Cited by 397Advanced MRI Techniques and ApplicationsOptical Imaging and Spectroscopy TechniquesAdvanced Neuroimaging Techniques and Applications

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Neurometabolic coupling in cerebral cortex reflects synaptic more than spiking activity

Viswanathan, Ahalya, Freeman, Ralph D·2007·Nature Neuroscience

DOI 10.1038/nn1977

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Abstract

In noninvasive neuroimaging, neural activity is inferred from local fluctuations in deoxyhemoglobin. A fundamental question of functional magnetic resonance imaging (fMRI) is whether the inferred neural activity is driven primarily by synaptic or spiking activity. The answer is critical for the interpretation of the blood oxygen level-dependent (BOLD) signal in fMRI. Here, we have used well-established visual-system circuitry to create a stimulus that elicits synaptic activity without associated spike discharge. In colocalized recordings of neural and metabolic activity in cat primary visual cortex, we observed strong coupling between local field potentials (LFPs) and changes in tissue oxygen concentration in the absence of spikes. These results imply that the BOLD signal is more closely coupled to synaptic activity.

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Authors: Viswanathan, A., & Freeman, R. D.
Affiliations: University of California, Berkeley (US)
Corresponding author: Freeman, Ralph D
ORCID: Freeman, Ralph D
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2007-09-09
Volume: 10
Issue: 10
Pages: 1308-1312
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn1977
OpenAlex: W2139354009
Cited by: 397
References: 32
Citations by year: 2026: 2 · 2025: 7 · 2024: 9 · 2023: 12 · 2022: 13 · 2021: 7 · 2020: 14 · 2019: 9 · 2018: 16 · 2017: 15 · 2016: 23 · 2015: 25 · 2014: 22 · 2013: 28 · 2012: 31
FWCI: 32.49
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ey003716-05)
National Eye Institute (EY 03716, EY 01175, R01EY001175)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords: neurometabolic coupling, BOLD signal, synaptic activity, spiking activity, local field potentials, cerebral cortex, primary visual cortex, tissue oxygen concentration, deoxyhemoglobin, functional MRI, cats
MeSH terms: Action Potentials, Animals, Cats, Dose-Response Relationship, Radiation, Evoked Potentials, Visual, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Oxygen, Photic Stimulation, Synapses, Visual Cortex, Visual Pathways

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Neurometabolic coupling in cerebral cortex reflects synaptic more than spiking activity

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