Oxytocin enhances cognitive control of food craving in women
Open accessAbstract
In developed countries, obesity has become an epidemic resulting in enormous health care costs for society and serious medical complications for individuals. The homeostatic regulation of food intake is critically dependent on top‐down control of reward‐driven food craving. There is accumulating evidence from animal studies that the neuropeptide oxytocin (OXT) is involved in regulating hunger states and eating behavior, but whether OXT also contributes to cognitive control of food craving in humans is still unclear. We conducted a counter‐balanced, double‐blind, within‐subject, pharmacological magnetic resonance imaging experiment involving 31 healthy women who received 24 IU of intranasal OXT or placebo and were scanned twice while they were exposed to pictures of palatable food. The participants were instructed either to imagine the immediate consumption or to cognitively control the urge to eat the food. Our results show a trend that OXT specifically reduced food craving in the cognitive control condition. On the neural level, these findings were paralleled by an increase of activity in the middle and superior frontal gyrus, precuneus, and cingulate cortex under OXT. Interestingly, the behavioral OXT effect correlated with the OXT‐induced changes in the prefrontal cortex and precuneus. Collectively, the present study provides first evidence that OXT plays a key role in the cognitive regulation of food craving in women by strengthening activity in a broad neurocircuitry implicated in top‐down control and self‐referential processing. Hum Brain Mapp 37:4276–4285, 2016. © 2016 Wiley Periodicals, Inc.
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Oxytocin strengthens top-down cognitive control by increasing middle frontal gyrus activity.
“Additionally, OXT strengthens top-down cognitive control strengthens top-down cognitive control by enhancing activity in the middle frontal gyrus (MFG) (Eckstein et al., 2015;Striepens et al., 2016).”
From Oxytocin enhances the pain‐relieving effects of social support in romantic couples (2019) · cites this paper as Striepens et al., 2016
An oxytocin-induced increase in prefrontal cortex activity may reflect enhanced top-down cognitive control.
“Additionally, an OXT-induced increase in activity in the PFC, where OXT receptors are highly expressed (Boccia, Petrusz, Suzuki, Marson, & Pedersen, 2013), may reflect enhanced top-down cognitive control that has been previously observed in the context of food craving behavior (Striepens et al., 2016) and fear extinction (Eckstein et al., 2015).”
From Oxytocin enhances the pain‐relieving effects of social support in romantic couples (2019) · cites this paper as Striepens et al., 2016
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- Authors
- Striepens, N., Schröter, F., Stoffel‐Wagner, B., Maier, W., Hurlemann, R., & Scheele, D.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Scheele, Dirk
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2016-07-06
- Volume
- 37
- Issue
- 12
- Pages
- 4276-4285
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC6867465
- OpenAlex
- W2462547029
- Cited by
- 63
- References
- 73
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 7 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 11 · 2018: 12 · 2017: 8
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Brain Mapping (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion)
- Funders
- German Research Foundation (Deutsche Forschungsgemeinschaft [DFG]) (HU1202/4-1 and BE 5465/2-1 (to R.H. and D.S.).)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, food cravings, cognitive control, top-down control, women, obesity, dietary habits, prefrontal cortex, precuneus, cingulate cortex, self-referential processing, intranasal administration, palatable food
- MeSH terms
- Administration, Intranasal, Adult, Analysis of Variance, Brain, Brain Mapping, Cognition, Double-Blind Method, Eating, Female, Food, Homeostasis, Humans, Imagination, Magnetic Resonance Imaging, Neural Pathways, Oxytocin, Psychotropic Drugs, Executive Function, Craving
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