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Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology
Open accessAbstract
Although organ fibrosis causes significant morbidity and mortality in chronic diseases, the lack of detailed knowledge about specific cellular contributors mediating fibrogenesis hampers the design of effective antifibrotic therapies. Different cellular sources, including tissue-resident and bone marrow-derived fibroblasts, pericytes and epithelial cells, have been suggested to give rise to myofibroblasts, but their relative contributions remain controversial, with profound differences between organs and different diseases. Here we employ a novel Cre-transgenic mouse that marks 99% of hepatic stellate cells (HSCs), a liver-specific pericyte population, to demonstrate that HSCs give rise to 82-96% of myofibroblasts in models of toxic, cholestatic and fatty liver disease. Moreover, we exclude that HSCs function as facultative epithelial progenitor cells in the injured liver. On the basis these findings, HSCs should be considered the primary cellular target for antifibrotic therapies across all types of liver disease.
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“Besides HSCs, other cells, including portal fibroblasts (particularly in cholestatic liver fibrosis), bone marrow-derived fibrocytes, and MSCs contribute to the pool of MFs as well, albeit to a minor extent [7, 13].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [13]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“hepatic stellate cells, the predominant (>95%) source of collagen-producing cells and myofibroblasts in liver fibrosis 15,43 .”
From Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis (2024) · cites this paper as [15]
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“In the fibrotic liver, activated HSCs (aHSCs) have been identified as the predominant source (> 80%) of MFs [7, 13].”
From Mechanisms, efficacy, and future perspectives of cellular-based therapies for liver fibrosis/cirrhosis: focusing on mesenchymal stromal cells (2025) · cites this paper as [13]
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In the citing paper
“Hepatic stellate cells - liver-resident fibroblasts - are central to liver fibrosis 15 and interplay with hepatocytes via cell-cell contact and soluble mediators that support hepatocyte development and homeostasis 16,17 .”
From Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis (2024) · cites this paper as [15]
In the citing paper
“Following injury, HSCs undergo a well-characterized activation process and become the primary fibrogenic cell type of the liver [221, 227, 228].”
From Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells (2025) · cites this paper as [227]
In the citing paper
“Fibrogenesis is driven by myofibroblasts, originating mainly from hepatic stellate cells (HSCs) and portal fibroblasts (3, 4) that acquire fibrogenic, proliferative, immunomodulatory, contractile, and angiogenic properties in response to liver injury (1, 5).”
From Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy (2024) · cites this paper as [4]
In the citing paper
“In rodent models of parenchymal injury, it is predominantly HSCs that activate and differentiate into myofibroblasts.112,113”
From Understanding the cellular interactome of non-alcoholic fatty liver disease (2022) · cites this paper as [113]
In the citing paper
“The majority of myofibroblasts in chemically-injured mouse models also derive from HSCs, and their depletion reduces liver fibrosis (52-54).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [53]
In the citing paper
“Other sources of myofibroblasts include vascular smooth muscle cells, mesothelial cells, and portal fibroblasts, out of which portal myofibroblasts marked by thymocyte differentiation antigen 1 (THY1) may play an outsized role in biliary fibrosis due to their physical localization in the portal region (53, 55-57) (58).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [53]
In the citing paper
“The primary cellular driver of liver fibrogenesis is activated hepatic stellate cells.”
From Nuclear receptors in liver fibrosis (2021) · cites this paper as [6]
In the citing paper
“While aHSCs represent the main source of fibrogenic MFs, [6]”
From Nuclear receptors in liver fibrosis (2021) · cites this paper as [6]
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Citations
Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Bataller, R., & Brenner, D. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24282 · Cited by 4,958
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
Friedman, S. L. (2008) · Physiological Reviews · doi:10.1152/physrev.00013.2007 · Cited by 2,842
Mechanisms of Hepatic Fibrogenesis
Friedman, S. L. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.003 · Cited by 2,687
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
TLR4 enhances TGF-β signaling and hepatic fibrosis
Seki, E., De Minicis, S., Österreicher, C. H., Kluwe, J., Osawa, Y., Brenner, D. A., & Schwabe, R. F. (2007) · Nature Medicine · doi:10.1038/nm1663 · Cited by 1,942
Self-citationThe myofibroblast in wound healing and fibrocontractive diseases
Gabbiani, G. (2003) · The Journal of Pathology · doi:10.1002/path.1427 · Cited by 1,630
Bataller, R. A. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524282c1 · Cited by 1,480
Flagged first, then by citations
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Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492
Mechanisms of hepatic stellate cell activation
Tsuchida, T., & Friedman, S. L. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.38 · Cited by 2,909
Hepatic stellate cells as key target in liver fibrosis
Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485
Diversity and biology of cancer-associated fibroblasts
Biffi, G., & Tuveson, D. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00048.2019 · Cited by 1,265
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
Roehlen, N., Crouchet, E., & Baumert, T. F. (2020) · Cells · doi:10.3390/cells9040875 · Cited by 1,237
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
Parola, M., & Pinzani, M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.002 · Cited by 1,217
Hepatic inflammation and fibrosis: Functional links and key pathways
Seki, E., & Schwabe, R. F. (2015) · Hepatology · doi:10.1002/hep.27332 · Cited by 972
Self-citationPathobiology of liver fibrosis: a translational success story
Lee, Y. A., Wallace, M. C., & Friedman, S. L. (2015) · Gut · doi:10.1136/gutjnl-2014-306842 · Cited by 911
Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD
Ferenbach, D. A., & Bonventre, J. V. (2015) · Nature Reviews Nephrology · doi:10.1038/nrneph.2015.3 · Cited by 892
Primary sclerosing cholangitis – a comprehensive review
Karlsen, T. H., Folseraas, T., Thorburn, D., & Vesterhus, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.07.022 · Cited by 868
Roles for chemokines in liver disease
Marra, F., & Tacke, F. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.06.043 · Cited by 829
Hepatic inflammatory responses in liver fibrosis
Hammerich, L., & Tacke, F. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00807-x · Cited by 803
Cell Death and Cell Death Responses in Liver Disease: Mechanisms and Clinical Relevance
Luedde, T., Kaplowitz, N., & Schwabe, R. F. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.018 · Cited by 785
Self-citationThe Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer
Affo, S., Yu, L.-X., & Schwabe, R. F. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100322 · Cited by 757
Self-citationFibroblast and myofibroblast activation in normal tissue repair and fibrosis
Younesi, F. S., Miller, A. E., Barker, T. H., Rossi, F. M. V., & Hinz, B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00716-0 · Cited by 755
Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis
Schwabe, R. F., Tabas, I., & Pajvani, U. B. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.311 · Cited by 671
Self-citationExtracellular matrix as a driver of progressive fibrosis
Herrera, J., Henke, C. A., & Bitterman, P. B. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93557 · Cited by 639
Tsuchida, T., Lee, Y. A., Fujiwara, N., Ybanez, M., Allen, B., Martins, S., Fiel, M. I., Goossens, N., Chou, H.-I., Hoshida, Y., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.011 · Cited by 583
Epithelial-mesenchymal transition in tissue repair and fibrosis
Stone, R. C., Pastar, I., Ojeh, N. O., Chen, V., Liu, S., Garzon, K. I., & Tomic‐Canic, M. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2464-0 · Cited by 591
Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications
Weiskirchen, R., Weiskirchen, S., & Tacke, F. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.06.003 · Cited by 567
High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers
Mederacke, I., Dapito, D. H., Affò, S., Uchinami, H., & Schwabe, R. F. (2015) · Nature Protocols · doi:10.1038/nprot.2015.017 · Cited by 548
Self-citationOrigin of myofibroblasts in the fibrotic liver in mice
Iwaisako, K., Jiang, C., Zhang, M., Cong, M., Moore-Morris, T. J., Park, T. J., Liu, X., Xu, J., Wang, P., Paik, Y.-H., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400062111 · Cited by 535
Banales, J. M., Huebert, R. C., Karlsen, T., Strazzabosco, M., LaRusso, N. F., & Gores, G. J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0125-y · Cited by 517
Mack, M. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.11.010 · Cited by 535
Zhang, Z., Yao, Z., Wang, L., Ding, H., Shao, J., Chen, A., Zhang, F., & Zheng, S. (2018) · Autophagy · doi:10.1080/15548627.2018.1503146 · Cited by 476
Mechanisms of liver fibrosis and its role in liver cancer
Dhar, D., Baglieri, J., Kisseleva, T., & Brenner, D. A. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219898141 · Cited by 449
Mesenchymal stem cells in fibrotic disease
El Agha, E., Kramann, R., Schneider, R. K., Li, X., Seeger, W., Humphreys, B. D., & Bellusci, S. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.011 · Cited by 430
The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells
Trivedi, P., Wang, S., & Friedman, S. L. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.026 · Cited by 427
Hinz, B. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.07.009 · Cited by 424
Rho, H., Terry, A. R., Chronis, C., & Hay, N. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.06.013 · Cited by 436
Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis
Dobie, R., Wilson-Kanamori, J. R., Henderson, B. E. P., Smith, J. R., Matchett, K. P., Portman, J. R., Wallenborg, K., Picelli, S., Zagorska, A., Pendem, S. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.024 · Cited by 420
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
Affo, S., Nair, A., Brundu, F., Ravichandra, A., Bhattacharjee, S., Matsuda, M., Chin, L., Filliol, A., Wen, W., Song, X., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.03.012 · Cited by 416
Self-citationHepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis
Wang, X., Zheng, Z., Caviglia, J. M., Corey, K. E., Herfel, T. M., Cai, B., Masia, R., Chung, R. T., Lefkowitch, J. H., Schwabe, R. F., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.016 · Cited by 413
Self-citationThe Hippo pathway effector YAP controls mouse hepatic stellate cell activation
Mannaerts, I., Leite, S. B., Verhulst, S., Claerhout, S., Eysackers, N., Thoen, L. F. R., Hoorens, A., Reynaert, H., Halder, G., & van Grunsven, L. A. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.011 · Cited by 410
The big five in fibrosis: Macrophages, myofibroblasts, matrix, mechanics, and miscommunication
Pakshir, P., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.019 · Cited by 396
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
Dias, D. O., Kim, H., Holl, D., Solnestam, B. W., Lundeberg, J., Carlén, M., Göritz, C., & Frisén, J. (2018) · Cell · doi:10.1016/j.cell.2018.02.004 · Cited by 406
Pathophysiological mechanisms of liver injury in COVID‐19
Nardo, A. D., Schneeweiss‐Gleixner, M., Bakail, M., Dixon, E. D., Lax, S., & Trauner, M. (2020) · Liver International · doi:10.1111/liv.14730 · Cited by 400
Daemen, S., Gainullina, A., Kalugotla, G., He, L., Chan, M. M., Beals, J. W., Liss, K. H., Klein, S., Feldstein, A. E., Finck, B. N., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108626 · Cited by 378
“Stellate cells are the primary collagen producing cell in the liver (Mederacke et al., 2013).”
Xu, X., Poulsen, K. L., Wu, L., Liu, S., Miyata, T., Song, Q., Wei, Q., Zhao, C., Lin, C., & Yang, J. B. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01119-3 · Cited by 387
Liver diseases: epidemiology, causes, trends and predictions
Gan, C., Yuan, Y., Shen, H., Gao, J., Kong, X., Che, Z., Guo, Y., Wang, H., Dong, E., & Xiao, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02072-z · Cited by 416
Han, L., Wu, Y., Fang, K., Sweeney, S., Roesner, U. K., Parrish, M., Patel, K., Walter, T., Piermattei, J., Trimboli, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-34464-6 · Cited by 369
Bhattacharjee, S., Hamberger, F., Ravichandra, A., Miller, M., Nair, A., Affo, S., Filliol, A., Chin, L., Savage, T. M., Yin, D., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146987 · Cited by 367
Self-citationThe HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76887 · Cited by 355
Self-citationHepatic stellate cells in physiology and pathology
Kamm, D. R., & McCommis, K. S. (2022) · The Journal of Physiology · doi:10.1113/jp281061 · Cited by 374
Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis
Filliol, A., Saito, Y., Nair, A., Dapito, D. H., Yu, L.-X., Ravichandra, A., Bhattacharjee, S., Affo, S., Fujiwara, N., Su, H., et al. (2022) · Nature · doi:10.1038/s41586-022-05289-6 · Cited by 349
Self-citationJun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 358
Taru, V., Szabo, G., Mehal, W., & Reiberger, T. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.06.016 · Cited by 344
Baglieri, J., Brenner, D. A., & Kisseleva, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071723 · Cited by 347
The myofibroblast, a key cell in normal and pathological tissue repair
Darby, I. A., Zakuan, N., Billet, F., & Desmoulière, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2110-0 · Cited by 328
Current treatment paradigms and emerging therapies for NAFLD/NASH
Raza, S. (2020) · Frontiers in bioscience · doi:10.2741/4892 · Cited by 329
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
Davidson, S., Efremova, M., Riedel, A., Mahata, B., Pramanik, J., Huuhtanen, J., Kar, G., Vento‐Tormo, R., Hagai, T., Chen, X. X., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107628 · Cited by 330
The role of mesenchymal–epithelial transition in endometrial function
Owusu-Akyaw, A., Krishnamoorthy, K., Goldsmith, L. T., & Morelli, S. S. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy035 · Cited by 323
Kanta, J. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00491 · Cited by 319
Andrews, T. S., Atif, J., Liu, J. C., Perciani, C. T., Ma, X., Thoeni, C., Slyper, M., Eraslan, G., Segerstolpe, A., Manuel, J., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1854 · Cited by 307
Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion
Williams, M. J., Clouston, A. D., & Forbes, S. J. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.11.034 · Cited by 308
The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis
Huebener, P., Pradère, J., Hernandez, C., Gwak, G., Caviglia, J. M., Mu, X., Loike, J. D., Jenkins, R. E., Antoine, D. J., & Schwabe, R. F. (2019) · Journal of Clinical Investigation · doi:10.1172/jci126975 · Cited by 301
Self-citationRecent advancement of molecular mechanisms of liver fibrosis
Seki, E., & Brenner, D. A. (2015) · Journal of Hepato-Biliary-Pancreatic Sciences · doi:10.1002/jhbp.245 · Cited by 302
Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis
Kheirollahi, V., Wasnick, R. M., Biasin, V., Vazquez‐Armendariz, A. I., Chu, X., Moiseenko, A., Weiß, A., Wilhelm, J., Zhang, J., Kwapiszewska, G., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10839-0 · Cited by 292
Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis
Gao, J., Wei, B., de Assuncao, T. M., Liu, Z., Hu, X., Ibrahim, S., Cooper, S. A., Cao, S., Shah, V. H., & Kostallari, E. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.044 · Cited by 288
Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner
Birbrair, A., Zhang, T., Files, D. C., Mannava, S., Smith, T. L., Wang, Z., Messi, M. L., Mintz, A., & Delbono, O. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt512 · Cited by 291
Activation of YAP attenuates hepatic damage and fibrosis in liver ischemia-reperfusion injury
Liu, Y., Lu, T., Zhang, C., Xu, J., Xue, Z., Busuttil, R. W., Xu, N., Xia, Q., Kupiec‐Weglinski, J. W., & Ji, H. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.05.029 · Cited by 281
Widjaja, A. A., Singh, B. K., Adami, E., Viswanathan, S., Dong, J., D’Agostino, G. A., Ng, B., Lim, W., Tan, J., Paleja, B. S., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.05.002 · Cited by 279
Weiskirchen, R., & Tacke, F. (2014) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2014.11.03 · Cited by 279
The PNPLA3 I148M variant modulates the fibrogenic phenotype of human hepatic stellate cells
Bruschi, F. V., Claudel, T., Tardelli, M., Caligiuri, A., Stulnig, T. M., Marra, F., & Trauner, M. (2017) · Hepatology · doi:10.1002/hep.29041 · Cited by 268
Schaub, J. R., Malato, Y., Gormond, C., & Willenbring, H. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.003 · Cited by 254
Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis
Ramachandran, P., Matchett, K. P., Dobie, R., Wilson-Kanamori, J. R., & Henderson, N. C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0304-x · Cited by 253
Cellular Mechanisms of Liver Fibrosis
Acharya, P., Chouhan, K., Weiskirchen, S., & Weiskirchen, R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.671640 · Cited by 252
Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis
Zhu, C., Kim, K., Wang, X., Bartolome, A., Salomao, M., Dongiovanni, P., Meroni, M., Graham, M. J., Yates, K. P., Diehl, A. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat0344 · Cited by 250
Self-citationYang, W., He, H., Wang, T., Su, N., Zhang, F., Jiang, K., Zhu, J., Zhang, C., Niu, K., Wang, L., et al. (2021) · Hepatology · doi:10.1002/hep.31987 · Cited by 250
Cellular Homeostasis and Repair in the Mammalian Liver
Stanger, B. Z. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170255 · Cited by 248
Pericytes at the intersection between tissue regeneration and pathology: Figure 1
Birbrair, A., Zhang, T., Wang, Z., Messi, M. L., Mintz, A., & Delbono, O. (2014) · Clinical Science · doi:10.1042/cs20140278 · Cited by 253
Identification, discrimination and heterogeneity of fibroblasts
Lendahl, U., Muhl, L., & Betsholtz, C. (2022) · Nature Communications · doi:10.1038/s41467-022-30633-9 · Cited by 256
Durán, Á., Hernandez, E. D., Reina‐Campos, M., Castilla, E. A., Subramaniam, S., Raghunandan, S., Roberts, L. R., Kisseleva, T., Karin, M., Díaz-Meco, M. T., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.09.004 · Cited by 243
Dou, C., Liu, Z., Tu, K., Zhang, H., Chen, C., Yaqoob, U., Wang, Y., Wen, J., van Deursen, J., Sicard, D., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.02.015 · Cited by 240
Helms, E. J., Berry, M. W., Chaw, R. C., DuFort, C. C., Sun, D., Onate, M. K., Oon, C., Bhattacharyya, S., Sanford-Crane, H., Horton, W., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0601 · Cited by 238
Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy
Iwakiri, Y., & Trebicka, J. (2021) · JHEP Reports · doi:10.1016/j.jhepr.2021.100316 · Cited by 245
Verbeke, L., Mannaerts, I., Schierwagen, R., Govaere, O., Klein, S., Vander Elst, I., Windmolders, P., Farre, R., Wenes, M., Mazzone, M., et al. (2016) · Scientific Reports · doi:10.1038/srep33453 · Cited by 236
Mechanical control of cardiac myofibroblasts
van Putten, S., Shafieyan, Y., & Hinz, B. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.025 · Cited by 240
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Leite, S. B., Roosens, T., El Taghdouini, A., Mannaerts, I., Smout, A. J., Najimi, M., Sokal, E., Noor, F., Chesne, C., & van Grunsven, L. A. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.026 · Cited by 234
Coll, M., Perea, L., Boon, R., Leite, S. B., Vallverdú, J., Mannaerts, I., Smout, A., El Taghdouini, A., Blaya, D., Rodrigo-Torres, D., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.05.027 · Cited by 233
Bates, J., Vijayakumar, A., Ghoshal, S., Marchand, B., Yi, S., Kornyeyev, D., Zagorska, A., Hollenback, D., Walker, K., Liu, K., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.037 · Cited by 230
Xiang, D.-M., Sun, W., Ning, B.-F., Zhou, T.-F., Li, X.-F., Zhong, W., Cheng, Z., Xia, M.-Y., Wang, X., Deng, X., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313392 · Cited by 229
Optimization of collagen type I-hyaluronan hybrid bioink for 3D bioprinted liver microenvironments
Mazzocchi, A. R., Devarasetty, M., Huntwork, R. C., Söker, S., & Skardal, A. (2018) · Biofabrication · doi:10.1088/1758-5090/aae543 · Cited by 235
Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies
Parola, M., & Pinzani, M. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101231 · Cited by 239
The origin of fibrogenic myofibroblasts in fibrotic liver
Kisseleva, T. (2017) · Hepatology · doi:10.1002/hep.28948 · Cited by 224
Martin, K., Pritchett, J. P., Llewellyn, J., Mullan, A. F., Athwal, V. S., Dobie, R., Harvey, E., Zeef, L. A. H., Farrow, S. N., Streuli, C. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms12502 · Cited by 223
The balancing act of the liver: tissue regeneration versus fibrosis
Cordero-Espinoza, L., & Huch, M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93562 · Cited by 233
Caliari, S. R., Perepelyuk, M., Cosgrove, B. D., Tsai, S. J., Lee, G. Y., Mauck, R. L., Wells, R. G., & Burdick, J. A. (2016) · Scientific Reports · doi:10.1038/srep21387 · Cited by 220
Ma, H.-Y., Yamamoto, G., Xu, J., Liu, X., Karin, D., Kim, J. Y., Alexandrov, L. B., Koyama, Y., Nishio, T., Benner, C., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2019.12.016 · Cited by 216
Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment
Mu, X., Español‐Suñer, R., Mederacke, I., Affò, S., Manco, R., Sempoux, C. L., Lemaigre, F. P., Adili, A., Yuan, D., Weber, A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77995 · Cited by 224
Self-citationBRD4 is a novel therapeutic target for liver fibrosis
Ding, N., Hah, N., Yu, R. T., Sherman, M. H., Benner, C., Leblanc, M., He, M., Liddle, C., Downes, M., & Evans, R. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522163112 · Cited by 211
Wang, S., Wang, X., Tan, Z., Su, Y., Liu, J., Chang, M., Yan, F., Chen, J., Chen, T., Li, C., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0242-8 · Cited by 214
Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis
Song, G., Pacher, M., Balakrishnan, A., Yuan, Q., Tsay, H.-C., Yang, D., Reetz, J., Brandes, S., Dai, Z., Pützer, B. M., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.01.010 · Cited by 208
Self-citationKoo, J. H., Lee, H. J., Kim, W. K., & Kim, S. G. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.09.039 · Cited by 211
Liu, X., Xu, J., Rosenthal, S., Zhang, L., McCubbin, R., Meshgin, N., Shang, L., Koyama, Y., Ma, H., Sharma, S., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.01.027 · Cited by 208
Fibrosis in IBD: from pathogenesis to therapeutic targets
Rieder, F., Mukherjee, P. K., Massey, W. J., Wang, Y., & Fiocchi, C. (2024) · Gut · doi:10.1136/gutjnl-2023-329963 · Cited by 218
Yang, Y. M., & Seki, E. (2015) · Current Pathobiology Reports · doi:10.1007/s40139-015-0093-z · Cited by 203
FXR agonists in NASH treatment
Adorini, L., & Trauner, M. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.07.034 · Cited by 200
Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer
Walraven, M., & Hinz, B. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.020 · Cited by 199
Akkız, H., Gieseler, R. K., & Canbay, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147873 · Cited by 191
Metadata
- Authors
- Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F.
- Affiliations
- Columbia University (US)
- Corresponding author
- Schwabe, Robert F.
- Venue
- Nature Communications
- Published
- 2013-11-22
- Volume
- 4
- Issue
- 1
- Pages
- 2823-2823
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4059406
- OpenAlex
- W1965588383
- Cited by
- 1,443
- References
- 56
- Citations by year
- 2026: 111 · 2025: 126 · 2024: 121 · 2023: 194 · 2022: 136 · 2021: 116 · 2020: 124 · 2019: 101 · 2018: 97 · 2017: 91 · 2016: 80 · 2015: 85 · 2014: 53 · 2013: 3
- FWCI
- 45.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- American Liver Foundation (ME 3723/1-1, 1F31DK091980)
- Case Western Reserve University
- Deutsche Forschungsgemeinschaft (1F31DK091980, ME 3723/1-1)
- National Institutes of Health
- University of California, San Diego
- National Cancer Institute (U54CA163111)
- National Institute of Diabetes and Digestive and Kidney Diseases (5R01DK76920, R01DK076920, F31DK091980, R01DK075830)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- hepatic stellate cells, liver fibrosis, myofibroblast origin, fibrogenesis, toxic liver injury, cholestatic liver disease, hepatic steatosis, antifibrotic therapy, bone marrow-derived fibroblasts, pericytes, epithelial progenitor cells
- MeSH terms
- Animals, Female, Liver Cirrhosis, Male, Mice, Inbred CBA, Mice, Inbred C57BL, Genes, Reporter, Integrases, Mice, Hepatic Stellate Cells, Myofibroblasts
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