Cited by 2,160Immune Response and InflammationImmunotherapy and Immune ResponsesImmune responses and vaccinations

The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.

Control of adaptive immunity by the innate immune system

Open access

Iwasaki, Akiko, Medzhitov, Ruslan·2015·Nature Immunology

Open this paper in CoChat — free account

Abstract

Microbial infections are recognized by the innate immune system both to elicit immediate defense and to generate long-lasting adaptive immunity. To detect and respond to vastly different groups of pathogens, the innate immune system uses several recognition systems that rely on sensing common structural and functional features associated with different classes of microorganisms. These recognition systems determine microbial location, viability, replication and pathogenicity. Detection of these features by recognition pathways of the innate immune system is translated into different classes of effector responses though specialized populations of dendritic cells. Multiple mechanisms for the induction of immune responses are variations on a common design principle wherein the cells that sense infections produce one set of cytokines to induce lymphocytes to produce another set of cytokines, which in turn activate effector responses. Here we discuss these emerging principles of innate control of adaptive immunity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/ni.3123

Cites

139 of 139 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Neutrophil Extracellular Traps Kill Bacteria
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Kawai, T., & Akira, S. (2010) · Nature Immunology · doi:10.1038/ni.1863 · Cited by 9,304
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618
Self-citation
IL-17 and th17 cells
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Plant pathogens and integrated defence responses to infection
Dangl, J. L., & Jones, J. D. G. (2001) · Nature · doi:10.1038/35081161 · Cited by 3,959
Approaching the asymptote? Evolution and revolution in immunology.Preprint
Janeway, C. (1989) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1989.054.01.003 · Cited by 3,396
Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436
The role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425
Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
Kärre, K., Ljunggren, H., Piontek, G., & Kiessling, R. (1986) · Nature · doi:10.1038/319675a0 · Cited by 2,333
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting
Merad, M., Sathe, P., Helft, J., Miller, J., & Mortha, A. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074950 · Cited by 2,309
Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., et al. (2008) · Science · doi:10.1126/science.1164206 · Cited by 2,081
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
Moro, K., Yamada, T., Tanabe, M., Takeuchi, T., Ikawa, T., Kawamoto, H., Furusawa, J.-I., Ohtani, M., Fujii, H., & Koyasu, S. (2009) · Nature · doi:10.1038/nature08636 · Cited by 1,994
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette-Zlatanova, B. C., Shlomchik, M. J., & Marshak‐Rothstein, A. (2002) · Nature · doi:10.1038/416603a · Cited by 1,929
Monocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840
IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors
Liu, Y.-J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115633 · Cited by 1,618
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
Dudziak, D., Kamphorst, A. O., Heidkamp, G. F., Buchholz, V. R., Trumpfheller, C., Yamazaki, S., Cheong, C., Liu, K., Lee, H., Park, C. G., et al. (2007) · Science · doi:10.1126/science.1136080 · Cited by 1,454
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli, L. A., Sonnenberg, G. F., Abt, M. C., Alenghat, T., Ziegler, C. G. K., Doering, T. A., Angelosanto, J., Laidlaw, B. J., Yang, C. Y., Sathaliyawala, T., et al. (2011) · Nature Immunology · doi:10.1038/ni.2131 · Cited by 1,327
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
Zhao, Y., Yang, J., Shi, J., Gong, Y., Lu, Q., Xu, H., Liu, L., & Shao, F. (2011) · Nature · doi:10.1038/nature10510 · Cited by 1,310
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
Abreu, M. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2707 · Cited by 1,288
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
Wu, J., & Chen, Z. J. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120156 · Cited by 1,212 · cited 2×
“When CD22 is engaged by its sialic acid ligand, it activates the lipid phosphatase SHIP, which converts phosphatidylinositol-(3,4,5)trisphosphate (generated by PI(3)K) into phosphatidylinositol-(3,4)-bisphosphate and thus inhibits downstream steps in the PI(3)K signaling pathway96.”
Background
C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
Dempsey, P. W., Allison, M. E. D., Akkaraju, S., Goodnow, C. C., & Fearon, D. T. (1996) · Science · doi:10.1126/science.271.5247.348 · Cited by 1,197
Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4
Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.014 · Cited by 1,066
Tissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology
Asselin‐Paturel, C., Boonstra, A., Dalod, M., Durand, I., Yessaad, N., Dezutter‐Dambuyant, C., Vicari, A. P., O’Garra, A., Biron, C. A., Brière, F., et al. (2001) · Nature Immunology · doi:10.1038/ni736 · Cited by 1,021
A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis
Salimi, M., Barlow, J. L., Saunders, S. P., Xue, L., Gutowska‐Owsiak, D., Wang, X., Huang, L.-C., Johnson, D., Scanlon, S. T., McKenzie, A. N. J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130351 · Cited by 1,012
The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch
Wilson, S. R., Thé, L., Batia, L. M., Beattie, K., Katibah, G. E., McClain, S. P., Pellegrino, M., Estandian, D., & Bautista, D. M. (2013) · Cell · doi:10.1016/j.cell.2013.08.057 · Cited by 989
Regulation of inflammasome signaling
Rathinam, V. A. K., Vanaja, S. K., & Fitzgerald, K. A. (2012) · Nature Immunology · doi:10.1038/ni.2237 · Cited by 960 · cited 1×
“When CD22 is engaged by its sialic acid ligand, it activates the lipid phosphatase SHIP, which converts phosphatidylinositol-(3,4,5)trisphosphate (generated by PI(3)K) into phosphatidylinositol-(3,4)-bisphosphate and thus inhibits downstream steps in the PI(3)K signaling pathway96.”
Background
Protective immune mechanisms in helminth infection
Anthony, R. M., Rutitzky, L. I., Urban, J. F., Stadecker, M. J., & Gause, W. C. (2007) · Nature reviews. Immunology · doi:10.1038/nri2199 · Cited by 959
Commensal bacteria at the interface of host metabolism and the immune system
Brestoff, J. R., & Artis, D. (2013) · Nature Immunology · doi:10.1038/ni.2640 · Cited by 945
Inflammasomes and Their Roles in Health and Disease
Lamkanfi, M., & Dixit, V. M. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155745 · Cited by 935
The aryl hydrocarbon receptor: multitasking in the immune system
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120245 · Cited by 909
Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen.
Plantinga, M., Guilliams, M., Vanheerswynghels, M., Deswarte, K., Branco-Madeira, F., Toussaint, W., Vanhoutte, L., Neyt, K., Killeen, N., Malissen, B., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.016 · Cited by 893
IRF4 Transcription Factor-Dependent CD11b+ Dendritic Cells in Human and Mouse Control Mucosal IL-17 Cytokine Responses
Schlitzer, A., McGovern, N. N., Teo, P., Zelante, T., Atarashi, K., Low, D., Ho, A. W. S., See, P., Shin, A., Wasan, P. S., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.011 · Cited by 884
Memory T Cell Subsets, Migration Patterns, and Tissue Residence
Mueller, S. N., Gebhardt, T., Carbone, F., & Heath, W. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095954 · Cited by 884
Type 2 Innate Signals Stimulate Fibro/Adipogenic Progenitors to Facilitate Muscle Regeneration
Heredia, J. E., Mukundan, L., Chen, F. M., Mueller, A. A., Deo, R. C., Locksley, R. M., Rando, T. A., & Chawla, A. (2013) · Cell · doi:10.1016/j.cell.2013.02.053 · Cited by 818
Cytokine-secreting follicular T cells shape the antibody repertoire
Reinhardt, R. L., Liang, H.-E., & Locksley, R. M. (2009) · Nature Immunology · doi:10.1038/ni.1715 · Cited by 807
MHC class I alloantigen specificity of Ly-49+ IL-2-activated natural killer cells
Karlhofer, F. M., Ribaudo, R. K., & Yokoyama, W. M. (1992) · Nature · doi:10.1038/358066a0 · Cited by 803
Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells
Haniffa, M. A., Shin, A., Bigley, V., McGovern, N. N., Teo, P., See, P., Wasan, P. S., Wang, X.-N., Malinarich, F., Malleret, B., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.012 · Cited by 786
Control of B-cell responses by Toll-like receptors
Pasare, C., & Medzhitov, R. M. (2005) · Nature · doi:10.1038/nature04267 · Cited by 752
Self-citation
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
Sancho, D., Joffre, O. P., Keller, A. M., Rogers, N. C., Martínez, D., Hernanz-Falcón, P., Rosewell, I., & Sousa, C. R. E. (2009) · Nature · doi:10.1038/nature07750 · Cited by 750
A cell biological view of Toll-like receptor function: regulation through compartmentalization
Barton, G. M., & Kagan, J. C. (2009) · Nature reviews. Immunology · doi:10.1038/nri2587 · Cited by 746
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells
Edelson, B. T., Wumesh, K. C., Juang, R., Kohyama, M., Benoît, L. A., Klekotka, P. A., Moon, C., Albring, J. C., Ise, W., Michael, D. G., et al. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091627 · Cited by 710
Stress, Inflammation, and Defense of Homeostasis
Chovatiya, R., & Medzhitov, R. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.030 · Cited by 704
Self-citation
Influenza virus activates inflammasomes via its intracellular M2 ion channel
Ichinohe, T., Pang, I. K., & Iwasaki, A. (2010) · Nature Immunology · doi:10.1038/ni.1861 · Cited by 632
Self-citation
B-1a and B-1b Cells Exhibit Distinct Developmental Requirements and Have Unique Functional Roles in Innate and Adaptive Immunity to S. pneumoniae
Haas, K. M., Poe, J. C., Steeber, D. A., & Tedder, T. F. (2005) · Immunity · doi:10.1016/j.immuni.2005.04.011 · Cited by 628
Multifarious roles of sialic acids in immunity
Varki, A. P., & Gagneux, P. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06517.x · Cited by 619
IRF4 Transcription-Factor-Dependent CD103+CD11b+ Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation
Persson, E. K., Uronen‐Hansson, H., Semmrich, M., Rivollier, A., Hägerbrand, K., Marsal, J., Guðjónsson, S., Håkansson, U., Reizis, B., Kotarsky, K., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.03.009 · Cited by 616
Functional Specializations of Human Epidermal Langerhans Cells and CD14+ Dermal Dendritic Cells
Klechevsky, E., Morita, R., Liu, M., Cao, Y., Coquery, S., Thompson-Snipes, L., Brière, F., Chaussabel, D., Zurawski, G., Palucka, K., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.013 · Cited by 616
B-1 and B-2 Cell–Derived Immunoglobulin M Antibodies Are Nonredundant Components of the Protective Response to Influenza Virus Infection
Baumgarth, N., Herman, O. C., Jager, G. C., Brown, L. E., Herzenberg, L. A., & Chen, J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.2.271 · Cited by 583
Development, Differentiation, and Diversity of Innate Lymphoid Cells
Diefenbach, A., Colonna, M., & Koyasu, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.005 · Cited by 560
Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine
Lewis, K. L. T., Caton, M. L., Bogunovic, M., Greter, M., Grajkowska, L. T., Ng, D., Klinakis, A., Charo, I. F., Jung, S., Gommerman, J. L., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.013 · Cited by 557
Clearance of influenza virus from the lung depends on migratory langerin+CD11b− but not plasmacytoid dendritic cells
Geurtsvankessel, C., Willart, M., van Rijt, L. V., Muskens, F., Kool, M., Baas, C., Thielemans, K., Bennett, C. L., Clausen, B., Hoogsteden, H., et al. (2008) · Journal of Experimental Medicine · doi:10.1084/jem.20071365 · Cited by 541
Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System
Vance, R. E., Isberg, R. R., & Portnoy, D. A. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.06.007 · Cited by 540
A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP
Doody, G. M., Justement, L. B., Delibrias, C., Matthews, R. J., Lin, J., Thomas, M. L., & Fearon, D. T. (1995) · Science · doi:10.1126/science.7618087 · Cited by 538
STING and the innate immune response to nucleic acids in the cytosol
Burdette, D. L., & Vance, R. E. (2013) · Nature Immunology · doi:10.1038/ni.2491 · Cited by 501
Welcome to the neighborhood: epithelial cell‐derived cytokines license innate and adaptive immune responses at mucosal sites
Saenz, S. A., Taylor, B. C., & Artis, D. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00713.x · Cited by 498
Host–Bacterial Symbiosis in Health and Disease
Chow, J., Lee, S. M., Shen, Y. L., Khosravi, A., & Mazmanian, S. K. (2010) · Advances in immunology · doi:10.1016/b978-0-12-381300-8.00008-3 · Cited by 485
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection
Robinson, M. J., Osorio, F., Rosas, M., Freitas, R. P., Schweighoffer, E., Groß, O., Verbeek, J. S., Ruland, J., Tybulewicz, V. L. J., Brown, G. D., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082818 · Cited by 483
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths
Gause, W. C., Wynn, T. A., & Allen, J. E. (2013) · Nature reviews. Immunology · doi:10.1038/nri3476 · Cited by 481
Control of T Helper 2 Responses by Transcription Factor IRF4-Dependent Dendritic Cells
Gao, Y., Nish, S. A., Jiang, R., Hou, L., Licona-Limón, P., Weinstein, J. S., Zhao, H., & Medzhitov, R. M. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.028 · Cited by 478
Self-citation
Re(de)fining the dendritic cell lineage
Satpathy, A. T., Wu, X., Albring, J. C., & MURPHY, K. M. M. (2012) · Nature Immunology · doi:10.1038/ni.2467 · Cited by 470
Skin-Resident Murine Dendritic Cell Subsets Promote Distinct and Opposing Antigen-Specific T Helper Cell Responses
Igyártó, B. Z., Haley, K. M., Ortner, D., Bobr, A., Gerami‐Nejad, M., Edelson, B. T., Zurawski, S., MALISSEN, B., Zurawski, G., Berman, J. G., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.005 · Cited by 454
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells
Uematsu, S., Jang, M. H., Chevrier, N., Guo, Z., Kumagai, Y., Yamamoto, M., Kato, H., Sougawa, N., Matsui, H., Kuwata, H., et al. (2006) · Nature Immunology · doi:10.1038/ni1362 · Cited by 450
Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity
Spencer, S. P., Wilhelm, C., Yang, Q., Hall, J. A., Bouladoux, N., Boyd, A., Nutman, T. B., Urban, J. F., Wang, J., Ramalingam, T. R., et al. (2014) · Science · doi:10.1126/science.1247606 · Cited by 447
Viral RNA detection by RIG-I-like receptors
Yoneyama, M., Onomoto, K., Jogi, M., Akaboshi, T., & Fujita, T. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.12.012 · Cited by 441
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
Guo, L., Wei, G., Zhu, J., Liao, W., Leonard, W. J., Zhao, K., & Paul, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906988106 · Cited by 423
Recognition of Bacteria by Inflammasomes
von Moltke, J., Ayres, J. S., Kofoed, E. M., Chavarría‐Smith, J., & Vance, R. E. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095944 · Cited by 420
Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition
Nakayamada, S., Kanno, Y., Takahashi, H., Jankovic, D. L., Lu, K. T., Johnson, T. A., Sun, H., Vahedi, G., Hakim, O., Handon, R., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.11.012 · Cited by 417
CD301b+ Dermal Dendritic Cells Drive T Helper 2 Cell-Mediated Immunity
Kumamoto, Y., Linehan, M. M., Weinstein, J. S., Laidlaw, B. J., Craft, J. E., & Iwasaki, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.029 · Cited by 413
Self-citation
Detection of prokaryotic mRNA signifies microbial viability and promotes immunity
Sander, L. E., Davis, M. J., Boekschoten, M. V., Amsen, D., Dascher, C. C., Ryffel, B., Swanson, J. A., Müller, M. M., & Blander, J. M. (2011) · Nature · doi:10.1038/nature10072 · Cited by 412
B1b Lymphocytes Confer T Cell-Independent Long-Lasting Immunity
Alugupalli, K. R., Leong, J. M., Woodland, R. T., Muramatsu, M., Honjo, T., & Gerstein, R. M. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.019 · Cited by 411
CD8α+ Dendritic Cells Are the Critical Source of Interleukin-12 that Controls Acute Infection by Toxoplasma gondii Tachyzoites
Mashayekhi, M., Sandau, M. M., Dunay, I. R., Frickel, E., Khan, A., Goldszmid, R. S., Sher, A., Ploegh, H. L., Murphy, T. L., Sibley, L. D., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.008 · Cited by 405
CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
Henri, S., Poulin, L. F., Tamoutounour, S., Ardouin, L., Guilliams, M., de Bovis, B., Devilard, É., Viret, C., Azukizawa, H., Kissenpfennig, A., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091964 · Cited by 402
Allergic host defences
Palm, N. W., Rosenstein, R. K., & Medzhitov, R. M. (2012) · Nature · doi:10.1038/nature11047 · Cited by 399 · cited 1×
“When CD22 is engaged by its sialic acid ligand, it activates the lipid phosphatase SHIP, which converts phosphatidylinositol-(3,4,5)trisphosphate (generated by PI(3)K) into phosphatidylinositol-(3,4)-bisphosphate and thus inhibits downstream steps in the PI(3)K signaling pathway96.”
BackgroundSelf-citation
Innate Lymphoid Cells in Inflammation and Immunity
McKenzie, A. N. J., Spits, H., & Eberl, G. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.006 · Cited by 384
Compartmentalized and systemic control of tissue immunity by commensals
Belkaid, Y., & Naik, S. (2013) · Nature Immunology · doi:10.1038/ni.2604 · Cited by 382
AhR sensing of bacterial pigments regulates antibacterial defence
Moura‐Alves, P., Fae, K. C., Houthuys, E., Dorhoi, A., Kreuchwig, A., Furkert, J., Barison, N., Diehl, A., Munder, A., Constant, P., et al. (2014) · Nature · doi:10.1038/nature13684 · Cited by 380
Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation
Torchinsky, M. B., Garaude, J., Martin, A. P., & Blander, J. M. (2009) · Nature · doi:10.1038/nature07781 · Cited by 364
Th17 cells in immunity to Candida albicans
Hernández-Santos, N., & Gaffen, S. L. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.04.008 · Cited by 361
Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens
Allen, J. E., & Wynn, T. A. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002003 · Cited by 351
Type I interferon dependence of plasmacytoid dendritic cell activation and migration
Asselin‐Paturel, C., Brizard, G., Chemin, K., Boonstra, A., O’Garra, A., Vicari, A. P., & Trinchieri, G. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041930 · Cited by 343
Characterization of resident and migratory dendritic cells in human lymph nodes
Segura, É., Valladeau‐Guilemond, J., Donnadieu, M., Sastre‐Garau, X., Soumelis, V., & Amigorena, S. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111457 · Cited by 326
The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling
Tang, H., Cao, W., Kasturi, S. P., Ravindran, R., Nakaya, H. I., Kundu, K., Murthy, N., Kepler, T. B., MALISSEN, B., & Pulendran, B. (2010) · Nature Immunology · doi:10.1038/ni.1883 · Cited by 319
CD103− and CD103+ Bronchial Lymph Node Dendritic Cells Are Specialized in Presenting and Cross-Presenting Innocuous Antigen to CD4+ and CD8+ T Cells
del Rio, M., Rodríguez-Barbosa, J.-I., Kremmer, E., & Förster, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6861 · Cited by 319
CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell–associated antigen
Desch, A. N., Randolph, G. J., MURPHY, K. M. M., Gautier, E. L., Kedl, R. M., Lahoud, M. H., Caminschi, I., Shortman, K., Henson, P. M., & Jakubzick, C. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110538 · Cited by 318
Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks.
Wada, T., Ishiwata, K., Koseki, H., Ishikura, T., Ugajin, T., Ohnuma, N., Obata, K., Ishikawa, R., Yoshikawa, S., Mukai, K., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42680 · Cited by 310
Pattern recognition: recent insights from Dectin-1
Reid, D. M., Gow, N. A. R., & Brown, G. D. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.003 · Cited by 306
Beyond pattern recognition: five immune checkpoints for scaling the microbial threat
Blander, J. M., & Sander, L. E. (2012) · Nature reviews. Immunology · doi:10.1038/nri3167 · Cited by 300
The dendritic cell receptor DNGR-1 controls endocytic handling of necrotic cell antigens to favor cross-priming of CTLs in virus-infected mice
Zelenay, S., Keller, A. M., Whitney, P. G., Schraml, B. U., Deddouche, S., Rogers, N. C., Schulz, O., Sancho, D., & Sousa, C. R. E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60644 · Cited by 290
Temporal changes in dendritic cell subsets, cross-priming and costimulation via CD70 control CD8+ T cell responses to influenza
Ballesteros‐Tato, A., León, B., Lund, F. E., & Randall, T. D. (2010) · Nature Immunology · doi:10.1038/ni.1838 · Cited by 268
BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway
Pone, E. J., Zhang, J., Mai, T., White, C. A., Li, G., Sakakura, J. K., Patel, P. J., Al-Qahtani, A. A., Zan, H., Xu, Z., et al. (2012) · Nature Communications · doi:10.1038/ncomms1769 · Cited by 252
Virus-induced Interferon α Production by a Dendritic Cell Subset in the Absence of Feedback Signaling In Vivo
Barchet, W., Cella, M., Odermatt, B., Asselin‐Paturel, C., Colonna, M., & Kalinke, U. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011666 · Cited by 252
Innate immune detection of microbial nucleic acids
Gürtler, C., & Bowie, A. G. (2013) · Trends in Microbiology · doi:10.1016/j.tim.2013.04.004 · Cited by 251
Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response
Hou, B., Saudan, P., Ott, G. S., Wheeler, M. L., Ji, M., Kuzmich, L., Lee, L. M., Coffman, R. L., Bachmann, M. F., & DeFranco, A. L. (2011) · Immunity · doi:10.1016/j.immuni.2011.01.011 · Cited by 237
Properdin: Emerging Roles of a Pattern-Recognition Molecule
Kemper, C., Atkinson, J. P., & Hourcade, D. E. (2009) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101250 · Cited by 236
Pattern recognition receptor function in neutrophils
Thomas, C. J., & Schroder, K. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.02.008 · Cited by 220
Tissue‐resident memory T cells
Shin, H., & Iwasaki, A. (2013) · Immunological Reviews · doi:10.1111/imr.12087 · Cited by 215
Self-citation
TLR Signaling Fine-Tunes Anti-Influenza B Cell Responses without Regulating Effector T Cell Responses
Heer, A. K., Shamshiev, A. T., Donda, A., Uematsu, S., Akira, S., Köpf, M., & Marsland, B. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2182 · Cited by 212
GM-CSF–dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization
King, I. L., Kroenke, M. A., & Segal, B. M. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20091844 · Cited by 196
Missing self recognition and self tolerance of natural killer (NK) cells
Raulet, D. H. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.03.003 · Cited by 195
Toll-Like Receptor Expression and Responsiveness of Distinct Murine Splenic and Mucosal B-Cell Subsets
Gururajan, M., Jacob, J., & Pulendran, B. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000863 · Cited by 194
Effector-triggered versus pattern-triggered immunity: how animals sense pathogens
Stuart, L. M., Paquette, N., & Boyer, L. (2013) · Nature reviews. Immunology · doi:10.1038/nri3398 · Cited by 192
Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes
Nish, S. A., & Medzhitov, R. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.009 · Cited by 186
Self-citation
Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol
Casson, C. N., Copenhaver, A. M., Zwack, E. E., Nguyen, H. T., Strowig, T., Javdan, B., Bradley, W. P., Fung, T. C., Flavell, R. A., Brodsky, I. E., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003400 · Cited by 181
The interleukin‐23 axis in intestinal inflammation
Ahern, P. P., Ízcue, A., Maloy, K. J., & Powrie, F. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00705.x · Cited by 181
Reciprocal regulation of IL‐23 and IL‐12 following co‐activation of Dectin‐1 and TLR signaling pathways
Dennehy, K. M., Willment, J. A., Williams, D. L., & Brown, G. D. (2009) · European Journal of Immunology · doi:10.1002/eji.200838543 · Cited by 180
CD8α+ Dendritic Cells Are an Obligate Cellular Entry Point for Productive Infection by Listeria monocytogenes
Edelson, B. T., Bradstreet, T. R., Hildner, K. M., Carrero, J. A., Frederick, K. E., Wumesh, K. C., Belizaire, R., Aoshi, T., Schreiber, R. D., Miller, M. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.012 · Cited by 179
Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism
Welty, N. E., Staley, C. M., Ghilardi, N., Sadowsky, M. J., Igyártó, B. Z., & Kaplan, D. H. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130728 · Cited by 171
Signals via the Adaptor MyD88 in B Cells and DCs Make Distinct and Synergistic Contributions to Immune Activation and Tissue Damage in Lupus
Teichmann, L. L., Schenten, D., Medzhitov, R. M., Kashgarian, M. J., & Shlomchik, M. J. (2013) · Immunity · doi:10.1016/j.immuni.2012.11.017 · Cited by 152
Self-citation
Innate Lymphoid Cells: Balancing Immunity, Inflammation, and Tissue Repair in the Intestine
Wojno, E. D. T., & Artis, D. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.10.003 · Cited by 151
Differential Requirements for NAIP5 in Activation of the NLRC4 Inflammasome
Lightfield, K. L., Persson, J., Trinidad, N. J., Brubaker, S. W., Kofoed, E. M., Sauer, J., Dunipace, E. A., Warren, S. E., Miao, E. A., & Vance, R. E. (2011) · Infection and Immunity · doi:10.1128/iai.01187-10 · Cited by 139
Prostaglandins and sickness behavior: Old story, new insights
Pecchi, E., Dallaporta, M., Jean, A., Thirion, S., & Troadec, J.-D. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.040 · Cited by 135
Batf3-Dependent CD11blow/− Peripheral Dendritic Cells Are GM-CSF-Independent and Are Not Required for Th Cell Priming after Subcutaneous Immunization
Edelson, B. T., Bradstreet, T. R., Wumesh, K. C., Hildner, K., Herzog, J., Sim, J. E., Russell, J. H., Murphy, T. L., Unanue, E. R., & MURPHY, K. M. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025660 · Cited by 127
Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction
Desch, A. N., Gibbings, S. L., Clambey, E. T., Janssen, W. J., Slansky, J. E., Kedl, R. M., Henson, P. M., & Jakubzick, C. (2014) · Nature Communications · doi:10.1038/ncomms5674 · Cited by 126
Innate lymphoid cells: new insights into function and development
Cortez, V. S., Robinette, M. L., & Colonna, M. (2015) · Current Opinion in Immunology · doi:10.1016/j.coi.2015.01.004 · Cited by 118
B Cell Intrinsic MyD88 Signals Drive IFN-γ Production from T Cells and Control Switching to IgG2c
Barr, T. A., Brown, S. L., Mastroeni, P., & Gray, D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803706 · Cited by 116
Diversity of animal immune receptors and the origins of recognition complexity in the deuterostomes
Buckley, K. M., & Rast, J. P. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.10.013 · Cited by 114
Cytokine-induced cytokine production by conventional and innate lymphoid cells
Guo, L., Junttila, I., & Paul, W. E. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.07.006 · Cited by 105
Cell mediated immunity to fungi: a reassessment
Romani, L. R. (2008) · Medical Mycology · doi:10.1080/13693780801971450 · Cited by 98
Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells
Cauley, L. S., & Lefrançois, L. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.96 · Cited by 94
Toll-like Receptor 7 Controls the Anti-Retroviral Germinal Center Response
Browne, E. P. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002293 · Cited by 90
Cytosolic surveillance and antiviral immunity
Rathinam, V. A. K., & Fitzgerald, K. A. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.11.004 · Cited by 89
Cutaneous basophil responses and immune resistance of guinea pigs to ticks: passive transfer with peritoneal exudate cells or serum.
Brown, S. J., & Askenase, P. W. (1981) · The Journal of Immunology · doi:10.4049/jimmunol.127.5.2163 · Cited by 84
A Unique Dermal Dendritic Cell Subset That Skews the Immune Response toward Th2
Murakami, R., Denda‐Nagai, K., Hashimoto, S.-I., Nagai, S., Hattori, M., & Irimura, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073270 · Cited by 78
Antiviral Instruction of Bone Marrow Leukocytes during Respiratory Viral Infections
Hermesh, T., Moltedo, B., Moran, T. M., & López, C. B. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.04.006 · Cited by 73
Alveolar Macrophages and Lung Dendritic Cells Sense RNA and Drive Mucosal IgA Responses
Bessa, J., Jegerlehner, A., Hinton, H. J., Pumpens, P., Saudan, P., Schneider, P., & Bachmann, M. F. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804004 · Cited by 71
Activation of B lymphocytes: integrating signals from CD19, CD22 and FcγRIIb1
Doody, G. M., Dempsey, P. W., & Fearon, D. T. (1996) · Current Opinion in Immunology · doi:10.1016/s0952-7915(96)80128-2 · Cited by 68
MyD88 Is Required for the Formation of Long-Term Humoral Immunity to Virus Infection
Guay, H., Andreyeva, T. A., Garcea, R. L., Welsh, R. M., & Szomolanyi‐Tsuda, E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5124 · Cited by 66
Osteopontin expression by CD103 − dendritic cells drives intestinal inflammation
Kourepini, E., Aggelakopoulou, M., Alissafi, T., Paschalidis, N., Simoes, D. C. M., & Panoutsakopoulou, V. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316447111 · Cited by 66
Dietary and commensal derived nutrients: shaping mucosal and systemic immunity
Spencer, S. P., & Belkaid, Y. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.07.006 · Cited by 54
Complementary diversification of dendritic cells and innate lymphoid cells
Briseño, C. G., Murphy, T. L., & MURPHY, K. M. M. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.04.006 · Cited by 51
Exciting Developments in the Immunology of Fungal Infections
Brown, G. D., & Netea, M. G. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.04.010 · Cited by 39

Flagged first, then by citations

Sorted by citations

Inflammation and tumor progression: signaling pathways and targeted intervention
Zhao, H., Wu, L., Yan, G., Chen, Y., Zhou, M., Wu, Y., & Li, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00658-5 · Cited by 3,058
Longitudinal analyses reveal immunological misfiring in severe COVID-19
Lucas, C., Wong, P., Klein, J., Castro, T. B. R., Silva, J., Sundaram, M., Ellingson, M. K., Mao, T., Oh, J. E., Israelow, B., et al. (2020) · Nature · doi:10.1038/s41586-020-2588-y · Cited by 2,074
Self-citation
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“, intracellular (viral and bacterial) infection: type I IFNs/IL-12, Th1, IgG1, IgG3; helminth infection: IL-4, Th2, IgG4, IgE; fungal infection: IL-23, Th17], hallmarking the close interplay between the innate and adaptive arm of the immune system (266, 368, 566).”
Background
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Galluzzi, L., Vitale, I., Warren, S., Adjemian, S., Agostinis, P., Buqué, A., Chan, T. A.-T., Coukos, G., Demaria, S., Deutsch, É., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000337 · Cited by 1,210
“221 Conversely, the microenvironment of dying cancer cells is a major determinant of their ability to initiate adaptive immune responses, even in the presence of sufficient antigenicity and adjuvanticity, 5 222 and this has major implications for the choice of experimental models for the assessment…”
Phagocytosis: An Immunobiologic Process
Gordon, S. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.026 · Cited by 902
“Iwasaki and Medzhitov have summarized in detail how specialized DC populations sense the nature of microbial intracellular infection to activate appropriate effector responses (Iwasaki and Medzhitov, 2015).”
Background

See all 2,160

Authors: Iwasaki, A., & Medzhitov, R.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Iwasaki, Akiko
Medzhitov, Ruslan
ORCID: Iwasaki, Akiko
Medzhitov, Ruslan
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-03-19
Volume: 16
Issue: 4
Pages: 343-353
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.3123
PMC: PMC4507498
OpenAlex: W2044757050
Cited by: 2,160
References: 139
Citations by year: 2026: 183 · 2025: 212 · 2024: 181 · 2023: 193 · 2022: 204 · 2021: 239 · 2020: 216 · 2019: 189 · 2018: 187 · 2017: 167 · 2016: 157 · 2015: 31
FWCI: 17.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Allergy and Infectious Diseases (R01AI064705, AI062428, AI 064705, R01AI062428, AI 081884, R56AI062428, AI089771, R01AI089771, R01AI054359, R37AI046688, AI046688, R01AI081884, R01AI046688)
National Institute of Diabetes and Digestive and Kidney Diseases (DK071754, R01DK071754)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: innate immunity, adaptive immunity, innate-adaptive immune crosstalk, pathogen recognition, dendritic cells, cytokines, lymphocyte activation, microbial infection, pattern recognition receptors
MeSH terms: Animals, Bacteria, Dendritic Cells, Fungi, Gene Expression Regulation, Helminths, Humans, Immunity, Innate, Intestines, Lung, Skin, Viruses, Lymphocyte Subsets, Cytokines, Receptors, Pattern Recognition, Adaptive Immunity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Control of adaptive immunity by the innate immune system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks