The pathogenic basis of malaria

The Resistance Factor to Plasmodium vivax in Blacks: The Duffy-Blood-Group Genotype,FyFy

Miller, L. H., Mason, S. J., Clyde, D. F., & McGinniss, M. H. (1976) · New England Journal of Medicine · doi:10.1056/nejm197608052950602 · Cited by 1,260

The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytes

Su, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219

Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human Placenta

Fried, M., & Duffy, P. E. (1996) · Science · doi:10.1126/science.272.5267.1502 · Cited by 1,108

Indicators of Life-Threatening Malaria in African Children

Marsh, K., Forster, D., Waruiru, C., Mwangi, I., Winstanley, M., Marsh, V., Newton, C., Winstanley, P., Warn, P., Peshu, N., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505253322102 · Cited by 1,097

Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes

Baruch, D. I., Pasloske, B. L., Singh, H. B., Bi, X., Ma, X. C., Feldman, M., Taraschi, T. F., & Howard, R. J. (1995) · Cell · doi:10.1016/0092-8674(95)90054-3 · Cited by 1,030

Switches in expression of plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes

Smith, J. D., Chitnis, C. E., Craig, A. G., Roberts, D. J., Hudson-Taylor, D. E., Peterson, D. S., Pinches, R., Newbold, C. I., & Miller, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90056-x · Cited by 1,005

The neglected burden of Plasmodium vivax malaria

Mendis, K., Sina, B., Marchesini, P., & Carter, R. (2001) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2001.64.97 · Cited by 970

Maternal antibodies block malaria

Fried, M., Nosten, F., Brockman, A., Brabin, B. J., & Duffy, P. E. (1998) · Nature · doi:10.1038/27570 · Cited by 659

Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population.

Snow, R. W., Craig, M., Deichmann, U., & Marsh, K. (1999) · PubMed · Cited by 652

Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria

Bull, P. C., Lowe, B. S., Kortok, M., Molyneux, C. S., Newbold, C. I., & Marsh, K. (1998) · Nature Medicine · doi:10.1038/nm0398-358 · Cited by 645

Rapid switching to multiple antigenic and adhesive phenotypes in malaria

Roberts, D. J., Craig, Berendt, A. R., Pinches, R., Nash, G., Marsh, K., & Newbold, C. I. (1992) · Nature · doi:10.1038/357689a0 · Cited by 619

An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration.

Turner, G. D. H., Morrison, H., Jones, M., Davis, T. M. E., Looareesuwan, S., BULEY, I. D., Gatter, K. C., Newbold, C., Pukritayakamee, S., & Nagachinta, B. (1994) · UWA Profiles and Research Repository (UWA) · Cited by 598

Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite

Aikawa, M., Miller, L., Johnson, J., & Rabbege, J. (1978) · The Journal of cell biology · doi:10.1083/jcb.77.1.72 · Cited by 582

P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1

Rowe, J. A., Moulds, J. M., Newbold, C. I., & Miller, L. H. (1997) · Nature · doi:10.1038/40888 · Cited by 581

Receptor and Ligand Domains for Invasion of Erythrocytes by Plasmodium falciparum

Sim, B. K. L., Chitnis, C. E., Wasniowska, K., Hadley, T. J., & Miller, L. H. (1994) · Science · doi:10.1126/science.8009226 · Cited by 545

Migration of Plasmodium Sporozoites Through Cells Before Infection

Mota, M. M., Pradel, G., Vanderberg, J. P., Hafalla, J. C. R., Frevert, U., Nussenzweig, R. S., Nussenzweig, V., & Rodrı́guez, A. (2001) · Science · doi:10.1126/science.291.5501.141 · Cited by 542

Developmental selection of var gene expression in Plasmodium falciparum

Chen, Q., Fernandez, V., Sundström, A., Schlichtherle, M., Datta, S., Hagblom, P., & Wahlgren, M. (1998) · Nature · doi:10.1038/28660 · Cited by 534

Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites.

Schofield, L., & Hackett, F. (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.1.145 · Cited by 500

Immunity to non-cerebral severe malaria is acquired after one or two infections

Gupta, S., Snow, R. W., Donnelly, C. A., Marsh, K., & Newbold, C. (1999) · Nature Medicine · doi:10.1038/6560 · Cited by 478

A family of erythrocyte binding proteins of malaria parasites.

Adams, J. H., Sim, B. K., Dolan, S. A., Fang, X., Kaslow, D. C., & Miller, L. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.7085 · Cited by 460

A reticulocyte-binding protein complex of plasmodium vivax merozoites

Galinski, M. R., Medina, C. C., Ingravallo, P., & Barnwell, J. W. (1992) · Cell · doi:10.1016/0092-8674(92)90642-p · Cited by 364

Receptor-Specific Adhesion and Clinical Disease in Plasmodium falciparum

Newbold, C., Warn, P., Black, G., Berendt, A., Craig, A., Snow, B., Msobo, M., Peshu, N., & Marsh, K. (1997) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1997.57.389 · Cited by 354

Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes.

Frevert, U., Sinnis, P., Cerami, C., Shreffler, W., Takacs, B., & Nussenzweig, V (1993) · The Journal of experimental medicine · doi:10.1084/jem.177.5.1287 · Cited by 351

Plasmodium Falciparum Malaria: Ultrastructure of Parasitized Erythrocytes in Cardiac Vessels

Luse, S. A., & Miller, L. H. (1971) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1971.20.655 · Cited by 345

Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species

Triglia, T., Healer, J., Caruana, S. R., Hodder, A. N., Anders, R. F., Crabb, B. S., & Cowman, A. F. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02175.x · Cited by 304

Platelet-mediated clumping of Plasmodium falciparum -infected erythrocytes is a common adhesive phenotype and is associated with severe malaria

Pain, A., Ferguson, D. J. P., Kai, O., Urban, B. C., Lowe, B., Marsh, K., & Roberts, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1805 · Cited by 303

The duffy receptor family of plasmodium knowlesi is located within the micronemes of invasive malaria merozoites

Adams, J. H., Hudson, D. E., Torii, M., Ward, G. E., Wellems, T. E., Aikawa, M., & Miller, L. H. (1990) · Cell · doi:10.1016/0092-8674(90)90295-p · Cited by 302

Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide

Wong, D., & Dorovini-Zis, K. (1992) · Journal of Neuroimmunology · doi:10.1016/0165-5728(92)90170-p · Cited by 301

Conservation of a Gliding Motility and Cell Invasion Machinery in Apicomplexan Parasites

Kappe, S. H. I., Bruderer, T., Gantt, S. M., Fujioka, H., Nussenzweig, V., & Ménard, R. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.937 · Cited by 295

Classification of adhesive domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 family

Smith, J. D., Subramanian, G., Gamain, B., Baruch, D. I., & Miller, L. H. (2000) · Molecular and Biochemical Parasitology · doi:10.1016/s0166-6851(00)00279-6 · Cited by 276

Different response to Plasmodium falciparum malaria in West African sympatric ethnic groups

Modiano, D., Petrarca, V., Sirima, B. S., Nebié, I., Diallo, D., Esposito, F., & Coluzzi, M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13206 · Cited by 267

Plasmodium falciparum Isolates from Infected Pregnant Women and Children Are Associated with Distinct Adhesive and Antigenic Properties

Beeson, J. G., Brown, G. V., Molyneux, M. E., Mhango, C., Dzinjalamala, F., & Rogerson, S. J. (1999) · The Journal of Infectious Diseases · doi:10.1086/314899 · Cited by 266

The Disulfide Bond Structure of Plasmodium Apical Membrane Antigen-1

Hodder, A. N., Crewther, P. E., Matthew, M. L. S. M., Reid, G. E., Moritz, R. L., Simpson, R. J., & Anders, R. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.29446 · Cited by 256

Molecular Aspects of Severe Malaria

Chen, Q., Schlichtherle, M., & Wahlgren, M. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.3.439 · Cited by 242

Glycosylphosphatidylinositol Anchors of Plasmodium falciparum

Naik, R. S., Branch, O. H., Woods, A. S., Vijaykumar, M., Perkins, D. J., Nahlen, B. L., Lal, A. A., Cotter, R. J., Costello, C. E., Ockenhouse, C. F., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1563 · Cited by 240

Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection

Buffet, P. A., Gamain, B., Scheidig, C., Baruch, D., Smith, J. D., Hernandez-Rivas, R., Pouvelle, B., Oishi, S., Fujii, N., Fusai, T., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12743 · Cited by 239

Abnormal Blood Flow and Red Blood Cell Deformability in Severe Malaria

Dondorp, A. M., Kager, P. A., Vreeken, J., & White, N. J. (2000) · Parasitology Today · doi:10.1016/s0169-4758(00)01666-5 · Cited by 237

Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway

Tachado, S. D., Gerold, P., McConville, M. J., Baldwin, T., Quilici, D., Schwarz, R. T., & Schofield, L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.5.1897 · Cited by 233

Emergence of FY*A null in a Plasmodium vivax -endemic region of Papua New Guinea

Zimmerman, P. A., Woolley, I., Masinde, G. L., Miller, S. M., McNamara, D. T., Hazlett, F., Mgone, C. S., Alpers, M. P., Genton, B., Boatin, B. A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13973 · Cited by 231

Antibodies that Inhibit Malaria Merozoite Surface Protein–1 Processing and Erythrocyte Invasion Are Blocked by Naturally Acquired Human Antibodies

Guevara Patiño, J. A., Holder, A. A., McBride, J. S., & Blackman, M. J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.10.1689 · Cited by 226

Molecular Basis of Sequestration in Severe and Uncomplicated Plasmodium falciparum Malaria: Differential Adhesion of Infected Erythrocytes to CD36 and ICAM-l

Ockenhouse, C. F., Ho, M., Tandon, N. N., Van Seventer, G. A., Shaw, S., White, N. J., Jamieson, Chulay, J. D., & Webster, H. K. (1991) · Journal of Infectious Diseases · doi:10.1093/infdis/164.1.163 · Cited by 215

Bacteraemia complicating severe malaria in children

Berkley, J., Mwarumba, S., Bramham, K., Lowe, B., & Marsh, K. (1999) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(99)90024-x · Cited by 213

Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum.

Dolan, S. A., Miller, L. H., & Wellems, T. E. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114753 · Cited by 209

Rolling and stationary cytoadhesion of red blood cells parasitized by Plasmodium falciparum: separate roles for ICAM‐1, CD36 and thrombospondin

Cooke, B. M., Berendt, A. R., Craig, A. G., MacGregor, J., Newbold, C. I., & Nash, G. B. (1994) · British Journal of Haematology · doi:10.1111/j.1365-2141.1994.tb04887.x · Cited by 192

Parasite Multiplication Potential and the Severity of Falciparum Malaria

Chotivanich, K., Udomsangpetch, R., Simpson, J. A., Newton, P., Pukrittayakamee, S., Looareesuwan, S., & White, N. J. (2000) · The Journal of Infectious Diseases · doi:10.1086/315353 · Cited by 191

Molecular mechanisms of cytoadherence in malaria

Ho, M., & White, N. J. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.6.c1231 · Cited by 191

Antibody Recognition of Plasmodium falciparum Erythrocyte Surface Antigens in Kenya: Evidence for Rare and Prevalent Variants

Bull, P. C., Lowe, B. S., Kortok, M., & Marsh, K. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.733-739.1999 · Cited by 179

Plasmodium falciparum–Infected Erythrocytes: Agglutination by Diverse Kenyan Plasma Is Associated with Severe Disease and Young Host Age

Bull, P. C., Kortok, M., Kai, O., Ndungu, F., Ross, A., Lowe, B. S., Newbold, C. I., & Marsh, K. (2000) · The Journal of Infectious Diseases · doi:10.1086/315652 · Cited by 173

Characterization of a Plasmodium falciparum erythrocyte-binding protein paralogous to EBA-175

Mayer, D. C. G., Kaneko, O., Hudson-Taylor, D. E., Reid, M. E., & Miller, L. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081075398 · Cited by 171

Cytoadherence, pathogenesis and the infected red cell surface in Plasmodium falciparum

Newbold, C., Craig, A., Kyes, S., Rowe, A., Fernandez-Reyes, D., & Fagan, T. (1999) · International Journal for Parasitology · doi:10.1016/s0020-7519(99)00049-1 · Cited by 168

Severe anaemia in children living in a malaria endemic area of Kenya

Newton, C. R. J. C., Warn, P. A., Winstanley, P. A., Peshu, N., Snow, R. W., Pasvol, G., & Marsh, K. (1997) · Tropical Medicine & International Health · doi:10.1046/j.1365-3156.1997.d01-238.x · Cited by 166

Fresh Isolates from Children with SeverePlasmodium falciparumMalaria Bind to Multiple Receptors

Heddini, A., Pettersson, F. H., Kai, O. K., Shafi, J., Obiero, J., Chen, Q., Barragán, A., Wahlgren, M., & Marsh, K. (2001) · Infection and Immunity · doi:10.1128/iai.69.9.5849-5856.2001 · Cited by 152

A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malaria

Preiser, P. R., Jarra, W., Capiod, T., & Snounou, G. (1999) · Nature · doi:10.1038/19309 · Cited by 136

Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum–infected erythrocytes to microvascular endothelial cells under flow

Yipp, B. G., Anand, S., Schollaardt, T., Patel, K. D., Looareesuwan, S., & Ho, M. (2000) · Blood · doi:10.1182/blood.v96.6.2292 · Cited by 134

Pathogenicity, stability, and immunogenicity of a knobless clone of Plasmodium falciparum in Colombian owl monkeys

Langreth, S. G., & Peterson, E. S. (1985) · Infection and Immunity · doi:10.1128/iai.47.3.760-766.1985 · Cited by 128

Plasmodium falciparum induces apoptosis in human mononuclear cells

Touré-Baldé, A., Sarthou, J. L., Aribot, G., Michel, P., Trape, J., Rogier, C., & Roussilhon, C. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.744-750.1996 · Cited by 125

A non-sense mutation in Cd36 gene is associated with protection from severe malaria

Pain, A., Urban, B. C., Kai, O. K., Casals‐Pascual, C., Shafi, J., Marsh, K., & Roberts, D. J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04662-6 · Cited by 120

Decoding the language of var genes and Plasmodium falciparum sequestration

Smith, J. D., Gamain, B., Baruch, D. I., & Kyes, S. (2001) · Trends in Parasitology · doi:10.1016/s1471-4922(01)02079-7 · Cited by 105

New insights into the epidemiology of malaria relevant for disease control

Snow, R. W., & Marsh, K. (1998) · British Medical Bulletin · doi:10.1093/oxfordjournals.bmb.a011689 · Cited by 98

Nitric Oxide Synthase Type 2 Promoter Polymorphisms, Nitric Oxide Production, and Disease Severity in Tanzanian Children with Malaria

Levesque, M. C., Hobbs, M. R., Anstey, N. M., Vaughn, T. N., Chancellor, J. A., Pole, A. R., Perkins, D. J., Misukonis, M. A., Chanock, S. J., Granger, D. L., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/315140 · Cited by 89

Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism?

Dobbie, M. S., Crawley, J., Waruiru, C., Marsh, K., & Surtees, R. A. H. (2000) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2000.62.284 · Cited by 88

Molecular insights into receptors used by malaria parasites for erythrocyte invasion

Chitnis, C. E. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200103000-00005 · Cited by 85

The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea

Patel, S. S., Mehlotra, R. K., Kastens, W., Mgone, C. S., Kazura, J. W., & Zimmerman, P. A. (2001) · Blood · doi:10.1182/blood.v98.12.3489 · Cited by 81

Transfusion for Respiratory Distress in Life-Threatening Childhood Malaria

English, M., Waruiru, C., & Marsh, K. (1996) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1996.55.525 · Cited by 76

A gene coding for a high-molecular mass rhoptry protein of Plasmodium yoelii

Keen, J. K., Sinha, K. A., Brown, K. N., & Holder, A. A. (1994) · Molecular and Biochemical Parasitology · doi:10.1016/0166-6851(94)90125-2 · Cited by 71

Adhesive receptors on malaria-parasitized red cells

Baruch, D. I. (1999) · Best Practice & Research Clinical Haematology · doi:10.1053/beha.1999.0051 · Cited by 64

An Immunohistochemical study of the pathology of fatal malaria

Turner, G., Morrison, H., Jones, M., Davis, T. I. 0.-0.-0.-7., Looareesuwan, S., Buley, I., Gatter, K., Newbold, C., Pukrittayakamee, S., Nagachinta, B., et al. (1994) · UWA Profiles and Research Repository (UWA) · Cited by 62

Why is the Pathology of Falciparum Worse than that of Vivax Malaria?

Clark, I. A., & Cowden, W. B. (1999) · Parasitology Today · doi:10.1016/s0169-4758(99)01535-5 · Cited by 53

Plasmodium falciparum-Infected Erythrocytes Adhere to the Proteoglycan Thrombomodulin in Static and Flow-Based Systems

Rogerson, S. J., Novakovic, S., Cooke, B. M., & Brown, G. V. (1997) · Experimental Parasitology · doi:10.1006/expr.1996.4142 · Cited by 49

Modifications in the CD36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36

Gamain, B., Smith, J. D., Miller, L. H., & Baruch, D. I. (2001) · Blood · doi:10.1182/blood.v97.10.3268 · Cited by 44

Bacterial strains isolated from blood cultures of Nigerian children with cerebral malaria

Prada, J., Alabi, S., Bienzle, U., & Kremsner, P. G. (1993) · The Lancet · doi:10.1016/0140-6736(93)92096-c · Cited by 39

Baseline immunity of the population and impact of insecticide-treated curtains on malaria infection.

Modiano, D., Petrarca, V., Sirima, S. B., Nebié, I., Luoni, G., Esposito, F., & Coluzzi, M. (1998) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1998.59.336 · Cited by 25

Biomechanics and biophysics of cancer cells☆

SURESH, S. (2007) · Acta Biomaterialia · doi:10.1016/j.actbio.2007.04.002 · Cited by 1,284

Mechanisms of Cell Protection by Heme Oxygenase-1

Gozzelino, R., Jeney, V., & Soares, M. P. (2010) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105600 · Cited by 1,241

Biomechanics approaches to studying human diseases

Lee, G. Y. H., & Lim, C. T. (2007) · Trends in Biotechnology · doi:10.1016/j.tibtech.2007.01.005 · Cited by 485

Antigenic Variation in Plasmodium falciparum

Scherf, A., Lopez-Rubio, J. J., & Riviere, L. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093134 · Cited by 447

The pathophysiology of vivax malaria

Anstey, N. M., Russell, B., Yeo, T. W., & Price, R. N. (2009) · Trends in Parasitology · doi:10.1016/j.pt.2009.02.003 · Cited by 428