The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Simultaneous Characterization of Perfluoroalkyl Carboxylate, Sulfonate, and Sulfonamide Isomers by Liquid Chromatography−Tandem Mass Spectrometry
Abstract
A comprehensive method was developed to simultaneously separate and detect perfluorinated acid (PFA) and PFA-precursor isomers using liquid chromatography-tandem mass spectrometry (LC-MS/MS). A linear perfluorooctyl stationary phase and acidified mobile phase increased separation efficiency, relative to alkyl stationary phases, for the many perfluoroalkyl carboxylate (PFCA), perfluoroalkyl sulfonate (PFSA), and perfluorooctyl sulfonamide (PFOSA) isomers and in combination with their distinct MS/MS transitions allowed full resolution of most isomers in standards. Utilizing the absence of the "9-series" and "0-series" product ions, several perfluorooctane sulfonate (C8F17SO3-, PFOS) isomers were structurally elucidated. In human serum, only perfluorooctane sulfonamide (C8F17SO2NH2, FOSA) and PFOS consisted of significant quantities of branched isomers, whereas PFCAs were predominantly linear. Interferences that coelute with the m/z 499 --> 80 transition of PFOS on alkyl stationary phases were simultaneously separated and identified as taurodeoxycholate isomers, removal of which permitted the use of the more sensitive m/z 80 product ion and a resulting 20-fold decrease in PFOS detection limits compared to the m/z 499 --> 99 transition (0.8 pg versus 20 pg using m/z 80 and 99, respectively). Interferences in human serum which caused a 10-20-fold over-reporting of perfluorohexane sulfonate (C6F13SO3-, PFHxS) concentrations on alkyl stationary phases were also simultaneously separated from linear PFHxS and identified as endogenous steroid sulfates. PFOSA isomers, generated with human microsomes, had different rates of metabolism, suggesting that the perfluoroalkyl branching pattern may affect the biological properties of individual isomers. This fact, and for reasons of improved accuracy and sensitivity, investigators are urged to utilize more efficient separation methods capable of isomer characterization in perfluoroalkyl research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Global Distribution of Perfluorooctane Sulfonate in Wildlife
Giesy, J. P., & Kannan, K. (2001) · Environmental Science & Technology · doi:10.1021/es001834k · Cited by 2,750
D'eon, J. C., Hurley, M. D., Wallington, T. J., & Mabury, S. A. (2006) · Environmental Science & Technology · doi:10.1021/es0520767 · Cited by 300
Ratio of perfluorochemical concentrations as a tracer of atmospheric deposition to surface waters
Simcik, M. F., & Dorweiler, K. J. (2005) · Environmental Science & Technology · doi:10.1021/es0511218 · Cited by 202
Cited by
Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641
Polyfluorinated Compounds: Past, Present, and Future
Lindstrom, A. B., Strynar, M. J., & Libelo, E. L. (2011) · Environmental Science & Technology · doi:10.1021/es2011622 · Cited by 1,628
Monitoring of Perfluorinated Compounds in Aquatic Biota: An Updated Review: PFCs in Aquatic Biota
Houde, M., De Silva, A. O., Muir, D. C. G., & Letcher, R. J. (2011) · Environmental Science & Technology · doi:10.1021/es104326w · Cited by 847
Biomonitoring of Perfluoroalkyl Acids in Human Urine and Estimates of Biological Half-Life
Zhang, Y., Beesoon, S., Zhu, L., & Martin, J. W. (2013) · Environmental Science & Technology · doi:10.1021/es401905e · Cited by 530
Self-citationMartin, J. W., Asher, B. J., Beesoon, S., Benskin, J. P., & Ross, M. S. (2010) · Journal of Environmental Monitoring · doi:10.1039/c0em00295j · Cited by 311
Self-citationLabadie, P., & Chevreuil, M. (2011) · Environmental Pollution · doi:10.1016/j.envpol.2010.10.039 · Cited by 272
Schulz, K., Silva, M. R., & Klaper, R. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139186 · Cited by 259
Olsen, G. W., Mair, D. C., Church, T. R., Ellefson, M. E., Reagen, W. K., Boyd, T. M., Herron, R. M., Medhdizadehkashi, Z., Nobiletti, J. B., Rios, J. A., et al. (2008) · Environmental Science & Technology · doi:10.1021/es800071x · Cited by 244
Spatial Trends of Anionic, Zwitterionic, and Cationic PFASs at an AFFF-Impacted Site
Nickerson, A., Rodowa, A. E., Adamson, D. T., Field, J. A., Kulkarni, P. R., Kornuc, J. J., & Higgins, C. P. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c04473 · Cited by 228
Beesoon, S., & Martin, J. W. (2015) · Environmental Science & Technology · doi:10.1021/es505399w · Cited by 223
Self-citationYu, N., Guo, H., Yang, J., Jin, L., Wang, X., Shi, W., Zhang, X., Yu, H., & Wei, S. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b02492 · Cited by 200
Liu, Y., Pereira, A. D. S., & Martin, J. W. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b00039 · Cited by 209
Self-citationChen, X., Zhu, L., Pan, X., Fang, S., Zhang, Y., & Yang, L. (2015) · Water Research · doi:10.1016/j.watres.2015.04.032 · Cited by 163
Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues
Pan, Y., Wang, J., Yeung, L. W. Y., Wei, S., & Dai, J. (2020) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2019.04.013 · Cited by 133
Hong, S., Khim, J. S., Wang, T., Naile, J. E., Park, J., Kwon, B.-O., Song, S. J., Ryu, J., Codling, G., Jones, P. D., et al. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2014.06.023 · Cited by 125
Pan, C.-G., Ying, G.-G., Liu, Y.-S., Zhang, Q.-Q., Chen, Z.-F., Peng, F.-J., & Huang, G.-Y. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2014.04.005 · Cited by 121
Gao, Y., Liang, Y., Gao, K., Wang, Y., Wang, C., Fu, J., Wang, Y., Jiang, G., & Jiang, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.04.027 · Cited by 116
Frigerio, G., Cafagna, S., Polledri, E., Mercadante, R., & Fustinoni, S. (2022) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03762-1 · Cited by 80
Norén, E., Lindh, C., Glynn, A., Rylander, L., Pineda, D., & Nielsen, C. (2021) · Environment International · doi:10.1016/j.envint.2021.106716 · Cited by 75
Source Elucidation of Perfluorinated Carboxylic Acids in Remote Alpine Lake Sediment Cores
Benskin, J. P., Phillips, V., St. Louis, V. L., & Martin, J. W. (2011) · Environmental Science & Technology · doi:10.1021/es2011176 · Cited by 71
Self-citationChen, H., Reinhard, M., Nguyen, T. V., You, L., He, Y., & Gin, K. Y.-H. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.04.091 · Cited by 64
Tsou, K., Antell, E., Duan, Y., Olivares, C. I., Yi, S., Alvarez-Cohen, L., & Sedlak, D. L. (2023) · ACS ES&T Water · doi:10.1021/acsestwater.3c00224 · Cited by 53
Liu, Y., Pereira, A. S., Beesoon, S., Vestergren, R., Berger, U., Olsen, G. W., Glynn, A., & Martin, J. W. (2015) · Environment International · doi:10.1016/j.envint.2014.11.014 · Cited by 45
Self-citationShan, G., Chen, X., & Zhu, L. (2015) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2015.07.074 · Cited by 45
Metadata
- Authors
- Benskin, J. P., Bataineh, M., & Martin, J. W.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-08-01
- Volume
- 79
- Issue
- 17
- Pages
- 6455-6464
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2087232329
- Cited by
- 253
- References
- 3
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
