Fast gapped-read alignment with Bowtie 2

Langmead, Ben, Salzberg, Steven L·2012·Nature Methods

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Items 101–200 of 909

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  5. Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
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  6. A draft human pangenome reference.
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  7. Biogeography and individuality shape function in the human skin metagenome
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  8. An environment-dependent transcriptional network specifies human microglia identity
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  9. Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function
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  10. Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
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  11. Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT
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  12. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics
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  13. Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
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  14. Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth
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  15. Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation
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  16. Probiotics, gut microbiota, and their influence on host health and disease
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  17. Towards precision medicine
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  18. Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
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  19. A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments
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  20. RETRACTED ARTICLE: Microbiome analyses of blood and tissues suggest cancer diagnostic approach
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  21. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals
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  22. An inhibitor of oxidative phosphorylation exploits cancer vulnerability
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  23. Microbial strain-level population structure and genetic diversity from metagenomes
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  24. Sensitive tumour detection and classification using plasma cell-free DNA methylomes
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  25. Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance
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  26. Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants
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  27. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response
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  28. Chromatin states define tumour-specific T cell dysfunction and reprogramming
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  29. Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease
    Blauwkamp, Timothy A., Thair, Simone, Rosen, Michael J., Blair, Lily, Lindner, Martin S., Vilfan, Igor D., Kawli, Trupti, Christians, Fred C., Venkatasubrahmanyam, Shivkumar, Wall, Gregory D. et al. · 2019 · Nature Microbiology
  30. Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells
    Han, Dali, Liu, Jun, Chen, Chuanyuan, Dong, Lihui, Liu, Yi, Chang, Renbao, Huang, Xiaona, Liu, Yuanyuan, Wang, Jianying, Dougherty, Urszula et al. · 2019 · Nature
  31. Cicero predicts cis-regulatory DNA interactions from single-cell chromatin accessibility data
    Pliner, Hannah A., Packer, Jonathan S., McFaline-Figueroa, José L., Cusanovich, Darren A., Daza, Riza M., Aghamirzaie, Delasa, Srivatsan, Sanjay, Qiu, Xiaojie, Jackson, Dana, Minkina, Anna et al. · 2018 · Molecular Cell
  32. The cohesin release factor WAPL restricts chromatin loop extension
    Haarhuis, Judith H.I., van der Weide, Robin H., Blomen, Vincent A., Yáñez-Cuna, J. Omar, Amendola, Mario, van Ruiten, Marjon S., Krijger, Peter H.L., Teunissen, Hans, Medema, René H., van Steensel, Bas et al. · 2017 · Cell
  33. Identification of essential genes for cancer immunotherapy
    Patel, Shashank J., Sanjana, Neville E., Kishton, Rigel J., Eidizadeh, Arash, Vodnala, Suman K., Cam, Maggie, Gartner, Jared J., Jia, Li, Steinberg, Seth M., Yamamoto, Tori N. et al. · 2017 · Nature
  34. Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state
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  35. Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism
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  36. A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility
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  37. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia
    Wong, Terrence N., Ramsingh, Giridharan, Young, Andrew L., Miller, Christopher A., Touma, Waseem, Welch, John S., Lamprecht, Tamara L., Shen, Dong, Hundal, Jasreet, Fulton, Robert S. et al. · 2015 · Nature
  38. American Gut: an Open Platform for Citizen-Science Microbiome Research
    McDonalda, Daniel, Hyde, Embriette, Debelius, Justine W., Morton, James T., Gonzalez, Antonio, Ackermann, Gail, Aksenov, Alexander A., Behsaz, Bahar, Brennan, Caitriona, Chen, Yingfeng et al. · 2018
  39. Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
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  40. Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis
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  41. The microbiome of uncontacted Amerindians
    Clemente, Jose C., Pehrsson, Erica C., Blaser, Martin J., Sandhu, Kuldip, Gao, Zhan, Wang, Bin, Magris, Magda, Hidalgo, Glida, Contreras, Monica, Noya-Alarcón, Óscar et al. · 2015 · Science Advances
  42. ChIP‐Atlas: a data‐mining suite powered by full integration of public ChIP‐seq data
    Oki, Shinya, Ohta, Tazro, Shioi, Go, Hatanaka, Hideki, Ogasawara, Osamu, Okuda, Yoshihiro, Kawaji, Hideya, Nakaki, Ryo, Sese, Jun, Meno, Chikara · 2018 · The EMBO Reports
  43. Classification of low quality cells from single-cell RNA-seq data
    Ilicic, Tomislav, Kim, Jong Kyoung, Kolodziejczyk, Aleksandra A., Bagger, Frederik Otzen, McCarthy, Davis James, Marioni, John C., Teichmann, Sarah A. · 2016 · Genome Biology
  44. Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
    Kuscu, Cem, Arslan, Sevki, Singh, Ritambhara, Thorpe, Jeremy, Adli, Mazhar · 2014 · Nature Biotechnology
  45. In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
    Musunuru, Kiran, Chadwick, Alexandra C., Mizoguchi, Taiji, Garcia, Sara P., DeNizio, Jamie E., Reiss, Caroline W., Wang, Kui, Iyer, Sowmya, Dutta, Chaitali, Clendaniel, Victoria et al. · 2021 · Nature
  46. Cell-cycle dynamics of chromosomal organization at single-cell resolution
    Nagano, Takashi, Lubling, Yaniv, Várnai, Csilla, Dudley, Carmel, Leung, Wing, Baran, Yael, Mendelson Cohen, Netta, Wingett, Steven, Fraser, Peter, Tanay, Amos · 2017 · Nature
  47. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
    Peng, Min, Yin, Na, Chhangawala, Sagar, Xu, Ke, Leslie, Christina S., Li, Ming O. · 2016 · Science
  48. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
    Han, Ting, Goralski, Maria, Gaskill, Nicholas, Capota, Emanuela, Kim, Jiwoong, Ting, Tabitha C., Xie, Yang, Williams, Noelle S., Nijhawan, Deepak · 2017 · Science
  49. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
    Nuñez, James K., Chen, Jin, Pommier, Greg C., Cogan, J. Zachery, Replogle, Joseph M., Adriaens, Carmen, Ramadoss, Gokul N., Shi, Quanming, Hung, King L., Samelson, Avi J. et al. · 2021 · Cell
  50. Roux-en-Y Gastric Bypass and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut Microbiome Contributing to Fat Mass Regulation
    Tremaroli, Valentina, Karlsson, Fredrik, Werling, Malin, Ståhlman, Marcus, Kovatcheva-Datchary, Petia, Olbers, Torsten, Fändriks, Lars, le Roux, Carel W., Nielsen, Jens, Bäckhed, Fredrik · 2015 · Cell Metabolism
  51. Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity
    Ioannou, Maria S., Jackson, Jesse, Sheu, Shu-Hsien, Chang, Chi-Lun, Weigel, Aubrey V., Liu, Hui, Pasolli, H. Amalia, Xu, C. Shan, Pang, Song, Matthies, Doreen et al. · 2019 · Cell
  52. Environmental factors shaping the gut microbiome in a Dutch population
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  53. Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor
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  54. New insights from uncultivated genomes of the global human gut microbiome
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  55. Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
    Rodgers, Ali B., Morgan, Christopher P., Leu, N. Adrian, Bale, Tracy L. · 2015 · Proceedings of the National Academy of Sciences
  56. Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
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  57. The Human Gut Virome Is Highly Diverse, Stable, and Individual Specific
    Shkoporov, Andrey N., Clooney, Adam G., Sutton, Thomas D.S., Ryan, Feargal J., Daly, Karen M., Nolan, James A., McDonnell, Siobhan A., Khokhlova, Ekaterina V., Draper, Lorraine A., Forde, Amanda et al. · 2019 · Cell Host & Microbe
  58. Potential roles of gut microbiome and metabolites in modulating ALS in mice
    Blacher, Eran, Bashiardes, Stavros, Shapiro, Hagit, Rothschild, Daphna, Mor, Uria, Dori-Bachash, Mally, Kleimeyer, Christian, Moresi, Claudia, Harnik, Yotam, Zur, Maya et al. · 2019 · Nature
  59. Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
    Maeder, Morgan L., Stefanidakis, Michael, Wilson, Christopher J., Baral, Reshica, Barrera, Luis Alberto, Bounoutas, George S., Bumcrot, David, Chao, Hoson, Ciulla, Dawn M., DaSilva, Jennifer A. et al. · 2019 · Nature Medicine
  60. Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells
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  61. Quantitative assessment of single-cell RNA-sequencing methods
    Wu, Angela R, Neff, Norma F, Kalisky, Tomer, Dalerba, Piero, Treutlein, Barbara, Rothenberg, Michael E, Mburu, Francis M, Mantalas, Gary L, Sim, Sopheak, Clarke, Michael F et al. · 2014 · Nature Methods
  62. Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
    Young, Andrew L., Challen, Grant A., Birmann, Brenda M., Druley, Todd E. · 2016 · Nature Communications
  63. Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
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  64. Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes
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  65. Formation of new chromatin domains determines pathogenicity of genomic duplications
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  66. A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens
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  67. DeepCRISPR: Optimized CRISPR guide RNA design by deep learning
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  68. Mitochondrial double-stranded RNA triggers antiviral signalling in humans
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  69. Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors
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  70. Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
    Li, Guolin, Xie, Cen, Lu, Siyu, Nichols, Robert G., Tian, Yuan, Li, Licen, Patel, Daxeshkumar, Ma, Yinyan, Brocker, Chad N., Yan, Tingting et al. · 2017 · Cell Metabolism
  71. Proteogenomic and metabolomic characterization of human glioblastoma
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  72. Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods
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  73. Loss of epigenetic information as a cause of mammalian aging
    Yang, Jae-Hyun, Hayano, Motoshi, Griffin, Patrick T., Amorim, João A., Bonkowski, Michael S., Apostolides, John K., Salfati, Elias L., Blanchette, Marco, Munding, Elizabeth M., Bhakta, Mital et al. · 2023 · Cell
  74. Identification and characterization of circular RNAs As a new class of putative biomarkers in human blood
    Memczak, Sebastian, Papavasileiou, Panagiotis, Peters, Oliver, Rajewsky, Nikolaus · 2015 · PLoS ONE
  75. Cooperative Binding of Transcription Factors Orchestrates Reprogramming
    Chronis, Constantinos, Fiziev, Petko, Papp, Bernadett, Butz, Stefan, Bonora, Giancarlo, Sabri, Shan, Ernst, Jason, Plath, Kathrin · 2017 · Cell
  76. Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments
    Karkman, Antti, Pärnänen, Katariina, Larsson, D. G. Joakim · 2019 · Nature Communications
  77. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks
    Imbeault, Michaël, Helleboid, Pierre-Yves, Trono, Didier · 2017 · Nature
  78. Ultrastructural Details of Mammalian Chromosome Architecture
    Krietenstein, Nils, Abraham, Sameer, Venev, Sergey V., Abdennur, Nezar, Gibcus, Johan, Hsieh, Tsung-Han S., Parsi, Krishna Mohan, Yang, Liyan, Maehr, René, Mirny, Leonid A. et al. · 2020 · Molecular Cell
  79. Subsistence strategies in traditional societies distinguish gut microbiomes
    Obregon-Tito, Alexandra J., Tito, Raul Y., Metcalf, Jessica, Sankaranarayanan, Krithivasan, Clemente, Jose C., Ursell, Luke K., Zech Xu, Zhenjiang, Van Treuren, Will, Knight, Rob, Gaffney, Patrick M. et al. · 2015 · Nature Communications
  80. Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans
    Rechavi, Oded, Houri-Ze’evi, Leah, Anava, Sarit, Goh, Wee Siong Sho, Kerk, Sze Yen, Hannon, Gregory J., Hobert, Oliver · 2014 · Cell
  81. Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion
    Yu, Yi-Ru, Imrichova, Hana, Wang, Haiping, Chao, Tung, Xiao, Zhengtao, Gao, Min, Rincon-Restrepo, Marcela, Franco, Fabien, Genolet, Raphael, Cheng, Wan-Chen et al. · 2020 · Nature Immunology
  82. Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
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  84. The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
    Bell, Robert J. A., Rube, H. Tomas, Kreig, Alex, Mancini, Andrew, Fouse, Shaun D., Nagarajan, Raman P., Choi, Serah, Hong, Chibo, He, Daniel, Pekmezci, Melike et al. · 2015 · Science
  85. Chromatin accessibility profiling by ATAC-seq
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  86. Human-Specific NOTCH2NL Genes Affect Notch Signaling and Cortical Neurogenesis
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  87. Laboratory mice born to wild mice have natural microbiota and model human immune responses
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  88. Neutralizing antibodies correlate with protection from SARS-CoV-2 in humans during a fishery vessel outbreak with a high attack rate
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  89. Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells
    Sloan, Steven A., Darmanis, Spyros, Huber, Nina, Khan, Themasap A., Birey, Fikri, Caneda, Christine, Reimer, Richard, Quake, Stephen R., Barres, Ben A., Paşca, Sergiu P. · 2017 · Neuron
  90. Current challenges and best-practice protocols for microbiome analysis
    Bharti, Richa, Grimm, Dominik G · 2021 · Briefings in Bioinformatics
  91. Widespread macromolecular interaction perturbations in human genetic disorders
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