Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study
Abstract
Background: Despite increasing awareness of the extent and severity of cognitive deficits in major depressive disorder (MDD), trials of cognitive remediation have not been conducted. We conducted a 10-week course of cognitive remediation in patients with long-term MDD to probe whether deficits in four targeted cognitive domains, (i) memory, (ii) attention, (iii) executive functioning and (iv) psychomotor speed, could be improved by this intervention. Method: We administered a computerized cognitive retraining package (PSSCogReHab) with demonstrated efficacy to 12 stable patients with recurrent MDD. Twelve matched patients with MDD and a group of healthy control participants were included for comparison; neither comparator group received the intervention that involved stimulation of cognitive functions through targeted, repetitive exercises in each domain. Results: Patients who received cognitive training improved on a range of neuropsychological tests targeting attention, verbal learning and memory, psychomotor speed and executive function. This improvement exceeded that observed over the same time period in a group of matched comparisons. There was no change in depressive symptom scores over the course of the trial, thus improvement in cognitive performance occurred independent of other illness variables. Conclusions: These results provide preliminary evidence that improvement of cognitive functions through targeted, repetitive exercises is a viable method of cognitive remediation in patients with recurrent MDD.
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Cognitive remediation therapies have proven effective in other psychiatric populations.
“cognitive remediation therapies that have proven effective in other psychiatric populations (Bowie et al., 2013;Deckersbach et al., 2010;Elgamal et al., 2007;Kurtz, 2012;Wykes et al., 2011)”
From A review of the relation between dissociation, memory, executive functioning and social cognition in military members and civilians with neuropsychiatric conditions (2016) · cites this paper as Elgamal et al., 2007
Data from studies evaluating the impact of cognitive remediation therapy on cognitive performance in major depressive disorder indicate a positive effect on neuropsychological tasks of attention, verbal learning and memory, psychomotor speed, and executive function.
“For example, data from studies evaluating the impact of cognitive remediation therapy on cognitive performance in MDD indicate a positive effect on neuropsychological tasks of attention, verbal learning and memory, psychomotor speed, and executive function [189, 190].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [189]
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- Authors
- ELGAMAL, S., McKINNON, M. C., RAMAKRISHNAN, K., JOFFE, R. T., & MacQUEEN, G.
- Affiliations
- McMaster University (CA)
- University of Medicine and Dentistry of New Jersey (US)
- Corresponding author
- MacQUEEN, GLENDA
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-07-05
- Volume
- 37
- Issue
- 9
- Pages
- 1229-1238
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2112005691
- Cited by
- 141
- References
- 39
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 8 · 2017: 15 · 2016: 13 · 2015: 23 · 2014: 11 · 2013: 9 · 2012: 8
- FWCI
- 2.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- cognitive remediation, major depressive disorder, computerized cognitive training, cognitive impairment, memory, attention, executive function, psychomotor speed, verbal learning, recurrent depression, long-term depression
- MeSH terms
- Adult, Attention, Cognition Disorders, Major Depressive Disorder, Female, Humans, Male, Memory Disorders, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Practice, Psychological, Problem Solving, Reaction Time, Remedial Teaching, Retention, Psychology, Therapy, Computer-Assisted, Treatment Outcome
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