Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

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Items 101–200 of 1,000

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2. In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation
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3. Microglia centered pathogenesis in ALS: insights in cell interconnectivity
   Dora Maria Tuna Oliveira Brites, Ana Rita Vaz · 2014 · Frontiers in Cellular Neuroscience
4. Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2
   Ferguson, Cole J., Lenk, Guy M., Meisler, Miriam H. · 2009 · Human Molecular Genetics
5. Functional pattern of brain FDG-PET in amyotrophic lateral sclerosis
   Marco Pagani, Adriano Chiò, Maria Consuelo Valentini, Johanna Öberg, Flavio Mariano Nobili, Andrea Calvo, Cristina Moglia, Davide Bertuzzo, Silvia Daniela Morbelli, Fabrizio De Carli et al. · 2014 · Neurology
6. Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models
   Luc Dupuis, Jean‐Philippe Loeffler · 2009 · Current Opinion in Pharmacology
7. Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene
   Hongxia Zhou, Cao Huang, Han Chen, Dian Wang, Carlisle P. Landel, Pedro Yuxing Xia, Robert P. Bowser, Yong-Jian Liu, Xu‐Gang Xia · 2010 · PLoS Genetics
8. Human glia can both induce and rescue aspects of disease phenotype in Huntington disease
   Benraiss, Abdellatif, Wang, Su, Herrlinger, Stephanie, Li, Xiaojie, Chandler-Militello, Devin, Mauceri, Joseph, Burm, Hayley B., Toner, Michael, Osipovitch, Mikhail, Jim Xu, Qiwu et al. · 2016 · Nature Communications
9. Autophagy and ALS: mechanistic insights and therapeutic implications
   Chua, Jason P., De Calbiac, Hortense, Kabashi, Edor, Barmada, Sami J. · 2022 · Autophagy
10. Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis
    Karin Forsberg, Peter Munch Andersen, Stefan L. Marklund, Thomas Brännström · 2011 · Acta Neuropathologica
11. Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS
    Shuying Sun, Ying Sun, Shuo‐Chien Ling, Laura Ferraiuolo, Melissa McAlonis‐Downes, Yiyang Zou, Kevin Drenner, Yin Wang, Dara Ditsworth, Seiya Tokunaga et al. · 2015 · Proceedings of the National Academy of Sciences
12. Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis.
    Tashiro, Yoshitaka, Urushitani, Makoto, Inoue, Haruhisa, Koike, Masato, Uchiyama, Yasuo, Komatsu, Masaaki, Tanaka, Keiji, Yamazaki, Maya, Abe, Manabu, Misawa, Hidemi et al. · 2012 · Journal of Biological Chemistry
13. Schwann Cell Mitochondrial Metabolism Supports Long-Term Axonal Survival and Peripheral Nerve Function
    Andreu Viader, Judith P. Golden, Robert H. Baloh, Robert E. Schmidt, Daniel A. Hunter, Jeffrey Milbrandt · 2011 · Journal of Neuroscience
14. Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
    Varcianna, André, Myszczynska, Monika A., Castelli, Lydia M., O'Neill, Brendan, Kim, Yeseul, Talbot, Jordan, Nyberg, Sophie, Nyamali, Immanuelle, Heath, Paul R., Stopford, Matthew J. et al. · 2019 · EBioMedicine
15. Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice
    Lijun Wang, David H. Gutmann, Raymond P. Roos · 2010 · Human Molecular Genetics
16. Distinct roles for motor neuron autophagy early and late in the SOD1 G93A mouse model of ALS
    Rudnick, Noam D., Griffey, Christopher J., Guarnieri, Paolo, Gerbino, Valeria, Wang, Xueyong, Piersaint, Jason A., Tapia, Juan Carlos, Rich, Mark M., Maniatis, Tom · 2017 · Proceedings of the National Academy of Sciences
17. Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism
    Laura Ferraiuolo, Kathrin Meyer, Thomas W. Sherwood, Jonathan S. Vick, Shibi B. Likhite, Ashley Frakes, Carlos J. Miranda, Lyndsey Braun, Paul Roy Heath, Ricardo Pineda et al. · 2016 · Proceedings of the National Academy of Sciences
18. Characterisation of the Expression of NMDA Receptors in Human Astrocytes
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19. Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis
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20. Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis
    Chunxing Yang, Hongyan Wang, Tao Qiao, Bin Yang, Leonardo Aliaga, Linghua Qiu, Weijia Tan, Johnny S. Salameh, Diane M. McKenna-Yasek, Thomas Smith et al. · 2014 · Proceedings of the National Academy of Sciences
21. Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice
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22. In vivo genome editing improves motor function and extends survival in a mouse model of ALS
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23. Astrocyte function and role in motor neuron disease: A future therapeutic target?
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24. Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death
    Daniela Rossi · 2015 · Progress in Neurobiology
25. Focal degeneration of astrocytes in amyotrophic lateral sclerosis
    Rossi, D, Brambilla, L, Valori, C F, Roncoroni, C, Crugnola, A, Yokota, T, Bredesen, D E, Volterra, A · 2008 · Cell Death & Differentiation
26. Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis
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27. Inflammation and neurovascular changes in amyotrophic lateral sclerosis
    Matthew C. Evans, Yvonne Couch, Nicola R. Sibson, Martin R. Turner · 2012 · Molecular and Cellular Neuroscience
28. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
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29. Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis
    Rebecca K. Sheean, Fiona C. McKay, Erika Cretney, Christopher R. Bye, Nirma D. Perera, Doris Tomas, Richard A. Weston, Karlene J. Scheller, Elvan Djouma, Parvathi Menon et al. · 2018 · JAMA Neurology
30. The Complex Molecular Biology of Amyotrophic Lateral Sclerosis (ALS)
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31. Mitochondrial dysfunction and intracellular calcium dysregulation in ALS
    Hibiki Kawamata, Giovanni Manfredi · 2010 · Mechanisms of Ageing and Development
32. Brain hypermetabolism in amyotrophic lateral sclerosis: a FDG PET study in ALS of spinal and bulbar onset
    Angelina Cistaro, Maria Consuelo Valentini, Adriano Chiò, Flavio Mariano Nobili, Andrea Calvo, Cristina Moglia, Anna Montuschi, Silvia Daniela Morbelli, Dario Salmaso, Piercarlo Fania et al. · 2011 · European Journal of Nuclear Medicine and Molecular Imaging
33. Peripheral Androgen Receptor Gene Suppression Rescues Disease in Mouse Models of Spinal and Bulbar Muscular Atrophy
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34. ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import
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35. CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves
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36. Muscle Expression of Mutant Androgen Receptor Accounts for Systemic and Motor Neuron Disease Phenotypes in Spinal and Bulbar Muscular Atrophy
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37. Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1
    Brian V. Lananna, Collin J. Nadarajah, Mariko Izumo, Michelle R. Cedeño, David Dayi Xiong, Julie M. Dimitry, Chak Foon Tso, Celia A. McKee, Percy Y. Griffin, Patrick W. Sheehan et al. · 2018 · Cell Reports
38. Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity
    Anastasya Birger, Israel Ben‐Dor, Miri Ottolenghi, Tikva Tako Turetsky, Yaniv Gil, Sahar Sweetat, Liat Perez, Vitali Belzer, Natania Casden, Debora Steiner et al. · 2019 · EBioMedicine
39. Innate immune activation in neurodegenerative diseases
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40. The microglial component of amyotrophic lateral sclerosis
    Clarke, Benjamin E, Patani, Rickie · 2020 · Brain
41. Extracellular ATP and the P2X7receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis
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42. Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders
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43. TDP-43 regulation of stress granule dynamics in neurodegenerative disease-relevant cell types
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44. Glia in the pathogenesis of neurodegenerative diseases
    Verkhratsky, Alexei, Parpura, Vladimir, Pekna, Marcela, Pekny, Milos, Sofroniew, Michael · 2014 · Biochemical Society Transactions
45. The Complement Factor C5a Contributes to Pathology in a Rat Model of Amyotrophic Lateral Sclerosis
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46. Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis
    Emiliano Trías, Sofía Ibarburu, Romina Barreto‐Núñez, Joël Babdor, Thiago Trovati Maciel, Matthias Guillo, Laurent Gros, Patrice C. Dubreuil, Pablo Díaz‐Amarilla, Patricia Cassina et al. · 2016 · Journal of Neuroinflammation
47. Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS
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48. Molecular pathology and genetic advances in amyotrophic lateral sclerosis: an emerging molecular pathway and the significance of glial pathology
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49. Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice
    Takayuki Kondo, Misato Funayama, Kayoko Tsukita, Akitsu Hotta, Akimasa Yasuda, Satoshi Nori, Shinjiro Kaneko, Masaya Nakamura, Ryōsuke Takahashi, Hideyuki Okano et al. · 2014 · Stem Cell Reports
50. From animal models to human disease: a genetic approach for personalized medicine in ALS
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51. SOD1, an unexpected novel target for cancer therapy.
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52. Ablation of Proliferating Microglia Does Not Affect Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis Caused by Mutant Superoxide Dismutase
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53. Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD
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54. Engineered lentiviral vector targeting astrocytes In vivo
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55. SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS
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56. Blockade of Gap Junction Hemichannel Suppresses Disease Progression in Mouse Models of Amyotrophic Lateral Sclerosis and Alzheimer's Disease
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57. Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers
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58. Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration
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59. Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration
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61. The past, present and future of stem cell clinical trials for ALS
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62. Astroglia In Neurological Diseases
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63. Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
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64. Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis
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65. Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis
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66. Semaphorins in Adult Nervous System Plasticity and Disease
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67. Review: Neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy
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68. Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes
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69. Inflammatory aspects of Alzheimer’s disease
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70. Astrogliosis in Amyotrophic Lateral Sclerosis: Role and Therapeutic Potential of Astrocytes
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71. Microglia-driven regulation of oligodendrocyte lineage cells, myelination, and remyelination
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72. Epigenetics in amyotrophic lateral sclerosis: a role for histone post-translational modifications in neurodegenerative disease
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73. Inflammation in ALS and SMA: Sorting out the good from the evil
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74. Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?
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75. SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments
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76. Neurotheranostics as Personalized Medicines
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77. Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1
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79. Cytoprotective protein C pathways and implications for stroke and neurological disorders
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80. A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
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81. The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis
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82. Motoneuron survival is promoted by specific exercise in a mouse model of amyotrophic lateral sclerosis
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83. Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis
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84. Immunity in amyotrophic lateral sclerosis: blurred lines between excessive inflammation and inefficient immune responses
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85. TGF-β as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications
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86. Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo
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88. Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology
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89. Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder
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90. Gap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseases
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91. A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome
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92. The homeostatic astroglia emerges from evolutionary specialization of neural cells
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93. The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis
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94. Astrocyte heterogeneity in the brain: from development to disease
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95. Neuromuscular Junction Dismantling in Amyotrophic Lateral Sclerosis
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96. Human Glial-Restricted Progenitor Transplantation into Cervical Spinal Cord of the SOD1G93A Mouse Model of ALS
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97. Treatment with trichostatin A initiated after disease onset delays disease progression and increases survival in a mouse model of amyotrophic lateral sclerosis
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98. Cellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
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99. Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse model
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100. Contribution of astrocytes to neuropathology of neurodegenerative diseases
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