The DOI matches its Crossref record.
Super pH-Sensitive Multifunctional Polymeric Micelle
Abstract
To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short time period. The micelle also showed pH-dependent dissociation, causing the enhanced release of doxorubicin from the carrier in early endosomal pH. The dissociated micellar components subsequently disrupt endosomal membrane.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
Sun, T., Zhang, Y. S., Pang, B., Hyun, D. C., Yang, M., & Xia, Y. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201403036 · Cited by 2,164
Polymers for Drug Delivery Systems
Liechty, W. B., Kryscio, D. R., Slaughter, B. V., & Peppas, N. A. (2010) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-073009-100847 · Cited by 1,608
Block copolymer micelles: preparation, characterization and application in drug delivery
Gaucher, G., Dufresne, M.-H., Sant, V. P., Kang, N., Maysinger, D., & Leroux, J.-C. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.09.034 · Cited by 1,498
Biodegradable synthetic polymers: Preparation, functionalization and biomedical application
Tian, H., Tang, Z., Zhuang, X., Chen, X., & Jing, X. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.06.004 · Cited by 1,293
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270
pH-Sensitive nano-systems for drug delivery in cancer therapy
Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A., & Liang, X.-J. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.11.009 · Cited by 1,121
Duan, X., & Li, Y. (2013) · Small · doi:10.1002/smll.201201390 · Cited by 926
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 914
Wang, Y., Zhou, K., Huang, G., Hensley, C., Huang, X., Ma, X., Zhao, T., Sumer, B. D., DeBerardinis, R. J., & Gao, J. (2014) · Nature Materials · doi:10.1038/nmat3819 · Cited by 773
Thermo-sensitive polymeric micelles based on poly (N-isopropylacrylamide) as drug carriers
Wei, H., Cheng, S.-X., Zhang, X.-Z., & Zhuo, R.-X. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.05.002 · Cited by 718
Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
Torchilin, V. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.026 · Cited by 583
Passive and Active Drug Targeting: Drug Delivery to Tumors as an Example
Torchilin, V. P. (2010) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-00477-3_1 · Cited by 573
Tang, J., Kong, B., Wu, H., Xu, M., Wang, Y., Wang, Y., Zhao, D., & Zheng, G. (2013) · Advanced Materials · doi:10.1002/adma.201303124 · Cited by 567
Functionalized micellar systems for cancer targeted drug delivery
Sutton, D., Nasongkla, N., Blanco, E., & Gao, J. (2007) · Pharmaceutical Research · doi:10.1007/s11095-006-9223-y · Cited by 557
Kim, S., Shi, Y., Kim, J. Y., Park, K., & Cheng, J.-X. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903380446 · Cited by 549
Moradi Kashkooli, F., Soltani, M., & Souri, M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.08.012 · Cited by 514
Polymeric nanomedicine for cancer therapy
Park, J. H., Lee, S., Kim, J.-H., Park, K., Kim, K., & Kwon, I. C. (2008) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2007.09.003 · Cited by 506
Extracellularly Activated Nanocarriers: A New Paradigm of Tumor Targeted Drug Delivery
Gullotti, E., & Yeo, Y. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900090z · Cited by 473
Lee, E. S., Oh, K. T., Kim, D., Youn, Y. S., & Bae, Y. H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.08.006 · Cited by 446
Self-citationDeng, C., Wu, J., Cheng, R., Meng, F., Klok, H.-A., & Zhong, Z. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.10.008 · Cited by 371
Jiang, T., Zhang, Z., Zhang, Y., Lv, H., Zhou, J., Li, C., Hou, L., & Zhang, Q. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.027 · Cited by 359
pH-sensitive poly (histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery
Wu, H., Zhu, L., & Torchilin, V. P. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.072 · Cited by 355
Ligand-installed nanocarriers toward precision therapy
Mi, P., Cabral, H., & Kataoka, K. (2020) · Advanced Materials · doi:10.1002/adma.201902604 · Cited by 350
Layer-by-Layer Nanoparticles with a pH-Sheddable Layer for in Vivo Targeting of Tumor Hypoxia
Poon, Z., Chang, D., Zhao, X., & Hammond, P. T. (2011) · ACS Nano · doi:10.1021/nn200876f · Cited by 343
Choi, K. Y., Han, H. S., Lee, E. S., Shin, J. M., Almquist, B. D., Lee, D. S., & Park, J. H. (2019) · Advanced Materials · doi:10.1002/adma.201803549 · Cited by 319
Self-citationPatil, Y., Sadhukha, T., Ma, L., & Panyam, J. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.01.021 · Cited by 317
Ph-responsive polymer–drug conjugates: design and progress
Pang, X., Jiang, Y., Xiao, Q., Leung, A. W., Hua, H., & Xu, C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.024 · Cited by 317
Bacteria‐Responsive Multifunctional Nanogel for Targeted Antibiotic Delivery
Xiong, M., Li, Y., Bao, Y., Yang, X., Hu, B., & Wang, J. (2012) · Advanced Materials · doi:10.1002/adma.201202847 · Cited by 299
Applications of polymer micelles for imaging and drug delivery
Movassaghian, S., Merkel, O. M., & Torchilin, V. P. (2015) · WIREs Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1332 · Cited by 276
Polymer particles that switch shape in response to a stimulus
Yoo, J.-W., & Mitragotri, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000346107 · Cited by 275
Enzyme-Responsive Nanoparticles for Anti-tumor Drug Delivery
Li, M., Zhao, G., Su, W.-K., & Shuai, Q. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.00647 · Cited by 253
Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery
Patil, Y. B., Toti, U. S., Khdair, A., Ma, L., & Panyam, J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.056 · Cited by 242
Oxime Linkage: A Robust Tool for the Design of pH-Sensitive Polymeric Drug Carriers
Jin, Y., Song, L., Su, Y., Zhu, L., Pang, Y., Qiu, F., Tong, G., Yan, D., Zhu, B., & Zhu, X. (2011) · Biomacromolecules · doi:10.1021/bm200956u · Cited by 216
Chen, J.-K., & Chang, C.-J. (2014) · Materials · doi:10.3390/ma7020805 · Cited by 193
Mizuhara, T., Saha, K., Moyano, D. F., Kim, C. S., Yan, B., Kim, Y., & Rotello, V. M. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201411615 · Cited by 182
Chen, T., Wu, W., Xiao, H., Chen, Y., Chen, M., & Li, J. (2016) · ACS Macro Letters · doi:10.1021/acsmacrolett.5b00765 · Cited by 87
Bone-targeted pH-responsive cerium nanoparticles for anabolic therapy in osteoporosis
Dou, C., Li, J., He, J., Luo, F., Yu, T., Dai, Q., Chen, Y., Xu, J., Yang, X., & Dong, S. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.04.038 · Cited by 84
Zhang, X., Qi, J., Lu, Y., Hu, X., He, W., & Wu, W. (2014) · Nanoscale Research Letters · doi:10.1186/1556-276x-9-185 · Cited by 54
A hyperbranched amphiphilic acetal polymer for pH-sensitive drug delivery
Cao, H., Chen, C., Xie, D., Chen, X., Wang, P., Wang, Y., Song, H., & Wang, W. (2018) · Polymer Chemistry · doi:10.1039/c7py01739a · Cited by 50
Sun, X.-L., Tsai, P.-C., Bhat, R., Bonder, E. M., Michniak-Kohn, B., & Pietrangelo, A. (2015) · Journal of Materials Chemistry B · doi:10.1039/c4tb01494d · Cited by 38
Luo, Y.-L., Yang, X.-L., Xu, F., Chen, Y.-S., & Zhao, X. (2014) · Colloid and Polymer Science · doi:10.1007/s00396-013-3149-9 · Cited by 28
Metadata
- Authors
- Lee, E. S., Na, K., & Bae, Y. H.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2005-01-25
- Volume
- 5
- Issue
- 2
- Pages
- 325-329
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2064576236
- Cited by
- 611
- References
- 0
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
