited by 2
The Role of Probiotics Prophylaxis Duration in Preventing Necrotizing Enterocolitis: A Single-Center Retrospective Study
Zhu, K., Yuan, L., Gao, H. J., Wang, X., Wang, J., Wang, L., & Deng, F. (2021) · Iranian Journal of Pediatrics · doi:10.5812/ijp.114996 · Cited by 2
İnsan bağırsak mikrobiyomunu COVID-19 için tedavi stratejileriyle ilişkilendiren mekanizmalar
Akın, N., & Özışık, D. (2023) · Uludağ Üniversitesi Ziraat Fakültesi dergisi/Bursa uludağ üniversitesi ziraat fakültesi dergisi · doi:10.20479/bursauludagziraat.1276832 · Cited by 2
[Retracted] Probiotics from Dairy Products on Intestinal Barrier Function Using Caco‐2 Cells under Microscope
Yao, P., Jiang, J., & Kong, Z. (2022) · BioMed Research International · doi:10.1155/2022/6293095 · Cited by 2
Retracted
Probiotics and Prebiotics in Healthy Ageing
Kadam, A., Kadam, D., Tungare, K., & Shah, H. S. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-83017-5_5 · Cited by 2
Dysbiosis and probiotic applications in autoimmune diseases
de Salis, L. V. V., Martins, L. S. A., Rodrigues, G. S. P., & de Oliveira, G. L. V. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824390-9.00004-9 · Cited by 2
Colorectal cancer: risk factors and potential of dietary probiotics in its prevention
Arora, R., Sharma, S., & Kumar, B. (2022) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-022-00083-4 · Cited by 2
Translation of Immunomodulatory Effects of Probiotics into Clinical Practice
Ryan, J. C., Narasimha, S. V., Pattison, R., Zackria, R., Ghobrial, Y., Basit, S. A., Ammar, T. A. R. A., Jayaraman, V., Stone, C. D., & Shih, D. Q. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.109864 · Cited by 2
Analysis of hypoxia-associated dendritic cells in colitic mice and effects of probiotics on IL-10 production in inflammatory dendritic-cells under hypoxia
Ogita, T., Miyamoto, J., Hirabayashi, Y., Rossi, M., Mazzarella, G., Takahashi, I., Tanabe, S., & Suzuki, T. (2019) · Beneficial Microbes · doi:10.3920/bm2018.0171 · Cited by 2
Prebiotics and Probiotics
Ullah, H., Daglia, M., & Khan, H. Z. (2022) · Wiley eBooks · doi:10.1002/9781119746843.ch5 · Cited by 2
Nutraceuticals Approach as a Treatment for Cancer Cachexia
Chiocchetti, G. D. M. E., Viana, L. R., Lopes‐Aguiar, L., Miyaguti, N. A. D. S., & Gomes‐Marcondes, M. C. C. (2022) · Wiley eBooks · doi:10.1002/9781119746843.ch14 · Cited by 2
Syndrome of increased epithelial permeability: opportunities of current pharmacotherapy
Туркина, С. В., Стаценко, М. Е., & Андреевна, Т. И. (2023) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-204-8-123-132 · Cited by 1
Ageing-associated gut dysbiosis deteriorates mouse cognition
Ju, H., Zhou, Y., Wei, W., Yan, H., Fang, H., Chen, Z., Sun, X., Shi, Y. P., & Fang, H. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024217 · Cited by 1
“5), a marker of intestinal neurons [26,27], was lower in aged mice than in young mice.”
Ascertaining the claims and reality of probiotic usage as an adjuvant therapy against virus-induced respiratory tract infections
Banerjee, A., Pal, S., Das, A. K., & Dhar, P. (2025) · Food and Humanity · doi:10.1016/j.foohum.2025.100725 · Cited by 1
Gut Microbiota Composition in Adolescents From Mexico City, Associations With Nutritional and Socioeconomic Factors: Results From a Pilot Study
Navarro, A., Rodea, G. E., Cruz-Montoya, A. H. D. L., Díaz-Velásquez, C. E., Vaca‐Paniagua, F., del Prado, A. N.-C., Tirado-Gómez, L. L., Vilchis-Reyes, A., de la Torre, G. G., Cruz-Licea, V., et al. (2026) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70386 · Cited by 2
Avian cecal microbiome response and resilience to Newcastle disease are dictated by breed background
Ameer, A., Saleem, F., Keating, C., Afzal, F., Irshad, H., Ahmed, K. P., Sattar, S., Ijaz, U. Z., & Javed, S. (2026) · Frontiers in Systems Biology · doi:10.3389/fsysb.2025.1659648 · Cited by 1
Genome-Informed Characterization of Lactiplantibacillus plantarum ND88 with Inhibitory Activity against Representative Oral Pathogens
Kim, H., Lee, H. H., Song, S., Haque, M. A., Razzak, M. A., Jang, M. J., Maki, K., & Ku, S. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-10992-1 · Cited by 2
Genomic and Functional Characterization of a Novel Gut-Derived Member of the Genus Collinsella With Probiotic-Associated Potential
Shamsuzzaman, M., Dahal, R. H., & Kim, S.-M. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11008-8 · Cited by 1
“…non-pathogenic actinobacteria isolated from fecal samples, including Bifidobacterium and Corynebacterium species, have been reported to suppress nitric oxide production in LPS-stimulated macrophages, reflect - ing immunomodulatory responses rather than direct anti-inflammatory effects [ 52, 53].”
Hypsizygus marmoreus polysaccharides protect against cisplatin-induced intestinal mucositis via modulation of gut microbiota, inflammation, and intestinal barrier function
Abusidu, M., Alioui, Y., Al-tibi, L., Alwayli, D., Ali, S., Rahman, M. U., Farooqui, N. A., Atta, A., Feng, B. L., Lu, S., et al. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1774118 · Cited by 1
Comparison of Viable and Heat‐Inactivated Lacticaseibacillus rhamnosus IDCC 3201: Anti‐Pathogenic, Anti‐Inflammatory, and Microbiota Modulating Effect
Kim, H., Lee, H., Bang, W. Y., Park, H., & Moon, J. S. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71780 · Cited by 1
Lactobacillus salivarius GZPH2 reshapes hepatopancreatic microbiome structure and enhances immunometabolism in Litopenaeus vannamei under farm conditions
Najnine, F., Guo, X., & Cai, J. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1762396 · Cited by 1
Milk fat globule membrane from cow, goat, and human differentially modulate Lacticaseibacillus rhamnosus GG: Proteomic insights from human MFGM
Sangam, S., Surati, U., Kumar, S., Bharti, B., Singh, M. K., Mallappa, R. H., & Pradhan, D. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152391 · Cited by 1
Effect of probiotic supplementation on Clostridioides difficile stool concentration in hospitalized patients in coma: A preliminary study
Dowgiałło‐Gornowicz, N., Botulińska, A., Sosnowska-Turek, E., Garbowicz, M., Zarucka, E., & Siwik, P. (2026) · Polish Annals of Medicine · doi:10.31648/paom/213335 · Cited by 1
Gut microbiome–mediated bioactive ingredients and health benefits of medicinal and edible fermented products: A comprehensive review
Liu, C., Zhang, S., Yue, Q., Sun, X., Zheng, K., Li, K., Su, L., & Zhao, L. (2026) · Folia Microbiologica · doi:10.1007/s12223-026-01468-4 · Cited by 1
Role of the gut microbiota–bile acid axis in liver fibrosis based on microbiomics and targeted metabolomics
Zhang, Y.-L., Gou, H.-Z., Li, Z.-J., Xi, J.-H., Wang, X.-J., Shang, J., Zhu, D., Ren, L., Shu, X.-J., & (38117), L. Z. (2026) · BMC Microbiology · doi:10.1186/s12866-026-05224-z · Cited by 1
“Currently, probiotics have good efficacy in the treatment of enterohepatic diseases due to their important functions such as improving the disordered state of GM and their metabolites, repairing the gut barrier, and regulating the body’s immunity [122, 123].”
Viable and Heat-Inactivated Bifidobacterium bifidum MIMBb75 Protect the Intestinal Barrier
Storr, M., & Gschwender, M. (2026) · Microorganisms · doi:10.3390/microorganisms14061349 · Cited by 1
Paradigm Shift of Microbiota-gut-brain Axis During Aging: Potential Role of Probiotics to Improve Cognitive Decline
Dutta, S., Dutta, T. K., Nanda, P. K., Dhar, P., Das, A. K., & Bhunia, A. K. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11136-1 · Cited by 2
Probiotic Characterization of Lactic Acid Bacteria Isolated from Traditional Pickles: A Functional and Safety Assessment
Aktaş, H., Aktaş, H. M., Karaman, M., & Çeti̇n, B. (2026) · Brazilian Archives of Biology and Technology · doi:10.1590/1678-4324-2026240325 · Cited by 1
Genome-wide safety evaluation and functional characterization of a fermentation strain for Mi Zhen
Shi, M., Guo, T., Lin, F., & Lin, Q. (2026) · Applied Food Research · doi:10.1016/j.afres.2026.102459 · Cited by 1
The Role of Gut Microbiota Interventions in the Management of Frailty Syndrome: A Scoping Review and Bibliometric Analysis
Jiao, Y., Li, L., Ji, X., & Cheng, H. (2026) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.70734 · Cited by 1
Forkhead Box Protein O1 is Linked to Anti-Inflammatory Probiotic Bacteria Acting through Nuclear Factor-κB Pathway
Mulet, A. P., Perelmuter, K., Bollati‐Fogolín, M., Crispo, M., & Grompone, G. (2017) · Journal of Microbial & Biochemical Technology · doi:10.4172/1948-5948.1000347 · Cited by 1
“Probiotic effects together with commensal microbes are crucial in barrier integrity and mucosal homeostasis in different body sites like the skin or the gut, among others [26,27].”
Background

Authors: Bron, P. A., Kleerebezem, M., Brummer, R.-J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M.
Affiliations: Nederlands Instituut Voor Zuivel Oonderzoek (NL)
Wageningen University & Research (NL)
Örebro University (SE)
Walloon Excellence in Lifesciences and Biotechnology (BE)
Nestlé (Switzerland) (CH)
Queen Mary University of London (GB)
Corresponding author: Bron, Peter A.
ORCID: Bron, Peter A.
Kleerebezem, Michiel
Brummer, Robert-Jan
Cani, Patrice D.
Mercenier, Annick
Wells, Jerry M.
Venue: British Journal Of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2017-01-14
Volume: 117
Issue: 1
Pages: 93-107
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114516004037
PMC: PMC5297585
OpenAlex: W2573938105
Cited by: 499
References: 232
Citations by year: 2026: 54 · 2025: 47 · 2024: 55 · 2023: 52 · 2022: 64 · 2021: 67 · 2020: 54 · 2019: 43 · 2018: 42 · 2017: 19
FWCI: 4.68
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (unspecified, 5 d)
Locations: British Journal Of Nutrition (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc-nd)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by-nc-nd)
Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
Funders: Fonds De La Recherche Scientifique - FNRS (WELBIO-CR-2012S-02R)
Walloon excellence in life sciences and biotechnology
FP7 Ideas: European Research Council (336452)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: probiotics, intestinal barrier function, epithelial barrier integrity, mucosal homeostasis, gastrointestinal diseases, irritable bowel syndrome, inflammatory bowel disease, necrotizing enterocolitis, obesity, diabetes mellitus, pathogen infection
MeSH terms: Animals, Humans, Intestinal Diseases, Intestines, Probiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Can probiotics modulate human disease by impacting intestinal barrier function?

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks