The promise and peril of chemical probes

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652

Specificity and mechanism of action of some commonly used protein kinase inhibitors

DAVIES, S. P., Reddy, H., Caivano, M., & Cohen, P. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510095 · Cited by 4,366

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,248

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide-dependent protein kinase and protein kinase C

Hidaka, H., Inagaki, M., Kawamoto, S., & Sasaki, Y. (1984) · Biochemistry · doi:10.1021/bi00316a032 · Cited by 2,688

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

Tamaoki, T., Nomoto, H., TAKAHASHI, I., Kato, Y., Morimoto, M., & Tomita, F. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90008-2 · Cited by 2,452

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Molina, D. M., Jafari, R., Ignatushchenko, M., Seki, T., Larsson, E. A., Dan, C., Sreekumar, L., Cao, Y., & Nordlund, P. (2013) · Science · doi:10.1126/science.1233606 · Cited by 2,261

Click Chemistry for Drug Development and Diverse Chemical–Biology Applications

Prakasam, T., Matosiuk, D., & Jóźwiak, K. (2013) · Chemical Reviews · doi:10.1021/cr200409f · Cited by 1,933

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,930

Targeting bromodomains: epigenetic readers of lysine acetylation

Filippakopoulos, P., & Knapp, S. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4286 · Cited by 1,298

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism

Yu, P. B., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., Lin, H. Y.-F., Bloch, K. D., & Peterson, R. T. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.54 · Cited by 1,059

High-Quality In Vivo Chemical Probes for Protein Kinases Disclosed in 2024

Serafim, R. A. M., & Gehringer, M. (2025) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.5c00293 · Cited by 1

From Silos to Synergy: Multidisciplinary Teams and Artificial Intelligence at the Helm of Research, Development, and Innovation

Badreldin, H. A., & Almosnid, N. M. (2025) · The SCAPE Journal for Multidisciplinary Research and Development · doi:10.4103/sjmr.sjmr_7_25 · Cited by 1

Promiscuously bioactive compounds are prevalent in widely used commercial drug repurposing libraries

Hu, H., Bowers, J., Shumate, J., Scampavia, L. D., Spicer, T., Yi, X., Antolín, A. A., & Baell, J. B. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118550 · Cited by 1

Artificial intelligence for small-molecule chemical probe design: why drug-centric models may not transfer cleanly

Carlucci, R., & Porta, E. O. J. (2026) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2026.1836983 · Cited by 1

Targeting the transcriptional coactivator p300/CBP in cancer: Mechanistic insights and translational implications for osteosarcoma

Masuda, T., Tatsumi, Y., Watanabe, T., & Kamikubo, Y. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108275 · Cited by 1

High-Throughput CETSA Identifies Small Molecule Modulators of ILT3 (LILRB4) with Functional Activity in Human iPSC-Derived Microglia for Alzheimer’s Disease

Abdel‐Rahman, S. A., & Gabr, M. T. (2026) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.6c00244 · Cited by 1

Development of NanoBRET Cellular Target Engagement Assays in Primary Neurons for Activating Mutants of p21-Activated Kinase 1

Capener, J. L., Badillo-Martinez, A., Awada, B., Davis‐Gilbert, Z. W., Krämer, T., Blair, C. S., Bashore, F. M., Al‐Ali, H., & Axtman, A. D. (2026) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6c00326 · Cited by 1

Hitting the target

Leestemaker, Y., & Ovaa, H. (2015) · Nature Methods · doi:10.1038/nmeth.3660 · Cited by 1

Drug discovery

Miller, S. M., Moos, W. H., Munk, B. H., & Munk, S. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100625-2.00011-8 · Cited by 1

Targeted Protein Degradation Chemical Probes

Galdeano, C., & Barril, X. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160745-00150 · Cited by 1

Computational Prediction of Chemical Tools for Identification and Validation of Synthetic Lethal Interaction Networks

Bhanumathy, K. K., Abuhussein, O., Vizeacoumar, F. S., Freywald, A., Vizeacoumar, F. J., Phenix, C. P., Price, E. W., & Cao, R. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1740-3_18 · Cited by 1

Drug discovery processes: When and where the rubber meets the road

Miller, S. M., Moos, W. H., Munk, B. H., Munk, S. A., Hart, C. P., & Spellmeyer, D. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824304-6.00025-0 · Cited by 1

Designer cannabinoids could be the key to pain relief without adverse effects

Greig, I. R., & Ross, R. A. (2025) · Nature · doi:10.1038/d41586-025-00546-w · Cited by 1

Histone Methylation Modifiers in Medical Therapeutics

Trojer, P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803239-8.00037-5 · Cited by 1

Risk Management in Early Discovery Medicinal Chemistry

Singh, G., Dahlin, J. L., & Walters, M. A. (2018) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2018.09.012 · Cited by 1

The Impact of Chemical Biology on Drug Discovery

Plettenburg, O. (2019) · Israel Journal of Chemistry · doi:10.1002/ijch.201900007 · Cited by 1

A chemoprobe tracks its target

Ansari, A. Z. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.h119.008945 · Cited by 1

Targeting der kleinen GTPasen über ihre regulatorischen Proteine

Gray, J. L., von Delft, F., & Brennan, P. E. (2019) · Angewandte Chemie · doi:10.1002/ange.201900585 · Cited by 1

Accelerating Chemical Tool Discovery by Academic Collaborative Models

Stechmann, B., & Fecke, W. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91138 · Cited by 1

A phenotypic approach to probing cellular outcomes using heterobivalent constructs

Bhadoria, R., Ping, K., Lohk, C., Järving, I., & Starkov, P. (2020) · Chemical Communications · doi:10.1039/c9cc09595k · Cited by 1

Assays to Characterize the Cellular Pharmacology of a Chemical Probe

Stefaniak, J., Galan, S. R. G., & Huber, K. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160745-00247 · Cited by 1

Update in Pediatric Neuro-Oncology

Khatua, S., & Pillay Smiley, N. (2019) · MDPI eBooks · doi:10.3390/books978-3-03897-540-3 · Cited by 1

Understanding the ancillary ligand effect on luminescent cyclometalated Ir(III) complex as a reporter for 2-acetylaminofluorene DNA(AAF-dG) adduct

Dayanidhi, D. P. E., & Vaidyanathan, V. G. (2021) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-021-01920-5 · Cited by 1

Actitud de los odontológos generales de Murcia en relación con la biopsia oral

López‐Jornet, P., Nicolás, A. P. V., Beneyto, Y. M., & Soria, M. F. (2007) · Medicina oral, patología oral y cirugía bucal · Cited by 1

Chemical Approaches for Beta-cell Biology

Vetere, A., Parekh, V. S., Modell, A. E., Shoba, V. M., Choudhary, A., & Wagner, B. K. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839165498-00001 · Cited by 1

Cutting Edge Chemical Biology: Report from the 2016 International Symposium on Chemical Biology, January 13–15, Geneva, Switzerland

Adibekian, A., & Stallforth, P. (2016) · ACS Chemical Biology · doi:10.1021/acschembio.6b00267 · Cited by 1

Development of Narrow Spectrum ATP-competitive Kinase Inhibitors as Probes for BIKE and AAK1Preprint

Couñago, R. M., Axtman, A. D., Capuzzi, S. J., de Azevedo, H. F. Z., Drewry, D. H., Elkins, J. M., Gileadi, O., Guimarães, C. R. W., Mascarello, A., Serafim, R. A. M., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/094631 · Cited by 1

Chemical Systems Biology Studies of Triple Negative Breast Cancer Cell Lines

Gautam, P. (2017) · Työväentutkimus Vuosikirja · Cited by 1

Drug Discovery Strategies for the Generation of Multitarget Ligands against Neglected Tropical Diseases

Gandini, A., Prati, F., Uliassi, E., & Bolognesi, M. L. (2017) · Methods and principles in medicinal chemistry · doi:10.1002/9783527674381.ch6 · Cited by 3

Meeting Proceedings from ICBS 2018—Toward Translational Impact

Mayerthaler, F., Finley, M., Pfeifer, T. A., & Antolín, A. A. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00169 · Cited by 1

A Structural View on Druggability

Egner, U., & Hillig, R. C. (2020) · Wiley eBooks · doi:10.1002/9781118681121.ch2 · Cited by 1

Negative controls of chemical probes can be misleadingPreprint

Lee, J., & Schapira, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.30.320465 · Cited by 1

Ten-Year Retrospective of the Vanderbilt Institute of Chemical Biology Chemical Synthesis Core

Kim, K., Christov, P. P., Romaine, I. M., Tian, J., Jana, S., Lamers, A. P., Dutter, B. F., Scaggs, T. D., Jeon, K., Guttentag, B., et al. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.0c00818 · Cited by 1

Illuminating kinase inhibitors biology by cell signaling profilingPreprint

Medvedev, A. V., Makarov, S. S., Medvedeva, L. A., Martsen, E., Gorman, K. L., Lin, B., & Makarov, S. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.03.486887 · Cited by 1

Identification of β-Strand Mediated Protein-Protein Interaction Inhibitors Using Ligand-Directed Fragment LigationPreprint

Hegedüs, Z., Hóbor, F., Shoemark, D. K., Celis, S., Lian, L., Trinh, C. H., Sessions, R. B., Edwards, T. A., & Wilson, A. J. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12429569 · Cited by 1

Activity‐Based Protein Profiling

(2004) · Encyclopedic Dictionary of Genetics, Genomics and Proteomics · doi:10.1002/0471684228.egp00145 · Cited by 1

High-Throughput Screening (HTS) Technology

Roy, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-21573-6_73-1 · Cited by 1

Coronavirus canSAR – a Data-Driven, AI-Enabled, Drug Discovery Resource for the Research CommunityPreprint

Mitsopoulos, C., Antolín, A. A., Villasclaras-Fernández, E. D., Micco, P. D., Mica, I. L., Tym, J. E., Che, K. H., Campbell, J. R., Sanfelice, D., Collins, I., et al. (2020) · ChemRxiv · doi:10.26434/chemrxiv.12286877 · Cited by 1

Reference compounds for characterizing cellular injury in high-content cellular morphology assaysPreprint

Dahlin, J. L., Hua, B. K., Zucconi, B. E., Nelson, S. D., Singh, S., Carpenter, A. E., Shrimp, J. H., Lima‐Fernandes, E., Wawer, M. J., Chung, L. P. W., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.12.499781 · Cited by 1

Developing, Choosing, and Using the Chemical Toolbox for Infectious Diseases Research

Moloney, A., & Maple, H. J. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00539 · Cited by 1

Peptidomimetic inhibitors of β-strand mediated protein-protein interactions: tuning binding affinity of intrinsically disordered sequences by covalent backbone modificationPreprint

Cawood, E. E., Baker, E. G., Edwards, T. A., Woolfson, D. N., Karamanos, T. K., & Wilson, A. J. (2023) · ChemRxiv · doi:10.26434/chemrxiv-2023-xglb4-v2 · Cited by 1

Understanding β-strand mediated protein-protein interactions using peptidomimetics: tuning binding affinity of intrinsically disordered sequences by covalent backbone modificationPreprint

Cawood, E. E., Baker, E. G., Edwards, T. A., Woolfson, D. N., Karamanos, T. K., & Wilson, A. J. (2023) · ChemRxiv · doi:10.26434/chemrxiv-2023-xglb4-v3 · Cited by 1

Identification and benchmarking of Myokinasib-II as a highly selective and potent chemical probe for exploring MLCK1 inhibitionPreprint

Kumar, G., Agarwala, P. K., Srivatsav, A. T., Ravula, A., Ashmitha, G., Balakrishnan, S., Kapoor, S., & Narayan, R. (2024) · ChemRxiv · doi:10.26434/chemrxiv-2024-4n9qr · Cited by 1

The Biochemistry of Chromatin Remodeling

Copeland, R. A. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00014

Multiobjective Optimization of Biological and Physical Properties in Drug Discovery

Gleeson, M. P., & Montanari, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12315-7

Research and discovery

Miller, S. M., Moos, W. H., Munk, B. H., & Munk, S. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100625-2.00012-x

Fortschritte bei der Ras‐Inhibition aus medizinisch‐chemischer Perspektive

Sautier, B., Nising, C. F., & Wortmann, L. (2016) · Angewandte Chemie · doi:10.1002/ange.201608270

Design of Clinical Studies in Early Development

Landis, M. S. (2017) · AAPS advances in the pharmaceutical sciences series · doi:10.1007/978-3-319-50042-3_9

Fragment-based screening of the oncogenic protein tyrosine phosphatase SHP2

Quill, L. (2017) · University of Birmingham Institutional Research Archive (University of Birmingham)

Utilizing a Microbial Natural Product to Investigate Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis

Shekhar‐Guturja, T. (2016) · TSpace (University of Toronto)

Small molecules and their roles in effective pre-clinical target validation

Clegg, M. A., Tomkinson, N. C. O., Prinjah, R. K., & Humphreys, P. G. (2017) · Strathprints: The University of Strathclyde institutional repository (University of Strathclyde)

Kinomes of selected parasitic helminths - fundamental and applied implications

Stroehlein, A. J. (2017) · Minerva Access (University of Melbourne)

The Polypharmacology Gap Between Chemical Biology and Drug Discovery

Antolín, A. A., & Mestres, J. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781788010139-00349

Epigenetic Vulnerabilities in Triple-Negative Breast Cancer

Kao, Y. I. (2017) · TSpace (University of Toronto)

Metal-free synthesis of chromeno[4,3-c]pyrazol-3(2H)-one derivatives

Dhamsaniya, A., Safi, S. K., Chhatbar, P., Trivedi, P., Pambhar, K., Mehta, V. P., & Shah, A. K. (2018) · Tetrahedron Letters · doi:10.1016/j.tetlet.2018.12.053

PREDICTIVE CHEMINFORMATICS ANALYSIS OF DIVERSE CHEMOGENOMICS DATA SOURCES: APPLICATIONS TO DRUG DISCOVERY, ASSAY INTERFERENCE, AND TEXT MINING

Capuzzi, S. J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/bs3n-4f22

Chemical Strategies for Evaluating New Drug Targets

Carter, A. J., Seupel, R., Brennan, P. E., Sundström, M., Introini, A., & Mueller‐Fahrnow, A. (2019) · Methods and principles in medicinal chemistry · doi:10.1002/9783527818242.ch1

Targeting the Ubiquitin Proteasome System in Pulmonary Fibrosis

Thorley, A. J., Krautwald, S., & Rowlands, D. J. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015783-00165

Discovery of novel inhibitors of the phosphatase activity of the soluble epoxide hydrolase

Kramer, J. S., Woltersdorf, S., Wittmann, S. K., Hiesinger, K., Klingler, F., Heering, J., Merk, D., Chaikuad, A., Pogoryelov, D., Steinhilber, D., et al. (2018) · The FASEB Journal · doi:10.1096/fasebj.2018.32.1_supplement.558.3

LIGAND DISCOVERY AND FUNCTIONAL CHARACTERIZATION OF MRGPRX FAMILY ORPHAN GPCRS

Lansu, K. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/p9r4-re19

Cyclic Peptides as Chemical Probes

Serrano, L., Roper, G., & Kawamura, A. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160745-00100

Proteostasis in Huntington’s Disease: Disease Mechanisms and Therapeutic OpportunitiesPreprint

Harding, R., & Tong, Y. (2018) · Preprints.org · doi:10.20944/preprints201801.0179.v1

Experiences in Academic and Industry Partnerships – Forging a Path to Translational Drug Discovery

Dolle, R. E., Barrault, D. V., Carragher, N. O., Andrews, P. D., Ebner, D. V., Hopkins, A., Kojima, H., Frye, S. V., Edwards, A., Dosa, P. I., et al. (2021) · Wiley eBooks · doi:10.1002/0471266949.bmc292

IN VITRO AND IN VIVO EFFICACY COMPARISON OF THREE CYANIDE ANTIDOTE CANDIDATES AND FLUORESCENT METHOD DEVELOPMENT FOR MEASURING THE SELECTED CYANIDE ANTIDOTE DIMETHYL TRISULFIDE AT LOW CONCENTRATIONS

Ralalage, G., & Dilhani, R. (2018)

Research fronts of Chemical Biology

Lv, S. (2021) · Pure and Applied Chemistry · doi:10.1515/pac-2020-1004

Utility of chemical probes for mass spectrometry based chemical proteomics

Bajrami, B., Martin, J. G., & Johnson, D. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821433-6.00003-9

A target engagement assay to assess uptake, potency and retention of antibiotics in living bacteriaPreprint

Couñago, R. M., Fanti, R. C. D. O., Vasconcelos, S. N. S., Catta‐Preta, C. M. C., Sullivan, J., Riboldi, G. P., dos Reis, C., Ramos, P. Z., Edwards, A. M., & Behr, M. A. (2021) · Research Square · doi:10.21203/rs.3.rs-1188756/v1

Structure-based design of a chemical probe set for the 5-HT 5A serotonin receptorPreprint

Levit, A., Strachan, R. T., Bráz, J. M., Craik, V., Slocum, S. T., Mangano, T. J., Amabo, V., O’Donnell, H. R., Lak, P., Basbaum, A. I., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.06.471449

Faculty Opinions recommendation of A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.

Swinney, D. C. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734749270.793576942

Applications of NMR Spectroscopy in FBDD

Bentley, M. R., Doak, B. C., Mohanty, B., & Scanlon, M. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-28275-6_127-1

Faculty Opinions recommendation of Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

Hoppe, T. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.731966527.793570381

Editorial

Fuchter, M. J. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.05.037

Chemical Probes

Donner, A. L., King, H., Brennan, P. E., Moustakim, M., & Zuercher, W. J. (2019) · Methods and principles in medicinal chemistry · doi:10.1002/9783527809257.ch6

Faculty Opinions recommendation of Donated chemical probes for open science.

Swinney, D. C. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733082327.793576941

Synthesis and optimization of pyrazolo [1,5-α] pyrimidine-based macrocyclic kinase inhibitors

Kurz, C. G. (2022) · doi:10.21248/gups.68695

Integrative analysis of GWAS and co-localisation data suggests novel genes associated with age-related multimorbidityPreprint

West, C. E., Karim, M. A., Falaguera, M. J., Speidel, L., Green, C., Logie, L., Schwartzentruber, J., Ochoa, D., Lord, J. M., Ferguson, M. A. J., et al. (2022) · medRxiv · doi:10.1101/2022.11.11.22282236

Targeted Small Molecule Drug Discovery

DiMartino, J. F. (2022) · Pediatric oncology · doi:10.1007/978-3-031-06357-2_2

Drug discovery: Standing on the shoulders of giants

Miller, S. M., Moos, W. H., Munk, B. H., Munk, S. A., Hart, C. P., & Spellmeyer, D. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824304-6.00001-8

Research and discovery: Essential partners but just a start

Miller, S. M., Moos, W. H., Munk, B. H., Munk, S. A., Hart, C. P., & Spellmeyer, D. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824304-6.00011-0

Supplementary Methods from PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma

Holst, F., Werner, H. M. J., Mjøs, S., Høivik, E. A., Kusonmano, K., Wik, E., Berg, A., Birkeland, E., Gibson, W. J., Halle, M. K., et al. (2023) · doi:10.1158/1078-0432.22475439.v1

Advances in Chemical Probing Concepts for Chemical Biology Applications

Arimondo, P. B., Essig, S., Schopfer, U., & Rufer, A. C. (2023) · ChemBioChem · doi:10.1002/cbic.202300319

Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and agingPreprint

Dutta, N., Gerke, J. A., Odron, S. F., Morris, J. D., Hruby, A. J., Torres, T. C., Shemtov, S. J., Clarke, J. G., Chang, M. C., Shaghasi, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.27.568896

Super-resolution single molecule network analysis (SuperResNET) detects changes to clathrin structure by small molecule inhibitorsPreprint

Wong, T. H., Khater, I. M., Hallgrimson, C., Li, Y. L., Hamarneh, G., & Nabi, I. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.07.583946

Chemical Coverage of the Human ReactomePreprint

Kwak, H. A., Liu, L., Tredup, C., Röhm, S., Prinos, P., Böttcher, J., & Schapira, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.23.590739

Transgenesis: In the Drug Discovery Process, Including Target Identification and Target Validation

Mukherjee, A., Das, S., Mondal, N. H., Choudhury, A., & Banerjee, S. (2024) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-97-1148-2_9

Targeting Histone Readers: Non-bromodomain Readers

Huang, X., Chen, Y., Xiao, Q., Shang, X., & Liu, Y. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837674916-00440

Drug Discovery for Chromatin Readers, Writers, Erasers, Remodelers and Epitranscriptomic Targets

(2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837674916-part3

Appendage- and Scaffold-Diverse Electrophilic and Photoreactive Probes for Integrated Phenotypic Screening–Target Identification Campaigns via a Minimalist Bifunctional Isocyanide

Jackson, P. A., Kisty, E. A., Pradhan, V., Swank, C., Bohrer, L., Nolan, T. L., Weerapana, E., & Lapinsky, D. J. (2024) · ACS Omega · doi:10.1021/acsomega.4c06879

Phänomik‐basierte Entdeckung neuer orthosterischer Cholinkinase Inhibitoren

Bauer, L. G., Ward, J., Saez, L. D., Sundström, Y., Tolvanen, T. A., Barrera, J. C. A., Kostidis, S., Rogers, C. M., Panagakou, I., Singh, U., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202420149

Multiobjective optimization of biological and physical properties in drug discovery

Gleeson, M. P., & Montanari, D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00014-5

Discovery and Evaluation of Active Site-Directed, Potent, and Selective Sulfophenyl Acetic Amide-Based Inhibitors for the Laforin Phosphatase

Lin, J., He, R., Qu, Z., Dong, J., Krabill, A. D., Wu, L., Bai, Y., Conroy, L. R., Bruntz, R. C., Miao, Y., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02580

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Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteomePreprint

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Identification and Characterization of a Small Molecule Ligand for the Huntingtin-HAP40 ComplexPreprint

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Introduction to Chemical Probes

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