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Dietary carbohydrates and fats in nonalcoholic fatty liver disease
Open accessAbstract
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically increased in parallel with the epidemic of obesity. Controversy has emerged around dietary guidelines recommending low-fat-high-carbohydrate diets and the roles of dietary macronutrients in the pathogenesis of metabolic disease. In this Review, the topical questions of whether and how dietary fats and carbohydrates, including free sugars, differentially influence the accumulation of liver fat (specifically, intrahepatic triglyceride (IHTG) content) are addressed. Focusing on evidence from humans, we examine data from stable isotope studies elucidating how macronutrients regulate IHTG synthesis and disposal, alter pools of bioactive lipids and influence insulin sensitivity. In addition, we review cross-sectional studies on dietary habits of patients with NAFLD and randomized controlled trials on the effects of altering dietary macronutrients on IHTG. Perhaps surprisingly, evidence to date shows no differential effects between free sugars, with both glucose and fructose increasing IHTG in the context of excess energy. Moreover, saturated fat raises IHTG more than polyunsaturated or monounsaturated fats, with adverse effects on insulin sensitivity, which are probably mediated in part by increased ceramide synthesis. Taken together, the data support the use of diets that have a reduced content of free sugars, refined carbohydrates and saturated fat in the treatment of NAFLD.
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“Hypocaloric low-carbohydrate diets and low-fat diets appear to be similarly effective in reducing liver lipid content and related biomarkers. 289,290”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [289]
In the citing paper
“Saturated fat has been shown to have a negative effect on liver steatosis in several short-term clinical trials. 289”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [289]
In the citing paper
“Intake of added sugars, especially fructose, plays a major role in MASLD development. 289”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [289]
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Cites
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
Chalasani, N., Younossi, Z., Lavine, J. E., Charlton, M., Cusi, K., Rinella, M., Harrison, S. A., Brunt, E. M., & Sanyal, A. J. (2018) · Hepatology · doi:10.1002/hep.29367 · Cited by 7,239
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.004 · Cited by 4,836
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Eslam, M., Newsome, P. N., Sarin, S. K., Anstee, Q. M., Targher, G., Romero-Gomez, M., Zelber-Sagi, S., Wai-Sun Wong, V., Dufour, J.-F., Schattenberg, J. M., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.03.039 · Cited by 4,472
Self-citationSteatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285
Donnelly, K. L., Smith, C. I., Schwarzenberg, S. J., Jessurun, J., Boldt, M. D., & Parks, E. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23621 · Cited by 3,604
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
Romeo, S., Kozlitina, J., Xing, C., Pertsemlidis, A., Cox, D., Pennacchio, L. A., Boerwinkle, E., Cohen, J. C., & Hobbs, H. H. (2008) · Nature Genetics · doi:10.1038/ng.257 · Cited by 3,416
MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease
Eslam, M., Sanyal, A. J., George, J., Sanyal, A., Neuschwander-Tetri, B., Tiribelli, C., Kleiner, D. E., Brunt, E., Bugianesi, E., Yki-Järvinen, H., et al. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.312 · Cited by 3,286
Self-citationKim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Mensink, R. P., Zock, P. L., Kester, A. D., & Katan, M. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.5.1146 · Cited by 2,811
Changes in diet and lifestyle and long-term weight gain in women and men
Mozaffarian, D., Hao, T., Rimm, E. B., Willett, W. C., & Hu, F. B. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1014296 · Cited by 2,527
Vilar-Gomez, E., Martinez-Perez, Y., Calzadilla-Bertot, L., Torres-Gonzalez, A., Gra-Oramas, B., Gonzalez-Fabian, L., Friedman, S. L., Diago, M., & Romero-Gomez, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.005 · Cited by 2,492
Eckel, R. H., Jakicic, J. M., Ard, J. D., de Jesus, J. M., Miller, N. H., Hubbard, V. S., Lee, I.-M., Lichtenstein, A. H., Loria, C. M., Millen, B. E., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437740.48606.d1 · Cited by 2,261
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257
Human Fatty Liver Disease: Old Questions and New Insights
Cohen, J. C., Horton, J. D., & Hobbs, H. H. (2011) · Science · doi:10.1126/science.1204265 · Cited by 2,089
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078
Stanhope, K. L., Schwarz, J. M., Keim, N. L., Griffen, S. C., Bremer, A. A., Graham, J. L., Hatcher, B., Cox, C. L., Dyachenko, A., Zhang, W., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37385 · Cited by 1,765
Singh, S., Allen, A. M., Wang, Z., Prokop, L. J., Murad, M. H., & Loomba, R. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.04.014 · Cited by 1,748
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
Anstee, Q. M., Targher, G., & Day, C. P. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.41 · Cited by 1,747
Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease
Castera, L., Friedrich-Rust, M., & Loomba, R. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.036 · Cited by 1,494
A lipidomic analysis of nonalcoholic fatty liver disease
Puri, P., Baillie, R. A., Wiest, M. M., Mirshahi, F., Choudhury, J., Cheung, O., Sargeant, C., Contos, M. J., & Sanyal, A. J. (2007) · Hepatology · doi:10.1002/hep.21763 · Cited by 1,338
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
Promrat, K., Kleiner, D. E., Niemeier, H. M., Jackvony, E., Kearns, M., Wands, J. R., Fava, J. L., & Wing, R. R. (2010) · Hepatology · doi:10.1002/hep.23276 · Cited by 1,330
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322
Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
Yki‐Järvinen, H. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70032-4 · Cited by 1,296
Self-citationMetabolic Effects of Fructose and the Worldwide Increase in Obesity
Tappy, L., & Lê, K.-A. (2010) · Physiological Reviews · doi:10.1152/physrev.00019.2009 · Cited by 1,256
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Vessby, B., Uusitupa, M., Hermansen, K., Riccardi, G., Rivellese, A. A., Tapsell, L. C., Nälsén, C., Berglund, L., Louheranta, A., Rasmussen, B. M., et al. (2001) · Diabetologia · doi:10.1007/s001250051620 · Cited by 1,119
Lambert, J. E., Ramos–Roman, M. A., Browning, J. D., & Parks, E. J. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.049 · Cited by 1,069
Hagström, H., Nasr, P., Ekstedt, M., Hammar, U., Stål, P., Hultcrantz, R., & Kechagias, S. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.07.027 · Cited by 1,067
McPherson, S., Hardy, T., Henderson, E., Burt, A. D., Day, C. P., & Anstee, Q. M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.11.034 · Cited by 1,059
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., & Klein, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904944106 · Cited by 972
Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. D., & Bäckhed, F. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.07.026 · Cited by 960
García‐Ruiz, C., Colell, A., Marı́, M., Morales, A., & Fernández-Checa, J. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11369 · Cited by 808
Ryan, M. C., Itsiopoulos, C., Thodis, T., Ward, G., Trost, N., Hofferberth, S., O’Dea, K., Desmond, P. V., Johnson, N. A., & Wilson, A. M. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.02.012 · Cited by 778
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776
Musso, G., Gambino, R., Michieli, F. D., Cassader, M., Rizzetto, M., Durazzo, M., Fagà, E., Silli, B., & Pagano, G. (2003) · Hepatology · doi:10.1053/jhep.2003.50132 · Cited by 772
Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease
Smith, G. I., Shankaran, M., Yoshino, M., Schweitzer, G. G., Chondronikola, M., Beals, J. W., Okunade, A. L., Patterson, B. W., Nyangau, E., Field, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134165 · Cited by 771
Bugianesi, E., Gastaldelli, A., Vanni, E., Gambino, R., Cassader, M., Baldi, S., Ponti, V., Pagano, G., Ferrannini, E., & Rizzetto, M. (2005) · Diabetologia · doi:10.1007/s00125-005-1682-x · Cited by 770
Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases
Samuel, V. T., & Shulman, G. I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.002 · Cited by 745
A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis.
McGarry, J. D., Mannaerts, G. P., & Foster, D. W. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108764 · Cited by 736
Turpin-Nolan, S. M., Nicholls, H. T., Willmes, D. M., Mourier, A., Brodesser, S., Wunderlich, C. M., Mauer, J., Xu, E., Hammerschmidt, P., Brönneke, H. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.08.002 · Cited by 713
Reduction in saturated fat intake for cardiovascular disease
Hooper, L., Martin, N., Abdelhamid, A., & Davey Smith, G. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011737 · Cited by 704
Sunny, N. E., Parks, E. J., Browning, J. D., & Burgess, S. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.004 · Cited by 672
Ceramides – Lipotoxic Inducers of Metabolic Disorders
Chaurasia, B., & Summers, S. A. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.07.006 · Cited by 644
The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids
Jang, C., Hui, S., Lu, W., Cowan, A. J., Morscher, R. J., Lee, G., Liu, W., Tesz, G. J., Birnbaum, M. J., & Rabinowitz, J. D. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.016 · Cited by 639
Fabbrini, E., Mohammed, B. S., Magkos, F., Korenblat, K. M., Patterson, B. W., & Klein, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.038 · Cited by 631
Gastaldelli, A., Cusi, K., Pettiti, M., Hardies, J., Miyazaki, Y., Berria, R., Buzzigoli, E., Sironi, A. M., Cersosimo, E., Ferrannini, E., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.068 · Cited by 629
Vos, M. B., Kaar, J. L., Welsh, J. A., Horn, L. V., Feig, D. I., Anderson, C. A. M., Patel, M. J., Muños, J. C., Krebs, N. F., Xanthakos, S. A., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000439 · Cited by 614
Korenblat, K. M., Fabbrini, E., Mohammed, B. S., & Klein, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.075 · Cited by 592
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
Kumashiro, N., Erion, D. M., Zhang, D., Kahn, M., Beddow, S. A., Chu, X., Still, C. D., Gerhard, G. S., Han, X., Dziura, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113359108 · Cited by 585
Farvid, M. S., Ding, M., Pan, A., Sun, Q., Chiuve, S. E., Steffen, L. M., Willett, W. C., & Hu, F. B. (2014) · Circulation · doi:10.1161/circulationaha.114.010236 · Cited by 567
Differential oxidation of individual dietary fatty acids in humans
DeLany, J. P., Windhauser, M. M., Champagne, C. M., & Bray, G. A. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.4.905 · Cited by 560
Zelber‐Sagi, S., Nitzan, D., Goldsmith, R., Webb, M., Blendis, L. M., Halpern, Z., & Oren, R. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.06.020 · Cited by 552
Differential oxidation of saturated and unsaturated fatty acids in vivo in the rat
Leyton, J., Drury, P., & Crawford, M. A. (1987) · British Journal Of Nutrition · doi:10.1079/bjn19870046 · Cited by 539
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease
European Association for the Study of the Liver (EASL), E. A. F. T. S. O. D. (. (2016) · Obesity Facts · doi:10.1159/000443344 · Cited by 531
The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD)
Safari, Z., & Gérard, P. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03011-w · Cited by 522
Pais, R., Charlotte, F., Fedchuk, L., Bédossa, P., Lebray, P., Poynard, T., & Ratziu, V. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.027 · Cited by 520
Samuel, V. T., Liu, Z.-X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X.-M., Monia, B. P., Bhanot, S., & Shulman, G. I. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30400 · Cited by 497
Bjermo, H., Iggman, D., Kullberg, J., Dahlman, I., Johansson, L., Persson, L., Berglund, J., Pulkki, K., Basu, S., Uusitupa, M., et al. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.030114 · Cited by 490
Mardinoğlu, A., Wu, H., Björnson, E., Zhang, C., Hakkarainen, A., Räsänen, S., Lee, S., Mancina, R. M., Bergentall, M., Pietiläinen, K. H., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.005 · Cited by 465
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
Chaurasia, B., Tippetts, T. S., Mayoral, R., Liu, J., Li, Y., Wang, L., Wilkerson, J. L., Sweeney, C. R., Pereira, R. F., Sumida, D. H., et al. (2019) · Science · doi:10.1126/science.aav3722 · Cited by 463
Luukkonen, P. K., Zhou, Y., Sädevirta, S., Leivonen, M., Arola, J., Orešič, M., Hyötyläinen, T., & Yki-Järvinen, H. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.002 · Cited by 461
Self-citationHorn, L. V., Carson, J. A. S., Appel, L. J., Burke, L. E., Economos, C. D., Karmally, W., Lancaster, K. J., Lichtenstein, A. H., Johnson, R. K., Thomas, R. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000462 · Cited by 442
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
Kirk, E., Reeds, D. N., Finck, B. N., Mayurranjan, M. S., Patterson, B. W., & Klein, S. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.048 · Cited by 440
Diraison, F., Moulin, P., & Beylot, M. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70061-7 · Cited by 435
Ryysy, L., Häkkinen, A. M., Goto, T., Vehkavaara, S., Westerbacka, J., Halavaara, J., & Yki-Järvinen, H. (2000) · Diabetes · doi:10.2337/diabetes.49.5.749 · Cited by 431
Self-citationRosqvist, F., Iggman, D., Kullberg, J., Cedernaes, J., Johansson, H.-E., Larsson, A., Johansson, L., Ahlström, H., Arner, P., Dahlman, I., et al. (2014) · Diabetes · doi:10.2337/db13-1622 · Cited by 429
Lassenius, M. I., Pietiläinen, K. H., Kaartinen, K., Pussinen, P. J., Syrjänen, J., Forsblom, C. M., Pörsti, I. H., Rissanen, A., Kaprio, J. A., Mustonen, J. T., et al. (2011) · Diabetes Care · doi:10.2337/dc10-2197 · Cited by 428
Luukkonen, P. K., Sädevirta, S., Zhou, Y., Kayser, B., Ali, A., Ahonen, L., Lallukka, S., Pelloux, V., Gaggini, M., Jian, C., et al. (2018) · Diabetes Care · doi:10.2337/dc18-0071 · Cited by 428
Self-citationKim, C.-W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Li, C., Ruddy, M., Chakravarthy, M., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.009 · Cited by 419
Raichur, S., Wang, S. T., Chan, P. W., Li, Y., Ching, J., Chaurasia, B., Dogra, S. K., Öhman, M. K., Takeda, K., Sugii, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.007 · Cited by 385
Dietary fat content modifies liver fat in overweight nondiabetic subjects
Westerbacka, J., Lammi, K., Häkkinen, A.-M., Rissanen, A., Salminen, I., Aro, A., & Yki-Järvinen, H. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1983 · Cited by 379
Self-citationII. Alcoholic liver injury involves activation of Kupffer cells by endotoxin
Thurman, R. G. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.4.g605 · Cited by 378
Biomarkers of NAFLD progression: a lipidomics approach to an epidemic
Gorden, D. L., Myers, D. S., Ivanova, P. T., Fahy, E., Maurya, M. R., Gupta, S., Min, J., Spann, N. J., McDonald, J. G., Kelly, S. L., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.p056002 · Cited by 372
Measurement of de novo hepatic lipogenesis in humans using stable isotopes.
Hellerstein, M. K., Christiansen, M., Kaempfer, S., Kletke, C., Wu, K. K., Reid, J., Mulligan, K. M., Hellerstein, N. S., & Shackleton, C. H. L. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115206 · Cited by 362
Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans
Mehta, N. N., McGillicuddy, F. C., Anderson, P. D., Hinkle, C. C., Shah, R. D., Pruscino, L., Tabita‐Martinez, J., Sellers, K. F., Rickels, M. R., & Reilly, M. P. (2009) · Diabetes · doi:10.2337/db09-0367 · Cited by 354
Xia, J. Y., Holland, W. L., Kusminski, C. M., Sun, K., Sharma, A. X., Pearson, M. J., Sifuentes, A. J., McDonald, J. G., Gordillo, R., & Scherer, P. E. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.007 · Cited by 352
Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis
Semple, R. K., Sleigh, A., Murgatroyd, P. R., Adams, C. A., Bluck, L. J. C., Jackson, S. J., Vottero, A., Kanabar, D. J., Charlton-Menys, V., Durrington, P. N., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37432 · Cited by 347
Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort
Havulinna, A. S., Sysi‐Aho, M., Hilvo, M., Kauhanen, D., Hurme, R., Ekroos, K., Salomaa, V. V., & Laaksonen, R. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307497 · Cited by 345
Eckel, R. H., Jakicic, J. M., Ard, J. D., Jesus, J. M. D., Miller, N. H., Hubbard, V. S., Lee, I.-M. M., Lichtenstein, A. H., Loria, C. M., Millen, B. E., et al. (2014) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · Cited by 343
Loomba, R., Kayali, Z., Noureddin, M., Ruane, P., Lawitz, E. J., Bennett, M., Wang, L., Harting, E., Tarrant, J. M., McColgan, B. J., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.027 · Cited by 340
Kotronen, A., Juurinen, L., Tiikkainen, M., Vehkavaara, S., & Yki–Järvinen, H. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.021 · Cited by 339
Self-citationHavel, R. J., Kane, J. P., BALASSE, E. O., Segel, N., & Basso, L. V. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106422 · Cited by 336
Weintraub, M. S., Zechner, R., Brown, A., Eisenberg, S., & Breslow, J. L. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113806 · Cited by 331
Fatty acid metabolism in adipose tissue, muscle and liver in health and disease
Frayn, K. N., Arner, P., & Yki‐Järvinen, H. (2006) · Essays in Biochemistry · doi:10.1042/bse0420089 · Cited by 329
Self-citationBrowning, J. D., Baker, J. A., Rogers, T., Davis, J., Satapati, S., & Burgess, S. C. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.007674 · Cited by 328
Johnston, B. C., Zeraatkar, D., Han, M. A., Vernooij, R. W. M., Valli, C., Dib, R. E., Marshall, C., Stover, P. J., Fairweather‐Tait, S. J., Wójcik, G., et al. (2019) · Annals of Internal Medicine · doi:10.7326/m19-1621 · Cited by 322
The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state
Hodson, L., & Gunn, P. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0256-9 · Cited by 321
Self-citationDietary Sugars Stimulate Fatty Acid Synthesis in Adults3
Parks, E. J., Skokan, L. E., Timlin, M. T., & Dingfelder, C. S. (2008) · Journal of Nutrition · doi:10.1093/jn/138.6.1039 · Cited by 320
CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity
Hammerschmidt, P., Ostkotte, D., Nolte, H., Gerl, M. J., Jaïs, A., Brunner, H. L., Sprenger, H., Awazawa, M., Nicholls, H. T., Turpin-Nolan, S. M., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.008 · Cited by 314
Haufe, S., Engeli, S., Kast, P., Böhnke, J., Utz, W., Haas, V., Hermsdorf, M., Mähler, A., Wiesner, S., Birkenfeld, A. L., et al. (2011) · Hepatology · doi:10.1002/hep.24242 · Cited by 307
Zelber-Sagi, S., Ivancovsky-Wajcman, D., Fliss Isakov, N., Webb, M., Orenstein, D., Shibolet, O., & Kariv, R. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.01.015 · Cited by 297
Apostolopoulou, M., Gordillo, R., Koliaki, C., Gancheva, S., Jelenik, T., De Filippo, E., Herder, C., Markgraf, D., Jankowiak, F., Esposito, I., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1318 · Cited by 284
Koutoukidis, D. A., Astbury, N. M., Tudor, K., Morris, E. M., Henry, J. A., Noreik, M., Jebb, S. A., & Aveyard, P. N. (2019) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2019.2248 · Cited by 279
Gepner, Y., Shelef, I., Schwarzfuchs, D., Zelicha, H., Tene, L., Yaskolka Meir, A., Tsaban, G., Cohen, N., Bril, N., Rein, M., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.030501 · Cited by 279
Zelber‐Sagi, S., Salomone, F., & Mlynarsky, L. (2017) · Liver International · doi:10.1111/liv.13435 · Cited by 273
Dietary habits and nutrient intake in non-alcoholic steatohepatitis
Toshimitsu, K., Matsuura, B., Ohkubo, I., Niiya, T., Furukawa, S., Hiasa, Y., Kawamura, M., Ebihara, K., & Onji, M. (2006) · Nutrition · doi:10.1016/j.nut.2006.09.004 · Cited by 269
Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys
Schwimmer, J. B., Ugalde‐Nicalo, P., Welsh, J. A., Angeles, J. E., Cordero, M., Adams, K. H., Alazraki, A. L., Durelle, J., Knight‐Scott, J., Newton, K. P., et al. (2019) · JAMA · doi:10.1001/jama.2018.20579 · Cited by 266
Cho, Y., Kim, D., Seo, W., Gao, B., Yoo, S., & Song, B. (2019) · Hepatology · doi:10.1002/hep.30652 · Cited by 266
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
Petersen, M. C., Madiraju, A. K., Gassaway, B. M., Marcel, M., Nasiri, A. R., Butrico, G. M., Marcucci, M., Zhang, D., Abulizi, A., Zhang, X., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86013 · Cited by 260
Oddy, W. H., Herbison, C. E., Jacoby, P., Ambrosini, G. L., O’Sullivan, T. A., Ayonrinde, O. T., Olynyk, J. K., Black, L. J., Beilin, L. J., Mori, T. A., et al. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.95 · Cited by 259
Deopurkar, R., Ghanim, H., Friedman, J., Abuaysheh, S., Sia, C. L., Mohanty, P., Viswanathan, P., Chaudhuri, A., & Dandona, P. (2010) · Diabetes Care · doi:10.2337/dc09-1630 · Cited by 256
Kotronen, A., Seppänen‐Laakso, T., Westerbacka, J., Kiviluoto, T. A., Arola, J. T., Ruskeepää, A., Orešič, M., & Yki‐Järvinen, H. (2008) · Diabetes · doi:10.2337/db08-1074 · Cited by 253
Self-citationArcher, E., Pavela, G., & Lavie, C. J. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.04.009 · Cited by 247
De novo lipogenesis in humans: metabolic and regulatory aspects
Hellerstein, M. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600744 · Cited by 246
Rosqvist, F., Kullberg, J., Ståhlman, M., Cedernaes, J., Heurling, K., Johansson, H.-E., Iggman, D., Wilking, H., Larsson, A. O., Eriksson, O., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00160 · Cited by 246
Schwarz, J., Neese, R. A., Turner, S., Dare, D., & Hellerstein, M. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118342 · Cited by 244
Whole body oxidation of dietary fatty acids: implications for energy utilization
Jones, P., Pencharz, P., & Clandinin, M. T. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/42.5.769 · Cited by 238
Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat
Schwarz, J., Noworolski, S. M., Wen, M., Dyachenko, A., Prior, J. L., Weinberg, M. E., Herraiz, L. A., Tai, V., Bergeron, N., Bersot, T. P., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3678 · Cited by 237
Gepner, Y., Shelef, I., Komy, O., Cohen, N., Schwarzfuchs, D., Bril, N., Rein, M., Serfaty, D., Kenigsbuch, S., Zelicha, H., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.04.013 · Cited by 236
Lotta, L. A., Wittemans, L. B. L., Zuber, V., Stewart, I. D., Sharp, S. J., Luan, J., Day, F. R., Li, C., Bowker, N., Cai, L., et al. (2018) · JAMA · doi:10.1001/jama.2018.19329 · Cited by 229
Bozzetto, L., Prinster, A., Annuzzi, G., Costagliola, L., Mangione, A., Vitelli, A., Mazzarella, R., Longobardo, M., Mancini, M., Vigorito, C., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0033 · Cited by 227
Properzi, C., O'Sullivan, T. A., Sherriff, J. L., Ching, H. L., Jeffrey, G. P., Buckley, R. F., Tibballs, J., MacQuillan, G. C., Garas, G., & Adams, L. A. (2018) · Hepatology · doi:10.1002/hep.30076 · Cited by 227
Non-alcoholic fatty liver disease (NAFLD): summary of NICE guidance
Glen, J., Floros, L., Day, C., & Pryke, R. (2016) · BMJ · doi:10.1136/bmj.i4428 · Cited by 224
Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects
Magkos, F., Su, X., Bradley, D. P., Fabbrini, E., Conte, C., Eagon, J. C., Varela, J. E., Brunt, E. M., Patterson, B. W., & Klein, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.03.003 · Cited by 223
Yaghootkar, H., Scott, R. A., White, C. C., Zhang, W., Speliotes, E. K., Munroe, P. B., Ehret, G., Bis, J. C., Fox, C. S., Walker, M., et al. (2014) · Diabetes · doi:10.2337/db14-0318 · Cited by 223
Sato, K., Gosho, M., Yamamoto, T., Kobayashi, Y., Ishii, N., Ohashi, T., Nakade, Y., Ito, K., Fukuzawa, Y., & Yoneda, M. (2014) · Nutrition · doi:10.1016/j.nut.2014.11.018 · Cited by 207
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance
Hernández, E. Á., KAHL, S., Seelig, A., Begovatz, P., Irmler, M., Kupriyanova, Y., Nowotny, B., Nowotny, P., Herder, C., Barosa, C., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci89444 · Cited by 205
Effects of insulin and acipimox on VLDL1 and VLDL2 apolipoprotein B production in normal subjects.
Malmström, R., Packard, C. J., CASLAKE, M. J., Bedford, D. K., Stewart, P., Yki‐Järvinen, H., Shepherd, J., & Taskinen, M. (1998) · Diabetes · doi:10.2337/diabetes.47.5.779 · Cited by 203
Self-citationAn Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice
Xie, C., Jiang, C., Shi, J., Gao, X., Sun, D., Sun, L., Wang, T., Takahashi, S., Anitha, M., Krausz, K. W., et al. (2016) · Diabetes · doi:10.2337/db16-0663 · Cited by 201
Relationship Between Body Fat Mass and Free Fatty Acid Kinetics in Men and Women
Mittendorfer, B., Magkos, F., Fabbrini, E., Mohammed, B. S., & Klein, S. (2009) · Obesity · doi:10.1038/oby.2009.224 · Cited by 199
Adiels, M., Westerbacka, J., Soro‐Paavonen, A., Häkkinen, A. ‐., Vehkavaara, S., CASLAKE, M. J., Packard, C. J., Olofsson, S.-O., Yki‐Järvinen, H., Taskinen, M., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0790-1 · Cited by 197
Self-citationJohnston, R. D., Stephenson, M. C., Crossland, H., Cordon, S. M., Palcidi, E., Cox, E. F., Taylor, M. A., Aithal, G. P., & Macdonald, I. A. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.012 · Cited by 197
Marventano, S., Salomone, F., Godos, J., Pluchinotta, F. R., Rio, D. D., Mistretta, A., & Grosso, G. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.03.012 · Cited by 197
Ma, J., Hennein, R., Liu, C., Long, M. T., Hoffmann, U., Jacques, P. F., Lichtenstein, A. H., Hu, F. B., & Levy, D. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.03.038 · Cited by 187
Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study
Lemaître, R. N., Yu, C., Hoofnagle, A. N., Nair, H., Jensen, P. N., Fretts, A. M., Umans, J. G., Howard, B. V., Sitlani, C. M., Siscovick, D. S., et al. (2018) · Diabetes · doi:10.2337/db17-1449 · Cited by 184
Ceramide Remodeling and Risk of Cardiovascular Events and Mortality
Peterson, L. R., Xanthakis, V., Duncan, M. S., Groß, S., Friedrich, N., Völzke, H., Felix, S. B., Jiang, H., Sidhu, R., Nauck, M. A., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007931 · Cited by 182
Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure
Kien, C. L., Bunn, J. Y., & Ugrasbul, F. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.2.320 · Cited by 178
Silbernagel, G., Machann, J., Unmuth, S., Schick, F., Stefan, N., Häring, H. U., & Fritsche, A. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451000574x · Cited by 173
Seppala-Lindroos, A. (2002) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.7.3023 · Cited by 168
Self-citationter Horst, K. W., Gilijamse, P. W., Versteeg, R. I., Ackermans, M. T., Nederveen, A. J., la Fleur, S. E., Romijn, J. A., Nieuwdorp, M., Zhang, D., Samuel, V. T., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.035 · Cited by 166
Sobrecases, H., Lê, K.-A., Bortolotti, M., Schneiter, P., Ith, M., Kreis, R., Boesch, C., & Tappy, L. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.03.003 · Cited by 161
Fats and fatty acid requirements for adults
Elmadfa, I., & Kornsteiner, M. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000228996 · Cited by 161
Marques-Lopes, I., Ansorena, D., Astiasarán, I., Forga, L., & Martínez, J. A. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.2.253 · Cited by 159
Vors, C., Pineau, G., Drai, J., Meugnier, E., Pesenti, S., Laville, M., Laugerette, F., Malpuech-Brugère, C., Vidal, H., & Michalski, M.-C. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2518 · Cited by 159
Sevastianova, K., Kotronen, A., Gastaldelli, A., Perttilä, J., Hakkarainen, A., Lundbom, J., Suojanen, L.-U., Orho‐Melander, M., Lundbom, N. M. I., Ferrannini, E., et al. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.012369 · Cited by 158
Self-citationWijarnpreecha, K., Thongprayoon, C., & Ungprasert, P. (2016) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000776 · Cited by 156
Gorden, D. L., Ivanova, P. T., Myers, D. S., McIntyre, J. O., VanSaun, M. N., Wright, J. K., Matrisian, L. M., & Brown, H. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022775 · Cited by 155
Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance
Yki‐Järvinen, H. (2015) · Nutrients · doi:10.3390/nu7115454 · Cited by 155
Self-citationYaghootkar, H., Lotta, L. A., Tyrrell, J., Smit, R. A. J., Jones, S. E., Donnelly, L. A., Beaumont, R. N., Campbell, A., Tuke, M. A., Hayward, C., et al. (2016) · Diabetes · doi:10.2337/db15-1671 · Cited by 151
Effects of a short-term overfeeding with fructose or glucose in healthy young males
Sock, E. T. N., Lê, K., Ith, M., Kreis, R., Boesch, C., & Tappy, L. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509992819 · Cited by 148
Noureddin, M., Zelber‐Sagi, S., Wilkens, L. R., Porcel, J., Boushey, C. J., Le Marchand, L., Rosen, H. R., & Setiawan, V. W. (2020) · Hepatology · doi:10.1002/hep.30967 · Cited by 148
Dissociating fatty liver and diabetes
Sun, Z., & Lazar, M. A. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.09.005 · Cited by 143
Lecoultre, V., Egli, L., Carrel, G., Theytaz, F., Kreis, R., Schneiter, P., Boss, A., Zwygart, K., Lê, K., Bortolotti, M., et al. (2013) · Obesity · doi:10.1002/oby.20377 · Cited by 143
Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease
Jump, D. B., Lytle, K. A., Depner, C. M., & Tripathy, S. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.07.007 · Cited by 142
Ceramide channels and their role in mitochondria-mediated apoptosis
Colombini, M. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.021 · Cited by 139
The Role of Dietary Sugars and De novo Lipogenesis in Non-Alcoholic Fatty Liver Disease
Moore, J. B., Gunn, P. J., & Fielding, B. A. (2014) · Nutrients · doi:10.3390/nu6125679 · Cited by 138
Self-citationKenneally, S., Sier, J. H., & Moore, J. B. (2017) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2017-000139 · Cited by 135
Self-citationHepatic secretion of VLDL fatty acids during stimulated lipogenesis in men
Aarsland, A. A., & Wolfe, R. R. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32553-0 · Cited by 133
van Herpen, N. A., Schrauwen-Hinderling, V. B., Schaart, G., Mensink, R. P., & Schrauwen, P. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2243 · Cited by 124
Amaro, A., Fabbrini, E., Kars, M., Yue, P., Schechtman, K. B., Schonfeld, G., & Klein, S. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.03.039 · Cited by 124
Jácome-Sosa, M., & Parks, E. J. (2014) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000080 · Cited by 123
Taskinen, M., Söderlund, S., Bogl, L. H., Hakkarainen, A., Matikainen, N., Pietiläinen, K. H., Räsänen, S., Lundbom, N. M. I., Björnson, E., Eliasson, B., et al. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12632 · Cited by 122
Croci, I., Byrne, N. M., Choquette, S., Hills, A. P., Chachay, V., Clouston, A. D., O'Moore‐Sullivan, T. M., Macdonald, G. A., Prins, J. B., & Hickman, I. J. (2012) · Gut · doi:10.1136/gutjnl-2012-302789 · Cited by 119
Marriott, B. P., Hunt, K. J., Malek, A. M., & Newman, J. C. (2019) · Nutrients · doi:10.3390/nu11092004 · Cited by 117
Stiede, K., Miao, W., Blanchette, H., Beysen, C., Harriman, G. C. B., Harwood, H. J., Kelley, H., Kapeller, R., Schmalbach, T., & Westlin, W. (2017) · Hepatology · doi:10.1002/hep.29246 · Cited by 115
Chen, H., Wang, J., Li, Z., Lam, C. W. K., Xiao, Y., Wu, Q., & Zhang, W. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16122192 · Cited by 112
Martínez-Gili, L., Torres, S., Baulies, A., Alarcón‐Vila, C., Elena, M., Fabriàs, G., Casas, J., Caballería, J., Fernández-Checa, J. C., & García‐Ruiz, C. (2015) · Oncotarget · doi:10.18632/oncotarget.6286 · Cited by 107
Dietary fructose induces endotoxemia and hepatic injury in calorically controlled primates
Kavanagh, K., Wylie, A. T., Tucker, K. L., Hamp, T. J., Gharaibeh, R. Z., Fodor, A. A., & Cullen, J. M. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.057331 · Cited by 106
Kim, C.-W., Addy, C., Kusunoki, J., Anderson, N. N., Deja, S., Fu, X., Burgess, S. C., Cai, L., Ruddy, M., Chakravarthy, M. V., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.011 · Cited by 105
Ji, Y., Yiorkas, A. M., Frau, F., Mook‐Kanamori, D. O., Staiger, H., Thomas, E. L., Atabaki‐Pasdar, N., Campbell, A., Tyrrell, J., Jones, S. E., et al. (2018) · Diabetes · doi:10.2337/db18-0708 · Cited by 102
Fructose Induced Endotoxemia in Pediatric Nonalcoholic Fatty Liver Disease
Jin, R., Willment, A., Patel, S. S., Sun, X., Song, M., Mannery, Y. O., Kosters, A., McClain, C. J., & Vos, M. B. (2014) · International Journal of Hepatology · doi:10.1155/2014/560620 · Cited by 101
Liu, L., Li, P., Liu, Y., & Zhang, Y. (2019) · Digestive Diseases and Sciences · doi:10.1007/s10620-019-05699-z · Cited by 101
Hepatic De Novo Lipogenesis in Obese Youth Is Modulated by a Common Variant in the GCKR Gene
Santoro, N., Caprio, S., Pierpont, B. M., Name, M. A. V., Savoye, M., & Parks, E. J. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1587 · Cited by 100
Dietary patterns are associated with prevalence of fatty liver disease in adults
Jia, Q., Xia, Y., Zhang, Q., Wu, H., Du, H., Liu, L., Wang, C., Shi, H., Guo, X., Liu, X., et al. (2015) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2014.297 · Cited by 98
Are Fruit Juices Healthier Than Sugar-Sweetened Beverages? A Review
Pepin, A., Stanhope, K. L., & Imbeault, P. (2019) · Nutrients · doi:10.3390/nu11051006 · Cited by 98
Taee, F. A., Zerafati-Shoae, N., Dehghani, M., Sadeghi, M., Baradaran, H. R., & Jazayeri, S. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1711-4 · Cited by 97
Reduced oxidation of dietary fat after a short term high-carbohydrate diet
Roberts, R., Bickerton, A. S. T., Fielding, B. A., Blaak, E. E., Wagenmakers, A. J. M., Chong, M. F., Gilbert, M., Karpe, F., & Frayn, K. N. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.824 · Cited by 92
Pang, J., Xu, W., Zhang, X., Wong, G. L., Chan, A. W. H., Chan, H., Tse, C., Shu, S. S., Choi, P. C., Chan, H. L., et al. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14119 · Cited by 91
Hu, W. M., Ross, J. S., Geng, T., Brice, S. E., & Cowart, L. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.186916 · Cited by 90
Sun, S. Z., Anderson, G. H., Flickinger, B. D., Williamson-Hughes, P. S., & Empie, M. W. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.07.068 · Cited by 88
Bravo, S., Lowndes, J., Sinnett, S., Yu, Z., & Rippe, J. (2013) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2012-0322 · Cited by 86
Petersen, K. F., Befroy, D. E., Dufour, S., Rothman, D. L., & Shulman, G. I. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.005 · Cited by 86
Green, C., Pramfalk, C., Charlton, C. A., Gunn, P. J., Cornfield, T., Pavlides, M., Karpe, F., & Hodson, L. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000871 · Cited by 85
Self-citationAhn, J., Jun, D. W., Lee, H. Y., & Moon, J. H. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.09.022 · Cited by 84
Utzschneider, K. M., Bayer-Carter, J. L., Arbuckle, M. D., Tidwell, J. M., Richards, T. L., & Craft, S. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512002966 · Cited by 81
Randomized Controlled Trial of a MUFA or Fiber-Rich Diet on Hepatic Fat in Prediabetes
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Gill, J. M. R., Brown, J. C., CASLAKE, M. J., Wright, D. M., Cooney, J., Bedford, D. K., Hughes, D. A., Stanley, J. C., & Packard, C. J. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.1.47 · Cited by 68
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Charidemou, E., Ashmore, T., Li, X., McNally, B. D., West, J. A., Liggi, S., Harvey, M., Orford, E., & Griffin, J. L. (2019) · JCI Insight · doi:10.1172/jci.insight.124819 · Cited by 52
Pramfalk, C., Pavlides, M., Banerjee, R., McNeil, C. A., Neubauer, S., Karpe, F., & Hodson, L. (2016) · Diabetes · doi:10.2337/db16-0236 · Cited by 51
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Metadata
- Authors
- Yki-Järvinen, H., Luukkonen, P. K., Hodson, L., & Moore, J. B.
- Affiliations
- University of Helsinki (FI)
- University of Oxford (GB)
- University of Leeds (GB)
- Venue
- Nature Reviews Gastroenterology & Hepatology
- Published
- 2021-07-13
- Volume
- 18
- Issue
- 11
- Pages
- 770-786
- ISSN
- 1759-5045 (ISSN-L)
- 1759-5053
- OpenAlex
- W3178703016
- Cited by
- 294
- References
- 222
- Citations by year
- 2026: 51 · 2025: 81 · 2024: 67 · 2023: 41 · 2022: 46 · 2021: 8
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- green
- ora.ox.ac.uk
- Locations
- Nature Reviews Gastroenterology & Hepatology (publishedVersion)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- Oxford University Research Archive (ORA) (University of Oxford) (submittedVersion, cc-by)
- Työväentutkimus Vuosikirja (submittedVersion)
- Funders
- British Heart Foundation (FS/15/56/31645)
- Novo Nordisk
- Novo Nordisk Fonden (NNF18OC0054504, NNF19OC0057503)
- Biotechnology and Biological Sciences Research Council (BBS/E/F/000PR10347, BB/N005600/1, BBS/E/F/00044434)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- non-alcoholic fatty liver disease, dietary carbohydrates, dietary fat, free sugars, fructose, glucose, saturated fat, polyunsaturated fat, monounsaturated fatty acids, intrahepatic triglyceride, hepatic lipid accumulation, insulin sensitivity, ceramide synthesis, bioactive lipids, macronutrient metabolism, obesity, low-fat high-carbohydrate diet
- MeSH terms
- Dietary Sugars, Ceramides, Dietary Carbohydrates, Dietary Fats, Dietary Fats, Unsaturated, Fructose, Glucose, Humans, Insulin Resistance, Liver, Triglycerides, Non-alcoholic Fatty Liver Disease
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