The DOI matches its Crossref record; 238 of the 238 references it cites were found in a registry or an index.
The pathophysiology of hypertension in patients with obesity
Open accessAbstract
The combination of obesity and hypertension is associated with high morbidity and mortality because it leads to cardiovascular and kidney disease. Potential mechanisms linking obesity to hypertension include dietary factors, metabolic, endothelial and vascular dysfunction, neuroendocrine imbalances, sodium retention, glomerular hyperfiltration, proteinuria, and maladaptive immune and inflammatory responses. Visceral adipose tissue also becomes resistant to insulin and leptin and is the site of altered secretion of molecules and hormones such as adiponectin, leptin, resistin, TNF and IL-6, which exacerbate obesity-associated cardiovascular disease. Accumulating evidence also suggests that the gut microbiome is important for modulating these mechanisms. Uric acid and altered incretin or dipeptidyl peptidase 4 activity further contribute to the development of hypertension in obesity. The pathophysiology of obesity-related hypertension is especially relevant to premenopausal women with obesity and type 2 diabetes mellitus who are at high risk of developing arterial stiffness and endothelial dysfunction. In this Review we discuss the relationship between obesity and hypertension with special emphasis on potential mechanisms and therapeutic targeting that might be used in a clinical setting.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“2) activation of the renin-angiotensin-aldosterone system (RAAS)”
From Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms (2015) · cites this paper as [37]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide: physiology, pathophysiology, and pharmacology.
Moncada, S., Palmer, R. M., & Higgs, E. A. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06663-3 · Cited by 15,525
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,739
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Prevalence of Overweight and Obesity in the United States, 1999-2004
Ogden, C. L., Carroll, M. D., Curtin, L. R., McDowell, M. A., Tabak, C. J., & Flegal, K. M. (2006) · JAMA · doi:10.1001/jama.295.13.1549 · Cited by 8,720
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
A Clinical Trial of the Effects of Dietary Patterns on Blood Pressure
Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Vogt, T. M., Cutler, J. A., Windhauser, M. M., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361601 · Cited by 5,981
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Prevalence of Overweight and Obesity in the United States
Crespo, C. J., & Smit, E. (2003) · Human Kinetics eBooks · doi:10.5040/9781718206601.ch-001 · Cited by 4,382
The importance of the ratio of omega-6/omega-3 essential fatty acids
Simopoulos, A. P. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00253-6 · Cited by 4,286
Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
Bray, G. A., Nielsen, S. J., & Popkin, B. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.537 · Cited by 1,990
Dawber, T. R. (1980) · Harvard University Press eBooks · doi:10.4159/harvard.9780674492097 · Cited by 1,965
Larsson, B., Svärdsudd, K., Welin, L., Wilhelmsen, L., Björntorp, P. A., & Tibblin, G. (1984) · BMJ · doi:10.1136/bmj.288.6428.1401 · Cited by 1,931
Relation of Body Fat Distribution to Metabolic Complications of Obesity*
KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Guzik, T. J., Hoch, N. E., Brown, K. A., McCann, L. A., Rahman, A., Dikalov, S., Goronzy, J., Weyand, C., & Harrison, D. G. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070657 · Cited by 1,736
Lapidus, L., Bengtsson, C., Larsson, B., Pennert, K. M., Rybo, E., & Sjöström, L. (1984) · BMJ · doi:10.1136/bmj.289.6454.1257 · Cited by 1,657
Huxley, R., Barzi, F., & Woodward, M. (2005) · BMJ · doi:10.1136/bmj.38678.389583.7c · Cited by 1,531
Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,475
Global obesity: trends, risk factors and policy implications
Malik, V., Willett, W. C., & Hu, F. B. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.199 · Cited by 1,470
The Degree of Masculine Differentiation of Obesities
Vague, J. (1956) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/4.1.20 · Cited by 1,393
Influence of Weight Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials
Neter, J. E., Stam, B. E., Kok, F. J., Grobbee, D. E., & Geleijnse, J. M. (2003) · Hypertension · doi:10.1161/01.hyp.0000094221.86888.ae · Cited by 1,391
Appel, L. J., Brands, M. W., Daniels, S. R., Karanja, N., Elmer, P. J., & Sacks, F. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000202568.01167.b6 · Cited by 1,304
Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism
Mazzali, M., Hughes, J., Kim, Y.-G., Jefferson, J. A., Kang, D., GORDON, K. L., Lan, H. Y., Kivlighn, S. D., & Johnson, R. J. (2001) · Hypertension · doi:10.1161/hy1101.092839 · Cited by 1,298
Mancia, G., Fagard, R. H., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T. C., Cífková, R., Backer, G. D., Dominiczak, A. F., et al. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328364ca4c · Cited by 1,187
Hyperinsulinemia produces both sympathetic neural activation and vasodilation in normal humans.
Anderson, E. A., Hoffman, R. P., Balon, T. W., Sinkey, C. A., & Mark, A. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115260 · Cited by 1,075
Food sources of nitrates and nitrites: The physiologic context for potential health benefits
Hord, N. G., Tang, Y., & Bryan, N. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27131 · Cited by 1,069
Ohkubo, T., Hozawa, A., Yamaguchi, J., Kikuya, M., Ohmori, K., Michimata, M., Matsubara, M., Hashimoto, J., Hoshi, H., Araki, T., et al. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00017 · Cited by 1,053
Stamler, R., Nissinen, A. M., Uusitalo, U. M., Rose, G., Pietinen, P., & Stamler, J. (1988) · Cited by 1,042
Murphy, E. F., Cotter, P. D., Healy, S., Marques, T. M., O’Sullivan, Ó., Fouhy, F., Clarke, S. F., O’Toole, P. W., Quigley, E. M. M., Stanton, C., et al. (2010) · Gut · doi:10.1136/gut.2010.215665 · Cited by 964
Regulation of inflammasome signaling
Rathinam, V. A. K., Vanaja, S. K., & Fitzgerald, K. A. (2012) · Nature Immunology · doi:10.1038/ni.2237 · Cited by 960
High prevalence of unrecognized sleep apnoea in drug-resistant hypertension
Logan, A. G., Perlikowski, S. M., Mente, A., Tisler, A., Tkacova, R., Niroumand, M., Leung, R. S. T., & Bradley, T. D. (2001) · Journal of Hypertension · doi:10.1097/00004872-200112000-00022 · Cited by 960
Inflammation, Immunity, and Hypertension
Harrison, D. G., Guzik, T. J., Lob, H. E., Madhur, M. S., Marvar, P. J., Thabet, S., Vinh, A., & Weyand, C. M. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.163576 · Cited by 893
The Endothelium and Its Role in Regulating Vascular Tone
Sandoo, A., Zanten, J. V., Metsios, G. S., Carroll, D., & Kitas, G. D. (2010) · The Open Cardiovascular Medicine Journal · doi:10.2174/1874192401004010302 · Cited by 890
Cavalcante, J. L., Lima, J. A. C., Redheuil, A. B., & Al-Mallah, M. H. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.12.017 · Cited by 881
Bailey, C. J., Gross, J. L., Pieters, A., Bastien, A., & List, J. F. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60407-2 · Cited by 873
Gut microbiome, obesity, and metabolic dysfunction
Tilg, H., & Kaser, A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58109 · Cited by 860
Epidemiologic and economic consequences of the global epidemics of obesity and diabetes
Yach, D., Stückler, D., & Brownell, K. D. (2006) · Nature Medicine · doi:10.1038/nm0106-62 · Cited by 856
Body Mass Index and the Prevalence of Hypertension and Dyslipidemia
Brown, C., HIGGINS, M. W., Donato, K. A., Rohde, F. C., Garrison, R. J., Obarzanek, E., Ernst, N. D., & Horan, M. J. (2000) · Obesity Research · doi:10.1038/oby.2000.79 · Cited by 851
The Relation of Adiposity to Blood Pressure and Development of Hypertension
Kannel, W. B., BRAND, N., SKINNER, J. J., Dawber, T. R., & MCNAMARA, P. M. (1967) · Annals of Internal Medicine · doi:10.7326/0003-4819-67-1-48 · Cited by 815
He, F. J., & MacGregor, G. A. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001459 · Cited by 810
Targeting gut microbiota in obesity: effects of prebiotics and probiotics
Delzenne, N. M., Neyrinck, A. M., Bäckhed, F., & Cani, P. D. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.126 · Cited by 805
Sugar, Uric Acid, and the Etiology of Diabetes and Obesity
Johnson, R. J., Nakagawa, T., Sánchez‐Lozada, L. G., Shafiu, M., Sundaram, S. S., Le, M. T., Ishimoto, T., Sautin, Y. Y., & Lanaspa, M. A. (2013) · Diabetes · doi:10.2337/db12-1814 · Cited by 791
Incidence and precursors of hypertension in young adults: The Framingham offspring study
Garrison, R. J., Kannel, W. B., Stokes, J., & Castelli, W. P. (1987) · Preventive Medicine · doi:10.1016/0091-7435(87)90087-9 · Cited by 789
Rahmoune, H., Thompson, P. W., Ward, J. M., Smith, C. D., Hong, G., & Brown, J. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3427 · Cited by 787
Developmental Origins of Health and Disease
Gillman, M. W. (2005) · New England Journal of Medicine · doi:10.1056/nejme058187 · Cited by 756
Ferrannini, E., Ramos, S. J., Salsali, A., Tang, W., & List, J. F. (2010) · Diabetes Care · doi:10.2337/dc10-0612 · Cited by 725
Ten Putative Contributors to the Obesity Epidemic
McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., Benca, R. M., Biggio, J., Boggiano, M. M., Eisenmann, J. C., et al. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372599 · Cited by 710
Body Weight, Weight Change, and Risk for Hypertension in Women
Huang, Z., Willett, W. C., Manson, J. E., ROSNER, B. A., Stampfer, M. J., Speizer, F. E., & Colditz, G. A. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00001 · Cited by 687
Does fish oil lower blood pressure? A meta-analysis of controlled trials.
Morris, M. C., Sacks, F. M., & ROSNER, B. A. (1993) · Circulation · doi:10.1161/01.cir.88.2.523 · Cited by 687
Putative contributors to the secular increase in obesity: exploring the roads less traveled
Keith, S. W., Redden, D. T., Katzmarzyk, P. T., Boggiano, M. M., Hanlon, E. C., Benca, R. M., Ruden, D., Pietrobelli, A., Barger, J. L., Fontaine, K. R., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803326 · Cited by 659
Kanai, Y., Lee, W. S., You, G., Brown, D., & Hediger, M. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci116972 · Cited by 628
Weight Loss and the Renin-Angiotensin-Aldosterone System
Engeli, S., Böhnke, J., Gorzelniak, K., Janke, J., Schling, P., Bäder, M., Luft, F. C., & Sharma, A. M. (2005) · Hypertension · doi:10.1161/01.hyp.0000154361.47683.d3 · Cited by 627
Fullston, T., Teague, E. M. C. O., Palmer, N. O., DeBlasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A., & Lane, M. (2013) · The FASEB Journal · doi:10.1096/fj.12-224048 · Cited by 600
The gut microbiota, obesity and insulin resistance
Shen, J., Obin, M. S., & Zhao, L. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.11.001 · Cited by 599
Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome
Lamers, D., Famulla, S., Wronkowitz, N., Hartwig, S., Lehr, S., Ouwens, D. M., Eckardt, K., Kaufman, J., Rydén, M., Müller, S., et al. (2011) · Diabetes · doi:10.2337/db10-1707 · Cited by 583
Arterial Stiffness and the Development of Hypertension
Liao, D., Arnett, D. K., Tyroler, H. A., Riley, W. A., Chambless, L. E., Szklo, M., & HEISS, G. M. (1999) · Hypertension · doi:10.1161/01.hyp.34.2.201 · Cited by 544
Role of insulin resistance in endothelial dysfunction
Muniyappa, R., & Sowers, J. R. (2013) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-012-9229-1 · Cited by 539
Self-citationNauck, M. A., Prato, S. D., Meier, J. J., Durán-Garcia, S., Rohwedder, K., Elze, M., & Parikh, S. J. (2011) · Diabetes Care · doi:10.2337/dc11-0606 · Cited by 535
Cardiovascular Biology of the Incretin System
Ussher, J. R., & Drucker, D. J. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1052 · Cited by 534
Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins
Hall, J. E., da Silva, A. A., do Carmo, J. M., Dubinion, J., Hamza, S., Munusamy, S., Smith, G., & Stec, D. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.113175 · Cited by 528
Landsberg, L., Aronne, L. J., Beilin, L. J., Burke, V., Igel, L. I., Lloyd‐Jones, D., & Sowers, J. (2013) · The Journal of Clinical Hypertension · doi:10.1111/jch.12049 · Cited by 528
Self-citationSympathetic Activity in Obese Subjects With and Without Obstructive Sleep Apnea
Narkiewicz, K., van de Borne, P. J. H., Cooley, R. L., Dyken, M. E., & Somers, V. K. (1998) · Circulation · doi:10.1161/01.cir.98.8.772 · Cited by 525
The Adventitia: Essential Regulator of Vascular Wall Structure and Function
Stenmark, K. R., Yeager, M. E., Kasmi, K. C. E., Nozik‐Grayck, E., Gerasimovskaya, E. V., Li, M., Riddle, S. R., & Frid, M. G. (2012) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183802 · Cited by 499
The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia
DeFronzo, R. A., Davidson, J. A., & Prato, S. D. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01511.x · Cited by 497
Does Supplementation of Diet With 'Fish Oil' Reduce Blood Pressure?
Appel, L. J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.12.1429 · Cited by 491
Physiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System
Engeli, S., Negrel, R., & Sharma, A. M. (2000) · Hypertension · doi:10.1161/01.hyp.35.6.1270 · Cited by 475
Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis
Brown, N. J. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.110 · Cited by 464
Witkowski, A., Prejbisz, A., Florczak, E., Kądziela, J., Śliwiński, P., Bieleń, P., Michałowska, I., Kabat, M., Warchoł, E., Januszewicz, M., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.173799 · Cited by 460
Alterations in left ventricular structure and function in young healthy obese women
Peterson, L. R., Waggoner, A. D., Schechtman, K. B., Meyer, T., Gropler, R. J., Barzilai, B., & Dávila-Román, V. G. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.062 · Cited by 449
Targeting the Circulating MicroRNA Signature of Obesity
Ortega, F. J., Mercader, J. M., Catalán, V., Moreno‐Navarrete, J. M., Pueyo, N., Sabater, M., Gómez‐Ambrosi, J., Anglada, R., Fernández‐Formoso, J. A., Ricart, W., et al. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2012.195776 · Cited by 443
Mechanisms of Sympathetic Activation in Obesity-Related Hypertension
Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., & Lambert, E. (2006) · Hypertension · doi:10.1161/01.hyp.0000242642.42177.49 · Cited by 443
Human adipocytes secrete mineralocorticoid-releasing factors
Ehrhart‐Bornstein, M., Lamounier‐Zepter, V., Schraven, A., Langenbach, J., Willenberg, H. S., Barthel, A., Hauner, H., McCann, S. M., Scherbaum, W. A., & Bornstein, S. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336140100 · Cited by 442
Baldwin, W., McRae, S., Marek, G. W., Wymer, D. C., Pannu, V., Baylis, C., Johnson, R. J., & Sautin, Y. Y. (2011) · Diabetes · doi:10.2337/db10-0916 · Cited by 442
Intrauterine programming of adult disease
Barker, D. J. P. (1995) · Molecular Medicine Today · doi:10.1016/s1357-4310(95)90793-9 · Cited by 430
Obesity-Related Hypertension: Epidemiology, Pathophysiology, and Clinical Management
Kotchen, T. A. (2010) · American Journal of Hypertension · doi:10.1038/ajh.2010.172 · Cited by 418
Epigenetics and cardiovascular disease
Ordovás, J. M., & Smith, C. E. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.104 · Cited by 413
Obesity: Impact on Cardiovascular Disease
Ades, P. A. (2000) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)64633-8 · Cited by 400
Hayden, M. R., & Tyagi, S. C. (2004) · Nutrition & Metabolism · doi:10.1186/1743-7075-1-10 · Cited by 397
Neural mechanisms in human obesity-related hypertension
Rumantir, M. S., Vaz, M., Jennings, G. L., Collier, G., Kaye, D. M., Seals, D. R., Wiesner, G. H., Brunner-La Rocca, H. P., & Esler, M. D. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917080-00012 · Cited by 396
Gao, Q., Wolfgang, M. J., Neschen, S., Morino, K., Horvath, T. L., Shulman, G. I., & Fu, X.-Y. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0303992101 · Cited by 385
Shah, Z., Kampfrath, T., Deiuliis, J. A., Zhong, J., Pineda, C. A., Ying, Z., Xu, X., Lü, B., Moffatt, S. D., Durairaj, R., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.041418 · Cited by 378
Siervo, M., Lara, J., Ogbonmwan, I., & Mathers, J. C. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.170233 · Cited by 375
Tran, L. T., Yuen, V. G., & McNeill, J. H. (2009) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-009-0184-4 · Cited by 374
Vallon, V., Rose, M., Gerasimova, M., Satriano, J., Platt, K. A., Koepsell, H., Cunard, R., Sharma, K., Thomson, S. C., & Rieg, T. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00409.2012 · Cited by 370
Sugar-Sweetened Beverages, Serum Uric Acid, and Blood Pressure in Adolescents
Nguyen, S. N., Choi, H. K., Lustig, R. H., & Hsu, C. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.01.015 · Cited by 365
Krauss, R. M., Winston, M. C., Fletcher, B. J., & Grundy, S. M. (1998) · Circulation · doi:10.1161/01.cir.98.14.1472 · Cited by 364
Metabolic effects of dietary fructose
Hallfrisch, J. G. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.9.2189777 · Cited by 359
Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors
McCurley, A., Pires, P. W., Bender, S. B., Aronovitz, M. A., Zhao, M. J., METZGER, D., Chambon, P., Hill, M. A., Dorrance, A. M., Mendelsohn, M. E., et al. (2012) · Nature Medicine · doi:10.1038/nm.2891 · Cited by 357
The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus
Kootte, R. S., Vrieze, A., Holleman, F., Dallinga‐Thie, G. M., Zoetendal, E. G., de Vos, W. M., Groen, A. K., Hoekstra, J. B. L., Stroes, E. S. G., & Nieuwdorp, M. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01483.x · Cited by 357
Glomerular Hyperfiltration in Experimental Diabetes Mellitus
Vallon, V., Richter, K., Blantz, R. C., Thomson, S. C., & Oßwald, H. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v10122569 · Cited by 356
Lambert, G. W., Straznicky, N. E., Lambert, É., Dixon, J. B., & Schlaich, M. P. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.02.002 · Cited by 352
Perez-Pozo, S. E., Schold, J. D., Nakagawa, T., Sánchez‐Lozada, L. G., Johnson, R. J., & Lillo, J. L. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.259 · Cited by 344
Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors
Meyer, M. R., Clegg, D. J., Prossnitz, E. R., & Barton, M. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02237.x · Cited by 338
Geurts, L., Lazarević, V., Derrien, M., Everard, A., Roye, M. V., Knauf, C., Valet, P., Girard, M., Muccioli, G. G., François, P., et al. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00149 · Cited by 335
Hypertension in overweight and obese primary care patients is highly prevalent and poorly controlled
BRAMLAGE, P., PITTROW, D., WITTCHEN, H., KIRCH, W., BOEHLER, S., LEHNERT, H., HOEFLER, M., UNGER, T., & SHARMA, A. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.05.017 · Cited by 328
Arterial Stiffening Precedes Systolic Hypertension in Diet-Induced Obesity
Weisbrod, R. M., Shiang, T., Al Sayah, L., Fry, J. L., Bajpai, S., Reinhart-King, C. A., Lob, H. E., Santhanam, L., Mitchell, G., Cohen, R. A., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01744 · Cited by 317
Renal Denervation Attenuates the Sodium Retention and Hypertension Associated With Obesity
Kassab, S., Kato, T., Wilkins, F. C., Chen, R., Hall, J. E., & Granger, J. P. (1995) · Hypertension · doi:10.1161/01.hyp.25.4.893 · Cited by 307
Adrenergic and Reflex Abnormalities in Obesity-Related Hypertension
Grassi, G., Seravalle, G., Dell’Oro, R., Turri, C., Bolla, G. B., & Mancia, G. (2000) · Hypertension · doi:10.1161/01.hyp.36.4.538 · Cited by 305
Landsberg, L., Aronne, L. J., Beilin, L. J., Burke, V., Igel, L. I., Lloyd‐Jones, D. M., & Sowers, J. R. (2012) · Obesity · doi:10.1002/oby.20181 · Cited by 296
Self-citationIs the Gut Microbiota a New Factor Contributing to Obesity and Its Metabolic Disorders?
Harris, K. A., Kassis, A. N., Major, G. C., & Chou, C. J. (2012) · Journal of Obesity · doi:10.1155/2012/879151 · Cited by 289
Leal, V. D. O., & Mafra, D. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.02.003 · Cited by 287
Messerli, F. H. (1981) · Archives of Internal Medicine · doi:10.1001/archinte.141.1.81 · Cited by 281
Resistant Hypertension, Obesity, Sleep Apnea, and Aldosterone: Theory and Therapy
Goodfriend, T. L., & Calhoun, D. A. (2004) · Hypertension · doi:10.1161/01.hyp.0000116223.97436.e5 · Cited by 279
Howard, B. V., Cowan, L. D., Go, O. T., Welty, T. K., Robbins, D. C., Lee, E. T., & Strong Heart Study Investigators (1998) · Diabetes Care · doi:10.2337/diacare.21.8.1258 · Cited by 275
The Inflammasome Puts Obesity in the Danger Zone
Stienstra, R., Tack, C. J., Kanneganti, T., Joosten, L. A. B., & Netea, M. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.10.011 · Cited by 275
Shihab, H. M., Meoni, L. A., Chu, A. Y., Wang, N.-Y., Ford, D. E., Liang, K.-Y., Gallo, J. J., & Klag, M. J. (2012) · Circulation · doi:10.1161/circulationaha.112.117333 · Cited by 274
Insulin Resistance and Heart Failure
Aroor, A. R., Mandavia, C. H., & Sowers, J. R. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.06.005 · Cited by 265
Self-citationImmunity as a link between obesity and insulin resistance
Kalupahana, N. S., Moustaïd‐Moussa, N., & Claycombe, K. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.011 · Cited by 264
Change in body mass index and its impact on blood pressure: a prospective population study
Drøyvold, W. B., Midthjell, K., Nilsen, T. I. L., & Holmen, J. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802944 · Cited by 248
Shirakawa, J., Fujii, H., Ohnuma, K., Sato, K., Ito, Y., Kaji, M., Sakamoto, E., Koganei, M., Sasaki, H., Nagashima, Y., et al. (2011) · Diabetes · doi:10.2337/db10-1338 · Cited by 246
Obesity and adipokines: effects on sympathetic overactivity
Smith, M. M., & Minson, C. T. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.221036 · Cited by 245
Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance
Aroor, A. R., McKarns, S. C., DeMarco, V. G., Jia, G., & Sowers, J. R. (2013) · Metabolism · doi:10.1016/j.metabol.2013.07.001 · Cited by 243
Self-citationUric Acid - Key Ingredient in the Recipe for Cardiorenal Metabolic Syndrome
Chaudhary, K. R., Malhotra, K., Sowers, J. R., & Aroor, A. R. (2013) · Cardiorenal Medicine · doi:10.1159/000355405 · Cited by 242
Self-citationDipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
Yazbeck, R., Howarth, G. S., & Abbott, C. A. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.08.003 · Cited by 242
GENDER DIFFERENCES IN SYMPATHETIC NERVOUS SYSTEM REGULATION
Hinojosa‐Laborde, C., Chapa, I., Lange, D. L., & Haywood, J. R. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.02995.x · Cited by 234
Hypertension: Physiology and Pathophysiology
Hall, J. E., Granger, J. P., do Carmo, J. M., da Silva, A. A., Dubinion, J., George, E., Hamza, S., Speed, J., & Hall, M. E. (2012) · Comprehensive Physiology · doi:10.1002/cphy.c110058 · Cited by 232
T Regulatory Lymphocytes Prevent Aldosterone-Induced Vascular Injury
Kasal, D. A. B., Barhoumi, T., Li, M. W., Yamamoto, N., Zdanovich, E., Rehman, A., Neves, M. F., Laurant, P., Paradis, P., & Schiffrin, E. L. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.181123 · Cited by 231
Wang, B., Zhong, J., Lin, H., Zhao, Z., Yan, Z., He, H., Ni, Y., Liu, D., & Zhu, Z. (2013) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12085 · Cited by 225
Phenotypic and functional switch of macrophages induced by regulatory CD4 + CD25 + T cells in mice
Liu, G., Ma, H., Qiu, L., Li, L., Cao, Y., Ma, J., & Zhao, Y. X. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.70 · Cited by 223
Mechanisms linking obesity to hypertension
Dorresteijn, J. A. N., Visseren, F. L. J., & Spiering, W. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00914.x · Cited by 218
Li, M., Sloboda, D. M., & Vickers, M. H. (2011) · Experimental Diabetes Research · doi:10.1155/2011/592408 · Cited by 217
Obstructive Sleep Apnea–Dependent and –Independent Adrenergic Activation in Obesity
Grassi, G. M., Facchini, A., Trevano, F. Q., Dell’Oro, R., Arenare, F., Tana, F., Bolla, G. B., Monzani, A., Robuschi, M., & Mancia, G. (2005) · Hypertension · doi:10.1161/01.hyp.0000174243.39897.6c · Cited by 214
Body Mass Index Predicts Aldosterone Production in Normotensive Adults on a High-Salt Diet
Bentley–Lewis, R., Adler, G. K., Perlstein, T. S., Seely, E. W., Hopkins, P. N., Williams, G. H., & Garg, R. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1088 · Cited by 213
Messerli, F. H. (1981) · Archives of Internal Medicine · doi:10.1001/archinte.1981.00340010073016 · Cited by 210
Zhong, J., Rao, X., & Rajagopalan, S. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.09.012 · Cited by 209
Diabetes Mellitus and Vascular Disease
Sowers, J. R. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.00612 · Cited by 206
Self-citationThe influence of perivascular adipose tissue on vascular homeostasis
Szasz, T., Bomfim, G. F., & Webb (2013) · Vascular Health and Risk Management · doi:10.2147/vhrm.s33760 · Cited by 205
The Role of the Renin-Angiotensin-Aldosterone System in Obesity-Related Renal Diseases
Rüster, C., & Wolf, G. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2012.12.002 · Cited by 192
Aroor, A. R., DeMarco, V. G., Jia, G., Sun, Z., Nistala, R., Meininger, G. A., & Sowers, J. R. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00161 · Cited by 192
Self-citationNoradrenaline turnover during under- and over-eating in normal weight subjects
O’Dea, K., Esler, M., Leonard, P., Stockigt, J. R., & Nestel, P. J. (1982) · Metabolism · doi:10.1016/0026-0495(82)90178-0 · Cited by 189
Immune mechanisms in hypertension and vascular injury
Schiffrin, E. L. (2013) · Clinical Science · doi:10.1042/cs20130407 · Cited by 186
Fructose: A Key Factor in the Development of Metabolic Syndrome and Hypertension
Khitan, Z. J., & Kim, D. H. (2013) · Journal of Nutrition and Metabolism · doi:10.1155/2013/682673 · Cited by 186
Regulatory mechanisms of Na + /glucose cotransporters in renal proximal tubule cells
Lee, Y. J., Lee, Y. J., & Han, H. J. (2007) · Kidney International · doi:10.1038/sj.ki.5002383 · Cited by 184
Kassan, M., Galán, M., Partyka, M., Trebak, M., & Matrougui, K. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.233262 · Cited by 181
Sehgel, N. L., Zhu, Y., Sun, Z., et al. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00232.2013 · Cited by 180
Ribas, V., Drew, B. G., Le, J., Soleymani, T., Daraei, P., Sitz, D., Mohammad, L., Henstridge, D. C., Febbraio, M. A., Hewitt, S. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104533108 · Cited by 179
Kröller‐Schön, S., Knorr, M., Hausding, M., Oelze, M. W., Schuff, A., Schell, R., Sudowe, S., Scholz, A., Daub, S., Karbach, S. H., et al. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs246 · Cited by 177
A unifying pathway for essential hypertension
Johnson, R. E., Rodríguez‐Iturbe, B., Kang, D.-H., Feig, D. I., & Herrera-Acosta, J. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.08.035 · Cited by 173
Barrett-Connor, E. L., Giardina, E. V., Gitt, A. K., Gudat, U., Steinberg, H. O., & Tschoepe, D. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.9.934 · Cited by 171
Obesity : impact on cardiovascular disease
Krauss, R. M., Winston, M. C., Fletcher, B. J., & Grundy, S. M. (1998) · PubMed · Cited by 171
Coles, L. T., & Clifton, P. M. (2012) · Nutrition Journal · doi:10.1186/1475-2891-11-106 · Cited by 167
A novel adipokine CTRP1 stimulates aldosterone production
Jeon, J. H., Kim, K., Kim, J. H., Baek, A., Cho, H., Lee, Y., Kim, J. W., Kim, D., Han, S. H., Lim, J., et al. (2008) · The FASEB Journal · doi:10.1096/fj.07-9412com · Cited by 167
Hadjiyanni, I., Siminovitch, K. A., Danska, J. S., & Drucker, D. J. (2010) · Diabetologia · doi:10.1007/s00125-009-1643-x · Cited by 166
Gupta, A. K., Nasothimiou, E. G., Chang, C. L., Sever, P. S., Dahlöf, B., & Poulter, N. R. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834a8a42 · Cited by 165
Disparate Cardiovascular Findings in Men and Women with Essential Hypertension
Messerli, F. H., GARAVAGLIA, G. E., SCHMIEDER, R. E., SUNDGAARD-RIISE, K., NUNEZ, B. D., & AMODEO, C. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-2-158 · Cited by 164
Mineralocorticoid Receptor–Mediated Vascular Insulin Resistance
Bender, S. B., McGraw, A. P., Jaffe, I. Z., & Sowers, J. R. (2013) · Diabetes · doi:10.2337/db12-0905 · Cited by 163
Self-citationDietary factors associated with hypertension
Zhao, D. H., Qi, Y., Zheng, Z., Wang, Y., Zhang, X.-Y., Li, H.-J., Liu, H.-H., Zhang, X., Du, J., & Liu, J. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.75 · Cited by 163
Schäfer, N., Lohmann, C., Winnik, S. H., van Tits, L. J., Miranda, M. X., Vergopoulos, A., Ruschitzka, F. T., Nussberger, J., Berger, S., Lüscher, T. F., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht095 · Cited by 163
Body fat distribution, blood pressure, and hypertension
Cassano, P. A., Segal, M. R., Vokonas, P., & Weiss, S. T. (1990) · Annals of Epidemiology · doi:10.1016/1047-2797(90)90017-m · Cited by 162
Vascular Inflammatory Cells in Hypertension
Harrison, D. G., Marvar, P. J., & Titze, J. M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00128 · Cited by 160
MicroRNAs in Insulin Resistance and Obesity
Williams, M. D., & Mitchell, G. M. (2012) · Experimental Diabetes Research · doi:10.1155/2012/484696 · Cited by 158
Jordan, J., Yumuk, V., Schlaich, M. P., Nilsson, P. M., Zahorska‐Markiewicz, B., Grassi, G. M., Schmieder, R. E., Engeli, S., & Finer, N. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283537347 · Cited by 156
Aldosterone and arterial hypertension
Tomaschitz, A., Pilz, S., Ritz, E., Obermayer-Pietsch, B. M., & Pieber, T. R. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.263 · Cited by 155
Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice
Yiannikouris, F. B., Gupte, M., Putnam, K., Thatcher, S. E., Charnigo, R. J., Rateri, D. L., Daugherty, A., & Cassis, L. A. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.192690 · Cited by 153
Autonomic Neural Regulation of the Immune System
Abboud, F. M., Harwani, S. C., & Chapleau, M. W. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.186833 · Cited by 152
Renal and Cardiac Effects of DPP-4 Inhibitors – from Preclinical Development to Clinical Research
Hocher, B., Reichetzeder, C., & Alter, M. (2012) · Kidney & Blood Pressure Research · doi:10.1159/000339028 · Cited by 145
The intracrine renin–angiotensin system
Kumar, R., Thomas, C., Yong, Q. C., Chen, W., & Baker, K. M. (2012) · Clinical Science · doi:10.1042/cs20120089 · Cited by 141
Appel, L. J., Miller, E. R., Seidler, A. J., & Whelton, P. K. (1993) · PubMed · Cited by 137
Is There a Rationale for Angiotensin Blockade in the Management of Obesity Hypertension?
Sharma, A. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000132568.71409.a2 · Cited by 136
Perivascular adipose tissue and vascular disease
Britton, K. A., & Fox, C. S. (2011) · Clinical Lipidology · doi:10.2217/clp.10.89 · Cited by 135
Fructose Feeding Increases Insulin Resistance but Not Blood Pressure in Sprague-Dawley Rats
D’Angelo, G., Elmarakby, A. A., Pollock, D. M., & Stepp, D. W. (2005) · Hypertension · doi:10.1161/01.hyp.0000182697.39687.34 · Cited by 135
Minireview: Epigenetics of Obesity and Diabetes in Humans
Slomko, H., Heo, H. J., & Einstein, F. H. (2012) · Endocrinology · doi:10.1210/en.2011-1759 · Cited by 134
Kurukulasuriya, L. R., Stas, S. N., Lastra, G., Manrique, C. M., & Sowers, J. R. (2011) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.06.004 · Cited by 130
Self-citationSleep Apnea Syndrome: A Possible Contributing Factor to Resistant Hypertension
Lavie, P., & Hoffstein, V. (2001) · SLEEP · doi:10.1093/sleep/24.6.721 · Cited by 126
Blanco‐Rivero, J., Cachofeiro, V., Lahera, V., Aras‐López, R., Márquez‐Rodas, I., Salaíces, M., Xavier, F. E., Ferrer, M., & Balfagón, G. (2005) · Hypertension · doi:10.1161/01.hyp.0000171479.36880.17 · Cited by 126
Regulation of the human Na+-dependent glucose cotransporter hSGLT2
Ghezzi, C., & Wright, E. M. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00115.2012 · Cited by 124
Altered renal sodium handling in men with abdominal adiposity: a link to hypertension
Strazzullo, P., Barba, G., Cappuccio, F. P., Siani, A., Trevisan, M., Farinaro, E., Pagano, E., Barbato, A., Iacone, R., & Galletti, F. (2001) · Journal of Hypertension · doi:10.1097/00004872-200112000-00007 · Cited by 124
The Role of Overweight and Obesity in the Cardiorenal Syndrome
Sowers, J. R., Whaley‐Connell, A. T., & Hayden, M. R. (2011) · Cardiorenal Medicine · doi:10.1159/000322822 · Cited by 121
Self-citationAbdominal obesity in the United States: prevalence and attributable risk of hypertension
Okosun, I. S., Prewitt, T., & Cooper, R. (1999) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000862 · Cited by 121
Lindsey, S. H., Yamaleyeva, L. M., Brosnihan, K. B., Gallagher, P. E., & Chappell, M. C. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.175174 · Cited by 112
Obesity-hypertension: the effects on cardiovascular and renal systems
Zhang, R., & Reisin, E. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)01254-1 · Cited by 110
Enhanced expressions of sodium–glucose cotransporters in the kidneys of diabetic Zucker rats
Tabatabai, N. M., Sharma, M., Blumenthal, S. S., & Petering, D. H. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.11.003 · Cited by 106
Impact of the obesity epidemic on hypertension and renal disease
Hall, J. E., Jones, D. W., Kuo, J. J., da Silva, A. A., Tallam, L. S., & Liu, J. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0084-z · Cited by 106
Manrique, C. M., DeMarco, V. G., Aroor, A. R., Mugerfeld, I., Garro, M., Habibi, J., Hayden, M. R., & Sowers, J. R. (2013) · Endocrinology · doi:10.1210/en.2013-1256 · Cited by 106
Self-citationGanta, C. K., Lü, N., Helwig, B. G., Blecha, F., Ganta, R. R., Zheng, L., Ross, C. R., Musch, T. I., Fels, R. J., & Kenney, M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00125.2005 · Cited by 106
Aroor, A. R., Sowers, J. R., Bender, S. B., Nistala, R., Garro, M., Mugerfeld, I., Hayden, M. R., Johnson, M. S., Salam, M., Whaley‐Connell, A. T., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1096 · Cited by 102
Self-citationSex Differences in Hypertension: Contribution of the Renin–Angiotensin System
Maric‐Bilkan, C., & Manigrasso, M. B. (2012) · Gender Medicine · doi:10.1016/j.genm.2012.06.005 · Cited by 102
Lurbe, E., Torró, I., Aguilar, F., Álvarez‐Pitti, J., Alcon, J., Pascual, J. M., & Redón, J. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.099234 · Cited by 102
Aldosterone Production and Insulin Resistance in Healthy Adults
Garg, R., Hurwitz, S., Williams, G. H., Hopkins, P. N., & Adler, G. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2521 · Cited by 99
Scuteri, A., Orrù, M., Morrell, C. H., Tarasov, K. V., Schlessinger, D., Uda, M., & Lakatta, E. G. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.11.045 · Cited by 97
Silverberg, D. S., & Oksenberg, A. (2001) · Current Hypertension Reports · doi:10.1007/s11906-001-0040-8 · Cited by 97
Williams, M. D. (2013) · Minerva Access (University of Melbourne) · Cited by 95
Inflammation in the pathophysiology of essential hypertension
Montecucco, F., Pende, A., Quercioli, A., & Mach, F. (2010) · Journal of Nephrology · doi:10.5301/jn.2010.4729 · Cited by 94
Uric Acid-Driven Th17 Differentiation Requires Inflammasome-Derived IL-1 and IL-18
Conforti‐Andreoni, C., Spreafico, R., Qian, H. L., Riteau, N., Ryffel, B., Ricciardi‐Castagnoli, P., & Mortellaro, A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101408 · Cited by 93
Implications for Public Health
Koenig, H. G., & Shohaib, S. A. (2014) · Springer eBooks · doi:10.1007/978-3-319-05873-3_15 · Cited by 89
Dietary Fructose and Hypertension
Madero, M., Perez-Pozo, S. E., Jalal, D. I., Johnson, R. J., & Sánchez‐Lozada, L. G. (2010) · Current Hypertension Reports · doi:10.1007/s11906-010-0163-x · Cited by 85
Drüppel, V., Kusche‐Vihrog, K., Großmann, C., et al. (2013) · The FASEB Journal · doi:10.1096/fj.13-228312 · Cited by 82
Ehrhart‐Bornstein, M., Arakelyan, K., Krug, A. W., Scherbaum, W. A., & Bornstein, S. R. (2004) · Endocrine Research · doi:10.1081/erc-200044122 · Cited by 80
Serum Uric Acid, Inflammation, and Nondipping Circadian Pattern in Essential Hypertension
Turak, O., Özcan, F., Tok, D., et al. (2012) · Journal of Clinical Hypertension · doi:10.1111/jch.12026 · Cited by 79
Aghamohammadzadeh, R., & Heagerty, A. M. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.663928 · Cited by 79
Thomsen, B., Ekstrøm, C. T., & Sørensen, T. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800907 · Cited by 77
T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance
Zhong, J., Rao, X., Braunstein, Z., Taylor, A., Narula, V. K., Hazey, J. W., Mikami, D. J., NEEDLEMAN, B. J., Rutsky, J., Sun, Q., et al. (2013) · Diabetes · doi:10.2337/db13-1094 · Cited by 76
Sørensen, T. I. A. (2009) · Proceedings of the Nutrition Society · doi:10.1017/s0029665108008847 · Cited by 75
Berry, K. L., Cameron, J. D., Dart, A. M., Dewar, E. M., Gatzka, C. D., Jennings, G., Liang, Y., Reid, C. M., & Kingwell, B. A. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52107.x · Cited by 74
Angiotensin II-dependent increased expression of Na + -glucose cotransporter in hypertension
Bautista, R., Manning, R., Martínez-Morales, F., Ávila-Casado, M. D. C., Soto, V., Medina, A., & Escalante, B. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00113.2003 · Cited by 72
Vascular insulin resistance in prehypertensive rats: Role of PI3-kinase/Akt/eNOS signaling
Li, R., Zhang, H., Wang, W., Wang, X., Huang, Y., Huang, C., & Gao, F. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.11.038 · Cited by 70
Ganu, R., Harris, R. A., Collins, K., & Aagaard, K. M. (2012) · ILAR Journal · doi:10.1093/ilar.53.3-4.306 · Cited by 70
An Update on Immune System Activation in the Pathogenesis of Hypertension
Ryan, M. J. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00603 · Cited by 68
Cited by
Sorted by citations
Obesity-Induced Hypertension: Interaction of Neurohumoral and Renal Mechanisms
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2015) · Circulation Research · doi:10.1161/circresaha.116.305697 · Cited by 1,360
Obesity, kidney dysfunction and hypertension: mechanistic links
Hall, J. E., do Carmo, J. M., da Silva, A. A., Wang, Z., & Hall, M. E. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0145-4 · Cited by 654
The Renin Angiotensin Aldosterone System in Obesity and Hypertension
Cabandugama, P. K., Gardner, M. J., & Sowers, J. R. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2016.08.009 · Cited by 168
Self-citationOvernutrition, mTOR signaling, and cardiovascular diseases
Jia, G., Aroor, A. R., Martinez-Lemus, L. A., & Sowers, J. R. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00262.2014 · Cited by 122
Self-citationGut hormones and gut microbiota: implications for kidney function and hypertension
Afsar, B., Vaziri, N. D., Aslan, G., Tarim, K., & Kanbay, M. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.10.007 · Cited by 63
Metadata
- Authors
- DeMarco, V. G., Aroor, A. R., & Sowers, J. R.
- Affiliations
- University of Missouri (US)
- Corresponding author
- Sowers, James R.
- Venue
- Nature Reviews Endocrinology
- Published
- 2014-04-15
- Volume
- 10
- Issue
- 6
- Pages
- 364-376
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- PMC
- PMC4308954
- OpenAlex
- W2012416246
- Cited by
- 545
- References
- 238
- Citations by year
- 2026: 30 · 2025: 41 · 2024: 38 · 2023: 70 · 2022: 48 · 2021: 51 · 2020: 56 · 2019: 53 · 2018: 40 · 2017: 41 · 2016: 40 · 2015: 26 · 2014: 11
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- CYTED Ciencia y Tecnología para el Desarrollo
- National Institutes of Health (5r01hl107910-03)
- National Heart, Lung, and Blood Institute (R01 HL73101‑01A1, R01 HL 107910-01, R01-HL-107910, R01HL073101)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- obesity, obesity-related hypertension, pathophysiology, visceral adipose tissue, endothelial dysfunction, sodium retention, glomerular hyperfiltration, proteinuria, insulin resistance, leptin resistance, adiponectin, resistin, TNF-α, interleukin-6, gut microbiota, uric acid, incretins, dipeptidyl peptidase IV, arterial stiffness, premenopausal women, type 2 diabetes, cardiovascular disease, kidney disease
- MeSH terms
- Cardiotonic Agents, Diet, Humans, Hypertension, Life Style, Obesity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
