The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O 2
Open accessAbstract
Endothelial nitric oxide (nitrogen monoxide) is synthesized at the intravascular/extravascular interface. We previously have reported the intravascular half-life of NO, as a result of consumption by erythrocytes, as approximately 2 ms. We report here studies designed to estimate the lifetime of NO in the parenchymal (extravascular) tissue and describe the implications of these results for the distribution of NO and oxygen concentration gradients away from the blood vessel. The rate of consumption of NO by parenchymal cells (hepatocytes) linearly depends on both NO and O 2 concentration. We estimate that the extravascular half-life of NO will range from 0.09 to > 2 s, depending on O 2 concentration and thus distance from the vessel. Computer modeling reveals that this phenomenon, coupled with reversible NO inhibition of cellular mitochondrial oxygen consumption, substantially extends the zone of adequate tissue cellular oxygenation away from the blood vessel, with an especially dramatic effect during conditions of increased tissue work (oxygen consumption). This represents a second action of NO, in addition to vasodilation, in enhancing tissue cellular respiration and provides a possible physiological function for the known reversible inhibition of mitochondrial respiration by low concentrations of NO.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This observation indicates that nitrite is utilized by the active muscle, potentially facilitating distribution of O2 to areas of high metabolic activity.
“This observation indicates that NO 2 -is utilized by the active muscle, potentially facilitating distribution of O 2 to areas of high metabolic activity (145).”
From Dietary Nitrate and Physical Performance (2018) · cites this paper as [145]
The intra- and extravascular half-lives of NO appear to be dependent on the availability of intracellular reactants of NO.
“The intra- and extravascular half-lives of NO, which have been measured to be in the range of 2 ms to >2 s, appear to be dependent on the availability of intracellular reactants of NO (47).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [47]
The intra- and extravascular half-lives of NO have been measured to be in the range of 2 ms to >2 s.
“The intra- and extravascular half-lives of NO, which have been measured to be in the range of 2 ms to >2 s, appear to be dependent on the availability of intracellular reactants of NO (47).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [47]
Significant diffusional barriers between the endothelium and the red blood cell decrease the inactivation of NO by HbO2.
“There are significant diffusional barriers between the endothelium and the red blood cell that decrease the inactivation of NO by HbO2.”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [47]
One key function of NO-mediated inhibition of respiration is to modulate O2 gradients and hypoxia-responsive targets in cells via inhibiting O2 consumption in respiring mitochondria.
“One key function of NO-mediated inhibition of respiration is to modulate O2 gradients and hypoxia-responsive targets in cells via inhibiting O2 consumption in respiring mitochondria (47).”
From What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology (2010) · cites this paper as [47]
Non-erythroid cells consume nitric oxide in a manner that depends on oxygen.
“Lancaster et al. have also demonstrated that non-erythroid cells consume NO in an oxygen-dependent fashion [82].”
From Signaling and stress: The redox landscape in NOS2 biology (2015) · cites this paper as [82]
The endogenous half-life of NO is in the range of 2 ms to greater than 2 s and appears to depend on the availability of reactants.
“The endogenous half-life of NO has been found to be in the range of 2 ms to > 2 s and appears to depend on the availability of reactants [81].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [81]
A key function of NO is to modulate oxygen gradients in cells and tissues by regulating hemoglobin action and by inhibiting oxygen consumption in respiring mitochondria.
“Thus, a key function of NO is to modulate O2 gradients in cells and tissues by regulating hemoglobin action and by inhibiting O2 consumption in respiring mitochondria [81].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [81]
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029 · see citing works
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works
Brown, G. C., & Cooper, C. E. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01290-3 · Cited by 1,055 · see citing works
Poderoso, J. J., Carreras, M. C., Lisdero, C., Riobó, N., Schöpfer, F., & Boveris, A. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0146 · Cited by 726 · see citing works
Nitric oxide and mitochondrial respiration
Brown, G. C. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00025-0 · Cited by 702 · see citing works
Control of coronary vascular tone by nitric oxide.
Kelm, M., & Schrader, J. (1990) · Circulation Research · doi:10.1161/01.res.66.6.1561 · Cited by 697 · see citing works
Simulation of the diffusion and reaction of endogenously produced nitric oxide.
Lancaster, J. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8137 · Cited by 689 · see citing works
Self-citationMechanism of NO-induced oxidation of myoglobin and hemoglobin
Eich, R. F., Li, T., Lemon, D. D., Doherty, D. H., Curry, S. R., Aitken, J. F., Mathews, A. J., Johnson, K. A., Smith, R. D., Phillips, et al. (1996) · Biochemistry · doi:10.1021/bi960442g · Cited by 613 · see citing works
Liu, X., Miller, M. J. S., Joshi, M. S., Thomas, D. D., & Lancaster, J. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2175 · Cited by 602 · see citing works
Self-citationWood, J., & Garthwaite, J. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90022-1 · Cited by 529 · see citing works
Diffusion-limited reaction of free nitric oxide with erythrocytes
Liu, X., Miller, M. J. S., Joshi, M. S., Sadowska-Krowicka, H., Clark, D. A., & Lancaster, J. R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.18709 · Cited by 512 · see citing works
Self-citationA Tutorial on the Diffusibility and Reactivity of Free Nitric Oxide
Lancaster, J. R. (1997) · Nitric Oxide · doi:10.1006/niox.1996.0112 · Cited by 495 · see citing works
Self-citationAutoxidation kinetics of aqueous nitric oxide
Ford, P. C., Wink, D. A., & Stanbury, D. M. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81748-o · Cited by 419 · see citing works
Estimation of nitric oxide production and reactionrates in tissue by use of a mathematical model
Vaughn, M. W., Kuo, L., & Liao, J. C. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.6.h2163 · Cited by 338 · see citing works
CYTOMORPHOMETRY OF DEVELOPING RAT LIVER AND ITS APPLICATION TO ENZYMIC DIFFERENTIATION
Greengard, O., Federman, M., & Knox, W. E. (1972) · The Journal of Cell Biology · doi:10.1083/jcb.52.2.261 · Cited by 317 · see citing works
Intravascular flow decreases erythrocyte consumption of nitric oxide
Liao, J. C., Hein, T. W., Vaughn, M. W., Huang, K., & Kuo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8757 · Cited by 300 · see citing works
Effective diffusion distance of nitric oxide in the microcirculation
Vaughn, M. W., Kuo, L., & Liao, J. C. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.274.5.h1705 · Cited by 252 · see citing works
CONTROL OF ELECTRON FLUX THROUGH THE RESPIRATORY CHAIN IN MITOCHONDRIA AND CELLS
Brand, M. D., & Murphy, M. P. (1987) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1987.tb01265.x · Cited by 240 · see citing works
Loss and Degradation of Enzyme-bound Heme Induced by Cellular Nitric Oxide Synthesis
Kim, Y., Bergonia, H. A., Müller, C., Pitt, B. R., Watkins, W. D., & Lancaster, J. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.5710 · Cited by 238 · see citing works
Self-citationCocks, T. M., Angus, J. A., Campbell, J. H., et al. (1985) · Journal of Cellular Physiology · doi:10.1002/jcp.1041230304 · Cited by 225 · see citing works
Torres, J., Darley-Usmar, V. M., & Wilson, M. T. (1995) · Biochemical Journal · doi:10.1042/bj3120169 · Cited by 206 · see citing works
Analysis of oxygen transport to tumor tissue by microvascular networks
Secomb, T. W., Hsu, R., Dewhirst, M. W., Klitzman, B. M., & Gross, J. F. (1993) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(93)90070-c · Cited by 204 · see citing works
Diffusion of nitric oxide and scavenging by blood in the vasculature
Butler, A. R., Megson, I. L., & Wright, P. G. R. (1998) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(98)00065-8 · Cited by 199 · see citing works
Vasodilatation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium
Coffman, J. D. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)61768-6 · Cited by 192 · see citing works
Gradients of O2 concentration in hepatocytes.
Jones, D. P., & Mason, H. S. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34627-6 · Cited by 190 · see citing works
Filho, I. P. T., Leunig, M., Yuan, F., Intaglietta, M., & Jain, R. K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2081 · Cited by 189 · see citing works
Gas-Phase Oxidation of Nitric Oxide: Chemical Kinetics and Rate Constant
Tsukahara, H., Ishida, T., & Mayumi, M. (1999) · Nitric Oxide · doi:10.1006/niox.1999.0232 · Cited by 185 · see citing works
Oxygen-Dependent Regulation of Mitochondrial Energy Metabolism by Nitric Oxide
Takehara, Y., Kanno, T., Yoshioka, T., Inoue, M., & Utsumi, K. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.0005 · Cited by 154 · see citing works
Czapski, G., & Goldstein, S. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00081-8 · Cited by 134 · see citing works
Diffusion of free nitric oxide
Lancaster, J. R. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68007-0 · Cited by 118 · see citing works
Self-citationLaycock, S. K., Vogel, T. R., Forfia, P. R., Tuzman, J., Xu, X., Ochoa, M., Thompson, C. I., Nasjletti, A., & Hintze, T. H. (1998) · Circulation Research · doi:10.1161/01.res.82.12.1263 · Cited by 118 · see citing works
Stevens, T. H., Brudvig, G. W., Bocian, D. F., & Chan, N. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.7.3320 · Cited by 112 · see citing works
Oxygen exchange in the microcirculation of hamster retractor muscle
Swain, D. P., & Pittman, R. N. (1989) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1989.256.1.h247 · Cited by 90 · see citing works
Loss of suppression of GSH synthesis at low cell density in primary cultures of rat hepatocytes
Lu, S. C.-L., & Ge, J. L. (1992) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1992.263.6.c1181 · Cited by 69 · see citing works
Cytokine Regulation of iNOS Expression in Human Glial Cells
Lee, S. C., & Brosnan, C. F. (1996) · Methods · doi:10.1006/meth.1996.0075 · Cited by 41 · see citing works
van Rossum, G. D. V. (1972) · Biochemical Journal · doi:10.1042/bj1290427 · Cited by 40 · see citing works
The Physical Properties of Nitric Oxide
Lancaster, J. R. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50014-9 · Cited by 32 · see citing works
Self-citationTissue Oxygenation Modifies Nitric Oxide Bioavailability
Heyman, S. N., Goldfarb, M., Darmon, D., & Brezis, M. (1999) · Microcirculation · doi:10.1111/j.1549-8719.1999.tb00102.x · Cited by 31 · see citing works
Nitric oxide as a regulator of tissue oxygen consumption
Wolin, M. S., Xie, Y.-W., & Hintze, T. H. (1999) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-199901000-00015 · Cited by 30 · see citing works
Bonner, F. T. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68008-2 · Cited by 29 · see citing works
Inoue, M., Nishikawa, M., Kasahara, E., et al. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00068-8 · Cited by 7 · see citing works
Interaction of Nitric Oxide with Iron-Dependent Enzymes
Lancaster, J. R. (1997) · Springer eBooks · doi:10.1007/978-3-662-03503-0_2 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690 · see citing works
Radical-free biology of oxidative stress
Jones, D. P. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00283.2008 · Cited by 1,213 · see citing works
The chemical biology of nitric oxide: Implications in cellular signaling
Thomas, D. D., Ridnour, L. A., Isenberg, J. S., Flores-Santana, W., Switzer, C. H., Donzelli, S., Hussain, P., Vecoli, C., Paolocci, N., Ambs, S., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.020 · Cited by 975 · see citing works
Self-citationNitric oxide in health and disease of the respiratory system
Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G. (2004) · Physiological Reviews · doi:10.1152/physrev.00034.2003 · Cited by 903 · see citing works
Bailey, S. J., Winyard, P., Vanhatalo, A., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Tarr, J., Benjamin, N., & Jones, A. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2009 · Cited by 759 · see citing works
Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans
Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689 · see citing works
Bailey, S. J., Fulford, J., Vanhatalo, A., Winyard, P. G., Blackwell, J. R., DiMenna, F. J., Wilkerson, D. P., Benjamin, N., & Jones, A. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00046.2010 · Cited by 607 · see citing works
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599 · see citing works
Vanhatalo, A., Bailey, S. J., Blackwell, J. R., DiMenna, F. J., Pavey, T. G., Wilkerson, D. P., Benjamin, N., Winyard, P. G., & Jones, A. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00206.2010 · Cited by 529 · see citing works
Mechanistic aspects of the reactions of nitric oxide with transition-metal complexes
Ford, P. C., & Lorkovic, I. M. (2002) · Chemical Reviews · doi:10.1021/cr0000271 · Cited by 525 · see citing works
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401 · see citing works
Espey, M. G. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.554 · Cited by 396 · see citing works
Acute Dietary Nitrate Supplementation Improves Cycling Time Trial Performance
LANSLEY, K. E., WINYARD, P. G., BAILEY, S. J., VANHATALO, A., WILKERSON, D. P., BLACKWELL, J. R., GILCHRIST, M., BENJAMIN, N., & JONES, A. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821597b4 · Cited by 388 · see citing works
What is the real physiological NO concentration in vivo?
Hall, C. N., & Garthwaite, J. (2009) · Nitric Oxide · doi:10.1016/j.niox.2009.07.002 · Cited by 378 · see citing works
Keeley, T. P., & Mann, G. E. (2019) · Physiological Reviews · doi:10.1152/physrev.00041.2017 · Cited by 329 · see citing works
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.11.006 · Cited by 320 · see citing works
Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease
Kenjale, A. A., Ham, K. L., Stabler, T., Robbins, J. L., Johnson, J. L., VanBruggen, M., Privette, G., Yim, E., Kraus, W. E., & Allen, J. D. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00071.2011 · Cited by 316 · see citing works
What Part of NO Don't You Understand? Some Answers to the Cardinal Questions in Nitric Oxide Biology
Hill, B. G., Dranka, B. P., Bailey, S. M., Lancaster, J. R., & Darley-Usmar, V. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.101618 · Cited by 310 · see citing works
Self-citationMitochondria: regulators of signal transduction by reactive oxygen and nitrogen species
Brookes, P. S., Levonen, A.-L., Shiva, S., Sarti, P., & Darley-Usmar, V. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00901-2 · Cited by 298 · see citing works
The functional nitrite reductase activity of the heme-globins
Gladwin, M. T., & Kim-Shapiro, D. B. (2008) · Blood · doi:10.1182/blood-2008-01-115261 · Cited by 293 · see citing works
Thomas, D. D., Espey, M. G., Ridnour, L. A., Hofseth, L. J., Mancardi, D., Harris, C. C., & Wink, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400453101 · Cited by 289 · see citing works
Self-citationRegulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274 · see citing works
“function of NO is to modulate O2 gradients in cells and tissues by regulating hemoglobin action and by inhibiting O2 consumption in respiring mitochondria [81].”
BackgroundMantena, S. K., Vaughn, D. P., Andringa, K. K., Eccleston, H. B., King, A. L., Abrams, G. A., Doeller, J. E., Kraus, D. W., Darley-Usmar, V. M., & Bailey, S. M. (2009) · Biochemical Journal · doi:10.1042/bj20080868 · Cited by 265 · see citing works
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248 · see citing works
Nitric Oxide in Macrophage Immunometabolism: Hiding in Plain Sight
Palmieri, E. M., McGinity, C., Wink, D. A., & McVicar, D. W. (2020) · Metabolites · doi:10.3390/metabo10110429 · Cited by 237 · see citing works
Mason, M. G., Nicholls, P., Wilson, M. T., & Cooper, C. E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506562103 · Cited by 233 · see citing works
Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia
Vanhatalo, A., Fulford, J., Bailey, S. J., Blackwell, J. R., Winyard, P. G., & Jones, A. M. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.216341 · Cited by 233 · see citing works
Patra, B., Peng, C.-C., Liao, W.-H., Lee, C.-H., & Tung, Y.-C. (2016) · Scientific Reports · doi:10.1038/srep21061 · Cited by 215 · see citing works
Joshi, M. S., Ferguson, T. B., Han, T. H., Hyduke, D. R., Liao, J. C., Rassaf, T., Bryan, N., Feelisch, M., & Lancaster, J. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152149699 · Cited by 216 · see citing works
Self-citationNitrite reductase activity of cytochrome c
Basu, S., Azarova, N. A., Font, M. D., King, S. B., Hogg, N., Gladwin, M. T., Shiva, S., & Kim-Shapiro, D. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806934200 · Cited by 214 · see citing works
Dietary Nitrate and Physical Performance
Jones, A. M., Thompson, C., Wylie, L. J., & Vanhatalo, A. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051622 · Cited by 206 · see citing works
Baker, P. R. S., Schopfer, F. J., Sweeney, S., & Freeman, B. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402587101 · Cited by 201 · see citing works
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.001 · Cited by 198 · see citing works
Król, M., & Kepinska, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010056 · Cited by 187 · see citing works
Cooper, C. E., & Giulivi, C. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00310.2006 · Cited by 176 · see citing works
Biological activity of nitric oxide in the plasmatic compartment
Wang, X., Tanus-Santos, J. E., Reiter, C. D., Dejam, A., Shiva, S., Smith, R. D., Hogg, N., & Gladwin, M. T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402201101 · Cited by 164 · see citing works
Hickok, J. R., Sahni, S., Shen, H., Arvind, A., Antoniou, C., Fung, L. W. M., & Thomas, D. D. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.030 · Cited by 155 · see citing works
Self-citationSignaling and stress: The redox landscape in NOS2 biology
Thomas, D. D., Heinecke, J. L., Ridnour, L. A., Cheng, R. Y., Kesarwala, A. H., Switzer, C. H., McVicar, D. W., Roberts, D. D., Glynn, S., Fukuto, J. M., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.002 · Cited by 150 · see citing works
Self-citationJones, A. M. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0036 · Cited by 144 · see citing works
Dietary Nitrate, Nitric Oxide, and Cardiovascular Health
Bondonno, C. P., Croft, K. D., & Hodgson, J. M. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2013.811212 · Cited by 141 · see citing works
Whole Beetroot Consumption Acutely Improves Running Performance
Murphy, M., Eliot, K., Heuertz, R. M., & Weiss, E. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2011.12.002 · Cited by 124 · see citing works
Superoxide fluxes limit nitric oxide-induced signaling
Thomas, D. D., Ridnour, L. A., Espey, M. G., Donzelli, S., Ambs, S., Hussain, S. P., Harris, C. C., DeGraff, W., Roberts, D. D., Mitchell, J. B., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602242200 · Cited by 121 · see citing works
Self-citationShiva, S., Oh, J.-Y., Landar, A. L., Ulasova, E., Venkatraman, A., Bailey, S. M., & Darley-Usmar, V. M. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.037 · Cited by 112 · see citing works
Lim, D. G., Sweeney, S., Bloodsworth, A., White, C. R., Chumley, P. H., Krishna, N. R., Schopfer, F., O'Donnell, V. B., Eiserich, J. P., & Freeman, B. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232409599 · Cited by 110 · see citing works
Hemoglobin-Mediated, Hypoxia-Induced Vasodilation via Nitric Oxide
Robinson, J. M., & Lancaster, J. R. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.f292 · Cited by 104 · see citing works
Self-citationJones, A. M., Wilkerson, D. P., Koppo, K., Wilmshurst, S., & Campbell, I. T. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.045799 · Cited by 94 · see citing works
Thomas, D. D., Miranda, K. M., Colton, C. A., Citrin, D., Espey, M. G., & Wink, D. A. (2003) · Antioxidants & Redox Signaling · doi:10.1089/152308603322110887 · Cited by 89 · see citing works
Self-citationMitochondria as metabolizers and targets of nitrite
Shiva, S. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.09.002 · Cited by 87 · see citing works
Myocardial protection by nitrite
Calvert, J. W., & Lefer, D. J. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp079 · Cited by 82 · see citing works
Bhushan, S., Kondo, K., Polhemus, D. J., Otsuka, H., Nicholson, C. K., Tao, Y.-X., Huang, H., Georgiopoulou, V. V., Murohara, T., Calvert, J. W., et al. (2014) · Circulation Research · doi:10.1161/circresaha.114.301475 · Cited by 69 · see citing works
No Improvement of Repeated-Sprint Performance With Dietary Nitrate
Martin, K., Smee, D., Thompson, K. G., & Rattray, B. (2014) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.2013-0384 · Cited by 58 · see citing works
On the Biologic Role of the Reaction of NO with Oxidized Cytochrome <i>c</i> Oxidase
Antunes, F., Boveris, A., & Cadenas, E. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1677 · Cited by 56 · see citing works
Absence of Nitric-oxide Synthase in Sequentially Purified Rat Liver Mitochondria
Venkatakrishnan, P., Nakayasu, E. S., Almeida, I. C., & Miller, R. T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003301 · Cited by 52 · see citing works
Dolanský, J., Henke, P., Kubát, P., Fraix, A., Sortino, S., & Mosinger, J. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b06233 · Cited by 52 · see citing works
Comparing the chemical biology of NO and HNO
Flores-Santana, W., Switzer, C., Ridnour, L. A., Basudhar, D., Mancardi, D., Donzelli, S., Thomas, D. D., Miranda, K. M., Fukuto, J. M., & Wink, D. A. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-1805-x · Cited by 50 · see citing works
Self-citationOxygen dependence of nitric oxide-mediated signaling
Hickok, J. R., Vasudevan, D., Jablonski, K., & Thomas, D. D. (2013) · Redox Biology · doi:10.1016/j.redox.2012.11.002 · Cited by 47 · see citing works
Self-citationCooper, C. (2003) · IUBMB Life · doi:10.1080/15216540310001628663 · Cited by 46 · see citing works
Bourdillon, N., Fan, J.-L., Uva, B., Müller, H., Meyer, P., & Kayser, B. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00288 · Cited by 44 · see citing works
Vanhatalo, A., Jones, A. M., Blackwell, J. R., Winyard, P. G., & Fulford, J. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00096.2014 · Cited by 39 · see citing works
Yapor, J. P., Lutzke, A., Pegalajar-Jurado, A., Neufeld, B. H., Damodaran, V. B., & Reynolds, M. M. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb01625h · Cited by 18 · see citing works
- Authors
- Thomas, D. D., Liu, X., Kantrow, S. P., & Lancaster, J. R.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-12-26
- Volume
- 98
- Issue
- 1
- Pages
- 355-360
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC14594
- OpenAlex
- W2058062846
- Cited by
- 760
- References
- 43
- Citations by year
- 2026: 21 · 2025: 41 · 2024: 40 · 2023: 28 · 2022: 37 · 2021: 36 · 2020: 35 · 2019: 35 · 2018: 28 · 2017: 25 · 2016: 30 · 2015: 29 · 2014: 31 · 2013: 26 · 2012: 33
- FWCI
- 9.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 46935, R01DK046935)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- nitric oxide, oxygen gradients, tissue oxygenation, liver parenchyma, hepatocytes, mitochondrial oxygen consumption, cellular respiration, oxygen consumption
- MeSH terms
- Animals, Computer Simulation, Diffusion, Endothelium, Vascular, Half-Life, Kinetics, Liver, Nitric Oxide, Oxygen, Oxygen Consumption, Cell Respiration, Hepatocytes, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
