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The promise and peril of chemical probes
Open accessAbstract
Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate misleading results. To help address these shortcomings, we will create a community-driven wiki resource to improve quality and convey current best practice.
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Cites
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Specificity and mechanism of action of some commonly used protein kinase inhibitors
DAVIES, S. P., Reddy, H., Caivano, M., & Cohen, P. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510095 · Cited by 4,366
Self-citationVlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,248
Hidaka, H., Inagaki, M., Kawamoto, S., & Sasaki, Y. (1984) · Biochemistry · doi:10.1021/bi00316a032 · Cited by 2,688
Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase
Tamaoki, T., Nomoto, H., TAKAHASHI, I., Kato, Y., Morimoto, M., & Tomita, F. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90008-2 · Cited by 2,452
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
Molina, D. M., Jafari, R., Ignatushchenko, M., Seki, T., Larsson, E. A., Dan, C., Sreekumar, L., Cao, Y., & Nordlund, P. (2013) · Science · doi:10.1126/science.1233606 · Cited by 2,261
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
Prakasam, T., Matosiuk, D., & Jóźwiak, K. (2013) · Chemical Reviews · doi:10.1021/cr200409f · Cited by 1,933
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,930
Targeting bromodomains: epigenetic readers of lysine acetylation
Filippakopoulos, P., & Knapp, S. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4286 · Cited by 1,298
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Yu, P. B., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., Lin, H. Y.-F., Bloch, K. D., & Peterson, R. T. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.54 · Cited by 1,059
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Butler, K. V., MacDonald, I. A., Hathaway, N. A., & Jin, J. J. (2017) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.7b00343 · Cited by 5
Self-citationActivity‐Based Protein Profiling
van Rooden, E. J., Bakker, A. T., Overkleeft, H. S., & van der Stelt, M. (2018) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0023406 · Cited by 6
Asquith, C. R. M., Bennett, J. M., Su, L., Laitinen, T., Elkins, J. M., Pickett, J. E., Wells, C. I., Li, Z., Willson, T. M., & Zuercher, W. J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/629220 · Cited by 5
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Afonine, P. V., Albert, A., Diederichs, K., Hermoso, J. A., Krissinel, E., Márquez, J. A., Panjikar, S., Solà, M., Thorn, A., & Usón, I. (2025) · Nature Reviews Methods Primers · doi:10.1038/s43586-025-00433-8 · Cited by 6
Sinha, S., Sinha, N., Perales, M., Tarrab, A., Nguyen, T.-D., Liu, L., Cantore, T., Alvarez, K., Patiyal, S., Mukherjee, S., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01111-4 · Cited by 3
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Capener, J. L., Krämer, T., Bashore, F. M., Flory, E., Li, F., Strang, B. L., & Axtman, A. D. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02609 · Cited by 4
Jiang, J., He, D., Ke, M., Qin, J., Yang, G., Yu, B., Wang, J., & Fang, P. (2026) · Nature Communications · doi:10.1038/s41467-026-68971-7 · Cited by 4
Dakal, T. C., Joseph, J. K., Deepika, D., Maurya, P. K., Sharma, N. K., & Rajagopal, S. (2025) · RSC Pharmaceutics · doi:10.1039/d4pm00331d · Cited by 5
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D’Agostino, S., Davies, C., Powers, M. V., & Clarke, P. A. (2025) · Biochemical Society Transactions · doi:10.1042/bst20241045 · Cited by 7
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Connell, W., Garcia, K., Goodarzi, H., & Keiser, M. J. (2024) · Communications Biology · doi:10.1038/s42003-024-06865-4 · Cited by 4
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Stöckmann, H., Marin, V. L., Nimmer, P. M., Balut, C., Davidson, D. J., Richardson, P. L., & Vasudevan, A. (2015) · ChemBioChem · doi:10.1002/cbic.201500590 · Cited by 4
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Rugen, M. D., Andriotis, V. M. E., & Field, R. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12657-5 · Cited by 4
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James, T. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7465-8_20 · Cited by 4
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Yang, X., Fu, H., & Ivanov, A. A. (2020) · RSC Medicinal Chemistry · doi:10.1039/d0md00012d · Cited by 4
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Fanti, R. C. D. O., Vasconcelos, S. N. S., Catta‐Preta, C. M. C., Sullivan, J., Riboldi, G. P., dos Reis, C. V., Ramos, P. Z., Edwards, A. M., Behr, M. A., & Couñago, R. M. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00073 · Cited by 4
Self-citationAchieving the promise and avoiding the peril of chemical probes using genetics
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Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation
Thomas, A., Serafini, M. T., Grant, E. K., Coombs, E. A. J., Bluck, J. P., Schiedel, M., McDonough, M. A., Reynolds, J. K., Lee, B., Platt, M. A., et al. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.3c00437 · Cited by 3
Asquith, C. R. M., East, M. P., Laitinen, T., Alamillo‐Ferrer, C., Hartikainen, E., Wells, C. I., Axtman, A. D., Drewry, D. H., Tizzard, G. J., Poso, A., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116357 · Cited by 4
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iNEXT Consortium (2018) · FEBS Letters · doi:10.1002/1873-3468.13062 · Cited by 4
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Qiao, Y., Hayashi, H., & Teo, S. C. (2020) · Chemistry - An Asian Journal · doi:10.1002/asia.202000541 · Cited by 4
Enhancing Chemogenomics with Predictive Pharmacology
James, T., Sardar, A. J., & Anighoro, A. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00445 · Cited by 4
The Evolving Role of the Medicinal Chemist
Lawton, G., & Nußbaumer, P. (2016) · Progress in medicinal chemistry · doi:10.1016/bs.pmch.2015.11.001 · Cited by 4
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Scanlon, M. J. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01244 · Cited by 4
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Barratt, C. L. R. (2015) · Molecular Human Reproduction · doi:10.1093/molehr/gav062 · Cited by 4
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Frye, S. V. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.119 · Cited by 4
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Komatsu, T., & Virdee, S. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00268 · Cited by 4
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Renaud, J. (2020) · Wiley eBooks · doi:10.1002/9781118681121.ch1 · Cited by 5
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Self-citationTarget deconvolution of HDAC pharmacopoeia highlights MBLAC2 as common off-targetPreprint
Lechner, S., Malgapo, M. I. P., Grätz, C., Baron, A., Rüther, P. L., Nadal, S., Stumpf, C., Loos, C., Ku, X., Prokofeva, P., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-646613/v1 · Cited by 4
Müller, C. E. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.2c00135 · Cited by 4
Braddock, M., & Jeziorski, K. (2026) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2026.2624023 · Cited by 3
Li, H., Zheng, W., Bian, W., Li, M. T., Fan, Z., Feng, Z., Liu, X. Q., Zhang, S., Lu, H., Huang, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-73774-x · Cited by 3
Heppner, D. E., MacDonald, M. R., Nasief, N. N., Naik, S. E., & Cunningham, S. (2026) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.6c00089 · Cited by 3
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Wilkins, K., Venkataramanan, S., & Floor, S. N. (2022) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2022.03.032 · Cited by 4
Mantilla, B. S., White, J. S., Mosedale, W. R. T., Gomm, A., Nelson, A. S., Smith, T., & Wright, M. H. (2024) · Communications Chemistry · doi:10.1038/s42004-024-01327-8 · Cited by 5
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Falkenstein, M., Elek, M., & Stark, H. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_254 · Cited by 3
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D’Alessandro, P. L., Buschmann, N., Kaufmann, M., Furet, P., Baysang, F., Brunner, R., Marzinzik, A. L., Vorherr, T. E., Stachyra, T., Ottl, J., et al. (2016) · Angewandte Chemie · doi:10.1002/ange.201608568 · Cited by 3
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Mohammad, I., Liebmann, K. L., & Miller, S. C. (2023) · Chemical Communications · doi:10.1039/d3cc02540c · Cited by 3
Hamsar, M. N., Sazili, A. Q., & Tohid, S. F. M. (2024) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2024.101026 · Cited by 3
Němec, V., Remeš, M., Beňovský, P., Böck, M. C., Šranková, E., Wong, J. F., Cros, J., Williams, E., Tse, L. H., Smil, D. V., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00629 · Cited by 3
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Wagner, B. K. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160745-00001 · Cited by 4
Baughman, B. M., Wang, H., An, Y., Kireev, D., Stashko, M. A., Jessen, H. J., Pearce, K. H., Frye, S. V., & Shears, S. B. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164378 · Cited by 3
Self-citationRetractedApplications of NMR Spectroscopy in FBDD
Bentley, M. R., Doak, B. C., Mohanty, B., & Scanlon, M. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-28388-3_127 · Cited by 3
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Tomohara, K., Hasegawa, N., Adachi, I., Horino, Y., & Nose, T. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126815 · Cited by 3
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Coussens, N. P., Kales, S. C., Henderson, M. J., Lee, O. W., Horiuchi, K. Y., Wang, Y., Chen, Q., Kuznetsova, E., Wu, J., Cheff, D. M., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/208439 · Cited by 3
Schnorrenberg, G. (2018) · Wiley eBooks · doi:10.1002/9783527808694.ch1 · Cited by 3
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Yang, X., Dickmander, R. J., Bayati, A., Taft-Benz, S., Smith, J. L., Wells, C. I., Madden, E. A., Brown, J. W., Lenarcic, E. M., Yount, B. L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.03.474779 · Cited by 3
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Scholzen, K., Zeisel, L., & Arnér, E. S. J. (2026) · Chem · doi:10.1016/j.chempr.2025.102868 · Cited by 2
Valenzuela-Hormazábal, P., Valero-Rojas, J., Martínez‐González, L., Ramos-Inza, S., Oviedo-Pino, V., González-Ortega, C., Hernando, G., López, J. J., Scorza, C., Echeverry, C., et al. (2026) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c02202 · Cited by 2
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Weissig, V., Joshi, M. D., & Migrino, R. Q. (2025) · Journal of Liposome Research · doi:10.1080/08982104.2025.2451776 · Cited by 2
Wong, T. H., Khater, I. M., Hallgrimson, C., Li, Y. L., Hamarneh, G., & Nabi, I. R. (2025) · Journal of Cell Science · doi:10.1242/jcs.263570 · Cited by 2
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Nabet, B., & Gray, N. S. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160691-00055 · Cited by 2
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Silva, D. V. (2015) · ChemBioChem · doi:10.1002/cbic.201500684 · Cited by 2
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Doler, C., Schweiger, M., Zimmermann, R., & Breinbauer, R. (2015) · ChemBioChem · doi:10.1002/cbic.201500501 · Cited by 2
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Sharlow, E. R. (2016) · Assay and Drug Development Technologies · doi:10.1089/adt.2016.734 · Cited by 2
Walter, J., & Hümpel, A. (2017) · Nomos Verlagsgesellschaft mbH & Co. KG eBooks · doi:10.5771/9783845270838 · Cited by 1
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Wang, L., & Yao, X. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821433-6.00008-8 · Cited by 2
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Ortíz, C., Ruatta, S., & Comini, M. A. (2022) · Computer-aided drug discovery and design · doi:10.1007/978-3-030-95895-4_4 · Cited by 2
Rayevsky, A. V., Poturai, A. S., Kravets, I. O., Pashenko, A. E., Borisova, Т., Tolstanova, G. M., Volochnyuk, D. M., Borysko, P., Vadzyuk, O. B., Alieksieieva, D. O., et al. (2022) · Molecules · doi:10.3390/molecules27175400 · Cited by 2
Licciardello, M. P., & Kubicek, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802208-5.00009-6 · Cited by 2
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Ung, P. M. U., DeVita, R. J., & Schlessinger, A. (2019) · Cell chemical biology · doi:10.1016/j.chembiol.2018.12.009 · Cited by 2
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Baker, M. (2015) · Nature · doi:10.1038/nature.2015.18027 · Cited by 2
Panov, A., & Gygi, S. P. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/751818 · Cited by 2
Asquith, C. R. M., Temme, L., Laitinen, T., Pickett, J. E., Kwarcinski, F. E., Sinha, P., Wells, C. I., Tizzard, G. J., Zutshi, R., & Drewry, D. H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.02.972943 · Cited by 3
Pang, K.-L., & Chin, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186674 · Cited by 2
Lemos, C., Schulze, V., Baumgart, S. J., Nevedomskaya, E., Heinrich, T. K., Lefranc, J., Bader, B., Christ, C. D., Briem, H., Kuhnke, L., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-47637/v1 · Cited by 2
Jones, L. H. (2021) · Wiley eBooks · doi:10.1002/0471266949.bmc256 · Cited by 2
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Veale, C. G. L., Talukdar, A., & Vauzeilles, B. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00209 · Cited by 2
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Metadata
- Authors
- Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., Buser-Doepner, C., Campbell, R. M., Carter, A. J., Cohen, P., Copeland, R. A., Cravatt, B., Dahlin, J. L., Dhanak, D., Edwards, A. M., Frederiksen, M., Frye, S. V., Gray, N., Grimshaw, C. E., Hepworth, D., Howe, T., Huber, K. V. M., Jin, J., Knapp, S., Kotz, J. D., Kruger, R. G., Lowe, D., Mader, M. M., Marsden, B., Mueller-Fahrnow, A., Müller, S., O'Hagan, R. C., Overington, J. P., Owen, D. R., Rosenberg, S. H., Ross, R., Roth, B., Schapira, M., Schreiber, S. L., Shoichet, B., Sundström, M., Superti-Furga, G., Taunton, J., Toledo-Sherman, L., Walpole, C., Walters, M. A., Willson, T. M., Workman, P., Young, R. N., & Zuercher, W. J.
- Affiliations
- University of Toronto (CA)
- Constellation Pharmaceuticals (United States) (US)
- National Institutes of Health (US)
- Monash University (AU)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Institute of Cancer Research (GB)
- University of Oxford (GB)
- Structural Genomics Consortium (CA)
- Pfizer (United States) (US)
- Eli Lilly (United States) (US)
- Boehringer Ingelheim (Germany) (DE)
- University of Dundee (GB)
- Epizyme (United States) (US)
- Scripps Research Institute (US)
- Mayo Clinic (US)
- Novartis (Switzerland) (CH)
- University of North Carolina at Chapel Hill (US)
- Harvard University (US)
- Janssen (United Kingdom) (GB)
- Austrian Academy of Sciences (AT)
- Icahn School of Medicine at Mount Sinai (US)
- Broad Institute (US)
- GlaxoSmithKline (United States) (US)
- Vertex Pharmaceuticals (United States) (US)
- European Bioinformatics Institute (GB)
- AbbVie (United States) (US)
- University of California, San Francisco (US)
- Karolinska University Hospital (SE)
- Howard Hughes Medical Institute (US)
- University of Minnesota (US)
- Simon Fraser University (CA)
- Corresponding author
- Edwards, Aled M
- ORCID
- Arrowsmith, Cheryl H
- Audia, James E
- Austin, Christopher
- Baell, Jonathan
- Blagg, Julian
- Bountra, Chas
- Brennan, Paul E
- Brown, Peter J
- Bunnage, Mark E
- Campbell, Robert M
- Carter, Adrian J
- Cohen, Philip
- Copeland, Robert A
- Dahlin, Jayme L
- Edwards, Aled M
- Frederiksen, Mathias
- Frye, Stephen V
- Gray, Nathanael
- Grimshaw, Charles E
- Hepworth, David
- Huber, Kilian V M
- Jin, Jian
- Knapp, Stefan
- Kotz, Joanne D
- Mader, Mary M
- Marsden, Brian
- Müller, Susanne
- Overington, John P
- Owen, Dafydd R
- Ross, Ruth
- Roth, Bryan
- Schapira, Matthieu
- Schreiber, Stuart L
- Shoichet, Brian
- Sundström, Michael
- Taunton, Jack
- Walters, Michael A
- Willson, Timothy M
- Workman, Paul
- Young, Robert N
- Zuercher, William J
- Venue
- Nature Chemical Biology
- Published
- 2015-07-21
- Volume
- 11
- Issue
- 8
- Pages
- 536-541
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- PMC
- PMC4706458
- OpenAlex
- W1516646538
- Cited by
- 839
- References
- 41
- Citations by year
- 2026: 37 · 2025: 57 · 2024: 62 · 2023: 67 · 2022: 67 · 2021: 81 · 2020: 86 · 2019: 75 · 2018: 79 · 2017: 98 · 2016: 103 · 2015: 25
- FWCI
- 48.56
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-10-20)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Chemical Biology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion, other-oa)
- Deakin Research Online (Deakin University) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- UNC Libraries
- Funders
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Harvard University
- University of Dundee
- Wellcome Trust (106169/Z/14/Z, 104104, 106169, 104104/A/14/Z, 100294)
- Constellation Pharmaceuticals
- Cancer Research UK (11566)
- University of Oxford
- Monash University
- Österreichischen Akademie der Wissenschaften
- University of Toronto
- National Institutes of Health
- University of North Carolina at Chapel Hill
- Novartis Institutes for BioMedical Research
- Medical Research Council (MR/K000985/1)
- National Institute of General Medical Sciences (R01GM103893)
- Janssen Research and Development
- National Center for Advancing Translational Sciences
- UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Click Chemistry and Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Computational Drug Discovery Methods
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
- Keywords
- chemical probes, best practices, wikis, research reproducibility, chemical biology
- MeSH terms
- Humans, Molecular Weight, Sensitivity and Specificity, Molecular Probes, Intellectual Property, Internet, Information Dissemination, Biomedical Research, Small Molecule Libraries
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