A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage

The Structure of Scientific Revolutions

Kuhn, T. S., & Schlegel, R. (1963) · Physics Today · doi:10.1063/1.3050879 · Cited by 35,538

THE STRUCTURE OF SCIENTIFIC REVOLUTIONS

MCGUIRE, J. E. (1963) · Philosophical Books · doi:10.1111/j.1468-0149.1963.tb00813.x · Cited by 8,424

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,506

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

Park, H., Li, Z., Yang, X. O., Chang, S. H., Nurieva, R., Wang, Y.-H., Wang, Y., Hood, L., Zhu, Z., Tian, Q., et al. (2005) · Nature Immunology · doi:10.1038/ni1261 · Cited by 4,265

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099

TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605

Transforming growth factor-β induces development of the TH17 lineage

Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

Duerr, R. H., Taylor, K. D., Brant, S. R., Rioux, J. D., Silverberg, M. S., Daly, M. J., Steinhart, A. H., Abraham, C., Regueiro, M., Griffiths, A., et al. (2006) · Science · doi:10.1126/science.1135245 · Cited by 3,039

The immunology of stroke: from mechanisms to translation

Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596

Development, cytokine profile and function of human interleukin 17-producing helper T cells

Wilson, N. J., Boniface, K., Chan, J. R., McKenzie, B. S., Blumenschein, W. M., Mattson, J. D., Basham, B., Smith, K., Chen, T., Morel, F., et al. (2007) · Nature Immunology · doi:10.1038/ni1497 · Cited by 2,035

The complex role of estrogens in inflammation

Straub, R. H. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0001 · Cited by 1,950

Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

Kebir, H., Kreymborg, K., Ifergan, I., Dodelet-Devillers, A., Cayrol, R., Bernard, M., Giuliani, F., Arbour, N., Becher, B., & Prat, A. (2007) · Nature Medicine · doi:10.1038/nm1651 · Cited by 1,759

ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context

Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604

Structure and signalling in the IL-17 receptor family

Gaffen, S. L. (2009) · Nature reviews. Immunology · doi:10.1038/nri2586 · Cited by 1,475

C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157

TH17 cells in development: an updated view of their molecular identity and genetic programming

Dong, C. (2008) · Nature reviews. Immunology · doi:10.1038/nri2295 · Cited by 1,064

Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease

Onishi, R. M., & Gaffen, S. L. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03240.x · Cited by 894

The role of COX‐2 in intestinal inflammation and colorectal cancer

Wang, D., & DuBois, R. N. (2010) · Oncogene · doi:10.1038/onc.2009.421 · Cited by 805

Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice

Meng, F., Wang, K., Aoyama, T., Grivennikov, S. I., Paik, Y., Scholten, D., Cong, M., Iwaisako, K., Liu, X., Zhang, M., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.05.049 · Cited by 711

The role of peripheral immune cells in the CNS in steady state and disease

Prinz, M., & Priller, J. (2017) · Nature Neuroscience · doi:10.1038/nn.4475 · Cited by 657

Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death

Toscano, M. A., Bianco, G. A., Ilarregui, J. M., Croci, D. O., Correale, J., Hernandez, J. D., Zwirner, N. W., Poirier, F., Riley, E. M., Baum, L. G., et al. (2007) · Nature Immunology · doi:10.1038/ni1482 · Cited by 653

T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses

King, C., Tangye, S. G., & Mackay, C. R. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090344 · Cited by 632

Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells

Marigo, I., Dolcetti, L., Serafini, P., Zanovello, P., & Bronte, V. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00602.x · Cited by 608

When worlds collide: Th17 and Treg cells in cancer and autoimmunity

Knochelmann, H. M., Dwyer, C. J., Bailey, S. R., Amaya, S. M., Elston, D. M., Mazza-McCrann, J. M., & Paulos, C. M. (2018) · Cellular & Molecular Immunology · doi:10.1038/s41423-018-0004-4 · Cited by 535

Regulation of immunological homeostasis in the respiratory tract

Holt, P. G., Strickland, D. H., Wikström, M. E., & Jahnsen, F. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2236 · Cited by 528

Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes

Pène, J., Chevalier, S., Preisser, L., Vénéreau, E., Guilleux, M.-H., Ghannam, S., Molès, J.-P., Danger, Y., Ravon, E., Lesaux, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7423 · Cited by 527

Multiple sclerosis

Nylander, A., & Hafler, D. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58649 · Cited by 495

Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors

Kawahara, K., Hohjoh, H., Inazumi, T., Tsuchiya, S., & Sugimoto, Y. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.07.008 · Cited by 488

CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis

Katoh, H., Wang, D., Daikoku, T., Sun, H., Dey, S. K., & DuBois, R. N. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.10.009 · Cited by 477

Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity

Sapone, A., Lammers, K. M., Casolaro, V., Cammarota, M., Giuliano, M. T., De Rosa, M., Stefanile, R., Mazzarella, G., Tolone, C., Russo, M. I., et al. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-23 · Cited by 452

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

Yang, J., Chu, Y., Yang, X., Gao, D., Zhu, L., Yang, X., Wan, L., & Li, M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24499 · Cited by 444

The interleukin-17 pathway is involved in human alcoholic liver disease # †

Lemmers, A., Moreno, C., Gustot, T., Maréchal, R., Degré, D., Demetter, P., de Nadai, P., Geerts, A., Quertinmont, E., Vercruysse, V., et al. (2009) · Hepatology · doi:10.1002/hep.22680 · Cited by 394

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

Guo, B., Chang, E. Y., & Cheng, G. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33342 · Cited by 371

Th17 cells in immunity to Candida albicans

Hernández-Santos, N., & Gaffen, S. L. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.04.008 · Cited by 361

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

Chiurchiù, V., Leuti, A., Dalli, J., Jacobsson, A., Battistini, L., Maccarrone, M., & Serhan, C. N. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf7483 · Cited by 359

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

Ajami, B., Samusik, N., Wieghofer, P., Ho, P. P., Crotti, A., Bjornson, Z., Prinz, M., Fantl, W. J., Nolan, G. P., & Steinman, L. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0100-x · Cited by 338

A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17

Gaffen, S. L., & Hajishengallis, G. (2008) · Journal of Dental Research · doi:10.1177/154405910808700908 · Cited by 334

Th17 Cells in Cancer: The Ultimate Identity Crisis

Bailey, S. R., Nelson, M. H., Himes, R. A., Li, Z., Mehrotra, S., & Paulos, C. M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00276 · Cited by 334

γδ T cells: an important source of IL-17

Roark, C. L., Simonian, P. L., Fontenot, A. P., Born, W. K., & O’Brien, R. L. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.006 · Cited by 325

Tumor microenvironments direct the recruitment and expansion of human Th17 cells

Su, X., Ye, J., Hsueh, E. C., Zhang, Y., Hoft, D. F., & Peng, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902813 · Cited by 324

The Pro-Inflammatory Cytokine, Interleukin-6, Enhances the Polarization of Alternatively Activated Macrophages

Fernando, M. R., Reyes, J. L., Iannuzzi, J., Leung, G., & McKay, D. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094188 · Cited by 314

Activation of the Cholinergic Anti-Inflammatory System by Nicotine Attenuates Neuroinflammation via Suppression of Th1 and Th17 Responses

Nizri, E., Irony-Tur-Sinai, M., Lory, O., Orr-Urtreger, A., Lavi, E., & Brenner, T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902212 · Cited by 304

IL-17–Mediated Immunity to the Opportunistic Fungal Pathogen Candida albicans

Conti, H. R., & Gaffen, S. L. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500909 · Cited by 301

Immune cells and CNS physiology: Microglia and beyond

Norris, G. T., & Kipnis, J. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180199 · Cited by 274

Molecular mechanisms underlying prostaglandin E2-exacerbated inflammation and immune diseases

Tsuge, K., Inazumi, T., Shimamoto, A., & Sugimoto, Y. (2019) · International Immunology · doi:10.1093/intimm/dxz021 · Cited by 263

Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection

Hou, W., Kang, H. S., & Kim, B. S. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082030 · Cited by 246

Cardiac myosin-Th17 responses promote heart failure in human myocarditis

Myers, J. M., Cooper, L. T., Kem, D. C., Stavrakis, S., Kosanke, S. D., Shevach, E. M., Fairweather, D., Stoner, J. A., Cox, C. J., & Cunningham, M. W. (2016) · JCI Insight · doi:10.1172/jci.insight.85851 · Cited by 230

Emerging tendency towards autoimmune process in major depressive patients: A novel insight from Th17 cells

Chen, Y., Jiang, T., Chen, P., Ouyang, J., Xu, G., Zeng, Z., & Sun, Y. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2010.10.029 · Cited by 209

Etiology and Pathogenesis of Psoriasis

Boehncke, W.-H. (2015) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2015.07.013 · Cited by 197

Dual role of tumour-infiltrating T helper 17 cells in human colorectal cancer

Amicarella, F., Muraro, M. G., Hirt, C., Cremonesi, E., Padovan, E., Mele, V, Governa, V, Han, J., Huber, X., Droeser, R. A., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-310016 · Cited by 189

Th1, Th2, and Th17 Effector T Cell-Induced Autoimmune Gastritis Differs in Pathological Pattern and in Susceptibility to Suppression by Regulatory T Cells

Stummvoll, G. H., DiPaolo, R. J., Huter, E. N., Davidson, T. S., Glass, D., Ward, J. M., & Shevach, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.3.1908 · Cited by 170

Minireview: glucocorticoids in autoimmunity: unexpected targets and mechanisms

Flammer, J. R., & Rogatsky, I. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0068 · Cited by 140

Critical Role of Proinflammatory Cytokine IL-6 in Allograft Rejection and Tolerance

Zhao, X., Boenisch, O., Yeung, M., Mfarrej, B., Yang, S., Turka, L. A., Sayegh, M. H., Iacomini, J., & Yuan, X. (2012) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2011.03770.x · Cited by 104

Experimental models of multiple sclerosis

Pachner, A. R. (2011) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328346c226 · Cited by 90

Reversal of Paralysis and Reduced Inflammation from Peripheral Administration of β-Amyloid in T H 1 and T H 17 Versions of Experimental Autoimmune Encephalomyelitis

Grant, J. L., Ghosn, E. E. B., Axtell, R. C., Herges, K., Kuipers, H. F., Woodling, N. S., Andreasson, K., Herzenberg, L. A., Herzenberg, L. A., & Steinman, L. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004145 · Cited by 92

HMGB1 blockade attenuates experimental autoimmune myocarditis and suppresses Th17‐cell expansion

Su, Z., Sun, C., Zhou, C., Liu, Y., Zhu, H., Sandoghchian, S., Zheng, D., Peng, T., Zhang, Y., Jiao, Z., et al. (2011) · European Journal of Immunology · doi:10.1002/eji.201141879 · Cited by 81

Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo

Ziesché, E., Scheiermann, P., Bachmann, M., Sadik, C. D., Hofstetter, C., Zwissler, B., Pfeilschifter, J., & Mühl, H. (2009) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2009.03969.x · Cited by 40

Ten years of proteomics in multiple sclerosis

Farias, A. S., Pradella, F., Schmitt, A., Santos, L. M. B., & Martins‐de‐Souza, D. (2014) · PROTEOMICS · doi:10.1002/pmic.201300268 · Cited by 40

Apolipoprotein E mediation of neuro-inflammation in a murine model of multiple sclerosis

Shin, S., Walz, K. A., Archambault, A. S., Sim, J., Bollman, B. P., Koenigsknecht-Talboo, J., Cross, A. H., Holtzman, D. M., & Wu, G. F. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.03.010 · Cited by 32

Distinct CCL2, CCL5, CCL11, CCL27, IL-17, IL-6, BDNF Serum Profiles Correlate to Different Job-Stress Outcomes

Polacchini, A., Girardi, D., Falco, A., Zanotta, N., Comar, M., De Carlo, N. A., & Tongiorgi, E. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.02.002 · Cited by 30

Life before seventeen: cloning of the IL-17 receptor

Gaffen, S. L. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102576 · Cited by 22

Succumbing to the laws of attraction: Exploring the sometimes pathogenic versatility of discrete immune logic

Fritsch, P., Craddock, T. J., del Rosario, R. M., Rice, M. A., Smylie, A., Folcik, V. A., de Vries, G., Fletcher, M. A., Klimas, N. G., & Broderick, G. (2013) · Systems Biomedicine · doi:10.4161/sysb.28948 · Cited by 16

Excessive Innate Immunity Steers Pathogenic Adaptive Immunity in the Development of Theiler’s Virus-Induced Demyelinating Disease

Kim, B. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105254 · Cited by 8