The stress-activated protein kinase subfamily of c-Jun kinases

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

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Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

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Signal transduction by the JNK group of MAP kinases

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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

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Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization

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Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

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The Neurobiology of Consolidations, Or, How Stable is the Engram?

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Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

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Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

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The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

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Regulation of transcription by MAP kinase cascades

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Excitotoxicity and stroke: Identifying novel targets for neuroprotection

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Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

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Modular binding domains in signal transduction proteins

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The Role of Oxidative Stress in Noise-Induced Hearing Loss

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The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

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The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades

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Mitogen-activated protein kinase cascades and regulation of gene expression

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Activation mechanism of the MAP kinase ERK2 by dual phosphorylation

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Inhibition of JNK activation through NF-κB target genes

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DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

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Mechanisms of tamoxifen resistance

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JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

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The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions

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Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

Hartmann, G., & Krieg, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.2.944 · Cited by 605

Targeting JNK for therapeutic benefit: from junk to gold?

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Raf meets Ras: completing the framework of a signal transduction pathway

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The ERK Cascade: Distinct Functions within Various Subcellular Organelles

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Lipopolysaccharide-mediated Reactive Oxygen Species and Signal Transduction in the Regulation of Interleukin-1 Gene Expression

Hsu, H.-Y., & Wen, M.-H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111883200 · Cited by 519

The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins

Yasuda, J., Whitmarsh, A. J., Cavanagh, J., Sharma, M., & Davis, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7245 · Cited by 458

Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

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Translocation of SAPK/JNK to Mitochondria and Interaction with Bcl-xL in Response to DNA Damage

Kharbanda, S., Saxena, S., Yoshida, K., Pandey, P., Kaneki, M., Wang, Q., Cheng, K., Chen, Y.-N., Campbell, A., Sudha, T., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.1.322 · Cited by 429

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

Chow, C.-W., Rincón, M., Cavanagh, J., Dickens, M., & Davis, R. J. (1997) · Science · doi:10.1126/science.278.5343.1638 · Cited by 357

Activation and Association of Stat3 with Src in v-Src-Transformed Cell Lines

Cao, X., Tay, A., Guy, G. R., & Tan, Y. H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1595 · Cited by 359

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

Ventura, J.-J., Cogswell, P., Flavell, R. A., Baldwin, A. S., & Davis, R. J. (2004) · Genes & Development · doi:10.1101/gad.1223004 · Cited by 303

Ceramide Activates the Stress-activated Protein Kinases

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Cellular Transformation and Malignancy Induced by ras Require c-jun

Johnson, R., Spiegelman, B., Hanahan, D., & Wisdom, R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4504 · Cited by 282

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

Ito, M., Yoshioka, K., Akechi, M., Yamashita, S., Takamatsu, N., Sugiyama, K., Hibi, M., Nakabeppu, Y., Shiba, T., & Yamamoto, K.-I. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7539 · Cited by 279

Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3

Kelkar, N., Gupta, S., Dickens, M., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1030-1043.2000 · Cited by 281

Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease

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Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter

Li, N., Kim, S., Wang, M., Froines, J., Sioutas, C., & Nel, A. (2002) · Inhalation Toxicology · doi:10.1080/089583701753678571 · Cited by 249

Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells

Guo, Y.-L., Baysal, K., Kang, B., Yang, L.-J., & Williamson, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.7.4027 · Cited by 249

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

Whitmarsh, A. J., Kuan, C.-Y., Kennedy, N. J., Kelkar, N., Haydar, T. F., Mordes, J. P., Appel, M., Rossini, A. A., Jones, S. N., Flavell, R. A., et al. (2001) · Genes & Development · doi:10.1101/gad.922801 · Cited by 238

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration

Xia, Y., Makris, C., Su, B., Li, E., Yang, J., Nemerow, G. R., & Karin, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5243 · Cited by 238

Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation

Itoh, M., Adachi, M., Yasui, H., Takekawa, M., Tanaka, H., & Imai, K. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0144 · Cited by 238

Serine Phosphorylation and Negative Regulation of Stat3 by JNK

Lim, C. P., & Cao, X. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.31055 · Cited by 225

Requirement of activation of JNK and p38 for environmental stress-induced erythroid differentiation and apoptosis and of inhibition of ERK for apoptosis

Nagata, Y., & Todokoro, K. (1999) · Blood · doi:10.1182/blood.v94.3.853.415a12_853_863 · Cited by 218

Identification of the Critical Features of a Small Peptide Inhibitor of JNK Activity

Barr, R. K., Kendrick, T. S., & Bogoyevitch, M. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107565200 · Cited by 211

The Role of Mitogen-activated Protein Kinase Phosphatase-1 in the Response of Alveolar Macrophages to Lipopolysaccharide

Zhao, Q., Shepherd, E. G., Manson, M. E., Nelin, L. D., Sorokin, A., & Liu, Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411760200 · Cited by 207

Thiol Antioxidants Inhibit the Adjuvant Effects of Aerosolized Diesel Exhaust Particles in a Murine Model for Ovalbumin Sensitization

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c-Jun N-Terminal Protein Kinase (JNK) 2/3 Is Specifically Activated by Stress, Mediating c-Jun Activation, in the Presence of Constitutive JNK1 Activity in Cerebellar Neurons

Coffey, E. T., Smiciene, G., Hongisto, V., Cao, J., Brecht, S., Herdegen, T., & Courtney, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04335.2002 · Cited by 184

Rosiglitazone, a Peroxisome Proliferator-Activated Receptor-γ, Inhibits the Jun NH2-Terminal Kinase/Activating Protein 1 Pathway and Protects the Heart From Ischemia/Reperfusion Injury

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CD28: a signalling perspective

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The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf

Li, W., Han, M., & Guan, K.-L. (2000) · Genes & Development · doi:10.1101/gad.14.8.895 · Cited by 129

Interleukin‐1β induces MMP‐9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor‐κB signaling pathways in human tracheal smooth muscle cells

Liang, K., Lee, C., Lin, W., Lin, C., Wu, C., Luo, S., & Yang, C. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.20992 · Cited by 128

Tumor Necrosis Factor-α Induces Interleukin-6 Production and Integrin Ligand Expression by Distinct Transduction Pathways

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Multiple pathways of apolipoprotein E signaling in primary neurons

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The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity

Zheng, C., Xiang, J., Hunter, T., & Lin, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.28966 · Cited by 110

Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two parallel mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-Jun N-terminal kinase

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Targeting MAPK Signaling in Age-Related Macular Degeneration

Kyosseva, S. V. (2016) · Ophthalmology and Eye Diseases · doi:10.4137/oed.s32200 · Cited by 74

Coordinated Regulation of Radioadaptive Response by Protein Kinase C and p38 Mitogen-Activated Protein Kinase

Shimizu, T., Kato, T., Tachibana, A., & Sasaki, M. S. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4582 · Cited by 73

Coxsackievirus B3 Infection Induces cyr61 Activation via JNK To Mediate Cell Death

Kim, S.-M., Park, J.-H., Chung, S.-K., Kim, J.-Y., Hwang, H.-Y., Chung, K.-C., Jo, I., Park, S.-I., & Nam, J.-H. (2004) · Journal of Virology · doi:10.1128/jvi.78.24.13479-13488.2004 · Cited by 70

Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells

Picher-Martel, V., Dutta, K., Phaneuf, D., Sobue, G., & Julien, J.-P. (2015) · Molecular Brain · doi:10.1186/s13041-015-0162-6 · Cited by 65

Tumor necrosis factor-α induces MMP-9 expression via p42/p44 MAPK, JNK, and nuclear factor-κB in A549 cells

LIN, C., TSENG, H., HSIEH, H., LEE, C., WU, C., CHENG, C., & YANG, C. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.01.032 · Cited by 65

Mitochondrial targeting of JNK/SAPK in the phorbol ester response of myeloid leukemia cells

Ito, Y., Mishra, N. C., Yoshida, K., Kharbanda, S., Saxena, S., & Kufe, D. (2001) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400886 · Cited by 62

Protective effect of a JNK inhibitor against retinal ganglion cell loss induced by acute moderate ocular hypertension.

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Regulation of Drosophila p38 activation by specific MAP2 kinase and MAP3 kinase in response to different stimuli

Zhuang, Z.-H., Zhou, Y., Yu, M.-C., Silverman, N., & Ge, B.-X. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2005.05.013 · Cited by 45

Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation

Mathiasen, D. P., Egebjerg, C., Andersen, S. H., Rafn, B., Puustinen, P., Khanna, A., Daugaard, M., Valo, E., Tuomela, S., Bøttzauw, T., et al. (2012) · Oncogene · doi:10.1038/onc.2011.230 · Cited by 44

Characterization of a novel JNK (c-Jun N-terminal kinase) inhibitory peptide

Ngoei, K. R. W., Catimel, B., Church, N., Lio, D. S., Dogovski, C., Perugini, M. A., Watt, P. M., Cheng, H.-C., Ng, D. C. H., & Bogoyevitch, M. A. (2011) · Biochemical Journal · doi:10.1042/bj20101244 · Cited by 31

Downregulation of insulin-like growth factor-binding protein 7 in cisplatin-resistant non-small cell lung cancer

Okamura, J., Huang, Y., Moon, D., Brait, M., Chang, X., & Sook-Kim, M. (2012) · Cancer Biology & Therapy · doi:10.4161/cbt.13.3.18695 · Cited by 28

Intra-Cellular Calcium Signaling Pathways (PKC, RAS/RAF/MAPK, PI3K) in Lamina Cribrosa Cells in Glaucoma

Irnaten, M., Duff, A., Clark, A., & O’Brien, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm10010062 · Cited by 27

Quantifying ERK2–protein interactions by fluorescence anisotropy: PEA-15 inhibits ERK2 by blocking the binding of DEJL domains

Callaway, K., Rainey, M. A., & Dalby, K. N. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.11.002 · Cited by 26

Phospholipase Cγ2 Mediates RANKL-stimulated Lymph Node Organogenesis and Osteoclastogenesis

Chen, Y., Wang, X., Di, L., Fu, G., Chen, Y., Bai, L., Liu, J., Feng, X., McDonald, J. M., Michalek, S., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802493200 · Cited by 27

A dominant negative form of the transcription factor c-Jun affects genes that have opposing effects on lipid homeostasis in mice

Drosatos, K., Sanoudou, D., Kypreos, K. E., Kardassis, D., & Zannis, V. I. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700986200 · Cited by 26

Phosphorylation of MAP kinase in corneal epithelial cells during wound healing

Imayasu, M., & Shimada, S. (2003) · Current Eye Research · doi:10.1076/ceyr.27.3.133.16055 · Cited by 24

A signature of Neanderthal introgression on molecular mechanisms of environmental responses

Findley, A. S., Zhang, X., Boye, C., Lin, Y. L., Kalita, C. A., Barreiro, L., Lohmueller, K. E., Pique-Regi, R., & Luca, F. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009493 · Cited by 14

5-Azacytidine engages an IRE1α-EGFR-ERK1/2 signaling pathway that stabilizes the LDL receptor mRNA

Mnasri, N., Mamarbachi, M., Allen, B. G., & Mayer, G. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2017.11.010 · Cited by 12