Cited by 479Memory and Neural MechanismsStress Responses and CortisolNeuroscience and Neuropharmacology Research

Mechanisms of late-onset cognitive decline after early-life stress

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Brunson, Kristen L., Kramár, Enikö, Lin, Bin, Chen, Yuncai, Colgin, Laura Lee, Yanagihara, Theodore K., Lynch, Gary, Baram, Tallie Z.·2005·The Journal of Neuroscience

Abstract

Progressive cognitive deficits that emerge with aging are a result of complex interactions of genetic and environmental factors. Whereas much has been learned about the genetic underpinnings of these disorders, the nature of "acquired" contributing factors, and the mechanisms by which they promote progressive learning and memory dysfunction, remain largely unknown. Here, we demonstrate that a period of early-life "psychological" stress causes late-onset, selective deterioration of both complex behavior and synaptic plasticity: two forms of memory involving the hippocampus, were severely but selectively impaired in middle-aged, but not young adult, rats exposed to fragmented maternal care during the early postnatal period. At the cellular level, disturbances to hippocampal long-term potentiation paralleled the behavioral changes and were accompanied by dendritic atrophy and mossy fiber expansion. These findings constitute the first evidence that a short period of stress early in life can lead to delayed, progressive impairments of synaptic and behavioral measures of hippocampal function, with potential implications to the basis of age-related cognitive disorders in humans.

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Crossref · 10.1523/jneurosci.2281-05.2005

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Authors
Brunson, K. L., Kramár, E., Lin, B., Chen, Y., Colgin, L. L., Yanagihara, T. K., Lynch, G., & Baram, T. Z.
Affiliations
University of California, Irvine (US)
Venue
The Journal of Neuroscience
Published
2005-10-12
Volume
25
Issue
41
Pages
9328-9338
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W1988059569
Cited by
479
References
76
Citations by year
2026: 17 · 2025: 20 · 2024: 28 · 2023: 24 · 2022: 30 · 2021: 37 · 2020: 31 · 2019: 26 · 2018: 25 · 2017: 20 · 2016: 26 · 2015: 21 · 2014: 27 · 2013: 26 · 2012: 18
FWCI
6.26
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders
  • National Institutes of Health (T32 AG00096, NS045260, AG00096)
  • National Institute on Aging (T32 AG00096, T32AG000096)
  • National Institute of Neurological Disorders and Stroke (P01NS045260, NS 28912, NS045260, R01NS028912, NS 39307, R01NS039307)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
early life stress, hippocampus, synaptic plasticity, long-term potentiation, dendritic atrophy, age-related cognitive decline, learning and memory impairment, postpartum stress, rats
MeSH terms
Age Factors, Animals, Cognition Disorders, Female, Hippocampus, Male, Maternal Behavior, Stress, Psychological, Time Factors, Rats, Sprague-Dawley, Age of Onset, Long-Term Potentiation, Rats, In Vitro Techniques

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