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The machinery of macroautophagy
Open accessAbstract
Autophagy is a primarily degradative pathway that takes place in all eukaryotic cells. It is used for recycling cytoplasm to generate macromolecular building blocks and energy under stress conditions, to remove superfluous and damaged organelles to adapt to changing nutrient conditions and to maintain cellular homeostasis. In addition, autophagy plays a critical role in cytoprotection by preventing the accumulation of toxic proteins and through its action in various aspects of immunity including the elimination of invasive microbes and its participation in antigen presentation. The most prevalent form of autophagy is macroautophagy, and during this process, the cell forms a double-membrane sequestering compartment termed the phagophore, which matures into an autophagosome. Following delivery to the vacuole or lysosome, the cargo is degraded and the resulting macromolecules are released back into the cytosol for reuse. The past two decades have resulted in a tremendous increase with regard to the molecular studies of autophagy being carried out in yeast and other eukaryotes. Part of the surge in interest in this topic is due to the connection of autophagy with a wide range of human pathophysiologies including cancer, myopathies, diabetes and neurodegenerative disease. However, there are still many aspects of autophagy that remain unclear, including the process of phagophore formation, the regulatory mechanisms that control its induction and the function of most of the autophagy-related proteins. In this review, we focus on macroautophagy, briefly describing the discovery of this process in mammalian cells, discussing the current views concerning the donor membrane that forms the phagophore, and characterizing the autophagy machinery including the available structural information.
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“ATG7 is strictly required for autophagosome formation; it is an E1-like activating enzyme present in ubiquitin-like conjugation systems that promotes both cleavage and lipidation of LC3 and GABARAP [43].”
From A gene toolbox for monitoring autophagy transcription (2021) · cites this paper as [43]
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“ULK1 is considered as the master regulator of autophagy induction, triggering a cascade of signals, through direct phosphorylation of ATG proteins, that culminate in autophagosome formation [3, 43].”
From A gene toolbox for monitoring autophagy transcription (2021) · cites this paper as [43]
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“Indeed, autophagy functions as a quality control mechanism, maintaining cellular homeostasis by destroying aggregate-prone proteins and damaged organelles [45].”
From Unlocking the Therapeutic Potential of Medicinal Plants for Alzheimer’s Disease: Preclinical to Clinical Trial Insights (2023) · cites this paper as [45]
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Cites
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227
Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue
Duve, C. D., Pressman, B. C., Gianetto, R., Wattiaux, R., & Appelmans, F. (1955) · Biochemical Journal · doi:10.1042/bj0600604 · Cited by 4,176
Autophagy: process and functionPreprint
Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 4,104
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347
Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3028 · Cited by 3,273
de Duve, C., & Wattiaux, R. (1966) · Annual Review of Physiology · doi:10.1146/annurev.ph.28.030166.002251 · Cited by 3,033
The Role of Atg Proteins in Autophagosome Formation
Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978
Autophagy in Health and Disease: A Double-Edged Sword
Shintani, T., & Klionsky, D. J. (2004) · Science · doi:10.1126/science.1099993 · Cited by 2,559
An Overview of Autophagy: Morphology, Mechanism, and Regulation
Parzych, K. R., & Klionsky, D. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5371 · Cited by 2,521
Autophagosome formation: core machinery and adaptations
Xie, Z., & Klionsky, D. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1102 · Cited by 2,237
A ubiquitin-like system mediates protein lipidation
Ichimura, Y., Kirisako, T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., et al. (2000) · Nature · doi:10.1038/35044114 · Cited by 2,139
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025
Mammalian autophagy: core molecular machinery and signaling regulation
Yang, Z., & Klionsky, D. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.014 · Cited by 1,956
Axe, E. L., Walker, S. A., Manifava, M., Chandra, P., Roderick, H. L., Habermann, A., Griffiths, G., & Ktistakis, N. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803137 · Cited by 1,885
Isolation and characterization of autophagy‐defective mutants of Saccharomyces cerevisiae
Tsukada, M., & Ohsumi, Y. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80398-e · Cited by 1,837
A protein conjugation system essential for autophagy
Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M. D., Klionsky, D. J., Ohsumi, M., & Ohsumi, Y. (1998) · Nature · doi:10.1038/26506 · Cited by 1,758
Inhibition of Macroautophagy Triggers Apoptosis
Boya, P., González‐Polo, R. A., Casares, N., Perfettini, J., Dessen, P., Larochette, N., Métivier, D., Meley, D., Souquère, S., Yoshimori, T., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1025-1040.2005 · Cited by 1,669
Autophagy: molecular machinery for self-eating
Yorimitsu, T., & Klionsky, D. J. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401765 · Cited by 1,566
Selective degradation of mitochondria by mitophagy
Kim, I., Rodriguez-Enriquez, S., & Lemasters, J. J. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.034 · Cited by 1,558
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Russell, R. C., Tian, Y., Yuan, H., Park, H. W., Chang, Y.-Y., Kim, J., Kim, H., Neufeld, T. P., Dillin, A., & Guan, K.-L. (2013) · Nature Cell Biology · doi:10.1038/ncb2757 · Cited by 1,529
Autophagy modulation as a potential therapeutic target for diverse diseases
Rubinsztein, D. C., Codogno, P., & Levine, B. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3802 · Cited by 1,464
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
Kabeya, Y., Mizushima, N., Yamamoto, A., Oshitani-Okamoto, S., Ohsumi, Y., & Yoshimori, T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01131 · Cited by 1,394
Itakura, E., Kishi‐Itakura, C., & Mizushima, N. (2012) · Cell · doi:10.1016/j.cell.2012.11.001 · Cited by 1,385
Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
Mizushima, N., Yamamoto, A., Hatano, M., Kobayashi, Y., Kabeya, Y., Suzuki, K., Tokuhisa, T., Ohsumi, Y., & Yoshimori, T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.657 · Cited by 1,361
Seglen, P. O., & Gordon, P. B. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.6.1889 · Cited by 1,360
Nix is a selective autophagy receptor for mitochondrial clearance
Novak, I., Kirkin, V., McEwan, D. G., Zhang, J., Wild, P., Rozenknop, A., Rogov, V., Löhr, F., Popovic, D., Occhipinti, A., et al. (2010) · The EMBO Reports · doi:10.1038/embor.2009.256 · Cited by 1,309
A Unified Nomenclature for Yeast Autophagy-Related Genes
Klionsky, D. J., Cregg, J. M., Dunn, W. A., Emr, S. D., Sakai, Y., Sandoval, I. V., Sibirny, A. А., Subramani, S. E., Thumm, M., Marten Veenhuis, A., et al. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00296-x · Cited by 1,305
Regulation of an ATG7 - beclin 1 Program of Autophagic Cell Death by Caspase-8
Yu, L., Alva, A. S., Su, H. C., Dutt, P., Freundt, E. C., Welsh, S. J., Baehrecke, E. H., & Lenardo, M. J. (2004) · Science · doi:10.1126/science.1096645 · Cited by 1,249
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
Itakura, E., Kishi, C., Inoue, K., & Mizushima, N. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-01-0080 · Cited by 1,176
Tor-Mediated Induction of Autophagy via an Apg1 Protein Kinase Complex
Kamada, Y., Funakoshi, T., Shintani, T., Nagano, K., Ohsumi, M., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1507 · Cited by 1,145
Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein
Liang, X. H., Kleeman, L. K., Jiang, H., Gordon, G. W., Goldman, J. E., Berry, G., Herman, B. A., & Levine, B. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8586-8596.1998 · Cited by 1,128
The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy
Fujita, N., Itoh, T., Omori, H., Fukuda, M., Noda, T., & Yoshimori, T. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1257 · Cited by 1,123
Ambra1 regulates autophagy and development of the nervous system
Fimia, G. M., Stoykova, A., Romagnoli, A., Giunta, L., Bartolomeo, S. D., Nardacci, R., Corazzari, M., Fuoco, C., Uçar, A., Schwartz, P. J., et al. (2007) · Nature · doi:10.1038/nature05925 · Cited by 1,082
The role of the Atg1/ULK1 complex in autophagy regulation
Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062
Suzuki, K., Kirisako, T., Kamada, Y., Mizushima, N., Noda, T., & Ohsumi, Y. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.5971 · Cited by 1,060
Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N., Yoshimori, T., Ohsumi, M., Takao, T., Noda, T., & Ohsumi, Y. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.263 · Cited by 1,024
Kihara, A., Noda, T., Ishihara, N., & Ohsumi, Y. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.519 · Cited by 1,004
The molecular machinery of autophagy: unanswered questions
Klionsky, D. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01620 · Cited by 960
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
Hara, T., Takamura, A., Kishi, C., Iemura, S.-I., Natsume, T., Guan, J.-L., & Mizushima, N. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200712064 · Cited by 904
Formation Process of Autophagosome Is Traced with Apg8/Aut7p in Yeast
Kirisako, T., Baba, M., Ishihara, N., Miyazawa, K., Ohsumi, M., Yoshimori, T., Noda, T., & Ohsumi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.2.435 · Cited by 881
HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein
Orvedahl, A., Alexander, D., Tallóczy, Z., Sun, Q., Wei, Y., Zhang, W., Burns, D., Leib, D. A., & Levine, B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2006.12.001 · Cited by 857
CYTOPLASMIC COMPONENTS IN HEPATIC CELL LYSOSOMES
Ashford, T. P., & Porter, K. R. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.12.1.198 · Cited by 849
The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy
Geng, J., & Klionsky, D. J. (2008) · EMBO Reports · doi:10.1038/embor.2008.163 · Cited by 825
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
Young, A. R. J., Chan, E. Y. W., Hu, X. W., Köchl, R., Crawshaw, S. G., High, S., Hailey, D. W., Lippincott-Schwartz, J., & Tooze, S. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03172 · Cited by 815
Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy
Kanki, T., Wang, K., Cao, Y., Baba, M., & Klionsky, D. J. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.014 · Cited by 812
Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy
Okamoto, K., Kondo-Okamoto, N., & Ohsumi, Y. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.013 · Cited by 797
Mizushima, N., Kuma, A., Kobayashi, Y., Yamamoto, A., Matsubae, M., Takao, T., Natsume, T., Ohsumi, Y., & Yoshimori, T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00381 · Cited by 791
Studies on the mechanisms of autophagy: formation of the autophagic vacuole.
Dunn, W. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.1923 · Cited by 787
Weidberg, H., Shvets, E., Shpilka, T., Shimron, F., Shinder, V., & Elazar, Z. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.74 · Cited by 777
Atg8 Controls Phagophore Expansion during Autophagosome Formation
Xie, Z., Nair, U., & Klionsky, D. J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1292 · Cited by 753
Hierarchy of Atg proteins in pre‐autophagosomal structure organization
Suzuki, K., Kubota, Y., Sekito, T., & Ohsumi, Y. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01050.x · Cited by 691
Orsi, A., Razi, M., Dooley, H. C., Robinson, D. J., Weston, A., Collinson, L., & Tooze, S. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0746 · Cited by 607
Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex
Oberstein, A., Jeffrey, P. D., & Shi, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700492200 · Cited by 585
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
Bartolomeo, S. D., Corazzari, M., Nazio, F., Oliverio, S., Lisi, G., Antonioli, M., Pagliarini, V., Matteoni, S., Fuoco, C., Giunta, L., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201002100 · Cited by 561
Isolation of autophagocytosis mutants of Saccharomyces cerevisiae
Thumm, M., Egner, R., Koch, B., Schlumpberger, M., Straub, M., Marten Veenhuis, A., & Wolf, D. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00672-5 · Cited by 560
Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes
Kim, P. K., Hailey, D. W., Mullen, R. T., & Lippincott‐Schwartz, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810611105 · Cited by 556
A New Protein Conjugation System in Human
Mizushima, N., Sugita, H., Yoshimori, T., & Ohsumi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.33889 · Cited by 521
Atg101, a novel mammalian autophagy protein interacting with Atg13
Hosokawa, N., Sasaki, T., Iemura, S.-I., Natsume, T., Hara, T., & Mizushima, N. (2009) · Autophagy · doi:10.4161/auto.5.7.9296 · Cited by 515
Harding, T. M., Morano, K. A., Scott, S. V., & Klionsky, D. J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.3.591 · Cited by 514
Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy
Kamada, Y., Yoshino, K., Kondo, C., Kawamata, T., Oshiro, N., Yonezawa, K., & Ohsumi, Y. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01344-09 · Cited by 505
An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis
Mari, M., Griffith, J., Rieter, E., Krishnappa, L., Klionsky, D. J., & Reggiori, F. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200912089 · Cited by 491
Self-citationApg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
Matsuura, A., Tsukada, M., Wada, Y., & Ohsumi, Y. (1997) · Gene · doi:10.1016/s0378-1119(97)00084-x · Cited by 489
Reggiori, F., Tucker, K. A., Stromhaug, P. E., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00402-7 · Cited by 476
Mercer, C. A., Kaliappan, A., & Dennis, P. B. (2009) · Autophagy · doi:10.4161/auto.5.5.8249 · Cited by 475
Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy
Otomo, C., Metlagel, Z., Takaesu, G., & Otomo, T. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2431 · Cited by 442
Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes
Puri, C., Renna, M., Bento, C. F., Moreau, K., & Rubinsztein, D. C. (2013) · Cell · doi:10.1016/j.cell.2013.08.044 · Cited by 439
CELLULAR DIFFERENTIATION IN THE KIDNEYS OF NEWBORN MICE STUDIED WITH THE ELECTRON MICROSCOPE
Clark, S. L. (1957) · The Journal of Cell Biology · doi:10.1083/jcb.3.3.349 · Cited by 432
Apg7p/Cvt2p: A Novel Protein-activating Enzyme Essential for Autophagy
Tanida, I., Mizushima, N., Kiyooka, M., Ohsumi, M., Ueno, T., Ohsumi, Y., & Kominami, E. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.5.1367 · Cited by 432
Uth1p Is Involved in the Autophagic Degradation of Mitochondria
Bhatia‐Kiššová, I., Deffieu, M. S., Manon, S., & Camougrand, N. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406960200 · Cited by 431
Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair
Rubinsztein, D. C., DiFiglia, M., Heintz, N., Nixon, R. A., Qin, Z., Ravikumar, B., Stefanis, L., & Tolkovsky, A. M. (2005) · Autophagy · doi:10.4161/auto.1.1.1513 · Cited by 424
Autophagic Processes in Yeast: Mechanism, Machinery and Regulation
Reggiori, F., & Klionsky, D. J. (2013) · Genetics · doi:10.1534/genetics.112.149013 · Cited by 419
Satoo, K., Noda, N. N., Kumeta, H., Fujioka, Y., Mizushima, N., Ohsumi, Y., & Inagaki, F. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.80 · Cited by 384
Klionsky, D. J., Cueva, R., & Yaver, D. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.2.287 · Cited by 373
Svp1p defines a family of phosphatidylinositol 3,5‐bisphosphate effectors
Dove, S. K., Piper, R. C., McEwen, R. K., Yu, J. W., King, M. C., Hughes, D. C., Thuring, J. W., Holmes, A. B., Cooke, F. T., Michell, R. H., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600203 · Cited by 366
Mechanism of Cargo Selection in the Cytoplasm to Vacuole Targeting Pathway
Shintani, T., Huang, W.-P., Stromhaug, P. E., & Klionsky, D. J. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00373-8 · Cited by 362
Studies on the mechanisms of autophagy: maturation of the autophagic vacuole.
Dunn, W. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.6.1935 · Cited by 362
PARTICIPATION OF LYSOSOMES IN CELLULAR AUTOPHAGY INDUCED IN RAT LIVER BY GLUCAGON
Deter, R. L., Baudhuin, P., & de Duve, C. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.35.2.c11 · Cited by 357
Tanida, I., Tanida-Miyake, E., Ueno, T., & Kominami, E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000752200 · Cited by 356
Mitophagy in Yeast Occurs through a Selective Mechanism
Kanki, T., & Klionsky, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802403200 · Cited by 335
Self-citationPKR-Dependent Xenophagic Degradation of Herpes Simplex Virus Type 1
Tallóczy, Z., Virgin, IV, & Levine, B. (2006) · Autophagy · doi:10.4161/auto.2176 · Cited by 334
PpAtg30 Tags Peroxisomes for Turnover by Selective Autophagy
Farré, J.-C., Manjithaya, R., Mathewson, R. D., & Subramani, S. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.011 · Cited by 331
The Cvt pathway as a model for selective autophagy
Lynch-Day, M. A., & Klionsky, D. J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.02.013 · Cited by 329
Stephan, J. S., Yeh, Y.-Y., Ramachandran, V., Deminoff, S. J., & Herman, P. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903316106 · Cited by 316
Atg17 Functions in Cooperation with Atg1 and Atg13 in Yeast Autophagy
Kabeya, Y., Kamada, Y., Baba, M., Takikawa, H., Sasaki, M., & Ohsumi, Y. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0669 · Cited by 304
A comprehensive glossary of autophagy-related molecules and processes (2ndedition)
Klionsky, D. J., Baehrecke, E. H., Brumell, J. H., Chu, C. T., Codogno, P., Cuervo, A. M., Debnath, J., Deretic, V. P., Elazar, Z., Eskelinen, E., et al. (2011) · Autophagy · doi:10.4161/auto.7.11.17661 · Cited by 298
Two Distinct Pathways for Targeting Proteins from the Cytoplasm to the Vacuole/Lysosome
Baba, M., Osumi, M., Scott, S. V., Klionsky, D. J., & Ohsumi, Y. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.7.1687 · Cited by 292
Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34
Miller, S., Tavshanjian, B., Oleksy, A., Perišić, O., Houseman, B. T., Shokat, K. M., & Williams, R. L. (2010) · Science · doi:10.1126/science.1184429 · Cited by 291
Prelysosomal convergence of autophagic and endocytic pathways
Gordon, P. B., & Seglen, P. O. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90556-6 · Cited by 281
Binding of the Atg1/ULK1 kinase to the ubiquitin‐like protein Atg8 regulates autophagy
Kraft, C., Kijańska, M., Kalie, E., Siergiejuk, E., Lee, S. S., Semplicio, G., Stoffel-Studer, I., Brezovich, A., Verma, M., Hansmann, I., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.225 · Cited by 277
Pex3‐anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae
Motley, A. M., Nuttall, J. M., & Hettema, E. H. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.151 · Cited by 275
Kim, J., Huang, W.-P., Stromhaug, P. E., & Klionsky, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109134200 · Cited by 272
Cvt19 Is a Receptor for the Cytoplasm-to-Vacuole Targeting Pathway
Scott, S. V., Guan, J., Hutchins, M. U., Kim, J., & Klionsky, D. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00263-5 · Cited by 269
Apg10p, a novel protein‐conjugating enzyme essential for autophagy in yeast
Shintani, T., Mizushima, N., Ogawa, Y., Matsuura, A., Noda, T., & Ohsumi, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5234 · Cited by 269
Tal, R., Winter, G., Ecker, N., Klionsky, D. J., & Abeliovich, H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m605940200 · Cited by 268
Atg9 Cycles Between Mitochondria and the Pre-Autophagosomal Structure in Yeasts
Reggiori, F., Shintani, T., Chong, H., Nair, U., & Klionsky, D. J. (2005) · Autophagy · doi:10.4161/auto.1.2.1840 · Cited by 266
Self-citationA Genomic Screen for Yeast Mutants Defective in Selective Mitochondria Autophagy
Kanki, T., Wang, K., Baba, M., Bartholomew, C. R., Lynch-Day, M. A., Du, Z., Geng, J., Mao, K., Yang, Z., Yen, W.-L., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-03-0225 · Cited by 266
Scott, S. V., Hefner-Gravink, A., Morano, K. A., Noda, T., Ohsumi, Y., & Klionsky, D. J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12304 · Cited by 263
Cvt9/Gsa9 Functions in Sequestering Selective Cytosolic Cargo Destined for the Vacuole
Kim, J., Kamada, Y., STRØMHAUG, P. E., Guan, J., Hefner-Gravink, A., Baba, M., Scott, S. V., Ohsumi, Y., Dunn, W. A., & Klionsky, D. J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.381 · Cited by 261
Bolender, R. P., & Weibel, E. R. (1973) · The Journal of Cell Biology · doi:10.1083/jcb.56.3.746 · Cited by 255
Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis
Ragusa, M. J., Stanley, R. E., & Hurley, J. H. (2012) · Cell · doi:10.1016/j.cell.2012.11.028 · Cited by 253
Structure of Atg5·Atg16, a Complex Essential for Autophagy
Matsushita, M., Suzuki, N. N., Obara, K., Fujioka, Y., Ohsumi, Y., & Inagaki, F. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609876200 · Cited by 250
Li, M., Hou, Y., Wang, J., Chen, X., Shao, Z.-M., & Yin, X. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.199059 · Cited by 250
Huang, W.-P., Scott, S. V., Kim, J., & Klionsky, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5845 · Cited by 241
An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase
Budovskaya, Y. V., Stephan, J. S., Deminoff, S. J., & Herman, P. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501046102 · Cited by 236
Obara, K., Sekito, T., & Ohsumi, Y. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-09-0841 · Cited by 230
Scott, S. V., Nice, D. C., Nau, J. J., Weisman, L. S., Kamada, Y., Keizer-Gunnink, I., Funakoshi, T., Veenhuis, M., Ohsumi, Y., & Klionsky, D. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002813200 · Cited by 227
Kim, J., Dalton, V. M., Eggerton, K. P., Scott, S. V., & Klionsky, D. J. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.5.1337 · Cited by 227
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
Huang, W., Choi, W.-Y., Hu, W., Mi, N., Guo, Q., Ma, M., Liu, M., Tian, Y., Lu, P., Wang, F., et al. (2012) · Cell Research · doi:10.1038/cr.2012.24 · Cited by 223
Pexophagy: The Selective Autophagy of Peroxisomes
Dunn, Jr., Cregg, J. M., Kiel, J. A. K. W., Klei, I. J. V. D., Oku, M., Sakai, Y., Sibirny, A. A., Stasyk, O. V., & Veenhuis, M. (2005) · Autophagy · doi:10.4161/auto.1.2.1737 · Cited by 222
He, C., Song, H., Yorimitsu, T., Monastyrska, I., Yen, W.-L., Legakis, J. E., & Klionsky, D. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606084 · Cited by 219
Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy
Baskaran, S., Ragusa, M. J., Bouřa, E., & Hurley, J. H. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.027 · Cited by 215
Yen, W.-L., Shintani, T., Nair, U., Cao, Y., Richardson, B. C., Li, Z., Hughson, F. M., Baba, M., & Klionsky, D. J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200904075 · Cited by 210
Hutchins, M. U., Marten Veenhuis, A., & Klionsky, D. J. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.22.4079 · Cited by 208
Yeast autophagosomes: de novo formation of a membrane structure
Noda, T. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02278-x · Cited by 207
van der Vaart, A., Griffith, J. M., & Reggiori, F. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-04-0345 · Cited by 195
Atg27 Is Required for Autophagy-dependent Cycling of Atg9
Yen, W.-L., Legakis, J. E., Nair, U., & Klionsky, D. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0612 · Cited by 190
Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae
Mao, K., Wang, K., Zhao, M., Xu, T., & Klionsky, D. J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201102092 · Cited by 189
Atg17 Regulates the Magnitude of the Autophagic Response
Cheong, H., Yorimitsu, T., Reggiori, F., Legakis, J. E., Wang, C.-W., & Klionsky, D. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0894 · Cited by 187
Structural Basis of Atg8 Activation by a Homodimeric E1, Atg7
Noda, N. N., Satoo, K., Fujioka, Y., Kumeta, H., Ogura, K., Nakatogawa, H., Ohsumi, Y., & Inagaki, F. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.035 · Cited by 186
Taherbhoy, A. M., Tait, S. W. G., Kaiser, S. E., Williams, A. H., Deng, A., Nourse, A., Hammel, M., Kurinov, I. V., Rock, C. O., Green, D. R., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.034 · Cited by 172
Aminopeptidase I Is Targeted to the Vacuole by a Nonclassical Vesicular Mechanism
Scott, S. V., Baba, M., Ohsumi, Y., & Klionsky, D. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.1.37 · Cited by 172
Krick, R., Busse, R. A., Scacioc, A., Stephan, M., Janshoff, A., Thumm, M., & Kühnel, K. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205128109 · Cited by 171
Structure of the Atg12–Atg5 conjugate reveals a platform for stimulating Atg8–PE conjugation
Noda, N. N., Fujioka, Y., Hanada, T., Ohsumi, Y., & Inagaki, F. (2012) · EMBO Reports · doi:10.1038/embor.2012.208 · Cited by 168
Li, X., He, L., Che, K. H., Funderburk, S. F., Pan, L., Pan, N., Zhang, M., Yue, Z., & Zhao, Y. (2012) · Nature Communications · doi:10.1038/ncomms1648 · Cited by 167
Atg12–Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site
Sakoh‐Nakatogawa, M., Matoba, K., Asai, E., Kirisako, H., Ishii, J., Noda, N. N., Inagaki, F., Nakatogawa, H., & Ohsumi, Y. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2527 · Cited by 162
Veenhuis, M., Douma, A., Harder, W., & Osumi, M. (1983) · Archives of Microbiology · doi:10.1007/bf00407757 · Cited by 162
Chemical Genetic Analysis of Apg1 Reveals A Non-kinase Role in the Induction of Autophagy
Abeliovich, H., Zhang, C., Dunn, W. A., Shokat, K. M., & Klionsky, D. J. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-07-0413 · Cited by 160
Sugawara, K., Suzuki, N. N., Fujioka, Y., Mizushima, N., Ohsumi, Y., & Inagaki, F. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00750.x · Cited by 158
Yamada, Y., Suzuki, N. N., Hanada, T., Ichimura, Y., Kumeta, H., Fujioka, Y., Ohsumi, Y., & Inagaki, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611473200 · Cited by 152
Analysis of the Membrane Structures Involved in Autophagy in Yeast by Freeze-Replica Method.
Baba, M., Osumi, M., & Ohsumi, Y. (1995) · Cell Structure and Function · doi:10.1247/csf.20.465 · Cited by 151
Determination of Four Sequential Stages during Microautophagy in Vitro
Kunz, J. B., Schwarz, H., & Mayer, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307905200 · Cited by 146
Transport of a Large Oligomeric Protein by the Cytoplasm to Vacuole Protein Targeting Pathway
Kim, J., Scott, S. V., Oda, M. N., & Klionsky, D. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.3.609 · Cited by 144
Fujioka, Y., Noda, N. N., Nakatogawa, H., Ohsumi, Y., & Inagaki, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053520 · Cited by 143
Sugawara, K., Suzuki, N. N., Fujioka, Y., Mizushima, N., Ohsumi, Y., & Inagaki, F. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509158200 · Cited by 139
Structure-based Analyses Reveal Distinct Binding Sites for Atg2 and Phosphoinositides in Atg18
Watanabe, Y., Kobayashi, T., Yamamoto, H., Hoshida, H., Akada, R., Inagaki, F., Ohsumi, Y., & Noda, N. N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.397570 · Cited by 138
The Proximal Tubule Cell in Experimental Hydronephrosis
Novikoff, A. B. (1959) · The Journal of Cell Biology · doi:10.1083/jcb.6.1.136 · Cited by 137
A HORMA domain in Atg13 mediates PI 3-kinase recruitment in autophagy
Jao, C. C., Ragusa, M. J., Stanley, R. E., & Hurley, J. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220306110 · Cited by 135
Yamada, T., Carson, A. R., Caniggia, I., Umebayashi, K., Yoshimori, T., Nakabayashi, K., & Scherer, S. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413957200 · Cited by 133
Beaulaton, J., & Lockshin, R. A. (1977) · Journal of Morphology · doi:10.1002/jmor.1051540104 · Cited by 132
A Cycling Protein Complex Required for Selective Autophagy
Legakis, J. E., Yen, W.-L., & Klionsky, D. J. (2007) · Autophagy · doi:10.4161/auto.4129 · Cited by 129
He, C., Baba, M., Cao, Y., & Klionsky, D. J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0544 · Cited by 127
The Crystal Structure of Plant ATG12 and its Biological Implication in Autophagy
Suzuki, N. N., Yoshimoto, K., Fujioka, Y., Ohsumi, Y., & Inagaki, F. (2005) · Autophagy · doi:10.4161/auto.1.2.1859 · Cited by 126
Seglen, P. O., Gordon, P. B., & Holen, I. (1990) · PubMed · Cited by 124
Glutathione Participates in the Regulation of Mitophagy in Yeast
Deffieu, M. S., Bhatia‐Kiššová, I., Salin, B., Galinier, A., Manon, S., & Camougrand, N. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.005181 · Cited by 124
Kabeya, Y., Noda, N. N., Fujioka, Y., Suzuki, K., Inagaki, F., & Ohsumi, Y. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.034 · Cited by 121
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity
Araki, Y., Ku, W.-C., Akioka, M., May, A. I., Hayashi, Y., Arisaka, F., Ishihama, Y., & Ohsumi, Y. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201304123 · Cited by 119
The peroxin Pex14p is involved in LC3-dependent degradation of mammalian peroxisomes
Hara‐Kuge, S., & Fujiki, Y. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.09.015 · Cited by 118
Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7–Atg3 and Atg7–Atg10 structures
Kaiser, S. E., Mao, K., Taherbhoy, A. M., Yu, S., Olszewski, J. L., Duda, D. M., Kurinov, I. V., Deng, A., Fenn, T. D., Klionsky, D. J., et al. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2415 · Cited by 108
Molecular Mechanisms and Regulation of Specific and Nonspecific Autophagy Pathways in Yeast
Nair, U., & Klionsky, D. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.r500016200 · Cited by 107
Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae
Kabeya, Y., Kawamata, T., Suzuki, K., & Ohsumi, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.150 · Cited by 105
Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I.
Oda, M. N., Scott, S. V., Hefner-Gravink, A., Caffarelli, A. D., & Klionsky, D. J. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.132.6.999 · Cited by 103
Mao, K., Chew, L. H., Inoue-Aono, Y., Cheong, H., Nair, U., Popelka, H., Yip, C. K., & Klionsky, D. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300064110 · Cited by 100
Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8
Hong, S., Kim, B.-W., Lee, K.-E., Kim, S. W., Jeon, H., Kim, J., & Song, H. K. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2165 · Cited by 100
Characterization of a novel autophagy-specific gene, ATG29
Kawamata, T., Kamada, Y., Suzuki, K., Kuboshima, N., Akimatsu, H., Ota, S., Ohsumi, M., & Ohsumi, Y. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.163 · Cited by 97
Atg18 function in autophagy is regulated by specific sites within its β-propeller
Rieter, E., Vinke, F. P., Bakula, D., Cebollero, E., Ungermann, C., Proikas‐Cezanne, T., & Reggiori, F. (2012) · Journal of Cell Science · doi:10.1242/jcs.115725 · Cited by 95
Yeh, Y.-Y., Wrasman, K., & Herman, P. K. (2010) · Genetics · doi:10.1534/genetics.110.116566 · Cited by 94
Aup1-mediated regulation of Rtg3 during mitophagy
Journo, D., Mor, A., & Abeliovich, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.048140 · Cited by 90
Receptor protein complexes are in control of autophagy
Mijaljica, D., Nazarko, T. Y., Brumell, J. H., Huang, W., Komatsu, M., Prescott, M., Simonsen, A., Yamamoto, A., Zhang, H., Klionsky, D. J., et al. (2012) · Autophagy · doi:10.4161/auto.21332 · Cited by 87
Osellame, L. D., & Duchen, M. R. (2013) · Autophagy · doi:10.4161/auto.25878 · Cited by 79
Glycogen autophagosomes in polymorphonuclear leukocytes induced by rickettsiae
Rikihisa, Y. (1984) · The Anatomical Record · doi:10.1002/ar.1092080302 · Cited by 79
Structural Insights into Atg10-Mediated Formation of the Autophagy-Essential Atg12-Atg5 Conjugate
Yamaguchi, M., Noda, N. N., Yamamoto, H., Shima, T., Kumeta, H., Kobashigawa, Y., Akada, R., Ohsumi, Y., & Inagaki, F. (2012) · Structure · doi:10.1016/j.str.2012.04.018 · Cited by 78
Autophagy receptors in developmental clearance of mitochondria
Novak, I., & Đikić, I. (2011) · Autophagy · doi:10.4161/auto.7.3.14509 · Cited by 75
Peroxisome Size Provides Insights into the Function of Autophagy-related Proteins
Nazarko, T. Y., Farré, J., & Subramani, S. E. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-03-0221 · Cited by 75
Finding a fitting shoe for Cinderella
Miller, S., Oleksy, A., Perišić, O., & Williams, R. L. (2010) · Autophagy · doi:10.4161/auto.6.6.12577 · Cited by 73
Activation of Atg1 kinase in autophagy by regulated phosphorylation
Kijańska, M., Dohnal, I., Reiter, W., Kaspar, S., Stoffel-Studer, I., Ammerer, G., Kraft, C., & Peter, M. (2010) · Autophagy · doi:10.4161/auto.6.8.13849 · Cited by 72
Kovács, A. L., Pálfia, Z., Réz, G., Vellai, T., & Kovács, J. (2007) · Autophagy · doi:10.4161/auto.4590 · Cited by 71
Mortensen, M., Ferguson, D. J. P., & Simon, A. K. (2010) · Cell Cycle · doi:10.4161/cc.9.10.11603 · Cited by 70
Yeh, Y.-Y., Shah, K. H., & Herman, P. K. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.250324 · Cited by 59
Atg9 Trafficking in Autophagy-Related Pathways
He, C., & Klionsky, D. J. (2007) · Autophagy · doi:10.4161/auto.3912 · Cited by 53
Selective Transport of α-Mannosidase by Autophagic Pathways
Watanabe, Y., Noda, N. N., Kumeta, H., Suzuki, K., Ohsumi, Y., & Inagaki, F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.143545 · Cited by 53
Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03739-0 · Cited by 48
Chew, L. H., Setiaputra, D., Klionsky, D. J., & Yip, C. K. (2013) · Autophagy · doi:10.4161/auto.25687 · Cited by 39
Dual role of Atg1 in regulation of autophagy-specific PAS assembly in Saccharomyces cerevisiae
Cheong, H., & Klionsky, D. J. (2008) · Autophagy · doi:10.4161/auto.6375 · Cited by 36
Structure and Function of Vps15 in the Endosomal G Protein Signaling Pathway ,
Heenan, E. J., Vanhooke, J. L., Temple, B. R. S., Betts, L., Sondek, J., & Dohlman, H. G. (2009) · Biochemistry · doi:10.1021/bi900621w · Cited by 33
Taylor, Jr., Chen, P.-H., Chou, C.-C., Patel, J., & Jin, S. V. (2012) · Autophagy · doi:10.4161/auto.20681 · Cited by 32
A multipleATGgene knockout strain for yeast two-hybrid analysis
Cao, Y., Nair, U., Yasumura-Yorimitsu, K., & Klionsky, D. J. (2009) · Autophagy · doi:10.4161/auto.5.5.8382 · Cited by 22
Quantitative regulation of vesicle formation in yeast non-specific autophagy
Geng, J., & Klionsky, D. J. (2008) · Autophagy · doi:10.4161/auto.6791 · Cited by 15
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Metadata
- Authors
- Feng, Y., He, D., Yao, Z., & Klionsky, D. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Klionsky, Daniel J
- Venue
- Cell Research
- Published
- 2013-12-24
- Volume
- 24
- Issue
- 1
- Pages
- 24-41
- ISSN
- 1001-0602 (ISSN-L)
- 1748-7838
- PMC
- PMC3879710
- OpenAlex
- W2044621729
- Cited by
- 2,083
- References
- 180
- Citations by year
- 2026: 84 · 2025: 130 · 2024: 193 · 2023: 180 · 2022: 238 · 2021: 215 · 2020: 200 · 2019: 185 · 2018: 177 · 2017: 161 · 2016: 161 · 2015: 109 · 2014: 45 · 2013: 3
- FWCI
- 12.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cell Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM053396)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- macroautophagy, autophagy machinery, phagophore formation, autophagosomes, autophagy-related proteins, autophagy regulation, lysosomes, cellular homeostasis, cytoprotection, neurodegenerative diseases, cancer, yeast autophagy
- MeSH terms
- Animals, Autophagy, Homeostasis, Humans, Lysosomes, Phagosomes, Pichia, Saccharomyces cerevisiae, Vacuoles, Protein Serine-Threonine Kinases
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