Shortwave-Infrared Fluorescent Molecular Imaging Probes Based on π-Conjugation Extended Indocyanine Green

Second window for in vivo imaging

Smith, A. M., Mancini, M. C., & Nie, S. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.326 · Cited by 2,848 · see citing works

Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer

von Minckwitz, G., Huang, C., Mano, M. S., Loibl, S., Mamounas, E. P., Untch, M., Wolmark, N., Rastogi, P., Schneeweiß, A., Redondo, A., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1814017 · Cited by 2,647 · see citing works

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

Coussens, L. M., Yang‐Feng, T. L., Liao, Y.-C., Chen, E., Gray, A., McGrath, J. P., Seeburg, P. H., Libermann, T. A., Schlessinger, J., Francke, U., et al. (1985) · Science · doi:10.1126/science.2999974 · Cited by 1,815 · see citing works

A small-molecule dye for NIR-II imaging

Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works

A Review of Indocyanine Green Fluorescent Imaging in Surgery

Alander, J., Kaartinen, I., Laakso, A., Pätilä, T., Spillmann, T., Tuchin, V., Venermo, M., & Välisuo, P. (2012) · International Journal of Biomedical Imaging · doi:10.1155/2012/940585 · Cited by 1,305 · see citing works

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

Baselga, J. M., Norton, L., Albanell, J., Kim, Y. M., & Mendelsohn, J. M. (1998) · PubMed · Cited by 996 · see citing works

Near-infrared absorbing dyes

FABIAN, J., Nakazumi, H., & Matsuoka, M. (1992) · Chemical Reviews · doi:10.1021/cr00014a003 · Cited by 968 · see citing works

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Zhu, S., Tian, R., Antaris, A. L., Chen, X. S., & Dai, H. (2019) · Advanced Materials · doi:10.1002/adma.201900321 · Cited by 968 · see citing works

Antibody–drug conjugates for cancer

Chau, C. H., Steeg, P. S., & Figg, W. D. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31774-x · Cited by 820 · see citing works

Fluorescence Properties and Metabolic Features of Indocyanine Green (ICG) as Related to Angiography

Desmettre, T. J., Devoisselle, J., & Mordon, S. R. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00123-5 · Cited by 762 · see citing works

Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green

Carr, J. A., Franke, D., Caram, J. R., Perkinson, C. F., Saif, M., Askoxylakis, V., Datta, M., Fukumura, D., Jain, R. K., Bawendi, M. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718917115 · Cited by 721 · see citing works

An Efficient 1064 nm NIR‐II Excitation Fluorescent Molecular Dye for Deep‐Tissue High‐Resolution Dynamic Bioimaging

Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658 · see citing works

A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

Antaris, A. L., Chen, H., Diao, S., Ma, Z., Zhang, Z., Zhu, S., Wang, J., Lozano, A. X., Fan, Q., Chew, L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15269 · Cited by 623 · see citing works

Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging

Ding, F., Zhan, Y., Lu, X., & Sun, Y. (2018) · Chemical Science · doi:10.1039/c8sc01153b · Cited by 540 · see citing works

Trastuzumab Emtansine: A Unique Antibody-Drug Conjugate in Development for Human Epidermal Growth Factor Receptor 2–Positive Cancer

LoRusso, P. M., Weiss, D., Guardino, E., Girish, S., & Sliwkowski, M. X. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0762 · Cited by 444 · see citing works

Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging

Cosco, E. D., Caram, J. R., Bruns, O. T., Franke, D., Day, R. A., Farr, E. P., Bawendi, M. G., & Sletten, E. M. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706974 · Cited by 415 · see citing works

Deep optical imaging of tissue using the second and third near-infrared spectral windows

Sordillo, L. A., Pu, Y., Pratavieira, S., Budansky, Y., & Alfano, R. R. (2014) · Journal of Biomedical Optics · doi:10.1117/1.jbo.19.5.056004 · Cited by 407 · see citing works

Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore

Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., et al. (2016) · Advanced Materials · doi:10.1002/adma.201600706 · Cited by 386 · see citing works

Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging

Li, B., Zhao, M., Feng, L., Dou, C., Ding, S., Zhou, G., Lu, L., Zhang, H., Chen, F., Li, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16924-z · Cited by 374 · see citing works

Repurposing Cyanine NIR‐I Dyes Accelerates Clinical Translation of Near‐Infrared‐II (NIR‐II) Bioimaging

Zhu, S., Hu, Z., Tian, R., Yung, B. C., Yang, Q., Zhao, S., Kiesewetter, D. O., Niu, G., Sun, H., Antaris, A. L., et al. (2018) · Advanced Materials · doi:10.1002/adma.201802546 · Cited by 349 · see citing works

Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time

Cosco, E. D., Spearman, A. L., Ramakrishnan, S., Lingg, J. G. P., Saccomano, M., Pengshung, M., Arús, B. A., Wong, K. C. Y., Glasl, S., Ntziachristos, V., et al. (2020) · Nature Chemistry · doi:10.1038/s41557-020-00554-5 · Cited by 343 · see citing works

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm

Tao, Z., Hong, G., Shinji, C., Chen, C., Diao, S., Antaris, A. L., Zhang, B., Zou, Y., & Dai, H. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201307346 · Cited by 330 · see citing works

Antibody–Drug Conjugates for Cancer Treatment

Lambert, J. M., & Berkenblit, A. (2018) · Annual Review of Medicine · doi:10.1146/annurev-med-061516-121357 · Cited by 314 · see citing works

Absolute Photoluminescence Quantum Yields of IR-26 Dye, PbS, and PbSe Quantum Dots

Semonin, O., Johnson, J. C., Luther, J., Midgett, A. G., Nozik, A., & Beard, M. (2010) · The Journal of Physical Chemistry Letters · doi:10.1021/jz100830r · Cited by 300 · see citing works

Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer

Sun, Y., Qu, C., Chen, H., He, M., Tang, C. C., Shou, K., Hong, S., Yang, M., Jiang, Y., Ding, B., et al. (2016) · Chemical Science · doi:10.1039/c6sc01561a · Cited by 294 · see citing works

Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window

Zhu, S., Yang, Q., Antaris, A. L., Yue, J., Ma, Z., Wang, H., Huang, W., Wan, H., Wang, J., Diao, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617990114 · Cited by 281 · see citing works

A General Strategy for Development of Activatable NIR‐II Fluorescent Probes for In Vivo High‐Contrast Bioimaging

Ren, T., Wang, Z., Xiang, Z., Lu, P., Lai, H., Yuan, L., Zhang, X., & Tan, W. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009986 · Cited by 273 · see citing works

Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics

Tian, R., Zeng, Q., Zhu, S., Lau, J., Chandra, S., Ertsey, R. D., Hettie, K. S., Teraphongphom, N. T., Hu, Z., Niu, G., et al. (2019) · Science Advances · doi:10.1126/sciadv.aaw0672 · Cited by 268 · see citing works

Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

Sun, Y., Ding, M., Zeng, X., Xiao, Y., Wu, H., Zhou, H., Ding, B., Qu, C., Hou, W., Aga, E.-B., et al. (2017) · Chemical Science · doi:10.1039/c7sc00251c · Cited by 265 · see citing works

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm

Tao, Z., Hong, G., Shinji, C., Chen, C., Diao, S., Antaris, A. L., Zhang, B., Zou, Y., & Dai, H. (2013) · Angewandte Chemie · doi:10.1002/ange.201307346 · Cited by 239 · see citing works

Indocyanine green fluorescence in second near-infrared (NIR-II) window

Starosolski, Z. A., Bhavane, R. C., Ghaghada, K. B., Vasudevan, S. A., Kaay, A., & Annapragada, A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187563 · Cited by 220 · see citing works

Bright and Stable NIR‐II J‐Aggregated AIE Dibodipy‐Based Fluorescent Probe for Dynamic In Vivo Bioimaging

Zhang, Q., Yu, P., Fan, Y., Sun, C., He, H., Liu, X., Lu, L., Zhao, M., Zhang, H., & Zhang, F. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202012427 · Cited by 216 · see citing works

3D NIR‐II Molecular Imaging Distinguishes Targeted Organs with High‐Performance NIR‐II Bioconjugates

Zhu, S., Herraiz, S., Yue, J., Zhang, M., Wan, H., Yang, Q., Ma, Z., Wang, Y., He, J. H., Antaris, A. L., et al. (2018) · Advanced Materials · doi:10.1002/adma.201705799 · Cited by 215 · see citing works

Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow

Ding, B., Xiao, Y., Zhou, H., Zhang, X., Qu, C., Xu, F., Deng, Z., Cheng, Z., & Hong, X. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01682 · Cited by 215 · see citing works

Activatable Fluorescence Probes for “Turn-On” and Ratiometric Biosensing and Bioimaging: From NIR-I to NIR-II

Chen, C., Tian, R., Zeng, Y., Chu, C., & Liu, G. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00734 · Cited by 214 · see citing works

Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR‐II Probe

Shou, K., Qu, C., Sun, Y., Chen, H., Chen, S., Zhang, L., Xu, H., Hong, X., Yu, A., & Cheng, Z. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700995 · Cited by 209 · see citing works

Inhibition of Cell Proliferation by an Anti-EGFR Aptamer

Li, N., Nguyen, H. H., Byrom, M., & Ellington, A. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020299 · Cited by 206 · see citing works

Isolation and characterization of a new human breast cancer cell line, KPL-4, expressing the Erb B family receptors and interleukin-6

Kurebayashi, J., Otsuki, T., Tang, C., Kurosumi, M., Yamamoto, S., Tanaka, K., Mochizuki, M., Nakamura, H., & Soono, H. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690114 · Cited by 196 · see citing works

Beyond the Cyanine Limit: Peierls Distortion and Symmetry Collapse in a Polymethine Dye

Tolbert, L. M., & Zhao, X. (1997) · Journal of the American Chemical Society · doi:10.1021/ja9626953 · Cited by 191 · see citing works

Molecular Imaging in the Second Near‐Infrared Window

Wan, H., Du, H., Wang, F., & Dai, H. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201900566 · Cited by 180 · see citing works

Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

Sun, Y., Zeng, X., Xiao, Y., Liu, C., Zhu, H., Zhou, H., Chen, Z., Xu, F., Wang, J., Zhu, M., et al. (2018) · Chemical Science · doi:10.1039/c7sc04774f · Cited by 161 · see citing works

Monoclonal antibody-based molecular imaging strategies and theranostic opportunities

Dammes, N., & Peer, D. (2020) · Theranostics · doi:10.7150/thno.37443 · Cited by 138 · see citing works

NIR-II fluorescence imaging using indocyanine green nanoparticles

Bhavane, R. C., Starosolski, Z. A., Stupin, I. V., Ghaghada, K. B., & Annapragada, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-32754-y · Cited by 123 · see citing works

Near-infrared heptamethine cyanines (Cy7): from structure, property to application

Feng, L., Chen, W., Ma, X., Liu, S. H., & Yin, J. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob01962c · Cited by 123 · see citing works

Developing a Bright NIR‐II Fluorophore with Fast Renal Excretion and Its Application in Molecular Imaging of Immune Checkpoint PD‐L1

Wan, H., Ma, H., Zhu, S., Wang, F., Tian, Y., Ma, R., Yang, Q., Hu, Z., Zhu, T., Wang, W., et al. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201804956 · Cited by 120 · see citing works

Live imaging of follicle stimulating hormone receptors in gonads and bones using near infrared II fluorophore

Feng, Y., Zhu, S., Antaris, A. L., Chen, H., Xiao, Y., Lu, X., Jiang, L., Diao, S., Yu, K., Wang, Y., et al. (2017) · Chemical Science · doi:10.1039/c6sc04897h · Cited by 113 · see citing works

NIR‐II Fluorescence Endoscopy for Targeted Imaging of Colorectal Cancer

Suo, Y., Wu, F., Xu, P., Shi, H., Wang, T., Liu, H., & Cheng, Z. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900974 · Cited by 105 · see citing works

Development and clinical application of anti-HER2 monoclonal and bispecific antibodies for cancer treatment

Yu, S., Liu, Q., Han, X., Qin, S., Zhao, W., Li, A., & Wu, K. (2017) · Experimental Hematology and Oncology · doi:10.1186/s40164-017-0091-4 · Cited by 100 · see citing works

Nature of the electronic transitions in thiacarbocyanines with a long polymethine chain

Lepkowicz, R. S., Przhonska, O. V., Hales, J. M., Fu, J., Hagan, D. J., Stryland, E. W. V., Bondar, M. V., Slominskiĭ, Y. L., & Kachkovski, A. D. (2004) · Chemical Physics · doi:10.1016/j.chemphys.2004.06.063 · Cited by 89 · see citing works

Synthesis and optical properties of emission-tunable PbS/CdS core–shell quantum dots for in vivo fluorescence imaging in the second near-infrared window

Tsukasaki, Y., Morimatsu, M., Nishimura, G., Sakata, T., Yasuda, H., Komatsuzaki, A., Watanabe, T. M., & Jin, T. (2014) · RSC Advances · doi:10.1039/c4ra06098a · Cited by 84 · see citing works

Fluorescence spectral properties of cyanine dye-labeled DNA oligomers on surfaces coated with silver particles

Malicka, J. B., Gryczyński, I., Fang, J., & Lakowicz, J. R. (2003) · Analytical Biochemistry · doi:10.1016/s0003-2697(03)00005-8 · Cited by 66 · see citing works

Cetuximab (Erbitux)

Bou-Assaly, W. B., & Mukherji, S. (2010) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2054 · Cited by 66 · see citing works

Ado-trastuzumab emtansine (T-DM1): a novel antibody-drug conjugate for the treatment of HER2-positive metastatic breast cancer

Baron, J. M., Boster, B. L., & Barnett, C. M. (2014) · Journal of Oncology Pharmacy Practice · doi:10.1177/1078155214527144 · Cited by 59 · see citing works

Monoclonal antibody-based optical molecular imaging probes; considerations and caveats in chemistry, biology and pharmacology

Kobayashi, H., Choyke, P. L., & Ogawa, M. (2016) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2016.05.015 · Cited by 57 · see citing works

Enhancement of aqueous stability and fluorescence brightness of indocyanine green using small calix[4]arene micelles for near-infrared fluorescence imaging

Jin, T., Tsuboi, S., Komatsuzaki, A., Imamura, Y., Muranaka, Y., Sakata, T., & Yasuda, H. (2016) · MedChemComm · doi:10.1039/c5md00580a · Cited by 51 · see citing works

Photophysical Tuning of Shortwave Infrared Flavylium Heptamethine Dyes via Substituent Placement

Pengshung, M., Li, J., Mukadum, F., Lopez, S. A., & Sletten, E. M. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c02213 · Cited by 42 · see citing works

Absolute Quantum Yield Measurements of Near-Infrared Emission with Correction for Solvent Absorption

Hoshi, R., Suzuki, K., Hasebe, N., Yoshihara, T., & Tobita, S. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b03297 · Cited by 36 · see citing works

Impact of Ion‐Pairing Effects on Linear and Nonlinear Photophysical Properties of Polymethine Dyes**

Pascal, S., Chi, S., Perry, J. W., Andraud, C., & Maury, O. (2020) · ChemPhysChem · doi:10.1002/cphc.202000731 · Cited by 33 · see citing works

Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours

Tsuboi, S., & Jin, T. (2020) · RSC Advances · doi:10.1039/d0ra04710d · Cited by 29 · see citing works

Recombinant Protein (Luciferase-IgG Binding Domain) Conjugated Quantum Dots for BRET-Coupled Near-Infrared Imaging of Epidermal Growth Factor Receptors

Tsuboi, S., & Jin, T. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00149 · Cited by 23 · see citing works

Monte Carlo Modeling of Shortwave-Infrared Fluorescence Photon Migration in Voxelized Media for the Detection of Breast Cancer

Iida, T., Kiya, S., Kubota, K., Jin, T., Seiyama, A., & Nomura, Y. (2020) · Diagnostics · doi:10.3390/diagnostics10110961 · Cited by 10 · see citing works

Fluorescent, Recombinant‐Protein‐Conjugated, Near‐Infrared‐Emitting Quantum Dots for in Vitro and in Vivo Dual‐Color Molecular Imaging

Tsuboi, S., & Jin, T. (2018) · ChemBioChem · doi:10.1002/cbic.201800506 · Cited by 9 · see citing works

Light Propagation and Interaction in Highly Scattering Media for Deep Tissue Imaging

Wang, W. B., Shi, L., Lu, L., Sordillo, L. A., Wang, L., Gayen, S. K., & Alfanoa, R. R. (2017) · doi:10.1201/9781315206554-5 · Cited by 3 · see citing works

The Spectrophotometric Characteristic of Immunoglobulin Conjugates for Diagnostics of Causative Agents of Especially Dangerous Infections

Спицын, А. Н., Utkin, D. V., Киреев, М. Н., Овчинникова, М. В., Kuznetsov, O. S., Erokhin, P. S., & Кочубей, В. И. (2020) · Optics and Spectroscopy · doi:10.1134/s0030400x20030182 · Cited by 2 · see citing works

Targeted multicolor in vivo imaging over 1,000 nm enabled by nonamethine cyanines

Bandi, V., Luciano, M., Saccomano, M., Patel, N. L., Bischof, T. S., Lingg, J. G. P., Tsrunchev, P., Nix, M. N., Ruehle, B., Sanders, C., et al. (2022) · Nature Methods · doi:10.1038/s41592-022-01394-6 · Cited by 184 · see citing works

Design of NIR-II high performance organic small molecule fluorescent probes and summary of their biomedical applications

Liu, X., Yu, B., Shen, Y., & Cong, H. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214609 · Cited by 151 · see citing works

Discovery of BODIPY J-aggregates with absorption maxima beyond 1200 nm for biophotonics

Wang, X., Jiang, Z., Liang, Z., Wang, T., Chen, Y., & Liu, Z. (2022) · Science Advances · doi:10.1126/sciadv.add5660 · Cited by 136 · see citing works

Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124 · see citing works

“Dual‐Key‐and‐Lock” NIR‐II NSCyanines Enable High‐Contrast Activatable Phototheranostics in Extrahepatic Diseases

Tian, Y., Chen, Z., Liu, S., Wu, F., Cao, W., Pang, D., & Xiong, H. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202309768 · Cited by 57 · see citing works

BOIMPY-Based NIR-II Fluorophore with High Brightness and Long Absorption beyond 1000 nm for In Vivo Bioimaging: Synergistic Steric Regulation Strategy

Liu, S., Xu, W., Li, X., Pang, D., & Xiong, H. (2022) · ACS Nano · doi:10.1021/acsnano.2c08619 · Cited by 56 · see citing works

Water-soluble chromenylium dyes for shortwave infrared imaging in mice

Jia, S., Lin, E. Y., Mobley, E. B., Lim, I., Guo, L., Kallepu, S., Low, P. S., & Sletten, E. M. (2023) · Chem · doi:10.1016/j.chempr.2023.08.021 · Cited by 54 · see citing works

NIR‐II cyanine@albumin fluorophore for deep tissue imaging and imaging‐guided surgery

Zhang, Y., Jia, Y., & Zhu, S. (2023) · SmartMat · doi:10.1002/smm2.1245 · Cited by 48 · see citing works

The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates

Piwoński, H., Nozue, S., & Habuchi, S. (2022) · ACS Nanoscience Au · doi:10.1021/acsnanoscienceau.1c00038 · Cited by 39 · see citing works

Repurposing Cyanine Photoinstability To Develop Near-Infrared Light-Activatable Nanogels for In Vivo Cargo Delivery

Hernandez, R. T., Lee, M. C., Yadav, A. K., & Chan, J. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c08187 · Cited by 34 · see citing works

Biocompatible and Water-Soluble Shortwave-Infrared (SWIR)-Emitting Cyanine-Based Fluorescent Probes for In Vivo Multiplexed Molecular Imaging

Swamy, M. M. M., Murai, Y., Monde, K., Tsuboi, S., Swamy, A. K., & Jin, T. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c01000 · Cited by 32 · see citing works

A facile indole probe for ultrasensitive immunosensor fabrication toward C-reactive protein sensing

Cheng, Y.-Y., Feng, X., Zhan, T., An, Q.-Q., Han, G., Chen, Z., & Kraatz, H. (2023) · Talanta · doi:10.1016/j.talanta.2023.124696 · Cited by 32 · see citing works

Extending optical chemical tools and technologies to mice by shifting to the shortwave infrared region

Wong, K. C. Y., & Sletten, E. M. (2022) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2022.102131 · Cited by 31 · see citing works

Near-infrared II cyanine fluorophores with large stokes shift engineered by regulating respective absorption and emission

Liu, D., He, Z., Gao, W., Shang, J., Yang, Y., Zhang, X., Li, X., Ma, H., & Shi, W. (2025) · Nature Communications · doi:10.1038/s41467-025-60241-2 · Cited by 32 · see citing works

Supramolecular Mitigation of the Cyanine Limit Problem

Li, D., & Smith, B. D. (2022) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.2c00179 · Cited by 29 · see citing works

Indocyanine polymethine fluorophores with extended π-conjugation emitting beyond 1,200 nm for enhanced NIR-II imaging

Ge, R.-T., Xiong, F., Chen, Z.-B., Wang, Y., Zheng, L., Zhou, J., Wu, D., & Zhang, S.-Y. (2025) · Chem · doi:10.1016/j.chempr.2025.102489 · Cited by 28 · see citing works

Xanthene‐Based Nitric Oxide‐Responsive Nanosensor for Photoacoustic Imaging in the SWIR Window

Rathnamalala, C. S. L., Hernandez, S., Lucero, M. Y., Swartchick, C. B., Shaik, A. K., Hammer, N. I., East, A. K., Gwaltney, S. R., Chan, J., & Scott, C. N. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202214855 · Cited by 28 · see citing works

High-Resolution Multicolor Shortwave Infrared Dynamic In Vivo Imaging with Chromenylium Nonamethine Dyes

Spearman, A. L., Lin, E. Y., Mobley, E. B., Chmyrov, A., Arús, B. A., Turner, D. W., Garcia, C. A., Bui, K., Rowlands, C. J., Bruns†, O. T., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c03673 · Cited by 28 · see citing works

Steric protection of near-infrared fluorescent dyes for enhanced bioimaging

Kommidi, S. S. R., Atkinson, K. M., & Smith, B. D. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01281j · Cited by 23 · see citing works

Current Status and Future Developments in NIR‐II‐emitting Organic Small Molecule Fluorophores for Bioimaging and Phototherapy

Ye, J., Wang, D., Yao, H., Cong, H., Shen, Y., & Yu, B. (2025) · Small · doi:10.1002/smll.202409722 · Cited by 22 · see citing works

Optical molecular imaging technology and its application in precise surgical navigation of liver cancer

He, P., Tang, H., Zheng, Y., Xu, X. D., Peng, X., Jiang, T., Xiong, Y., Zhang, Y., Zhang, L. Y., & Liu, G. (2024) · Theranostics · doi:10.7150/thno.102671 · Cited by 19 · see citing works

Current and Developing Lymphatic Imaging Approaches for Elucidation of Functional Mechanisms and Disease Progression

Aron, A., & Zavaleta, C. L. (2023) · Molecular Imaging and Biology · doi:10.1007/s11307-023-01827-4 · Cited by 18 · see citing works

Fluorescent Tracers for In Vivo Imaging of Lymphatic Targets

Russell, P. S., Velivolu, R., Maldonado-Zimbrón, V. E., Hong, J., Kavianinia, I., Hickey, A. J., Windsor, J. A., & Phillips, A. R. J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.952581 · Cited by 16 · see citing works

Less Is More: Donor Engineering of a Stable Molecular Dye for Bioimaging in the NIR-IIb Window

Wang, T., Qin, Y., Wang, J., Xu, Y., Guo, J., Zhu, Y., Zhang, H., Qin, Y., Qi, Z., Fu, H., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02866 · Cited by 16 · see citing works

Molecular Engineering of Ultrabright Biomimetic NanoGhost for Site‐Selective Tumor Imaging and Biodistribution

Prasad, R., Prerna, K., Temgire, M., Banerjee, P., Kumari, R., Kundu, G. C., Hattila, D., Mangannavar, C. V., Meena, A. S., Gorain, M., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401233 · Cited by 13 · see citing works

( E )-Selective Weinreb Amide-Type Horner–Wadsworth–Emmons Reaction: Effect of Reaction Conditions, Substrate Scope, Isolation of a Reactive Magnesium Phosphonoenolate, and Applications

Murata, T., Tsutsui, H., & Shiina, I. (2024) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.4c01140 · Cited by 12 · see citing works

ανβ3 integrin-targeted ICG-derived probes for imaging-guided surgery and photothermal therapy of oral cancer

Men, C., Zhang, Y., Shi, P., Tang, Z., & Cheng, X. (2023) · The Analyst · doi:10.1039/d3an01761c · Cited by 11 · see citing works

Construction of Machine Learning Models to Predict the Maximum Absorption Wavelength Considering the Solute and Solvent and Inverse Analysis of the Models

Ochiai, H., & Kaneko, H. (2025) · ACS Omega · doi:10.1021/acsomega.4c07490 · Cited by 9 · see citing works

Chromenylium Star Polymers: Merging Water Solubility and Stealth Properties with Shortwave Infrared Emissive Fluorophores

Mobley, E. B., Lin, E. Y., & Sletten, E. M. (2024) · ACS Central Science · doi:10.1021/acscentsci.4c01570 · Cited by 8 · see citing works

Shortwave infrared diffuse optical wearable probe for quantification of water and lipid content in emulsion phantoms using deep learning

Spink, S. S., Pilvar, A., Wei, L. L., Frias, J., Anders, K., Franco, S. T., Rose, O., Freeman, M., Bag, G., Huang, H., et al. (2023) · Journal of Biomedical Optics · doi:10.1117/1.jbo.28.9.094808 · Cited by 8 · see citing works

Bridging the Translation of ICG-1-Maltotriose: A Multimodal Sensor for Monitoring and Detecting Bacterial Infections

Zlitni, A., Yang, S., Achterberg, F. B., Gowrishankar, G., Steinberg, I., Azevedo, E. C., Gambhir, S. S., & Valdez, T. A. (2024) · ACS Sensors · doi:10.1021/acssensors.3c02005 · Cited by 8 · see citing works

Site-specific albumin tagging with chloride-containing near-infrared cyanine dyes: molecular engineering, mechanism, and imaging applications

Su, Q., Zhang, Y., & Zhu, S. (2023) · Chemical Communications · doi:10.1039/d3cc04200f · Cited by 7 · see citing works

Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice

Swamy, M. M. M., Tsuboi, S., Murai, Y., Monde, K., & Jin, T. (2022) · RSC Advances · doi:10.1039/d2ra03315a · Cited by 7 · see citing works

Rotaxane Formation Increases Squaraine Fluorescence Brightness beyond 900 nm by 25-fold

Lau, J. Y., Shi, K., Oliver, A. G., & Smith, B. D. (2025) · Organic Letters · doi:10.1021/acs.orglett.5c02456 · Cited by 6 · see citing works

DNA-Based Near-Infrared Voltage Sensors

Giammanco, G., Veneziano, R., Dunn, B., Such, N., Cressman, J. R., & Chitnis, P. V. (2023) · ACS Sensors · doi:10.1021/acssensors.3c01429 · Cited by 6 · see citing works

Application of NIR Fluorescent Materials in Imaging and Treatment of Tumors of Different Depths

Yu, M., Liu, X., Wang, S., Qin, Z., Hu, B., Li, Z., & Sun, S. (2025) · Nanomaterials · doi:10.3390/nano15110811 · Cited by 5 · see citing works

Chromenylium and Flavylium Polymethine Fluorophores Light Up the Shortwave Infrared Region

Mobley, E. B., & Sletten, E. M. (2026) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5c00892 · Cited by 4 · see citing works

Modern Cyanine Dye‐Based Photosensitizers for Medical Applications

Zhou, X., Han, F., Zhang, Y., Du, J., Sun, W. C., Fan, J., & Peng, X. (2026) · Angewandte Chemie International Edition · doi:10.1002/anie.4952408 · Cited by 4 · see citing works

Depth detection limit of a fluorescent object in tissue-like medium with background emission in continuous-wave measurements: a phantom study

Nishimura, G., Suzuki, T., Yamada, Y., Niwa, H., & KOIKE, T. (2024) · Journal of Biomedical Optics · doi:10.1117/1.jbo.29.9.097001 · Cited by 4 · see citing works

“Dual‐Key‐and‐Lock” NIR‐II NSCyanines Enable High‐Contrast Activatable Phototheranostics in Extrahepatic Diseases

Tian, Y., Chen, Z., Liu, S., Wu, F., Cao, W., Pang, D., & Xiong, H. (2023) · Angewandte Chemie · doi:10.1002/ange.202309768 · Cited by 4 · see citing works

Visualizing and mapping Aβ plaques by curcumin-derived NIR sensors: Multitarget theranostic agents for Alzheimer's disease

Sarabia‐Vallejo, Á., Clerigué, J., Martín, M. A., López‐Alvarado, P., Ran, C., & Menéndez, J. C. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109559 · Cited by 3 · see citing works

Advances in near-infrared fluorescence imaging for biomedicine

Wu, H., Li, X., Liu, Z., Song, F., Cai, R., Chen, H., & Zhang, G. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.217892 · Cited by 4 · see citing works

In Situ Generation of Quinoliziniums for Dual Visible Light‐Induced Gold(III)‐Catalyzed Alkynylation and Peptide Modification

Wa‐Yi, O., Tantipanjaporn, A., Deng, J., Tang, R., Kung, K. K., Sit, H., Lai, C. N., & Wong, M. (2024) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.202400339 · Cited by 3 · see citing works

Shortwave Infrared (SWIR)-Emitting Tamoxifen-Conjugated Cyanine Dyes for Estrogen Receptor-Targeted Cancer Imaging

Swamy, A. K., Swamy, M. M. M., Yuyama, K., Jin, T., & Monde, K. (2025) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5c00310 · Cited by 3 · see citing works

Fluorescence molecular imaging-guided photodynamic therapy for early breast cancer in the prone position: Feasibility evaluation with Monte Carlo simulations

Minegishi, Y., & Nomura, Y. (2025) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2025.104498 · Cited by 3 · see citing works

A near-infrared fluorescent long-chain fatty acid toward optical imaging of cardiac metabolism in living mice

Swamy, M. M. M., Zubir, M. Z. M., MUTMAINAH, M., Tsuboi, S., Murai, Y., Monde, K., Hirano, K., & Jin, T. (2022) · The Analyst · doi:10.1039/d2an00999d · Cited by 3 · see citing works

Advancing hepatobiliary diagnosis and treatment using shortwave-infrared fluorescence imaging with ICG-C9

Hatta, K., Tanaka, R., Kimura, K., Yamashita, N., Li, J., Kunisada, T., & Ishizawa, T. (2025) · BioScience Trends · doi:10.5582/bst.2025.01113 · Cited by 1 · see citing works

Silicon Flavylium Polymethine Dyes for Shortwave Infrared Imaging

Wilson, Q. D., Mobley, E. B., Lin, E. Y., Li, B. Y., Hua, A. S., Liu, D., Caram, J. R., & Sletten, E. M. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c05967 · Cited by 1 · see citing works

Polymethine Chromophores for NIR-II Phototheranostics: From Molecular Engineering to Nanoformulation-Enabled Bioapplications

Ran, X., Zhang, Y.-M., Xia, W.-L., Li, L.-X., Zhang, F., Cao, Y.-S., Yu, X.-Q., & Li, K. (2026) · ACS Nano · doi:10.1021/acsnano.6c08317 · Cited by 1 · see citing works

Enamel microcrack inspection using near-infrared light transillumination with fluorescence staining

Maseki, T., FURUKI, K., SUGIYAMA, R., Nakazawa, M., Komoto, M., & Maeno, M. (2024) · Dental Materials Journal · doi:10.4012/dmj.2023-336 · Cited by 1 · see citing works

NIR Emissive Biomimetic Ghost Nanovesicles for Site-Selective Solid Tumor ImagingPreprint

PRASAD, R., Prerna, K., Temgire, M., Banerjee, P., Kumari, R., Kundu, G. C., Kumari, S., Bellare, J., Dubey, V. K., Chandra, P., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4616433/v1

Engineering visible-to-ultraviolet emission switching of benzothiazole-based mechanoresponsive materials

Yoshino, R., Kobayashi, K., Yang, P., Fukumoto, H., Yasui, M., Yamada, S., Konno, T., & Morita, M. (2025) · CrystEngComm · doi:10.1039/d5ce00379b

Application value of indocyanine green fluorescence imaging in assessing blood supply during laparoscopic radical resection of rectal cancer

Wu, C., Huang, Q., Ye, K., & Xu, C.-H. (2025) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2025.12944

Near-Infrared and Shortwave Infrared Building Blocks for Activity-Based Sensors in Animals

Wang, T., Li, X. L., Guo, L., & Jia, S. (2026) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.6c00039

Magnetic circularly polarized (electro)luminescence: Principles, materials, and applications

Imai, Y., & Yagi, S. (2026) · Journal of Photochemistry and Photobiology C Photochemistry Reviews · doi:10.1016/j.jphotochemrev.2026.100767

Modern Cyanine Dye‐Based Photosensitizers for Medical Applications

Zhou, X., Han, F., Zhang, Y., Du, J., Sun, W. C., Fan, J., & Peng, X. (2026) · Angewandte Chemie · doi:10.1002/ange.4952408

Shortwave-Infrared (SWIR) Tetrabenzannulated Silicon-Rhodamine

Wang, D., Wang, B., Geng, W., Zhang, Y., Wang, X., Shen, Z., Qiu, Y., Hu, X., Yao, Y., Jiang, N., et al. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.6c07990

Coordination chemistry of NIR-II chromophore–metal hybrids for deep-tissue cancer theranostics

Bhowmik, R., Raza, M. K., Musib, D., & Roy, M. (2026) · Dalton Transactions · doi:10.1039/d6dt01459c

Micelle remodeling restores the intrinsic brightness of polymethine dyes for high-resolution shortwave infrared imaging

Jiang, Y., Zhang, W., Zou, J., Lu, Z., & Tang, W. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.182781

Biocompatible and Water-Soluble Shortwave-Infrared (SWIR)-Emitting Cyanine-Based Fluorescent Probes for In Vivo Multiplexed Molecular Imaging

Swamy, M. M. M., Murai, Y., Monde, K., Tsuboi, S., Swamy, A. K., & Jin, T. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c01000 · Cited by 32 · see citing works

Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green

Carr, J. A., Franke, D., Caram, J. R., Perkinson, C. F., Saif, M., Askoxylakis, V., Datta, M., Fukumura, D., Jain, R. K., Bawendi, M. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718917115 · Cited by 721 · see citing works

Shortwave Infrared (SWIR)-Emitting Tamoxifen-Conjugated Cyanine Dyes for Estrogen Receptor-Targeted Cancer Imaging

Swamy, A. K., Swamy, M. M. M., Yuyama, K., Jin, T., & Monde, K. (2025) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5c00310 · Cited by 3 · see citing works

Shortwave-infrared (SWIR) fluorescence molecular imaging using indocyanine green–antibody conjugates for the optical diagnostics of cancerous tumours

Tsuboi, S., & Jin, T. (2020) · RSC Advances · doi:10.1039/d0ra04710d · Cited by 29 · see citing works

Ambient Light Resistant Shortwave Infrared Fluorescence Imaging for Preclinical Tumor Delineation via the pH Low-Insertion Peptide Conjugated to Indocyanine Green

Larney, B. M., Kim, M., Roberts, S. S., Skubal, M., Hsu, H., Ogirala, A., Pratt, E. C., Pillarsetty, N., Heller, D. A., Lewis, J. S., et al. (2023) · Journal of Nuclear Medicine · doi:10.2967/jnumed.123.265686 · Cited by 7 · see citing works