Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

Sanyal, Arun J., Chalasani, Naga, Kowdley, Kris V., McCullough, Arthur, Diehl, Anna Mae, Bass, Nathan M., Neuschwander-Tetri, Brent A., Lavine, Joel E. +8 more·2010·New England Journal of Medicine

Cited by (180)

Items 101–180 of 180

  1. The effectiveness and acceptability of Mediterranean diet and calorie restriction in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis
    Haigh, Laura, Kirk, Colette, El Gendy, Khalil, Gallacher, Jennifer, Errington, Linda, Mathers, John C., Anstee, Quentin M. · 2022 · Clinical Nutrition
  2. Oxidative stress and antioxidants: Distress or eustress?
    Niki, Etsuo · 2016 · Archives of Biochemistry and Biophysics
  3. Collagen biology and non‐invasive biomarkers of liver fibrosis
    Karsdal, Morten A., Daniels, Samuel J., Holm Nielsen, Signe, Bager, Cecilie, Rasmussen, Daniel G.K., Loomba, Rohit, Surabattula, Rambabu, Villesen, Ida Falk, Luo, Yi, Shevell, Diane et al. · 2020 · Liver International
  4. Novel therapeutic targets for cholestatic and fatty liver disease
    Trauner, Michael, Fuchs, Claudia Daniela · 2022 · Gut
  5. Vitamin E improves transplant-free survival and hepatic decompensation among patients with nonalcoholic steatohepatitis and advanced fibrosis
    Vilar‐Gomez, Eduardo, Vuppalanchi, Raj, Gawrieh, Samer, Ghabril, Marwan, Saxena, Romil, Cummings, Oscar W., Chalasani, Naga · 2020 · Hepatology
  6. Fibrosis progression rate in biopsy-proven nonalcoholic fatty liver disease among people with diabetes versus people without diabetes: a multicenter study
    Huang, Daniel Q., Wilson, Laura A., Behling, Cynthia, Kleiner, David E., Kowdley, Kris V., Dasarathy, Srinivasan, Amangurbanova, Maral, Terrault, Norah A., Diehl, Anna Mae, Chalasani, Naga et al. · 2023 · Gastroenterology
  7. Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease
    Souza-Mello, Vanessa · 2015 · World Journal of Hepatology
  8. Effect of Weight Loss on Magnetic Resonance Imaging Estimation of Liver Fat and Volume in Patients With Nonalcoholic Steatohepatitis
    Patel, Niraj S., Doycheva, Iliana, Peterson, Michael R., Hooker, Jonathan, Kisselva, Tatiana, Schnabl, Bernd, Seki, Ekihiro, Sirlin, Claude B., Loomba, Rohit · 2015 · Clinical Gastroenterology and Hepatology
  9. Empagliflozin Improves Liver Steatosis and Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
    Chehrehgosha, Haleh, Sohrabi, Masoud Reza, Ismail-Beigi, Faramarz, Malek, Mojtaba, Reza Babaei, Mohammad, Zamani, Farhad, Ajdarkosh, Hossein, Khoonsari, Mahmood, Fallah, Afshin Eshghi, Khamseh, Mohammad E. · 2021 · Diabetes Therapy
  10. Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease?
    Huttasch, Maximilian, Roden, Michael, Kahl, Sabine · 2024 · Metabolism
  11. Pathophysiology of NASH: perspectives for a targeted treatment
    Marra, Fabio, Lotersztajn, Sophie · 2013 · Current Pharmaceutical Design
  12. GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)
    Alkhouri, Naim, Lawitz, Eric, Noureddin, Mazen, DeFronzo, Ralph, Shulman, Gerald I. · 2020 · Expert Opinion on Investigational Drugs
  13. IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner
    Nishizawa, Hitoshi, Iguchi, Genzo, Fukuoka, Hidenori, Takahashi, Michiko, Suda, Kentaro, Bando, Hironori, Matsumoto, Ryusaku, Yoshida, Kenichi, Odake, Yukiko, Ogawa, Wataru et al. · 2016 · Scientific Reports
  14. Improvements in histologic features and diagnosis associated with improvement in fibrosis in nonalcoholic steatohepatitis: results from the nonalcoholic steatohepatitis clinical research network treatment trials
    Brunt, Elizabeth M., Kleiner, David E., Wilson, Laura A., Sanyal, Arun J., Neuschwander‐Tetri, Brent A., for the Nonalcoholic Steatohepatitis Clinical Research Network · 2019 · Hepatology
  15. Placebo-controlled, randomised clinical trial: High-dose resveratrol treatment for non-alcoholic fatty liver disease
    Heebøll, Sara, Kreuzfeldt, Martin, Hamilton-Dutoit, Stephen, Kjær Poulsen, Marianne, Stødkilde-Jørgensen, Hans, Møller, Holger Jon, Jessen, Niels, Thorsen, Kasper, Kristina Hellberg, Ylva, Bønløkke Pedersen, Steen et al. · 2016 · Scandinavian Journal of Gastroenterology
  16. Efficacy and safety of anti-hyperglycaemic drugs in patients with non-alcoholic fatty liver disease with or without diabetes: An updated systematic review of randomized controlled trials
    Mantovani, A., Byrne, C.D., Scorletti, E., Mantzoros, C.S., Targher, G. · 2020 · Diabetes & Metabolism
  17. The effectiveness of liraglutide in nonalcoholic fatty liver disease patients with type 2 diabetes mellitus compared to sitagliptin and pioglitazone
    Ohki, Takamasa, Isogawa, Akihiro, Iwamoto, Masahiko, Ohsugi, Mitsuru, Yoshida, Haruhiko, Toda, Nobuo, Tagawa, Kazumi, Omata, Masao, Koike, Kazuhiko · 2012 · The Scientific World Journal
  18. Lipid metabolism in MASLD and MASH: From mechanism to the clinic
    Carli, Fabrizia, Della Pepa, Giuseppe, Sabatini, Silvia, Vidal Puig, Antonio, Gastaldelli, Amalia · 2024 · JHEP Reports
  19. Breakthroughs in therapies for NASH and remaining challenges
    Ratziu, Vlad, Francque, Sven, Sanyal, Arun · 2022 · Journal of Hepatology
  20. Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis
    Yu, Junjie, Zhu, Changyu, Wang, Xiaobo, Kim, KyeongJin, Bartolome, Alberto, Dongiovanni, Paola, Yates, Katherine P., Valenti, Luca, Carrer, Michele, Sadowski, Thorsten et al. · 2021 · Science Translational Medicine
  21. Obeticholic acid-a new therapy in PBC and NASH
    Chapman, Roger W, Lynch, Kate D · 2020 · British Medical Bulletin
  22. Effects of combined exenatide and pioglitazone therapy on hepatic fat content in type 2 diabetes
    Sathyanarayana, Padma, Jogi, Medhavi, Muthupillai, Raja, Krishnamurthy, Ramkumar, Samson, Susan L., Bajaj, Mandeep · 2011 · Obesity
  23. Non-alcoholic Fatty Liver Disease (NAFLD) as a Neglected Metabolic Companion of Psychiatric Disorders: Common Pathways and Future Approaches
    Soto-Angona, Óscar, Anmella, Gerard, Valdés-Florido, María José, De Uribe-Viloria, Nieves, Carvalho, Andre F., Penninx, Brenda W. J. H., Berk, Michael · 2020 · BMC Medicine
  24. EDP-305 in patients with NASH: a phase II double-blind placebo-controlled dose-ranging study
    Ratziu, Vlad, Rinella, Mary E., Neuschwander-Tetri, Brent A., Lawitz, Eric, Denham, Douglas, Kayali, Zeid, Sheikh, Aasim, Kowdley, Kris V., Desta, Taddese, Elkhashab, Magdy et al. · 2022 · Journal of Hepatology
  25. Relationship Between Changes in Serum Levels of Keratin 18 and Changes in Liver Histology in Children and Adults With Nonalcoholic Fatty Liver Disease
    Vuppalanchi, Raj, Jain, Ajay K., Deppe, Ross, Yates, Katherine, Comerford, Megan, Masuoka, Howard C., Neuschwander-Tetri, Brent A., Loomba, Rohit, Brunt, Elizabeth M., Kleiner, David E. et al. · 2014 · Clinical Gastroenterology and Hepatology
  26. Understanding the cellular interactome of non-alcoholic fatty liver disease
    Wallace, Sebastian J., Tacke, Frank, Schwabe, Robert F., Henderson, Neil C. · 2022 · JHEP Reports
  27. A CONSORT-Compliant, Randomized, Double-Blind, Placebo-Controlled Pilot Trial of Purified Anthocyanin in Patients With Nonalcoholic Fatty Liver Disease
    Zhang, Pei-Wen, Chen, Feng-Xia, Li, Di, Ling, Wen-Hua, Guo, Hong-Hui · 2015 · Medicine
  28. Hepatocellular carcinoma in the setting of non-cirrhotic nonalcoholic fatty liver disease and the metabolic syndrome: US experience
    Perumpail, Ryan B., Wong, Robert J., Ahmed, Aijaz, Harrison, Stephen A. · 2015 · Digestive Diseases and Sciences
  29. Nonalcoholic fatty liver disease – current status and future directions
    Demir, Münevver, Lang, Sonja, Steffen, Hans‐Michael · 2015 · Journal of Digestive Diseases
  30. The effect of coffee consumption on the non-alcoholic fatty liver disease and liver fibrosis: a meta-analysis of 11 epidemiological studies
    Hayat, Umar, Siddiqui, Ali A., Okut, Hayrettin, Afroz, Saba, Tasleem, Syed, Haris, Ahmed · 2021 · Annals of Hepatology
  31. International liver transplantation consensus statement on end-stage liver disease due to nonalcoholic steatohepatitis and liver transplantation
    Tsochatzis, Emmanuel, Coilly, Audrey, Nadalin, Silvio, Levistky, Josh, Tokat, Yaman, Ghobrial, Mark, Klinck, John, Berenguer, Marina · 2019 · Transplantation
  32. Improved hepatic lipid composition following short-term exercise in nonalcoholic fatty liver disease
    Haus, Jacob M., Solomon, Thomas P.J., Kelly, Karen R., Fealy, Ciaran E., Kullman, Emily L., Scelsi, Amanda R., Lu, Lan, Pagadala, Mangesh R., McCullough, Arthur J., Flask, Chris A. et al. · 2013 · The Journal of Clinical Endocrinology & Metabolism
  33. Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis
    Schon, Hans-Theo, Bartneck, Matthias, Borkham-Kamphorst, Erawan, Nattermann, Jacob, Lammers, Twan, Tacke, Frank, Weiskirchen, Ralf · 2016 · Frontiers in Pharmacology
  34. Liver safety of statins in prediabetes or T2DM and nonalcoholic steatohepatitis: post hoc analysis of a randomized trial
    Bril, Fernando, Portillo Sanchez, Paola, Lomonaco, Romina, Orsak, Beverly, Hecht, Joan, Tio, Fermin, Cusi, Kenneth · 2017 · The Journal of Clinical Endocrinology & Metabolism
  35. The Multifaceted Roles of Macrophages in NAFLD Pathogenesis
    Vonderlin, Joscha, Chavakis, Triantafyllos, Sieweke, Michael, Tacke, Frank · 2023 · Cellular and Molecular Gastroenterology and Hepatology
  36. Nutrition in the management of cirrhosis and its neurological complications
    Bémeur, Chantal, Butterworth, Roger F. · 2014 · Journal of Clinical and Experimental Hepatology
  37. Evaluation of PXL065–deuterium-stabilized (R)-pioglitazone in patients with NASH: a phase II randomized placebo-controlled trial (DESTINY-1)
    Harrison, Stephen A., Thang, Carole, Bolze, Sébastien, Dewitt, Sheila, Hallakou-Bozec, Sophie, Dubourg, Julie, Bedossa, Pierre, Cusi, Kenneth, Ratziu, Vlad, Grouin, Jean-Marie et al. · 2023 · Journal of Hepatology
  38. Systematic review with network meta-analysis: comparative efficacy of pharmacologic therapies for fibrosis improvement and resolution of NASH
    Majzoub, Abdul M., Nayfeh, Tarek, Barnard, Abbey, Munaganuru, Nagambika, Dave, Shravan, Singh, Siddharth, Murad, Mohammad Hassan, Loomba, Rohit · 2021 · Alimentary Pharmacology & Therapeutics
  39. Standardisation of diet and exercise in clinical trials of NAFLD-NASH: Recommendations from the Liver Forum
    Glass, Oliver, Filozof, Claudia, Noureddin, Mazen, Berner-Hansen, Mark, Schabel, Elmer, Omokaro, Stephanie O., Schattenberg, Jörn M., Barradas, Katherine, Miller, Veronica, Francque, Sven et al. · 2020 · Journal of Hepatology
  40. Why Do So Many Nonalcoholic Steatohepatitis Trials Fail?
    Ratziu, Vlad, Friedman, Scott L. · 2023 · Gastroenterology
  41. Vildagliptin and Pioglitazone in Patients With Impaired Glucose Tolerance After Kidney Transplantation: A Randomized, Placebo-Controlled Clinical Trial
    Werzowa, Johannes, Hecking, Manfred, Haidinger, Michael, Lechner, Felix, Döller, Dominik, Pacini, Giovanni, Stemer, Gunar, Pleiner, Johannes, Frantal, Sophie, Säemann, Marcus D. · 2013 · Transplantation
  42. Diabetes medications and risk of HCC
    Plaz Torres, Maria Corina, Jaffe, Ariel, Perry, Rachel, Marabotto, Elisa, Strazzabosco, Mario, Giannini, Edoardo G. · 2022 · Hepatology
  43. Antibody-Directed Glucocorticoid Targeting to CD163 in M2-Type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes
    Svendsen, Pia, Graversen, Jonas H., Etzerodt, Anders, Hager, Henrik, Røge, Rasmus, Grønbæk, Henning, Christensen, Erik I., Møller, Holger J., Vilstrup, Hendrik, Moestrup, Søren K. · 2017 · Molecular Therapy - Methods & Clinical Development
  44. Pioglitazone even at low dosage improves NAFLD in type 2 diabetes: clinical and pathophysiological insights from a subgroup of the TOSCA.IT randomised trial
    Della Pepa, Giuseppe, Russo, Marco, Vitale, Marilena, Carli, Fabrizia, Vetrani, Claudia, Masulli, Maria, Riccardi, Gabriele, Vaccaro, Olga, Gastaldelli, Amalia, Rivellese, Angela A. et al. · 2021 · Diabetes Research and Clinical Practice
  45. Screening for nonalcoholic steatohepatitis in individuals with type 2 diabetes: a cost-effectiveness analysis
    Corey, Kathleen E., Klebanoff, Matthew J., Tramontano, Angela C., Chung, Raymond T., Hur, Chin · 2016 · Digestive Diseases and Sciences
  46. An Evaluation of the Collagen Fragments Related to Fibrogenesis and Fibrolysis in Nonalcoholic Steatohepatitis
    Luo, Yi, Oseini, Abdul, Gagnon, Robert, Charles, Edgar D., Sidik, Kurex, Vincent, Robert, Collen, Rebeca, Idowu, Michael, Contos, Melissa J., Mirshahi, Faridoddin et al. · 2018 · Scientific Reports
  47. Do thiazolidinediones still have a role in treatment of type 2 diabetes mellitus?
    Consoli, A., Formoso, G. · 2013 · Diabetes, Obesity and Metabolism
  48. A critical review of endpoints for non-cirrhotic NASH therapeutic trials
    Ratziu, Vlad · 2018 · Journal of Hepatology
  49. Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity
    Guy, Cynthia D., Suzuki, Ayako, Abdelmalek, Manal F., Burchette, James L., Diehl, Anna Mae, for the NASH CRN · 2015 · Hepatology
  50. Efficacy and safety of glucagon-like peptide-1 receptor agonists in non-alcoholic fatty liver disease: A systematic review and meta-analysis
    Dong, Yajie, Lv, Qingguo, Li, Sheyu, Wu, Yuan, Li, Ling, Li, Juan, Zhang, Fang, Sun, Xin, Tong, Nanwei · 2017 · Clinics and Research in Hepatology and Gastroenterology
  51. The immune landscape in nonalcoholic steatohepatitis
    Narayanan, Sowmya, Surette, Fionna A., Hahn, Young S. · 2016 · Immune Network
  52. Gut-pancreas-liver Axis as a target for treatment of NAFLD/NASH
    Svegliati-Baroni, Gianluca, Patrício, Bárbara, Lioci, Gessica, Macedo, Maria Paula, Gastaldelli, Amalia · 2020 · International Journal of Molecular Sciences
  53. Cost-effectiveness analysis: risk stratification of nonalcoholic fatty liver disease (NAFLD) by the primary care physician using the NAFLD fibrosis score
    Tapper, Elliot B., Hunink, M. G. Myriam, Afdhal, Nezam H., Lai, Michelle, Sengupta, Neil · 2016 · PLoS ONE
  54. Pioglitazone and bariatric surgery are the most effective treatments for non-alcoholic steatohepatitis: a hierarchical network meta-analysis
    Panunzi, Simona, Maltese, Sabina, Verrastro, Ornella, Labbate, Luca, De Gaetano, Andrea, Pompili, Maurizio, Capristo, Esmeralda, Bornstein, Stefan R., Mingrone, Geltrude · 2021 · Diabetes, Obesity and Metabolism
  55. Novel metabolites and roles for α-tocopherol in humans and mice discovered by mass spectrometry–based metabolomics
    Johnson, Caroline H, Slanař, Ondřej, Krausz, Kristopher W, Kang, Dong Wook, Patterson, Andrew D, Kim, Jung-Hwan, Luecke, Hans, Gonzalez, Frank J, Idle, Jeffrey R · 2012 · The American Journal of Clinical Nutrition
  56. Plasma insulin, leptin, adiponectin, resistin, ghrelin, and melatonin in nonalcoholic steatohepatitis patients treated with melatonin
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  57. Management of metabolic-associated fatty liver disease: The diabetology perspective
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  58. Change in hepatic fat content measured by MRI does not predict treatment-induced histological improvement of steatohepatitis
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  59. Metabolic syndrome and its association with nonalcoholic steatohepatitis
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  60. Impact of Time-Restricted Feeding and Dawn-to-Sunset Fasting on Circadian Rhythm, Obesity, Metabolic Syndrome, and Nonalcoholic Fatty Liver Disease
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  61. SGLT2 inhibitor treatment outcome in nonalcoholic fatty liver disease complicated with diabetes mellitus: the long-term effects on clinical features and liver histopathology
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  62. Which treatment for type 2 diabetes associated with non-alcoholic fatty liver disease?
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  63. Insulin Signaling as a Potential Natural Killer Cell Checkpoint in Fatty Liver Disease
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  64. Treatment Candidacy for Pharmacologic Therapies for NASH
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  65. Comparative efficacy of glucagon-like peptide 1 (GLP-1) receptor agonists, pioglitazone and vitamin E for liver histology among patients with nonalcoholic fatty liver disease: systematic review and pilot network meta-analysis of randomized controlled trials
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  66. Pharmacological treatment of MASLD: contemporary treatment and future perspectives
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  67. Managing diabetes in patients with chronic liver disease
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  68. Dietary vitamin E intake is associated with a reduced risk of developing digestive diseases and nonalcoholic fatty liver disease
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  69. Updated S2k clinical practice guideline on non-alcoholic fatty liver disease (NAFLD) issued by the German society of gastroenterology, digestive and metabolic diseases (DGVS)–April 2022–AWMF Registration No.: 021–025
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  70. Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease
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  71. Insulin Resistance Is Central to Long-Term Reversal of Histologic Nonalcoholic Steatohepatitis After Metabolic Surgery
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  72. Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms
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  73. The association of nonalcoholic steatohepatitis and obstructive sleep apnea
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  74. Mechanisms, screening modalities and treatment options for individuals with non‐alcoholic fatty liver disease and type 2 diabetes
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  75. Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH
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  77. Mouse model of NASH that replicates key features of the human disease and progresses to fibrosis stage 3
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  78. Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver
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  79. Spontaneous Fluctuations in Liver Biochemistries in Patients with Compensated NASH Cirrhosis: Implications for Drug Hepatotoxicity Monitoring
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  80. Advances and Emerging Therapies in the Treatment of Non-alcoholic Steatohepatitis
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