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Elevated plasma ghrelin levels in Prader–Willi syndrome
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Citations
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · cited 1×
“that increases food intake, body weight and growth-hormone (GH) secretion as potently as any known peptid”
BackgroundA preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940
Self-citationA mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346
Self-citationMelanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., & Froguel, P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9238 · Cited by 897 · cited 1×
“Mutations that affect signaling by leptin and melanocortins were hypothesized to contribute to human obesity based on their important roles in body-weight regulation in rodent models, and compelling support for this hypothesis now exist”
BackgroundSelf-citationGenome Organization, Function, and Imprinting in Prader-Willi and Angelman Syndromes
Nicholls, R. D., & Knepper, J. L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.153 · Cited by 625
Cited by
Ghrelin: Structure and Function
Kojima, M., & Kangawa, K. (2005) · Physiological Reviews · doi:10.1152/physrev.00012.2004 · Cited by 2,810
Cassidy, S. B., Schwartz, S., Miller, J. L., & Driscoll, D. J. (2012) · Genetics in Medicine · doi:10.1038/gim.0b013e31822bead0 · Cited by 1,452
Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., et al. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.005 · Cited by 1,034
Self-citationGhrelin and the short- and long-term regulation of appetite and body weight
Cummings, D. E. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.022 · Cited by 620
Self-citationHavel, P. J. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00132.x · Cited by 607
Jerlhag, E., Egecioglu, E., Dickson, S. L., Douhan, A., Svensson, L., & Engel, J. A. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00041.x · Cited by 431
Korner, J., Bessler, M., Cirilo, L. J., Conwell, I. M., Daud, A., Restuccia, N. L., & Wardlaw, S. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1076 · Cited by 417
LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor
Ge, X., Yang, H., Bednarek, M. A., Galon-Tilleman, H., Chen, P., Chen, M., Lichtman, J. S., Wang, Y., Dalmas, O., Yin, Y., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.10.016 · Cited by 376
Hormonal regulation of food intake
Stanley, S., Wynne, K., McGowan, B., & Bloom, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00015.2004 · Cited by 372
Tang-Christensen, M., Vrang, N., Ortmann, S., Bidlingmaier, M., Horvath, T. L., & Tschöp, M. (2004) · Endocrinology · doi:10.1210/en.2004-0529 · Cited by 226
The physiology of gastric emptying
Hellström, P. M., Grybäck, P., & Jacobsson, H. (2006) · Best Practice & Research Clinical Anaesthesiology · doi:10.1016/j.bpa.2006.02.002 · Cited by 223
Neural Mechanisms Underlying Hyperphagia in Prader‐Willi Syndrome
Holsen, L. M., Zarcone, J. R., Brooks, W. M., Butler, M. G., Thompson, T. I., Ahluwalia, J. S., Nollen, N. L., & Savage, C. R. (2006) · Obesity · doi:10.1038/oby.2006.118 · Cited by 189
Ghrelin regulation of glucose metabolism
Poher, A.-L., Tschöp, M. H., & Müller, T. D. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.015 · Cited by 186
The Integrative Role of CNS Fuel-Sensing Mechanisms in Energy Balance and Glucose Regulation
Sandoval, D., Cota, D., & Seeley, R. J. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.120806.095256 · Cited by 178
Unraveling the Genetics of Human Obesity
Mutch, D. M., & Clément, K. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020188 · Cited by 169
“One candidate protein that may mediate the severe hyperphagia of PWS is the gastric hormone ghrelin [41], via its regulation of hunger and stimulation of growth hormone [8].”
BackgroundSelf-citationObesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis
Rahmouni, K. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.00920 · Cited by 150
Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity
Horwitz, A., & Birk, R. (2023) · Nutrients · doi:10.3390/nu15153445 · Cited by 143
New targets to treat obesity and the metabolic syndrome
Martin, K. A., Mani, M. V., & Mani, A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.093 · Cited by 121
Miller, J. L., James, G. A., Goldstone, A. P., Couch, J. A., He, G., Driscoll, D. J., & Liu, Y. (2007) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.099044 · Cited by 119
Central Nervous System Regulation of Energy Metabolism: Ghrelin versus Leptin
Nogueiras, R., Tschöp, M. H., & Zigman, J. M. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1433.054 · Cited by 115
Kent, B. A., Beynon, A. L., Hornsby, A. K. E., Bekinschtein, P., Bussey, T. J., Davies, J. S., & Saksida, L. M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.015 · Cited by 94
The role of ghrelin in the regulation of glucose homeostasis
Alamri, B. N., Shin, K., Chappe, V., & Anini, Y. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0018 · Cited by 93
Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism
Dimaraki, E. V., & Jaffe, C. A. (2007) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-006-9022-0 · Cited by 84
Role of ghrelin in the pathophysiology of gastrointestinal disease
Cheung, C. K., & Wu, J. C.-Y. (2013) · Gut and Liver · doi:10.5009/gnl.2013.7.5.505 · Cited by 68
Hinton, E. C., Holland, A. J., Gellatly, M. S. N., Soni, S., & Owen, A. M. (2006) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.2006.00812.x · Cited by 50
Somogyi, V., Gyorffy, A., Scalise, T. J., Kiss, D. S., Goszleth, G., Bartha, T., Frenyo, V. L., & Zsarnovszky, A. (2011) · Nutrition Research Reviews · doi:10.1017/s0954422411000035 · Cited by 37
Ghrelin’s Role as a Major Regulator of Appetite and Its Other Functions in Neuroendocrinology
Lim, C. T., Kola, B., Korbonits, M., & Grossman, A. B. (2010) · Progress in Brain Research · doi:10.1016/s0079-6123(10)82008-4 · Cited by 34
Metadata
- Authors
- Cummings, D. E., Clement, K., Purnell, J. Q., Vaisse, C., Foster, K. E., Frayo, R. S., Schwartz, M. W., Basdevant, A., & Weigle, D. S.
- Venue
- Nature Medicine
- Published
- 2002-07
- Volume
- 8
- Issue
- 7
- Pages
- 643-644
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2068134092
- Cited by
- 600
- References
- 6
- FWCI
- 23.35
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.