Cited by 263SARS-CoV-2 and COVID-19 ResearchCOVID-19 epidemiological studiesVaccine Coverage and Hesitancy

Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine

Open access
Mizrahi, Barak, Lotan, Roni, Kalkstein, Nir, Peretz, Asaf, Perez, Galit, Ben-Tov, Amir, Chodick, Gabriel, Gazit, Sivan +1 more·2021·Nature Communications

Published version of a preprint

Abstract

The short-term effectiveness of a two-dose regimen of the BioNTech/Pfizer mRNA BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine was widely demonstrated. However, long term effectiveness is still unknown. Leveraging the centralized computerized database of Maccabi Healthcare Services (MHS), we assessed the correlation between time-from-vaccine and incidence of breakthrough infection between June 1 and July 27, the date of analysis. After controlling for potential confounders as age and comorbidities, we found a significant 1.51 fold (95% CI, 1.38–1.66) increased risk for infection for early vaccinees compared to those vaccinated later that was similar across all ages groups. The increased risk reached 2.26- fold (95% CI, 1.80–3.01) when comparing those who were vaccinated in January to those vaccinated in April. This preliminary finding of vaccine waning as a factor of time from vaccince should prompt further investigations into long-term protection against different strains.

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Authors
Mizrahi, B., Lotan, R., Kalkstein, N., Peretz, A., Perez, G., Ben-Tov, A., Chodick, G., Gazit, S., & Patalon, T.
Affiliations
  • Maccabi Healthcare Services (IL)
  • Tel Aviv University (IL)
Corresponding author
Lotan, Roni
Venue
Nature Communications
Published
2021-11-04
Volume
12
Issue
1
Pages
6379-6379
ISSN
2041-1723 (ISSN-L)
OpenAlex
W3209833474
Cited by
261
References
18
Citations by year
2026: 1 · 2025: 4 · 2024: 18 · 2023: 55 · 2022: 140 · 2021: 43
FWCI
20.35
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • medRxiv (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
Keywords
SARS-CoV-2, breakthrough infection, BNT162b2, mRNA vaccines, vaccine waning, time since vaccination, long-term vaccine effectiveness, COVID-19 pandemic, Maccabi Healthcare Services
MeSH terms
COVID-19, SARS-CoV-2, COVID-19 Vaccines, BNT162 Vaccine, Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Time Factors, Vaccination, Young Adult

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