Inducible cyclooxygenase may have anti-inflammatory properties

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

Mitchell, J. A., Akarasereenont, P., Thiemermann, C., Flower, R. J., & Vane, J. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11693 · Cited by 1,659

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic.

Masferrer, J. L., Zweifel, B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G., Isakson, P. C., & Seibert, K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3228 · Cited by 1,310

Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

Funk, C. D. (2001) · Science · doi:10.1126/science.294.5548.1871 · Cited by 3,817

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932

Resolution of inflammation: the beginning programs the end

Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232

Nonresolving Inflammation

Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183

Resolvins

Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650

Lipid mediator class switching during acute inflammation: signals in resolution

Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453

The role of cyclooxygenases in inflammation, cancer, and development

Williams, C. S., Mann, M., & DuBois, R. N. (1999) · Oncogene · doi:10.1038/sj.onc.1203286 · Cited by 1,417

The IKK NF-κB system: a treasure trove for drug development

Karin, M., Yamamoto, Y., & Wang, Q. M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1279 · Cited by 1,364

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

Serhan, C. N., & Levy, B. D. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97943 · Cited by 1,344

Regulatory interactions between muscle and the immune system during muscle regeneration

Tidball, J. G., & Villalta, S. A. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00735.2009 · Cited by 1,105

Resolution of in flammation: state of the art, definitions and terms

Serhan, C. N., Brain, S. D., Buckley, C. D., Gilroy, D. W., Haslett, C., O'Neill, L. A. J., Perretti, M., Rossi, A. G., & Wallace, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7227rev · Cited by 1,045

Resolvins and protectins in inflammation resolution

Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996

Resolution of inflammation: a new therapeutic frontier

Fullerton, J. N., & Gilroy, D. W. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.39 · Cited by 937

Resolution of Inflammation: What Controls Its Onset?

Sugimoto, M. A., Sousa, L. P., Pinho, V., Perretti, M., & Teixeira, M. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00160 · Cited by 638

Protectins and maresins: new pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

Serhan, C. N. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100322 · Cited by 421

Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2

Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.36-45.2004 · Cited by 407

Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells

Marra, F., Efsen, E., Romanelli, R. G., Caligiuri, A., Pastacaldi, S., Batignani, G., Bonacchi, A., Caporale, R., Laffi, G., Pinzani, M., et al. (2000) · Gastroenterology · doi:10.1053/gast.2000.9365 · Cited by 409

Mechanism of Action of Acetaminophen: Is There a Cyclooxygenase 3?

Botting, R. M. (2000) · Clinical Infectious Diseases · doi:10.1086/317520 · Cited by 350

The role of PPARs in inflammation and immunity

Clark, R. B. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.3.388 · Cited by 337

Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats

Wallace, J. L., Vong, L., McKnight, W., Dicay, M., & Martin, G. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.012 · Cited by 308

COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease

Willoughby, D. A., Moore, A. R., & Colville-Nash, P. R. (2000) · The Lancet · doi:10.1016/s0140-6736(99)12031-2 · Cited by 298

Formation and signaling actions of electrophilic lipids

Schopfer, F. J., Cipollina, C., & Freeman, B. A. (2011) · Chemical Reviews · doi:10.1021/cr200131e · Cited by 299

Targeting inflammation in metabolic syndrome

Welty, F. K., Alfaddagh, A., & Elajami, T. K. (2016) · Translational Research · doi:10.1016/j.trsl.2015.06.017 · Cited by 287

Feedback control of cyclooxygenase-2 expression through PPARγ

Inoue, H., Tanabe, T., & Umesono, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001387200 · Cited by 276

Is resolution the end of inflammation?

Feehan, K. T., & Gilroy, D. W. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.01.006 · Cited by 229

Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice

Viola, J. R., Lemnitzer, P., Jansen, Y., Csaba, G., Winter, C., Neideck, C., Silvestre-Roig, C., Dittmar, G., Döring, Y., Drechsler, M., et al. (2016) · Circulation Research · doi:10.1161/circresaha.116.309492 · Cited by 226

PPARs and lipid ligands in inflammation and metabolism

Harmon, G. S., Lam, M. T., & Glass, C. K. (2011) · Chemical Reviews · doi:10.1021/cr2001355 · Cited by 216

Cutting edge: differential production of prostaglandin D2 by human helper T cell subsets

Tanaka, K., Ogawa, K., Sugamura, K., Nakamura, M., Takano, S., & Nagata, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2277 · Cited by 204

On phagocytes and macular degeneration

Guillonneau, X., Eandi, C. M., Paques, M., Sahel, J.-A., Sapieha, P., & Sennlaub, F. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.06.002 · Cited by 185

Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation

Calippe, B., Augustin, S., Beguier, F., Charles-Messance, H., Poupel, L., Conart, J.-B., Hu, S. J., Lavalette, S., Fauvet, A., Rayes, J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.01.006 · Cited by 168

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome

Werner, M., Jordan, P. M., Romp, E., Czapka, A., Rao, Z., Kretzer, C., Koeberle, A., Garscha, U., Pace, S., Claesson, H., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802509r · Cited by 156

Identification and structure elucidation of the pro‐resolving mediators provides novel leads for resolution pharmacology

Dalli, J., & Serhan, C. N. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14336 · Cited by 138

Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases

Panigrahy, D., Gartung, A., Yang, J., Yang, H., Gilligan, M. M., Sulciner, M. L., Bhasin, S. S., Bielenberg, D. R., Chang, J., Schmidt, B. A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127282 · Cited by 132

Anandamide Inhibits Nuclear Factor-κB Activation through a Cannabinoid Receptor-Independent Pathway

Sancho, R., Calzado, M. A., Di Marzo, V., Appendino, G., & Muñoz, E. (2003) · Molecular Pharmacology · doi:10.1124/mol.63.2.429 · Cited by 120

Cyclooxygenase Inhibition as a Strategy to Ameliorate Brain Injury

Hurley, S. D., Olschowka, J. A., & O'Banion, M. K. (2002) · Journal of Neurotrauma · doi:10.1089/089771502753460196 · Cited by 110

Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives

Schopfer, F. J., Batthyany, C., Baker, P. R. S., Bonacci, G., Cole, M. P., Rudolph, V., Groeger, A. L., Rudolph, T. K., Nadtochiy, S., Brookes, P. S., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.025 · Cited by 104

Modulation of Macrophage Phenotype by Soluble Product(s) Released from Neutrophils

Daley, J. M., Reichner, J. S., Mahoney, E. J., Manfield, L., Henry, W. L., Mastrofrancesco, B., & Albina, J. E. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2265 · Cited by 101

Association of a New-Type Prostaglandin D2 Receptor CRTH2 with Circulating T Helper 2 Cells in Patients with Atopic Dermatitis

Iwasaki, M., Nagata, K., Takano, S., Takahashi, K., Ishii, N., & Ikezawa, Z. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01862.x · Cited by 86

Nitric Oxide Synthase Inhibitors Have Opposite Effects on Acute Inflammation Depending on Their Route of Administration

Paul-Clark, M. J., Gilroy, D. W., Willis, D., Willoughby, D. A., & Tomlinson, A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.1169 · Cited by 76

Atf3 negatively regulates Ptgs2/Cox2 expression during acute inflammation

Hellmann, J., Tang, Y., Zhang, M. J., Hai, T., Bhatnagar, A., Srivastava, S., & Spite, M. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.01.001 · Cited by 74

Quantitative analysis of the role of fiber length on phagocytosis and inflammatory response by alveolar macrophages

Padmore, T., Stark, C., Turkevich, L. A., & Champion, J. A. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.09.031 · Cited by 74

Activated Hepatic Stellate Cells Mediate the Differentiation of Macrophages

Chang, J., Hisamatsu, T., Shimamura, K., Yoneno, K., Adachi, M., Naruse, H., Igarashi, T., Higuchi, H., Matsuoka, K., Kitazume, M. T., et al. (2013) · Hepatology Research · doi:10.1111/j.1872-034x.2012.01111.x · Cited by 56

15‐Deoxy‐Δ12,14‐prostaglandin J2regulates the functional state and the survival of microglial cells through multiple molecular mechanisms

Bernardo, A., Ajmone‐Cat, M. A., Levi, G., & Minghetti, L. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02045.x · Cited by 45

Effect of the dietary intake of melatonin- and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins

Marhuenda, J., Medina, S., Martínez-Hernández, P., Arina, S., Zafrilla, P., Mulero, J., Oger, C., Galano, J.-M., Durand, T., Solana, A., et al. (2017) · Food Funct. · doi:10.1039/c7fo01081h · Cited by 22

Inhibition of the diclofenac‐induced cyclooxygenase‐2 activity by paracetamol in cultured macrophages is not related to the intracellular lipid hydroperoxide tone

Ayoub, S. S., Joshi, A., Chol, M., Gilroy, D. W., & Seed, M. P. (2011) · Fundamental & Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00842.x · Cited by 4