The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Cell Death
Open accessAbstract
This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-associated cell death, and necrosis. The authors discuss the clinical implications of each of these types of cell death and indicate where advances in our understanding have inspired new forms of therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Apoptosis in the Pathogenesis and Treatment of Disease
Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524
Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., El-Deiry, W. S., Golstein, P., Green, D. R., et al. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.150 · Cited by 3,399
Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347
p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa
Villunger, A., Michalak, E. M., Coultas, L., Müllauer, F., Böck, G., Ausserlechner, M. J., Adams, J. M., & Strasser, A. (2003) · Science · doi:10.1126/science.1090072 · Cited by 1,327
Self-citationBCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M., & Korsmeyer, S. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.16.6961 · Cited by 1,252
Kuwana, T., Bouchier-Hayes, L., Chipuk, J. E., Bonzon, C., Sullivan, B. A., Green, D. R., & Newmeyer, D. D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.003 · Cited by 1,185
Regulation of autophagy by cytoplasmic p53
Tasdemir, E., Maiuri, M. C., Galluzzi, L., Vitale, I., Djavaheri-Mergny, M., D'Amelio, M., Criollo, A., Morselli, E., Zhu, C., Harper, F., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1730 · Cited by 1,132
Cell death by necrosis: towards a molecular definition
Golstein, P., & Kroemer, G. (2007) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.11.001 · Cited by 1,044
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
Kim, H., Rafiuddin-Shah, M., Tu, H.-C., Jeffers, J. R., Zambetti, G. P., Hsieh, J. J.-D., & Cheng, E. H.-Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1499 · Cited by 874
Research works printed but not linked: 109
- 10.1038/35083653 · DOI
- 10.1016/j.coi.2007.05.004 · DOI · Paper page
- Majno G, 1995, Am J Pathol, 146, 3
- 10.1146/annurev.immunol.21.120601.141029 · DOI · Paper page
- 10.1172/JCI26321 · DOI
- 10.1016/j.molmed.2006.04.003 · DOI
- 10.1038/nrd2658 · DOI · Paper page
- 10.1038/nrm2245 · DOI · Paper page
- 10.1038/nrc1738 · DOI · Paper page
- 10.1038/nri2161 · DOI · Paper page
- 10.1038/ncb0608-637 · DOI
- 10.1172/JCI26274 · DOI
- 10.1101/gad.1376506 · DOI · Paper page
- 10.1016/j.bbabio.2006.06.014 · DOI · Paper page
- 10.1016/j.cell.2007.07.013 · DOI
- Laster SM, 1988, J Immunol, 141, 2629, 10.4049/jimmunol.141.8.2629 · DOI · Paper page
- 10.1038/bjc.1972.33 · DOI · Paper page
- 10.1038/nri1568 · DOI · Paper page
- 10.1038/nrm2308 · DOI · Paper page
- 10.1038/sj.cdd.4400877 · DOI
- 10.1002/hep.21062 · DOI · Paper page
- 10.1101/gad.1063703 · DOI · Paper page
- 10.1016/j.tcb.2008.06.002 · DOI
- 10.1053/j.gastro.2005.06.006 · DOI
- 10.1016/j.immuni.2007.12.017 · DOI · Paper page
- 10.1016/j.cell.2005.05.019 · DOI · Paper page
- 10.1093/emboj/17.3.706 · DOI · Paper page
- 10.1038/onc.2008.299 · DOI
- 10.1016/S0092-8674(00)80434-1 · DOI · Paper page
- 10.1016/S0092-8674(00)00008-8 · DOI · Paper page
- 10.1016/j.cell.2007.10.042 · DOI
- 10.1038/sj.cdd.4401596 · DOI
- 10.1038/23730 · DOI · Paper page
- 10.2337/db07-1692 · DOI
- 10.1016/j.cell.2007.03.017 · DOI
- 10.1101/gad.897601 · DOI · Paper page
- 10.1126/science.1133289 · DOI · Paper page
- 10.1016/j.tcb.2008.01.007 · DOI · Paper page
- 10.1016/j.molcel.2004.12.030 · DOI · Paper page
- 10.1126/science.286.5445.1735 · DOI · Paper page
- 10.1016/S1535-6108(03)00244-7 · DOI · Paper page
- 10.1182/blood-2005-04-1595 · DOI · Paper page
- 10.1038/335440a0 · DOI · Paper page
- 10.1038/348331a0 · DOI · Paper page
- 10.1038/nrd2656 · DOI · Paper page
- 10.1073/pnas.0606176103 · DOI · Paper page
- 10.1200/JCO.2008.17.2064 · DOI
- 10.1007/s10875-007-9161-4 · doi:10.1007/s10875-007-9161-4
- 10.1002/9780470697405.ch2 · DOI
- 10.1056/NEJMra041996 · DOI · Paper page
- 10.1126/science.287.5455.947 · doi:10.1126/science.287.5455.947
- 10.1126/science.287.5455.1056 · DOI · Paper page
- 10.1213/ane.0b013e31818cdb29 · DOI
- 10.1002/hep.21664 · DOI
- 10.1056/NEJMoa071142 · DOI · Paper page
- 10.1212/01.wnl.0000277487.04281.db · DOI · Paper page
- 10.1097/00003246-199907000-00002 · DOI · Paper page
- Hotchkiss RS, 2001, J Immunol, 166, 6952, 10.4049/jimmunol.166.11.6952 · DOI · Paper page
- 10.1097/00003246-200009000-00016 · DOI
- 10.1038/nri1943 · DOI · Paper page
- 10.2174/138161208784980617 · doi:10.2174/138161208784980617
- 10.1083/jcb.12.1.198 · DOI · Paper page
- 10.1038/labinvest.2009.8 · DOI
- 10.1172/JCI26185 · DOI · Paper page
- 10.1172/JCI26390 · DOI · Paper page
- 10.1039/b804606a · DOI
- 10.2174/157015908784533897 · DOI
- 10.1158/1078-0432.CCR-07-1595 · DOI · Paper page
- 10.1126/science.312.5777.1160 · DOI
- 10.1038/cdd.2008.131 · DOI · Paper page
- 10.1038/ncb1634 · DOI · Paper page
- 10.1111/j.1600-0463.2007.00858.x · DOI
- 10.1038/ncb1426 · DOI · Paper page
- 10.1084/jem.185.8.1481 · DOI · Paper page
- 10.1016/j.bcp.2008.07.041 · DOI · Paper page
- 10.1146/annurev.pharmtox.44.101802.121804 · DOI
- 10.1016/j.febslet.2007.05.038 · DOI
- 10.1084/jem.20072152 · DOI · Paper page
- 10.1091/mbc.01-05-0272 · DOI · Paper page
- 10.1038/nrd1718 · DOI · Paper page
- 10.2174/156652408784221306 · DOI · Paper page
- 10.1038/nri1594 · DOI · Paper page
- 10.1126/stke.2872005pe26 · DOI
- 10.1126/stke.3582006pe44 · DOI
- Sato T, 2008, J Immunol, 181, 197, 10.4049/jimmunol.181.1.197 · DOI
- 10.1038/ni914 · DOI
- 10.1093/hmg/ddl036 · DOI · Paper page
- 10.1128/MCB.25.3.1025-1040.2005 · DOI · Paper page
- 10.1172/JCI26322 · DOI · Paper page
- 10.1038/ncb1482 · DOI · Paper page
- 10.1128/MCB.02141-06 · DOI · Paper page
- 10.1172/JCI33700 · DOI · Paper page
- 10.1038/nrm2451 · DOI · Paper page
- 10.1016/j.bbrc.2006.12.098 · DOI
- 10.1016/j.it.2005.06.004 · DOI · Paper page
- 10.1615/CritRevImmunol.v23.i12.20 · DOI
- 10.1038/35003208 · DOI · Paper page
- 10.1073/pnas.1031788100 · DOI
- 10.1038/cdd.2008.100 · DOI
- 10.1146/annurev.med.59.061506.110403 · doi:10.1146/annurev.med.59.061506.110403
- 10.1016/S0733-8651(05)70198-3 · DOI
- 10.1158/1078-0432.CCR-07-0950 · DOI
- 10.1038/onc.2008.302 · DOI · Paper page
- 10.1016/j.coph.2008.06.016 · DOI · Paper page
- 10.1074/jbc.M503113200 · DOI
- 10.1016/j.neuroscience.2008.09.007 · DOI
- 10.1053/j.jvca.2008.02.011 · doi:10.1053/j.jvca.2008.02.011
- 10.1002/mus.21059 · DOI
- 10.1016/j.nurt.2008.10.030 · DOI
Cited by
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
Czabotar, P. E., Lessene, G., Strasser, A., & Adams, J. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3722 · Cited by 3,219
Self-citationMacrophages: master regulators of inflammation and fibrosis
Wynn, T., & Barron, L. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255354 · Cited by 1,392
Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging
Green, D. R., Galluzzi, L., & Kroemer, G. (2011) · Science · doi:10.1126/science.1201940 · Cited by 1,245
The immune system’s role in sepsis progression, resolution, and long-term outcome
Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880
Pathophysiology of Sickle Cell Disease
Sundd, P., Gladwin, M. T., & Novelli, E. M. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012838 · Cited by 813
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
Delbridge, A. R. D., Grabow, S., Strasser, A., & Vaux, D. L. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.17 · Cited by 752
Self-citationHepatocyte Death: A Clear and Present Danger
Malhi, H., Guicciardi, M. E., & Gores, G. J. (2010) · Physiological Reviews · doi:10.1152/physrev.00061.2009 · Cited by 477
Cancer across the tree of life: cooperation and cheating in multicellularity
Aktipis, C. A., Boddy, A. M., Jansen, G., Hibner, U., Hochberg, M. E., Maley, C. C., & Wilkinson, G. S. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0219 · Cited by 466
Kebschull, M., Demmer, R. T., & Papapanou, P. N. (2010) · Journal of Dental Research · doi:10.1177/0022034510375281 · Cited by 429
Many players in BCL-2 family affairs
Moldoveanu, T., Follis, A. V., Kriwacki, R. W., & Green, D. R. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.12.006 · Cited by 421
Macrophage Plasticity and Polarization in Liver Homeostasis and Pathology
Sica, A., Invernizzi, P., & Mantovani, A. (2014) · Hepatology · doi:10.1002/hep.26754 · Cited by 422
Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia
Clay, H. B., Daws, S., & Konradi, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.007 · Cited by 399
Ischemia-Reperfusion Injury in Stroke
Nour, M., Scalzo, F., & Liebeskind, D. S. (2012) · Interventional Neurology · doi:10.1159/000353125 · Cited by 316
Große, L., Wurm, C. A., Brüser, C., Neumann, D., Jans, D. C., & Jakobs, S. (2016) · The EMBO Journal · doi:10.15252/embj.201592789 · Cited by 281
MAPK signaling in inflammation-associated cancer development
Huang, P., Han, J., & Hui, L. (2010) · Protein & Cell · doi:10.1007/s13238-010-0019-9 · Cited by 273
A Review of the Local Pathophysiologic Bases of Burn Wound Progression
Shupp, J. W., Nasabzadeh, T. J., Rosenthal, D. S., Jordan, M. H., Fidler, P., & Jeng, J. C. (2010) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181f93571 · Cited by 236
Circadian Clock, Cancer, and Chemotherapy
Sancar, A., Lindsey-Boltz, L. A., Gaddameedhi, S., Selby, C. P., Ye, R., Chiou, Y.-Y., Kemp, M. G., Hu, J., Lee, J. H., & Ozturk, N. (2015) · Biochemistry · doi:10.1021/bi5007354 · Cited by 170
Glucocorticoid dose determines osteocyte cell fate
Jia, J., Yao, W., Guan, M., Dai, W., Shahnazari, M., Kar, R., Bonewald, L., Jiang, J. X., & Lane, N. E. (2011) · The FASEB Journal · doi:10.1096/fj.11-182519 · Cited by 157
BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice
Ke, F., Voss, A., Kerr, J. B., O'Reilly, L. A., Tai, L., Echeverry, N., Bouillet, P., Strasser, A., & Kaufmann, T. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.210 · Cited by 113
Self-citationKono, H., Karmarkar, D., Iwakura, Y., & Rock, K. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902485 · Cited by 101
Costal-Oliveira, F., Stransky, S., Guerra-Duarte, C., Naves de Souza, D. L., Vivas-Ruiz, D. E., Yarlequé, A., Sanchez, E. F., Chávez-Olórtegui, C., & Braga, V. M. M. (2019) · Scientific Reports · doi:10.1038/s41598-018-37435-4 · Cited by 86
Apoptosis and autophagy in polycystic kidney disease (PKD)
Nowak, K. L., & Edelstein, C. L. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109518 · Cited by 71
Consequences of the combined loss of BOK and BAK or BOK and BAX
Ke, F., Bouillet, P., Kaufmann, T., Strasser, A., Kerr, J., & Voss, A. K. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.176 · Cited by 72
Self-citationAutophagy and Its Implications Against Early Full Nutrition Support in Critical Illness
Van Dyck, L., Casaer, M. P., & Gunst, J. (2018) · Nutrition in Clinical Practice · doi:10.1002/ncp.10084 · Cited by 70
Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors
Yasugi, M., Takigawa, N., Ochi, N., Ohashi, K., Harada, D., Ninomiya, T., Murakami, T., Honda, Y., Ichihara, E., Tanimoto, M., et al. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.04.012 · Cited by 6
Metadata
- Authors
- Hotchkiss, R. S., Strasser, A., McDunn, J. E., & Swanson, P. E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2009-10-15
- Volume
- 361
- Issue
- 16
- Pages
- 1570-1583
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W161836838
- Cited by
- 1,154
- References
- 16
- FWCI
- 29.41
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
